0000950103-05-001289 Sample Contracts

AGREEMENT AND PLAN OF MERGER dated as of April 21, 2005 among TRANSKARYOTIC THERAPIES, INC., SHIRE PHARMACEUTICALS GROUP PLC and SPARTA ACQUISITION CORPORATION
Agreement and Plan of Merger • April 25th, 2005 • Shire Pharmaceuticals Group PLC • Pharmaceutical preparations • Delaware

AGREEMENT AND PLAN OF MERGER (this “Agreement”) dated as of April 21, 2005, among Transkaryotic Therapies, Inc., a Delaware corporation (the “Company”), Shire Pharmaceuticals Group plc, a public limited company incorporated under the laws of England and Wales (“Parent”), and Sparta Acquisition Corporation, a Delaware corporation and a wholly-owned subsidiary of Parent (“Merger Subsidiary”).

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EXCLUSIVE LICENSE AGREEMENT
Exclusive License Agreement • April 25th, 2005 • Shire Pharmaceuticals Group PLC • Pharmaceutical preparations • Delaware

THIS EXCLUSIVE LICENSE AGREEMENT (this “Agreement”), effective as of the Effective Date (as defined below) is between Transkaryotic Therapies, Inc., a corporation organized under the laws of the State of Delaware with its principal offices at 700 Main Street, Cambridge, Massachusetts 02139 (“TKT”), and Shire Pharmaceutical Group plc, a public limited company incorporated under the laws of England and Wales (“Shire”). TKT and Shire may be referred to herein individually as a "Party" or collectively as the "Parties".

VOTING AGREEMENT
Voting Agreement • April 25th, 2005 • Shire Pharmaceuticals Group PLC • Pharmaceutical preparations • Delaware

This VOTING AGREEMENT (this “Agreement”), dated as of April 21, 2005, is among Shire Pharmaceuticals Group plc, a public limited company incorporated under the laws of England and Wales (“Parent”), Warburg, Pincus Equity Partners, L.P., a Delaware limited partnership (“WPEP”), Warburg, Pincus Netherlands Equity Partners I, C.V., a Netherlands Commanditaire Vennootschap (“WPNEP I”), Warburg, Pincus Netherlands Equity Partners III, C.V., a Netherlands Commanditaire Vennootschap (“WPNEP III” and together with WPNEP I, collectively the “Netherlands Entities”), and Warburg Pincus & Co., a New York general partnership (“WP&Co.”, WPEP and each of the Netherlands Entities are each referred to herein as a “Stockholder” and collectively as the “Stockholders”).

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