0000950135-07-007087 Sample Contracts

PLEDGE AND SECURITY AGREEMENT dated as of November 16, 2007 Among THE ENTITIES LISTED ON SCHEDULE A HERETO, as Pledgors and THE BANK OF NEW YORK TRUST COMPANY, N.A., as Collateral Agent
Pledge and Security Agreement • November 16th, 2007 • Molecular Insight Pharmaceuticals, Inc. • Pharmaceutical preparations

In consideration of the purchase of the Bonds (as hereinafter defined) issued under the Indenture by and among Molecular Insight Pharmaceuticals, Inc. and The Bank of New York Trust Company, N.A., as Trustee, Molecular Insight Pharmaceuticals, Inc., a Massachusetts corporation and each of the Subsidiary Guarantors party from time to time thereto (each a “Pledgor” and collectively the “Pledgors”) hereby agree with The Bank of New York Trust Company, N.A., as Collateral Agent, as follows (with certain terms used herein being defined in Article 7):

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AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT
Registration Rights Agreement • November 16th, 2007 • Molecular Insight Pharmaceuticals, Inc. • Pharmaceutical preparations • New York

THIS AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT (this “Agreement”) is made as of this 16th day of November, 2007, by and among:

INDENTURE Dated as of November 16, 2007, among MOLECULAR INSIGHT PHARMACEUTICALS, INC., THE GUARANTORS PARTY FROM TIME TO TIME HERETO, as Subsidiary Guarantors, and THE BANK OF NEW YORK TRUST COMPANY, N.A., as Trustee and as Collateral Agent Senior...
Indenture • November 16th, 2007 • Molecular Insight Pharmaceuticals, Inc. • Pharmaceutical preparations • New York

INDENTURE, dated as of November 16, 2007 (this “Indenture”), among MOLECULAR INSIGHT PHARMACEUTICALS, INC., a Massachusetts corporation (the “Company”), the SUBSIDIARY GUARANTORS (as herein defined) party from time to time hereto and THE BANK OF NEW YORK TRUST COMPANY, N.A., a national banking association, as Trustee (in such capacity, the “Trustee”) and Collateral Agent (in such capacity, the “Collateral Agent”).

Warrant No. [___] Dated: November , 2007
Molecular Insight Pharmaceuticals, Inc. • November 16th, 2007 • Pharmaceutical preparations • New York

MOLECULAR INSIGHT PHARMACEUTICALS, INC., a Massachusetts corporation (the “Company”), hereby certifies that, for value received, [ ] or its registered assigns (the “Holder”), is entitled to purchase from the Company up to shares of common stock, $0.01 par value per share (the “Common Stock”), of the Company (each such share, a “Warrant Share” and all such shares, the “Warrant Shares”) at an exercise price equal to $5.87 per share (as adjusted from time to time as provided in Section 9 , the “Exercise Price”), at any time on or after the date hereof (the “Initial Exercise Date”) and through and including the date that is five years from the date of issuance hereof (the “Expiration Date”), and subject to the following terms and conditions including, without limitation, the terms and conditions set forth in Section 4. This Warrant (this “Warrant”) is issued pursuant to that certain Purchase Agreement, dated as of the date hereof, between the Company and the Holder (the “Purchase Agreement

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