Exhibit 10.125 November 16, 2000 Mr. Bogdan Dziurzynski c/o MedImmune, Inc. 35 W. Watkins Mill Road Gaithersburg, MD 20878 Dear Bob: Reference is made to your Employment Agreement, dated as of November 1, 1998 (the "Employment Agreement"), with...

Exhibit 10.125












                                                     November 16, 2000


Xx. Xxxxxx Xxxxxxxxxxx
c/o MedImmune, Inc.
00 X. Xxxxxxx Xxxx Xxxx
Xxxxxxxxxxxx, XX 00000


Dear Xxx:

                  Reference is made to your Employment Agreement, dated as of November 1, 1998 (the "Employment Agreement"), with
MedImmune, Inc. (the "Company").

                  The Employment Agreement is hereby amended so that the Employment Period referred to in Section 2 thereof is
extended to November 1, 2002.  All other provisions of the Employment Agreement remain unchanged.

                                                     Very truly yours,

                                                     MEDIMMUNE, INC.


                                                     By: /s/ Xxxxx X. Xxxx
                                                            Xxxxx X. Xxxx
                                                            Chief Executive Officer

Accepted and agreed to by:



/s/ Xxxxxx Xxxxxxxxxxx
Xxxxxx Xxxxxxxxxxx

Date:     12/5/00