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EXHIBIT 10.2
YEAST TECHNOLOGY LICENSE AGREEMENT
YEAST TECHNOLOGY LICENSE AGREEMENT (the "Agreement"), dated as of
February 15, 2000, by and between Cadus Pharmaceutical Corporation, a Delaware
corporation with offices at 000 Xxxxx Xxxxxx, Xxx Xxxx, Xxx Xxxx 00000
("CADUS") and OSI Pharmaceuticals, Inc., a Delaware corporation with offices at
000 Xxxxxxx Xxxxxxxxx Xxxxxxxxx, Xxxxxxxxx, Xxx Xxxx 00000 ("OSI").
WITNESSETH:
WHEREAS, CADUS is the owner of, or has acquired the rights to, CADUS
Technology; and
WHEREAS, OSI desires to obtain a non-exclusive license for the use and
practice of CADUS Technology, and CADUS is willing to grant such non-exclusive
license, upon the terms and conditions hereinafter set forth;
NOW, THEREFORE, in consideration of the foregoing recitals and the mutual
covenants and agreements of the Parties contained in this Agreement, the
Parties agree as follows:
1. DEFINITIONS
For the purposes of this Agreement, the following terms shall have the
meanings set forth in this Section 1:
"CADUS Patents" shall mean all patents and patent applications to the
extent they claim CADUS Technology, which are or become owned by CADUS or to
which CADUS otherwise has, now or in the future, the right to grant licenses.
Included within the definition of CADUS Patents are all continuations,
continuations-in-part, divisions, patents of addition, reissues, renewals,
extensions, registrations, confirmations, re-examinations thereof and any
provisional applications.
"CADUS Technology" shall mean all proprietary inventions, improvements,
discoveries, claims, formulae, processes, trade secrets and technologies owned
by CADUS or to which CADUS has the right to grant licenses or sublicenses as of
the Effective Date, relating to technology involving the transfection,
expression and functional coupling of Targets into yeast cells and mammalian
cell lines and the development of such yeast cells and mammalian cell lines as
screening assays for the discovery of human diagnostics and therapeutics.
"CADUS Technology" shall include, without limitation, the bioinformatics
databases owned by CADUS required to fully utilize and develop the CADUS
Technology.
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"Covered Material" means a Hybrid Yeast Cell, a Plasmid, a Mammalian Cell
Line or any material that is a Derivative of it. "Covered Material" includes a
Derivative of a Derivative of a Hybrid Yeast Cell, a Plasmid or a Mammalian
Cell Line.
"Derivative" shall mean any of the following: (1) any substance derived
from or expressed or modified by a Hybrid Yeast Cell, a Plasmid or a Mammalian
Cell Line; (ii) any substance that contains or incorporates a Hybrid Yeast
Cell, a Plasmid or a Mammalian Cell Line; or (iii) any fragment of any of the
foregoing.
"Effective Date" shall mean the date of this Agreement as set forth at
the beginning of this Agreement.
"Hybrid Yeast Cells" shall mean genetically modified yeast cells, which
are owned by CADUS.
"Injunction" shall mean the injunction, dated February 23, 1999, issued
by the United States District Court for the Southern District of California in
the SIBIA Litigation.
"Mammalian Cell Lines" shall mean mammalian cell lines which are owned by
CADUS.
"Party" shall mean CADUS or OSI and, when used in the plural, shall mean
CADUS and OSI.
"Person" shall mean any natural person, corporation, firm, business
trust, joint venture, association, university, organization, company,
partnership or other business entity, or any government or any agency or
political subdivision thereof.
"Plasmid" shall mean plasmids which are owned by CADUS.
"Product" shall mean any compound, formulation or composition whose
utility is identified using CADUS Technology.
"Proprietary" shall mean, with respect to intellectual property,
intellectual property that is (in whole or in part) not in the public domain at
the time of transfer to the other party.
"SIBIA Litigation" shall mean SIBIA Neurosciences, Inc. v. Cadus
Pharmaceutical Corporation, Civil Action Number 961231 lEG POR.
"Target" shall mean any biological molecular entity that provides a
specific interaction with compounds, extracts, broths or other screening
samples.
"Third Party" shall mean any Person who or which is neither a Party nor
an affiliate of a Party.
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2. REPRESENTATIONS AND WARRANTIES
2.1 Representations and Warranties of Both Parties. Each Party
represents and warrants to the other Party that: (i) it is free to enter into
this Agreement; (ii) in so doing, it will not violate any other agreement to
which it is a party; (iii) it has taken all corporate action necessary to
authorize the execution and delivery of this Agreement and the performance of
its obligations under this Agreement; and (iv) this Agreement constitutes a
valid and binding obligation of such Party and is enforceable against it in
accordance with its terms.
2.2 Representations and Warranties of CADUS. CADUS hereby
represents and warrants to OSI that:
(a) It is the owner, or a licensee, of the CADUS
Technology and CADUS Patents and has the right to grant licenses therefor; and
(b) During the term of this Agreement, it shall
maintain its licenses to Cadus Technology licensed to it.
3. GRANT OF LICENSE
3.1 License Grant. Subject to the terms and conditions of this
Agreement, CADUS hereby grants to OSI, a non-exclusive, royalty-free, worldwide
right and license to use and practice the CADUS Technology and CADUS Patents
other than to identify and select compounds in a method that infringes any of
the claims of United States Patent No. 5,401,629 so long as any such claim
remains outstanding and in effect.
3.2 No Violation of Injunction. OSI acknowledges that it has
reviewed the Injunction and covenants that, in practicing the CADUS Technology
and CADUS Patents, OSI
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will not violate the terms of the Injunction or cause CADUS to be in violation
of the terms of the Injunction so long as the Injunction remains outstanding
and in effect.
3.3 No Right to Sublicense. OSI shall not have the right to
sublicense its rights hereunder. During the term of this Agreement, OSI may
practice the CADUS Technology and CADUS Patents in connection with assay
development and screening for Third Parties pursuant to collaborative research
programs with such Third Parties ("Third Party Collaborators"), provided that
such assay development and screening takes place at OSI's facilities and is
conducted by OSI personnel. In addition, a Third Party Collaborator may utilize
assays developed by OSI using CADUS Technology to test compounds solely during
the term and in furtherance of its collaboration with OSI.
3.4 Reservation of Rights. CADUS is retaining all rights to the
CADUS Technology and CADUS Patents that are not specifically being licensed to
OSI pursuant to Section 3.1 hereof.
3.5 Ownership of CADUS Technology. The Parties acknowledge and
agree that all CADUS Technology is now and shall be solely owned or licensed by
CADUS and that OSI shall have no right, title or interest therein except as
explicitly set forth in this Agreement.
3.6 Provision of Access to CADUS Technology. Subject to the
confidentiality provisions of Section 10.1, CADUS shall provide to OSI: (i) an
electronic copy of its database of Covered Material, (ii) an electronic copy of
its database of G protein-coupled receptors that are not proprietary to any
Third Party and (iii) an electronic copy of the bioinformatics databases owned
by CADUS required to fully utilize and develop the CADUS Technology.
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4. ACCESS TO COVERED MATERIAL.
4.1 Access to Covered Material. On or prior to the date hereof,
CADUS has delivered to OSI an aliquot of each Covered Material listed on
Exhibit A annexed hereto. During the term of this Agreement, CADUS shall
provide to OSI an aliquot of each Covered Material not listed on Exhibit A
annexed hereto that is requested by OSI in accordance with the procedure set
forth below. OSI may request a Covered Material by sending to Xx. Xxxxx Xxxxxx
at Department of Molecular Biology, Xxxxx Xxxxxx Laboratory, Xxxxxxxxx
Xxxxxxxxxx, Xxxxxxxxxx Xxxx, Xxxxxxxxx, Xxx Xxxxxx 00000 (or to such other
person at such other place as CADUS may hereafter designate) a written request
for such Covered Material. OSI shall pay to Xx. Xxxxx Xxxxxx or such other
person the incremental cost of retrieval and shipment of such Covered Material
promptly after the receipt of an invoice therefor. CADUS shall ship such
Covered Material to OSI within 15 days of its receipt of such written request.
OSI shall have the right to use Covered Material only during the term of this
Agreement.
4.2 No Transfer of Covered Material. OSI shall not provide any
Covered Material to any Third Party other than a contract research organization
or Third Party Collaborator that has executed a confidentiality agreement with
respect to the Covered Material containing provisions similar to Section 10
hereof. OSI shall promptly destroy all Covered Material in its possession upon
the termination of this Agreement. OSI will not take or send Covered Material
to any location other than the facilities of OSI or a contract research
organization or Third Party Collaborator that has executed a confidentiality
agreement with respect to the Covered Material containing provisions similar to
Section 10 hereof without CADUS's prior written consent.
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4.3 No Warranties As To Covered Material. Any Covered Material
delivered pursuant to this Agreement is understood to be experimental in nature
and may have hazardous properties. It is supplied AS IS. CADUS MAKES NO
REPRESENTATIONS AND EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS OR
IMPLIED. THERE ARE NO EXPRESS OR IMPLIED WARRANTIES OF MERCHANTABILITY OR
FITNESS FOR A PARTICULAR PURPOSE, OR THAT THE USE OF THE COVERED MATERIAL WILL
NOT INFRINGE ANY PATENT, COPYRIGHT, TRADEMARK, OR OTHER PROPRIETARY RIGHTS.
4.4 Compliance with Laws. OSI agrees to use the Covered Material
in compliance with all applicable statutes and regulations including, for
example, those relating to research involving the use of animals or recombinant
DNA.
5. LICENSE AND MAINTENANCE FEES
5.1 License and Access Fees. In consideration of the license
granted to OSI by CADUS pursuant to Section 3.1 hereof, OSI shall pay to CADUS
a license fee of $100,000 payable on the Effective Date. In consideration of
the access to CADUS Technology (Section 3.6) and to Covered Material (Section
4.1), OSI shall pay to CADUS an access fee of $600,000 payable on the Effective
Date.
5.2 Maintenance Fee. OSI shall also pay to CADUS an annual
maintenance fee of $100,000 payable on each of the first ten anniversaries of
the Effective Date during the term of this Agreement.
5.3 Special Fee. If the Injunction is lifted or dissolved, OSI
shall pay to CADUS a supplemental license fee of $250,000 within ten (10) days
after the receipt of notice of the lifting or dissolution of the Injunction.
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5.4 No Refunds. None of the fees paid by OSI to CADUS pursuant to
Section 5 shall be refundable for any reason whatsoever.
6. PATENTS
6.1 No Obligation to Prosecute or Maintain Patents. CADUS shall
not have any obligation to prosecute or maintain CADUS Patents. Notwithstanding
the foregoing, CADUS shall not abandon any of the United States patent
applications constituting CADUS Patents set forth on Exhibit B until such time
as (i) the corresponding foreign patent application has been published or (ii)
CADUS has taken the appropriate steps with the United States Patent and
Trademark Office to dedicate such patent application to the public.
6.2 Infringement. OSI shall give CADUS prompt written notice of
any claim or allegation received by it that the use of CADUS Technology
constitutes an infringement of a Third Party patent or patents. OSI shall have
the primary right to control the defense of any such claim against OSI with
counsel of its own choosing. CADUS agrees to cooperate with OSI, at OSI's
expense, in any reasonable manner deemed by OSI to be necessary in defending
such action. Notwithstanding the foregoing, CADUS shall, in its own discretion
and at its own cost, be entitled to participate through counsel of its own
choosing in any such action.
6.3 Patent Enforcement.
(a) With respect to any alleged infringement
involving a claim(s) of any patents covering CADUS Technology, CADUS shall have
the first right, but not the duty, to institute patent infringement actions
against third parties. If CADUS does not institute an infringement proceeding
against an offending third party, OSI shall have the right, but not the duty,
to institute such an action.
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(b) The costs and expenses of any action instituted
pursuant to this Section 6.3 (including fees of attorneys and other
professionals) shall be borne by the Party instituting the action, or, if the
Parties elect to cooperate in instituting and maintaining such action, such
costs and expenses shall be borne by the Parties in such proportions as they
may agree in writing. Each Party shall execute all necessary and proper
documents and take such actions as shall be appropriate to allow the other
Party to institute and prosecute such infringement actions (if such other Party
has the right to institute and prosecute such infringement actions pursuant to
this Section 6.3). Any award paid by Third Parties as a result of such an
infringement action (whether by way of settlement or otherwise) shall be paid
to the Party who instituted and maintained such action, or, if both Parties
instituted and maintained such action, such award shall be allocated among the
Parties in proportion to their respective contributions to the costs and
expenses incurred in such action, or as they may have otherwise agreed.
Notwithstanding the above, CADUS shall receive 25% of any such award by way of
settlement or otherwise after deducting legal and other reasonable expenses.
7. TERM AND TERMINATION
7.1 Term. This Agreement shall become effective as of the
Effective Date and shall remain in full force and effect until terminated as
provided in this Section 7.
7.2 Termination by OSI. OSI may terminate this Agreement at any
time by giving CADUS thirty (30) days prior written notice of termination.
7.3 Termination for Breach. Failure by either Party to comply
with any of the obligations contained in this Agreement shall entitle the other
Party to give to the defaulting Party notice specifying the nature of the
default and requiring it to cure such default. If such default is not cured
within 30 days after the receipt of such notice, the notifying Party shall be
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entitled, without prejudice to any of its other rights conferred on it by this
Agreement, in addition to any other remedies available to it by law or in
equity, to terminate this Agreement by giving written notice to take effect
immediately upon delivery of such notice. The right of either Party to
terminate this Agreement shall not be affected in any way by its waiver or
failure to take action with respect to any previous default.
7.4 Termination for Bankruptcy. CADUS may terminate this
Agreement if, at any time, OSI shall file in any court or agency pursuant to
any statute or regulation of any state or country, a petition in bankruptcy or
insolvency or for reorganization or for an arrangement or for the appointment
of a receiver or trustee of OSI or of its assets, or if OSI proposes a written
agreement of composition or extension of its debts, or if OSI shall be served
with an involuntary petition against it, filed in any insolvency proceeding,
and such petition shall not be dismissed within sixty (60) days after the
filing thereof, or if OSI shall propose or be a party to any dissolution or
liquidation, or if OSI shall make an assignment for the benefit of creditors.
7.5 No Termination in Event of CADUS Bankruptcy. CADUS and OSI
acknowledge that this Agreement and the license granted herein comes within
Section 365(n) of Xxxxx 00, Xxxxxx Xxxxxx Code (the "Bankruptcy Code"). CADUS
acknowledges that if CADUS, as a debtor in possession, or a trustee in
bankruptcy in a case under the Bankruptcy Code, rejects the Purchase Agreement
or this Agreement, OSI may elect to retain its rights under this Agreement as
provided in Section 365(n) of the Bankruptcy Code. Upon written request of OSI
to CADUS or the bankruptcy trustee, CADUS shall not interfere with the rights
of OSI as provided in this Agreement.
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7.6 Survival of Certain Provisions. The following provisions of
this Agreement will survive the termination of this Agreement: Sections 2.1,
3.5, 4.2, 4.3, 4.4, 8, 9, 10 and 11.
8. DISPUTE RESOLUTION
8.1 Dispute Resolution. If one of the Parties hereto declares
that a dispute between the Parties has arisen related to this Agreement, such
dispute shall, in the first instance, be the subject of good faith negotiations
between the Parties to resolve such dispute. Should the negotiations not lead
to a settlement of the dispute within thirty (30) days of the date of the
meeting, the Parties shall refer the dispute to a mutually acceptable mediation
service to resolve the dispute. The mediation shall be attended by individuals
from within each Party who have decision-making authority with respect to the
matter in question. If the mediation does not lead to a settlement of the
dispute within thirty (30) days of the date of the meeting, then the Parties
shall submit the issue to arbitration before a panel of arbitrators under the
commercial rules of the American Arbitration Association. Unless the Parties
otherwise agree, the arbitration will be held in New York, New York. The panel
of arbitrators shall consist of three parties: one selected by each Party, as
well as a disinterested third party that the two arbitrators shall name. The
third arbitrator shall be a person who has had experience in the business of
biotechnology licensing. If a qualified person in this field cannot be found
and agreed upon, the two arbitrators shall use their own discretion and select
a third arbitrator with qualifications as they deem appropriate. The three
arbitrators shall be given full power to hear and finally determine and dispose
of all disputes between the parties that may arise from or that are related to
this Agreement. The arbitrator will make their ruling in writing no later than
thirty (30) days after the hearing. The decision of two of the three
arbitrators will be binding
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on the Parties. No Party has a right to appeal the ruling, to any court or
otherwise. Judgment upon the decision rendered may be entered in any court
having jurisdiction or application may be made to such court of a judicial
acceptance of the award and an order of enforcement, as the case may be. Each
Party shall pay its own attorney's fees. All fees and expenses payable with
respect to the mediation and arbitration proceedings shall be shared by both
Parties during the course of the mediation and arbitration proceedings, but, in
the case of arbitration, shall be reimbursed in favor of the prevailing Party
after the arbitration ruling is rendered. Notwithstanding this Section 8.1,
CADUS shall have the right to seek injunctive relief pursuant to Section 11.12
hereof.
9. INDEMNITY. INSURANCE AND REPRESENTATIONS
9.1 Indemnity. OSI agrees to indemnify, hold harmless and defend
CADUS, its directors, officers, employees and agents against any and all
claims, suits, losses, damages, costs, fees and expenses, including attorney
fees, resulting from or arising out of the exercise of this license, including
from OSI's use, storage or disposal of the Covered Material or manufacture,
distribution or sale or Product(s), unless such losses, damages, costs, fees
and expenses arise from the use of CADUS Technology constituting an
infringement of a Third Party patent or patents. CADUS shall not be responsible
for the negligence or intentional wrongdoing of OSI.
9.2 Insurance. At the time of its sale of Product(s), OSI shall
maintain in force at its sole cost and expense, with reputable insurance
companies, general liability insurance and products liability insurance
coverage that names CADUS as a beneficiary and protects against liability under
Section 9.1 above in such amount as is customary in the
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industry. CADUS shall have the right to ascertain from time to time that such
coverage exists, such right to be exercised in a reasonable manner.
9.3 Warranties and Representations. Nothing in this Agreement
shall be deemed to be a representation or warranty by CADUS of the validity of
any of the CADUS Patents or the accuracy, safety, efficacy or usefulness for
any purpose of any technology licensed hereunder. CADUS shall have no
obligation, express or implied, to supervise, monitor, review or otherwise
assume responsibility for the production, manufacture, testing, marketing or
sale of any Product(s), and CADUS shall have no liability whatsoever to OSI or
any Third Parties for or on account of any injury, loss or damage, of any kind
or nature, sustained by, or any damage assessed or asserted against, or any
other liability incurred by or imposed upon OSI, its affiliates or
sublicensees, or any other person or entity arising out of or in connection
with or resulting from: (i) the production, use or sale of any Product(s); (ii)
the use of any CADUS Technology; or (iii) any advertising or other promotional
activities with respect to any of the foregoing.
10. CONFIDENTIALITY
10.1 CADUS Technology. All CADUS Technology and Covered Material
that is disclosed or provided to OSI shall be maintained by OSI in confidence
and shall not be disclosed to any other person, firm or agency, governmental or
private, or used for purposes other than those set forth in this Agreement,
without the prior written consent of CADUS, except to the extent that such
information:
(i) is known at the time of its receipt by OSI as
documented by written records dated prior to such disclosure;
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(ii) is in the public domain other than through the
fault of OSI;
(iii) is subsequently disclosed to OSI by a Third
Party who may lawfully do so and who is not under an obligation of
confidentiality to CADUS; or
(iv) is required to be disclosed in a judicial or
administrative proceeding after legal remedies for maintaining the subject
matter in confidence have been exhausted.
10.2 Duration of Confidentiality Obligation. OSI's obligations of
confidentiality shall continue during the term of this Agreement and for a
period of five years thereafter.
11. MISCELLANEOUS
11.1 Relationship of Parties. Nothing in this Agreement is
intended or shall be deemed to constitute a partnership, agency,
employer-employee or joint venture relationship between the Parties. No Party
shall incur any debts or make any commitments for the other.
11.2 Assignment. Neither Party shall be entitled to assign its
rights or transfer its obligations hereunder without the express written
consent of the other Party hereto, except that CADUS may assign its rights and
transfer its obligations hereunder to a purchaser of CADUS Technology and OSI
may assign its rights and transfer its obligations hereunder to any assignee of
all or substantially all of its assets. No assignment and transfer shall be
valid and effective unless and until the assignee/transferee shall agree in
writing to be bound by the provisions of this Agreement.
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11.3 Further Actions. Each Party agrees to execute, acknowledge
and deliver such further instruments, and to do all such other acts, as may be
necessary or appropriate in order to carry out the purposes and intent of this
Agreement.
11.4 Notice. Any notice or request required or permitted to be
given under or in connection with this Agreement (other than requests pursuant
to Section 4.1 hereof) shall be deemed to have been sufficiently given in
writing and personally delivered or sent by registered or certified mail
(return receipt requested), facsimile transmission (receipt verified), express
courier service (signature required), or telegram, prepaid, to the Party for
which such notice is intended, at the address set forth for such Party below:
(a) In the case of OSI, to:
OSI Pharmaceuticals, Inc.
000 Xxxxxxx Xxxxxxxxx Xxxxxxxxx
Xxxxxxxxx, Xxx Xxxx 00000
Attention: President
Facsimile No.: (000) 000-0000
with a copy to:
Squadron, Ellenoff, Plesent & Xxxxxxxxx, LLP
000 Xxxxx Xxxxxx Xxx Xxxx, Xxx Xxxx 00000
Attention: Xxxx X. Xxxxxxxx, Esq.
Facsimile No.: (000) 000-0000
(b) In the case of CADUS, to:
Cadus Pharmaceutical Corporation
000 Xxxxx Xxxxxx
Xxx Xxxx, Xxx Xxxx 00000
Attention: President
Facsimile No.: (000) 000-0000
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With a copy to:
Xxxxxxxx Xxxxx Singer & Xxxxxxxxx, LLP
000 Xxxxxxxxx Xxxxxx
Xxx Xxxx, Xxx Xxxx 00000
Attention: Xxxxxxx X. Xxxxxxx, Esq.
Facsimile No.: (000) 000-0000
or to such other address for such Party as it shall have specified by like
notice to the other Party, provided that notices of a change of address shall be
effective only upon receipt thereof. If sent by mail, facsimile transmission,
express courier service, or telegram, the date of mailing or transmission shall
be deemed to be the date on which such notice or request has been given.
11.5 Use of Name. Except as otherwise provided herein, neither
Party shall have any right, express or implied, to use in any manner the name
or other designation of the other Party or any other trade name or trademark of
the other Party for any purpose in connection with the performance of this
Agreement.
11.6 Waiver. A waiver by either Party of any of the terms and
conditions of this Agreement in any instance shall not be deemed or construed
to be a waiver of such term or condition for the future, or of any subsequent
breach hereof. All rights, remedies, undertakings, obligations and agreements
contained in this Agreement shall be cumulative and none of them shall be in
limitation of any other remedy, right, undertaking, obligation or agreement of
either Party.
11.7 Export Control Laws. OSI agrees to abide by all laws and
regulations of the United States controlling the export of technical data,
computer software, biological materials, laboratory prototypes and other
commodities and technology.
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11.8 Severability. When possible, each provision of this
Agreement will be interpreted in such manner as to be effective and valid under
applicable law, but if any provision of this Agreement is held to be prohibited
by or invalid under applicable law, such provision will be ineffective only to
the extent of such prohibition or invalidity, without invalidating the
remainder of this Agreement, and the Parties shall negotiate in good faith to
modify this Agreement to preserve (to the extent possible) their original
intent.
11.9 Amendment. No amendment, modification or supplement of any
provisions of this Agreement shall be valid or effective unless made in writing
and signed by a duly authorized officer of each Party.
11.10 Governing Law. This Agreement shall be governed by, and
construed and enforced in accordance with, the laws of the State of New York,
without regard to its choice of law principles.
11.11 Entire Agreement. This Agreement sets forth the entire
agreement and understanding between the Parties as to the subject matter hereof
and supercedes any previous agreements and understandings between the Parties
with respect to the subject matter hereof including without limitation the
Technology License Agreement between the Parties dated as of July 30, 1999.
11.12 Injunctive Relief. OSI acknowledges that, in the event of
its breach or threatened breach of any of the provisions of this Agreement,
CADUS would sustain great and irreparable injury and damage. Therefore, in
addition to any other remedies which CADUS may have under this Agreement or
otherwise, CADUS shall be entitled to an injunction issued by any court of
competent jurisdiction restraining such breach or threatened breach. This
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Section 11.12 shall not, however, be construed as a waiver of any of the rights
which CADUS may have for damages or otherwise.
11.13 Counterparts. This Agreement may be executed simultaneously
in any number of counterparts, any one of which need not contain the signature
of more than one Party but all such counterparts taken together shall
constitute one and the same agreement.
11.14 Descriptive Headings. The descriptive headings of this
Agreement are for convenience only and shall be of no force or effect in
construing or interpreting any of the provisions of this Agreement.
IN WITNESS WHEREOF, each of the Parties has caused this Agreement
to be executed by its duly authorized officer as of the date first above
written.
CADUS PHARMACEUTICAL CORPORATION
By: /s/ Xxxxxxx Woler
-----------------------------
Xxxxxxx Woler, President
OSI PHARMACEUTICALS, INC.
By: /s/ Xxxxx Xxxxxxx
-----------------------------
Xxxxx Xxxxxxx, President
and Chief Executive Officer
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EXHIBIT A
--------------------------------------------------------------------------------------------------------------------------
STRAIN_ID MATINGTYPE GENOTYPENEW P1NAME P2NAME P3NAME
--------------------------------------------------------------------------------------------------------------------------
1141 @ FUS1p-HIS3 can1 far1*1442 gpa1(41)-G@i2 his3 leu2 lys2
ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
1316 @ FUS1p-HIS3 can1 far1*1442 gpa1*1163 his3 leu2 lys2
ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
1455 a FUS1p-HIS3 bar1::hisG far1-1 his3 leu2 ste14::TRP1
tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
1892 a FUS1p-HIS3 bar1::hisG his3 leu2 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
4600 @ FUS1p-HIS3 can1 far1*1442 gpa1*1163 his3 leu2 lys2
ste14::trp1::LYS2 ste3*1156 ste4*2393 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
6259 a FUS1p-HIS3 bar1::hisG far1-1 his3 leu2 lys2
ste14::trp1::LYS2 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
6492 a FUS1p-HIS3 bar1::hisG far1*1442 his3 leu2 tbt1-1 trp1
ura3
--------------------------------------------------------------------------------------------------------------------------
6550 @ FUS1p-HIS3 can1 far1*1442 gpa1*1163 his3 leu2 lys2
npr2::nFUS1p-CAN1 ste14::trp1::LYS2 ste3*1156 tbt1-1
trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
7967 @ FUS1p-HIS3 can1 far1*1442 gpa1(41)-G@i3 his3 leu2 lys2
ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
8342 @ FUS1p-HIS3 can1 far1*1442 gpa1p-rG@sE10K his3 leu2 lys2
ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
8344 @ FUS1p-HIS3 can1 far1*1442 gpa1p-rG@sE10K;D229S his3 leu2
lys2 ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
A-1
19
--------------------------------------------------------------------------------------------------------------------------
STRAIN_ID MATINGTYPE GENOTYPENEW P1NAME P2NAME P3NAME
--------------------------------------------------------------------------------------------------------------------------
8350 @ FUS1p-HIS3 can1 far1*1442 gpa1p-rG@sD229S his3 leu2 lys2
ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
8362 @ FUS1p-HIS3 can1 far1*1442 gpa1p-rG@sE10K his3 leu2 lys2 CP1584 CP1766
ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
8719 @ FUS1p-HIS3 ade2*3447 ade8*3457 can1 far1*1442
gpa1(41)-G@i2 his3 leu2 lys2 ste14::trp1::LYS2 ste3*1156
tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
9034 @ FUS1p-HIS3 can1 far1*1442 gpa1(41)-G@16(S270P) his3 leu2
lys2 ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
9434 @ FUS1p-HIS3 can1 cyh2 far1*1442 gpa1(41)-G@i2 his3 leu2
lys2 ste14::trp1::LYS2 ste18g6-3841 ste3*1156 tbt1-1
trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
9438 @ FUS1p-HIS3 can1 far1*1442 gpa1*1163 his3 leu2 lys2
ste14::trp1::LYS2 ste18g6-3841 ste3*1156 tbt1-1 trp1
ura3
--------------------------------------------------------------------------------------------------------------------------
9571 @ FUS1p-HIS3 GPA1-3907 can1 far1*1442 his3 leu2 lys2
ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
9595 @ FUS1p-HIS3 can1 far1*1442 gpa1(41)-G@i2 his3 lys2 CP1584 CP3776
ste14::trp1::LYS2 ste3*1156 xxx0-0 xxx0
--------------------------------------------------------------------------------------------------------------------------
9603 @ D314) FUS1p-HIS3 L291, can1 far1*1442
gpa1(41)-G@16(S270P, his3 leu2 lys2 ste14::trp1::LYS2
ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
9664 a FUS1p-HIS3 can1 far1*1442 gpa1*1163 his3 leu2 lys2
ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
9791 @ FUS1p-HIS3 ade2*3447 ade8*3457 can1 far1*1442 gpa1*1163
his3 leu2 lys2 ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1
ura3
--------------------------------------------------------------------------------------------------------------------------
A-2
20
--------------------------------------------------------------------------------------------------------------------------
STRAIN_ID MATINGTYPE GENOTYPENEW P1NAME P2NAME P3NAME
--------------------------------------------------------------------------------------------------------------------------
9805 @ FUS1p-HIS3 can1 far1*1442 gpa1*1163 his3 leu2 lys2 CP3390 CP4110
ste14::trp1::LYS2 ste18g6-3841 ste3*1156 tbt1-1 trp1
ura3
--------------------------------------------------------------------------------------------------------------------------
9863 @ FUS1p-HIS3 ade2*3447ade8*3457 can1 far1*1442
gpa1(41)-G@16(S270P) his3 leu2 lys2 ste14::trp1::LYS2
ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
9875 @ FUS1p-HIS3 ade2*3447 ade8*3457 can1 far1*1442
gpa1p-rG@sE10K his3 leu2 lys2 ste14::trp1::LYS2
ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
9881 @ FUS1p-HIS3 can1 far1*1442 gpa1*1163 his3 leu2 lys2 CP1947 CP3390 CP4110
ste14::trp1::LYS2 ste18g6-3841 ste3*1156 tbt1-1 trp1
ura3
--------------------------------------------------------------------------------------------------------------------------
10091 @ FUS1p-HIS3 ade2*3447 ade8*3457 can1 far1*1442 gpa1*1163
his3 leu2 lys2 ste14::trp1::LYS2 ste18g6-3841 ste3*1156
tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
10097 trp1-289
--------------------------------------------------------------------------------------------------------------------------
10098 gal4
--------------------------------------------------------------------------------------------------------------------------
10099 ade
--------------------------------------------------------------------------------------------------------------------------
10100 leu
--------------------------------------------------------------------------------------------------------------------------
10101 lys
--------------------------------------------------------------------------------------------------------------------------
10103 @ FUS1p-HIS3 ade2*3447 ade8*3457 can1 cyh2 far1*1442
gpa1(41)-G@i2 his3 leu2 lys2 ste14::trp1::LYS2
ste18g6-3841 ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
A-3
21
--------------------------------------------------------------------------------------------------------------------------
STRAIN_ID MATINGTYPE XXXXXXXXXXX X0XXXX X0XXXX X0XXXX
--------------------------------------------------------------------------------------------------------------------------
10106 @ FUS1p-HIS3 ade2*3447 ade8*3457 can1 far1*1442
gpa1p-rG@sE10K;D229S his3 leu2 lys2 ste14::trp1::LYS2
ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
10131 @ FUS1p-HIS3 GPA1-3907 ade2*3447 ade8*3457 can1 far1*1442
his3 leu2 lys2 ste14::trp1::LYS2 ste18g6-3841 ste3*1156
tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
10132 @ FUS1p-HIS3 ade2*3447 ade8*3457 can1 far1*1442
gpa1(41)-G@16(S270P) his3 leu2 lys2 ste14::trp1::LYS2
ste18g6-3841 ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
10151 @ FUS1p-HIS3 GPA1p-G@sD229S ade2*3447 ade8*3457 can1
far1*1442 his3 leu2 lys2 ste14::trp1::LYS2 ste18g6-3841
ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
10175 @ FUS1p-HIS3 ade2*3447 ade8*3457 can1 far1*1442
gpa1p-rG@sD229S his3 leu2 lys2 ste14::trp1::LYS2
ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
10199 ura
--------------------------------------------------------------------------------------------------------------------------
10319 @ FUS1p-HIS3 ade2*3447 ade8*3457 can1 far1*1442
gpa1(41)-G@i3 his3 leu2 lys2 ste14::trp1::LYS2
ste18g6-3841 ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
10519 @ FUS1p-HIS3 GPA1p-G@sE10K ade2*3447 ade8*3457 can1
far1*1442 his3 leu2 lys2 ste14::trp1::LYS2 ste18g6-3841
ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
10560 @ FUS1p-HIS3 GPA1-3907 ade2*3447 ade8*3457 can1 far1*1442
his3 leu2 lys2 sst2*1056 ste14::trp1::LYS2 ste18g6-3841
ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
10562 @ FUS1p-HIS3 S270P can1 far1*1442 gpa1(41)-G@16 his3 leu2
lys2 ste14::trp1::LYS2 ste18g6-3841 ste3*1156 tbt1-1
trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
10565 @ FUS1p-HIS3 GPA1p-G@sD229S can1 far1*1442 his3 leu2 lys2
ste14::trp1::LYS2 ste18g6-3841 ste3*1156 tbt1-1 trp1
ura3
--------------------------------------------------------------------------------------------------------------------------
A-4
22
--------------------------------------------------------------------------------------------------------------------------
STRAIN_ID MATINGTYPE XXXXXXXXXXX X0XXXX X0XXXX X0XXXX
--------------------------------------------------------------------------------------------------------------------------
10652 @ FUS1p-HIS3 GPA1p-ratG@i1 ade2*3447 ade8*3457 can1
far1*1442 his3 leu2 lys2 ste14::trp1::LYS2 ste18g6-3841
ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
10734 a FUS1p-HIS3 can1 far1*1442 gpa1*1163 his3 leu2 lys2
ste14::trp1::LYS2 ste2* ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
10771 a ade1 cdc24-1 his2 leu2 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
10772 a ade1 cdc42-1 his2 leu2 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
10942 @ FUS1p-HIS3 can1 far1*1442 gpa1*1163 his3 leu2 lys2
ste14::trp1::LYS2 ste18g601-4060 ste3*1156 tbt1-1 trp1
ura3
--------------------------------------------------------------------------------------------------------------------------
10981 @ FUS1p-HIS3 GPA1-3907 can1 far1*1442 his3 leu2 lys2
sst2*2 ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
11063 @ FUS1p-HIS3 GPA1p-G@sE10K can1 far1*1442 his3 leu2 lys2
ste14::trp1::LYS2 ste18g6-3841 ste3*1156 tbt1-1 trp1
ura3
--------------------------------------------------------------------------------------------------------------------------
11066 @ FUS1p-HIS3 GPA1p-G@sE10K;D229S ade2*3447 ade8*3457 can1
far1*1442 his3 leu2 lys2 ste14::trp1::LYS2 ste18g6-3841
ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
11067 @ FUS1p-HIS3 GPA1p-G@sE10K;D229S can1 far1*1442 his3 leu2
lys2 ste14::trp1::LYS2 ste18g6-3841 ste3*1156 tbt1-1
trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
11366 a FUS1p-HIS3 GPA1-3907 can1 far1*1442 his3 leu2 lys2
ste14::trp1::LYS2 ste2* ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
11368 a FUS1p-HIS3 can1 far1*1442 gpa1p-G@sD229S his3 leu2 lys2
ste14::trp1::LYS2 ste2* ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
A-5
23
--------------------------------------------------------------------------------------------------------------------------
STRAIN_ID MATINGTYPE XXXXXXXXXXX X0XXXX X0XXXX X0XXXX
--------------------------------------------------------------------------------------------------------------------------
11647 a FUS1p-HIS3 can1 far1*1442 gpa1(41)-G@i2 his3 leu2 lys2
ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
11714 @ FUS1p-HIS3 can1 far1*1442 gpa1p-rG@sG226A his3 leu2 lys2
ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
11715 @ FUS1p-HIS3 can1 far1*1442 gpa1p-rG@sQ227L his3 leu2 lys2
ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
11777 @ FUS1p-HIS3 can1 far1*1442 gpa1*1163 his3 leu2 lys2 CP1947 CP3390 CP4421
ste14::trp1::LYS2 ste18g601-4060 ste3*1156 tbt1-1 trp1
ura3
--------------------------------------------------------------------------------------------------------------------------
11778 @ FUS1p-HIS3 can1 far1*1442 gpa1*1163 his3 leu2 lys2 CP1179 CP1947 CP4261
sst2*2 ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
11845 @ FUS1p-HIS3 ade2*3447 ade8*3457 can1 far1*1442 gpa1*1163
his3 leu2 lys2 sst2*1056 ste14::trp1::LYS2 ste18g6-3841
ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
12025 @ FUS1p-HIS3 GPA1p-G@sD229S can1 far1*1442 leu2 lys2
ste14::trp1::LYS2 ste3*1156 stp22::TRP1ste18g6-3841
tbt1-1 trp1his3ade2*3447ade8*3457 ura3
--------------------------------------------------------------------------------------------------------------------------
12201 @ FUS1p-HIS3 can1 far1*1442 gpa1*1163 his3 leu2 lys2
ste14::trp1::LYS2 ste18g6-3841 ste3*1156 stp22::hisG
tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
12220 a FUS1p-HIS3 can1 far1*1442 gpa1(41)-G@i2 his3 leu2 lys2
ste14::trp1::LYS2 ste2*1154 ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
12357 @ FUS1p-HIS3 GPA1-3907 can1 far1*1442 his3 leu2 lys2
sst2*2 ste14::trp1::LYS2 ste3*1156 stp22::hisG tbt1-1
trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
12444 @ FUS1p-HIS3 can1 far1*1442 gpa1*1163 his3 leu2 lys2
ste14::trp1::LYS2 ste3*1156 ste5 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
A-6
24
--------------------------------------------------------------------------------------------------------------------------
STRAIN_ID MATINGTYPE XXXXXXXXXXX X0XXXX X0XXXX X0XXXX
--------------------------------------------------------------------------------------------------------------------------
12660 @ FUS1p-HIS3 can1 far1*1442 gpa1(41)-G@i3 his3 leu2 lys2 CP1584 CP5095
ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
12670 @ FUS1p-HIS3 GPA1p-G@sN254D can1 far1*1442 his3 leu2 lys2
ste14::trp1::LYS2 ste18g6-3841 ste3*1156 tbt1-1 trp1
ura3
--------------------------------------------------------------------------------------------------------------------------
12872 @ FUS1p-HIS3 can1 far1*1442 gpa1(41)-G@i2A235T his3 leu2
lys2 ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
12946 @ FUS1p-HIS3 GPA1G@i2(5) can1 far1*1442 his3 leu2 lys2
sst2*2 ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
12949 @ FUS1p-HIS3 GPA1-G@12(5) can1 far1*1442 his3 leu2 lys2
sst2*2 ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
12950 @ FUS1p-HIS3 GPA1-G@q(5) can1 far1*1442 his3 leu2 lys2
sst2*2 ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
12952 @ FUS1p-HIS3 GPA1-G@s(5) can1 far1*1442 his3 leu2 lys2
sst2*2 ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
12954 @ FUS1p-HIS3 can1 far1*1442 gpa1*1163 his3 leu2 lys2
sst2*2 ste14::trp1::LYS2 ste18*2377 ste3*1156 tbt1-1
trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
12970 @ FUS1p-HIS3 can1 far1*1442 gpa1*1163 his3 leu2 lys2
ste14::trp1::LYS2 ste20::KanR ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
12971 @ FUS1p-HIS3 can1 far1*1442 gpa1*1163 his3 leu2 lys2
ste14::trp1::LYS2 ste20::KanR ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
13189 @ FUS1p-HIS3 can1 far1*1442 gpa1*1163 his3 leu2 lys2 CP1947 CP3390 CP5116
ste14::trp1::LYS2 ste18g6-3841 ste3*1156 tbt1-1 trp1
ura3
--------------------------------------------------------------------------------------------------------------------------
A-7
25
--------------------------------------------------------------------------------------------------------------------------
STRAIN_ID MATINGTYPE XXXXXXXXXXX X0XXXX X0XXXX X0XXXX
--------------------------------------------------------------------------------------------------------------------------
13193 @ FUS1p-HIS3 can1 far1*1442 gpa1*1163 his3 leu2 lys2
sst2*2 ste14::trp1::LYS2 ste18g6-3841 ste3*1156 tbt1-1
trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
13385 @ FUS1p-HIS3 GPA1G@i2(5) ade2*3447 ade8*3457 can1
far1*1442 his3 leu2 lys2 sst2*1056 ste14::trp1::LYS2
ste18g6-3841 ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
13387 @ FUS1p-HIS3 GPA1G@12(5) ade2*3447 ade8*3457 can1
far1*1442 his3 leu2 lys2 sst2*1056 ste14::trp1::LYS2
ste18g6-3841 ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
13389 @ FUS1p-HIS3 GPA1G@q(5) ade2*3447 ade8*3457 can1 far1*1442
his3 leu2 lys2 sst2*1056 ste14::trp1::LYS2 ste18g6-3841
ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
13391 @ FUS1p-HIS3 GPA1G@s(5) ade2*3447 ade8*3457 can1 far1*1442
his3 leu2 lys2 sst2*1056 ste14::trp1::LYS2 ste18g6-3841
ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
13393 @ FUS1p-HIS3 GPA1G@i2(5) can1 far1*1442 his3 leu2 lys2
sst2*2 ste14::trp1::LYS2 ste18g6-3841 ste3*1156 tbt1-1
trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
13395 @ FUS1p-HIS3 GPA1G@12(5) can1 far1*1442 his3 leu2 lys2
sst2*2 ste14::trp1::LYS2 ste18g6-3841 ste3*1156 tbt1-1
trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
13397 @ FUS1p-HIS3 GPA1G@q(5) can1 far1*1442 his3 leu2 lys2
sst2*2 ste14::trp1::LYS2 ste18g6-3841 ste3*1156 tbt1-1
trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
13399 @ FUS1p-HIS3 GPA1G@s(5) can1 far1*1442 his3 leu2 lys2
sst2*2 ste14::trp1::LYS2 ste18g6-3841 ste3*1156 tbt1-1
trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
13771 @ FUS1p-HIS3 can1 far1*1442 gpa1(41)-G@16 his3 leu2 lys2
ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
13934 @ FUS1p-HIS3 can1 far1*1442 gpa1*1163 his3 leu2 lys2 CP1947 CP4259 CP5298
ste14::trp1::LYS2 ste18g6-3841 ste3*1156 tbt1-1 trp1
ura3
A-8
26
--------------------------------------------------------------------------------------------------------------------------
STRAIN_ID MATINGTYPE GENOTYPENEW P1NAME P2NAME P3NAME
--------------------------------------------------------------------------------------------------------------------------
--------------------------------------------------------------------------------------------------------------------------
13937 @ FUS1p-HIS3 can1 cyh2 far1*1442 gpa1(41)-G@i2 his3 leu2
lys2 ste14::trp1::LYS2 ste18g26-5261 ste3*1156 tbt1-1
trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
13947 @ FUS1p-HIS3 STE18g26-5363 can1 far1*1442 gpa1*1163 his3
leu2 lys2 ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
14011 @ FUS1p-HIS3 GPA1p-G@sE10K can1 far1*1442 his3 leu2 lys2 CP1584 CP5396
ste14::trp1::LYS2 ste18g6-3841 ste3*1156 tbt1-1 trp1
ura3
--------------------------------------------------------------------------------------------------------------------------
14012 @ FUS1p-HIS3 GPA1p-G@sD229S can1 far1*1442 leu2 lys2 CP1947 CP5394
ste14::trp1::LYS2 ste3*1156 stp22::TRP1ste18g6-3841
tbt1-1 trp1his3ade2*3447ade8*3457 ura3
--------------------------------------------------------------------------------------------------------------------------
14016 @ FUS1p-HIS3 can1 far1*1442 gpa1::klURA3 his3 leu2 lys2
sst2*2 ste14::trp1::LYS2 ste18g6-3841 ste3*1156 tbt1-1
trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
14078 @ FUS1p-HIS3 ade2*3447 ade8*3457 can1 cyh2 far1*1442
gpa1(41)-G@i2 his3 leu2 lys2 ste14::trp1::LYS2
ste18g6-3841 ste3*1156 ste5*4276 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
14637 @ E10K FUS1p-HIS3 GPA1p-G@s can1 far1*1442 his3 leu2 lys2
pho3*4602 pho4::KAN ste14::trp1::LYS2 ste3*1156 tbt1-1
trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
14638 @ E10K;A249T FUS1p-HIS3 GPA1p-G@s can1 cyh2 far1*1442 his3
leu2 lys2 ste14::trp1::LYS2 ste18g6-3841 ste3*1156
tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
14640 @ FUS1p-HIS3 GPA1p-GPA1-G@z(5) can1 cyh2 far1*1442 his3
leu2 lys2 ste14::trp1::LYS2 ste18g6-3841 ste3*1156
tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
14706 @ ste18g6-3841 GPA+3907 sst2*2 far1*1442 tbt1-1 fus1-HIS3
can1 ste14::trp1::LYS2 ste3*1156 lys2 ura3 leu2 trp1 his3
--------------------------------------------------------------------------------------------------------------------------
15070 @ FUS1p-HIS3 GPA1G@z(5) STE18g6-3841 can1 far1*1442 his3
leu2 lys2 sst2*2 ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1
ura3
--------------------------------------------------------------------------------------------------------------------------
A-9
27
--------------------------------------------------------------------------------------------------------------------------
STRAIN_ID MATINGTYPE XXXXXXXXXXX X0XXXX X0XXXX X0XXXX
--------------------------------------------------------------------------------------------------------------------------
15072 @ FUS1p-HIS3 GPA1G@16(6) STE18g6-3841 can1 far1*1442 his3
leu2 lys2 sst2*2 ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1
ura3
--------------------------------------------------------------------------------------------------------------------------
15074 @ FUS1p-HIS3 GPA1G@13(5) STE18g6-3841 can1 far1*1442 his3
leu2 lys2 sst2*2 ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1
ura3
--------------------------------------------------------------------------------------------------------------------------
15203 a lys9
--------------------------------------------------------------------------------------------------------------------------
15204 @ lys9
--------------------------------------------------------------------------------------------------------------------------
15347 @ FUS1p-HIS3 GPA1G@z(5) can1 far1*1442 his3 leu2 lys2
sst2*2 ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
15349 @ FUS1p-HIS3 GPA1G@13(5) can1 far1*1442 his3 leu2 lys2
sst2*2 ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
15351 @ FUS1p-HIS3 GPA1G@16(6) can1 far1*1442 his3 leu2 lys2
sst2*2 ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
15427 @ E10K FUS1p-HIS3 GPA1p-G@s can1 far1*1442 his3 leu2 lys2 CP1766 CP5223
pho3*4602 pho4::KAN ste14::trp1::LYS2 ste3*1156 tbt1-1
trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
15659 @ FUS1p-HIS3 can1 far1*1442 gpa1*1163 his3 leu2 lys2
sst2*2 ste14::trp1::LYS2 ste3*1156 stp22::hisG tbt1-1
trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
15836 @ FUS1p-HIS3 can1 far1*1442 gpa1*1163 his3 leu2 lys2 CP1930 CP1947 CP5042
sst2*2 ste14::trp1::LYS2 ste3*1156 stp22::hisG tbt1-1
trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
16160 @ FUS1p-HIS3 GPA1-3907 can1 far1*1442 his3 leu2 lys2
sst2*2 ste14::trp1::LYS2 ste18g26-5363 ste3*1156 tbt1-1
trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
A-10
28
--------------------------------------------------------------------------------------------------------------------------
STRAIN_ID MATINGTYPE XXXXXXXXXXX X0XXXX X0XXXX X0XXXX
--------------------------------------------------------------------------------------------------------------------------
16463 @ FUS1p-HIS3 GPA1p-G@sD229S can1 far1*1442 his3 leu2 lys2
ste14::trp1::LYS2 ste18g26-5363 ste3*1156 tbt1-1 trp1
ura3
--------------------------------------------------------------------------------------------------------------------------
16637 @ FUS1p-HIS3 GPA1-3907 can1 far1*1442 his3 leu2 lys2
sst2*2 ste14::trp1::LYS2 ste3*1156 tbt1-1
trp1::TRP1::nFUS1p-GFPS65T ura3::URA3::nFUS1p-GFPS65T
--------------------------------------------------------------------------------------------------------------------------
16961 @ FUS1p-HIS3 GPA1p-G@sD229S STE18g6-3841 ade2*3447
ade8*3457 can1 far1*1442 his3 leu2 lys2
ste14::trp1::LYS2 ste3*1156 stp22::hisG tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
17002 @ FUS1p-HIS3 G@q(1-11)-GPA1(6-467)-G@q(5) STE18g6-3841
can1 far1*1442 his3 leu2 lys2 sst2*2 ste14::trp1::LYS2
ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
17004 @ FUS1p-HIS3 STE18g6-3841 can1 far1*1442 his3 leu2 lys2
ratG@sE10K-G@q(6) sst2*2 ste14::trp1::LYS2 ste3*1156
tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
17007 @ FUS1p-HIS3 STE18g6-3841 can1 far1*1442 his3 leu2 lys2
ratG@sD229S-G@q(6) sst2*2 ste14::trp1::LYS2 ste3*1156
tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
17008 @ FUS1p-HIS3 GPA1-G@s(6) STE18g6-3841 can1 far1*1442 his3
leu2 lys2 sst2*2 ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1
ura3
--------------------------------------------------------------------------------------------------------------------------
17010 @ FUS1p-HIS3 G@q(1-21)-GPA1(24-467)-G@q(5) STE18g6-3841
can1 far1*1442 his3 leu2 lys2 sst2*2 ste14::trp1::LYS2
ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
17012 @ FUS1p-HIS3 G@q(1-11)-GPA1(6-467)-G@q(5) can1 far1*1442
his3 leu2 lys2 sst2*2 ste14::trp1::LYS2 ste3*1156 tbt1-1
trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
17014 @ FUS1p-HIS3 can1 far1*1442 his3 leu2 lys2
ratG@sE10K-G@q(6) sst2*2 ste14::trp1::LYS2 ste3*1156
tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
17016 @ FUS1p-HIS3 can1 far1*1442 his3 leu2 lys2
ratG@sD229S-G@q(6) sst2*2 ste14::trp1::LYS2 ste3*1156
tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
A-11
29
--------------------------------------------------------------------------------------------------------------------------
STRAIN_ID MATINGTYPE XXXXXXXXXXX X0XXXX X0XXXX X0XXXX
--------------------------------------------------------------------------------------------------------------------------
17018 @ FUS1p-HIS3 GPA1-G@s(6) can1 far1*1442 his3 leu2 lys2
sst2*2 ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
17020 @ FUS1p-HIS3 G@q(1-21)-GPA1(24-467)-G@q(5) can1 far1*1442
his3 leu2 lys2 sst2*2 ste14::trp1::LYS2 ste3*1156 tbt1-1
trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
17062 @ FUS1p-HIS3 GPA1-G@i2(5) can1 far1*1442 his3 leu2 lys2
pho3*4602 pho4::KAN sst2*1056 ste14::trp1::LYS2
ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
17063 @ FUS1p-HIS3 GPA1-G@q(5) can1 far1*1442 his3 leu2 lys2
pho3*4602 pho4::KAN sst2*1056 ste14::trp1::LYS2
ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
17426 @ FUS1p-HIS3 his3 lys2 sst2*2 GPA1G@q(5) can1 far1*1442
leu2 ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1 ura3
STE18g26-5363
--------------------------------------------------------------------------------------------------------------------------
17549 @ FUS1p-HIS3 can1 far1*1442 gpa1*1163 his3 kre1::HisG leu2
lys2 ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
17551 @ FUS1p-HIS3 can1 far1*1442 gpa1*1163 his3 kre1::HisG leu2
lys2 sst2*2 ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
17553 @ XXX0x-XXX0 XXX00x0-0000 can1 far1*1442 gpa1*1163 his3
kre1::HisG leu2 lys2 ste14::trp1::LYS2 ste3*1156 tbt1-1
trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
17555 @ XXX0x-XXX0 XXX00x0-0000 can1 far1*1442 gpa1*1163 his3
kre1::HisG leu2 lys2 sst2*2 ste14::trp1::LYS2 ste3*1156
tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
17624 a FUS1p-HIS3 GPA1-3907 can1 far1*1442 his3 leu2 lys2
sst2*2 ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
17625 @ FUS1p-HIS3 GPA1-3907 can1 far1*1442 his3 leu2 lys2
nap-16 sst2*2 ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1
ura3
--------------------------------------------------------------------------------------------------------------------------
A-12
30
--------------------------------------------------------------------------------------------------------------------------
STRAIN_ID MATINGTYPE XXXXXXXXXXX X0XXXX X0XXXX X0XXXX
--------------------------------------------------------------------------------------------------------------------------
17626 @ FUS1p-HIS3 GPA1-3907 can1 far1*1442 his3 leu2 lys2
nap-17 sst2*2 ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1
ura3
--------------------------------------------------------------------------------------------------------------------------
17627 @ FUS1p-HIS3 GPA1-3907 can1 far1*1442 his3 leu2 lys2
nap-39 sst2*2 ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1
ura3
--------------------------------------------------------------------------------------------------------------------------
17628 @ FUS1p-HIS3 GPA1-3907 can1 far1*1442 his3 leu2 lys2
nap-43 sst2*2 ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1
ura3
--------------------------------------------------------------------------------------------------------------------------
17629 @ FUS1p-HIS3 GPA1-3907 can1 far1*1442 his3 leu2 lys2
nap-61 sst2*2 ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1
ura3
--------------------------------------------------------------------------------------------------------------------------
17630 @ FUS1p-HIS3 GPA1-3907 can1 far1*1442 his3 leu2 lys2
nap-63 sst2*2 ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1
ura3
--------------------------------------------------------------------------------------------------------------------------
17631 @ FUS1p-HIS3 GPA1-3907 can1 far1*1442 his3 leu2 lys2
nap-64 sst2*2 ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1
ura3
--------------------------------------------------------------------------------------------------------------------------
17632 @ FUS1p-HIS3 can1 far1*1442 gpa1*1163 his3 leu2 lys2
nap-16 sst2*2 ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1
ura3
--------------------------------------------------------------------------------------------------------------------------
17633 @ FUS1p-HIS3 can1 far1*1442 gpa1*1163 his3 leu2 lys2
nap-17 sst2*2 ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1
ura3
--------------------------------------------------------------------------------------------------------------------------
17634 @ FUS1p-HIS3 can1 far1*1442 gpa1*1163 his3 leu2 lys2
nap-39 sst2*2 ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1
ura3
--------------------------------------------------------------------------------------------------------------------------
17635 @ FUS1p-HIS3 can1 far1*1442 gpa1*1163 his3 leu2 lys2
nap-43 sst2*2 ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1
ura3
--------------------------------------------------------------------------------------------------------------------------
17636 @ FUS1p-HIS3 can1 far1*1442 gpa1*1163 his3 leu2 lys2
nap-61 sst2*2 ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1
ura3
--------------------------------------------------------------------------------------------------------------------------
A-13
31
--------------------------------------------------------------------------------------------------------------------------
STRAIN_ID MATINGTYPE XXXXXXXXXXX X0XXXX X0XXXX X0XXXX
--------------------------------------------------------------------------------------------------------------------------
17637 @ FUS1p-HIS3 can1 far1*1442 gpa1*1163 his3 leu2 lys2
nap-63 sst2*2 ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1
ura3
--------------------------------------------------------------------------------------------------------------------------
17638 @ FUS1p-HIS3 can1 far1*1442 gpa1*1163 his3 leu2 lys2
nap-64 sst2*2 ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1
ura3
--------------------------------------------------------------------------------------------------------------------------
17749 @ FUS1p-HIS3 GPA1G@s(5) STE18g6-3841 can1 far1*1442 his3 CP1584 CP1947 CP6281
leu2 lys2 sst2*2 ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1
ura3
--------------------------------------------------------------------------------------------------------------------------
17750 @ FUS1p-HIS3 GPA1G@s(5) STE18g6-3841 can1 far1*1442 his3 CP1584 CP1947 CP6281
leu2 lys2 sst2*2 ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1
ura3
--------------------------------------------------------------------------------------------------------------------------
17751 @ FUS1p-HIS3 GPA1-G@i2(5) can1 dap2*6253 far1*1442 his3
leu2 lys2 sst2*2 ste13*6077 ste14::trp1::LYS2 ste3*1156
tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
17843 a FUS1p-HIS3 bar1::hisG far1*1442 gpa1*1163 his3 leu2
tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
17879 @ FUS1p-HIS3 GPA1-3907 can1 far1*1442 his3
leu2::LEU2::PGKp-A2aR lys2 sst2*2 ste14::trp1::LYS2
ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
17880 a FUS1p-HIS3 bar1::hisG his3 leu2 sst2*1056 ste2*1154
tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
18039 @ FUS1p-HIS3 GPA1p-G@sD229S STE18g6-3841 ade2*3447 CP1584 CP1947 CP4111
ade8*3457 can1 far1*1442 his3 leu2 lys2
ste14::trp1::LYS2 ste3*1156 stp22::hisG tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
18043 @ FUS1p-HIS3 GPA1G@o(5) STE18g6-3841 can1 far1*1442 his3
leu2 lys2 sst2*2 ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1
ura3
--------------------------------------------------------------------------------------------------------------------------
18045 @ FUS1p-HIS3 GPA1G@o(5) can1 far1*1442 his3 leu2 lys2
sst2*2 ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
A-14
32
--------------------------------------------------------------------------------------------------------------------------
STRAIN_ID MATINGTYPE XXXXXXXXXXX X0XXXX X0XXXX X0XXXX
--------------------------------------------------------------------------------------------------------------------------
18158 @ FUS1p-HIS3 GPA1-3907 can1 far1*1442 his3 leu2 lys2
nap-16 sst2*2 ste14::trp1::LYS2 ste3*1156 stp22::hisG
tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
18189 @ FUS1p-HIS3 GPA1-3907 can1 far1*1442 his3 leu2 lys2
nap-16 sst2*2 ste14::trp1::LYS2 ste3*1156 stp22::hisG
tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
18190 @ FUS1p-HIS3 GPA1G@z(5) STE18g6-3841 can1 far1*1442 his3
kre1::hisG leu2 lys2 sst2*2 ste14::trp1::LYS2 ste3*1156
tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
18222 @ FUS1p-HIS3 GPA1G@z(5) STE18g6-3841 can1 far1*1442 his3 CP1947 CP6131
kre1::hisG leu2 lys2 sst2*2 ste14::trp1::LYS2 ste3*1156
tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
18774 @ FUS1p-HIS3 lys2 can1 far1*1442 his3 leu2 pho3*4602
pho4::KAN sst2*1056 ste14::trp1::LYS2 ste3*1156 tbt1-1
trp1 ura3 GPA1p-GPA1-G@s(6)
--------------------------------------------------------------------------------------------------------------------------
19029 @ FUS1p-HIS3 G@q(1-21)-GPA1(24-467)-G@q(5) STE18g6-3841
can1 far1*1442 his3 kre1::HisG leu2 lys2 sst2*2
ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
19039 @ FUS1p-HIS3 GPA1p-GPA1-G@s(6) can1 far1*1442 his3 leu2 CP5226 CP6281
lys2 pho3*4602 pho4::KAN sst2*1056 ste14::trp1::LYS2
ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
19055 @ FUS1p-HIS3 GPA1p-GPA1-G@s(6) can1 far1*1442 his3 leu2 CP5226 CP1766
lys2 pho3*4602 pho4::KAN sst2*1056 ste14::trp1::LYS2
ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
19063 @ FUS1p-HIS3 GPA1-G@q(5) GPA1G@q(5) can1 far1*1442 his3 CP6513 CP1930
leu2 lys2 pho3*4602 pho4::KAN sst2*1056
ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
19493 @ FUS1p-HIS3 his3 lys2 sst2*2 can1 far1*1442 leu2
ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1 ura3
GPA1p-G@11(1-11)-GPA1(6-467)-G@q(355-359)-GPA1t
--------------------------------------------------------------------------------------------------------------------------
19496 @ FUS1p-HIS3 his3 lys2 GPA1G@q(5) can1 cyh2 far1*1442 leu2
pho3*4602 pho4::KANMX2 sst2*1056 ste14::trp1::LYS2
ste3*1156 xxx0-0 xxx0
trp1::TRP1::STE12p-SV40NLS(MGAPPKKKRKVA)-PHO4(228-312)-
STE12(1-587,EAS,670-688)-ADH1t
--------------------------------------------------------------------------------------------------------------------------
A-15
33
--------------------------------------------------------------------------------------------------------------------------
STRAIN_ID MATINGTYPE XXXXXXXXXXX X0XXXX X0XXXX X0XXXX
--------------------------------------------------------------------------------------------------------------------------
19507 @ FUS1p-HIS3 his3 lys2 sst2*2 can1 far1*1442 leu2
ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1 ura3
GPA1p-G@q(1-24)-GPA1(27-467)-G@q(355-359)-GPA1t
--------------------------------------------------------------------------------------------------------------------------
19509 @ FUS1p-HIS3 his3 lys2 sst2*2 can1 far1*1442 leu2
ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1 ura3
GPA1p-G@q(1-32)-GPA1(35-467)-G@q(355-359)-GPA1t
--------------------------------------------------------------------------------------------------------------------------
19511 @ FUS1p-HIS3 his3 lys2 sst2*2 can1 far1*1442 leu2
ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1 ura3
STE18g6-3841
GPA1p-G@11(1-11)-GPA1(6-467)-G@q(355-359)-GPA1t
--------------------------------------------------------------------------------------------------------------------------
19512 @ FUS1p-HIS3 his3 lys2 sst2*2 can1 far1*1442 leu2
ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1 ura3
STE18g6-3841
GPA1p-G@11(1-11)-GPA1(6-467)-G@q(355-359)-GPA1t
--------------------------------------------------------------------------------------------------------------------------
19513 @ FUS1p-HIS3 his3 lys2 sst2*2 can1 far1*1442 leu2
ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1 ura3
STE18g6-3841
--------------------------------------------------------------------------------------------------------------------------
19514 @ FUS1p-HIS3 his3 lys2 sst2*2 can1 far1*1442 leu2
ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1 ura3
STE18g6-3841
--------------------------------------------------------------------------------------------------------------------------
19515 @ FUS1p-HIS3 his3 lys2 sst2*2 can1 far1*1442 leu2
ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1 ura3
XXX00x0-0000
XXX0x-X@x(0-00)-XXX0(00-000)-X@x(000-000)-XXX0x
--------------------------------------------------------------------------------------------------------------------------
19598 @ FUS1p-HIS3 GPA1-G@i2(5) his3 lys2 can1 far1*1442 leu2 CP6555 CP5095
pho3*4602 pho4::KAN sst2*1056 ste14::trp1::LYS2
ste3*1156 tbt1-1 trp1 ura3
--------------------------------------------------------------------------------------------------------------------------
19608 @ FUS1p-HIS3 lys2 can1 far1*1442 gpa1*1163 his3 leu2
ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1 ura3
STE18g26-5363 GPA1-G@s(5)-5102
--------------------------------------------------------------------------------------------------------------------------
19608 @ FUS1p-HIS3 lys2 can1 far1*1442 gpa1*1163 his3 leu2
ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1 ura3
STE18g26-5363 GPA1-G@s(5)-5102
--------------------------------------------------------------------------------------------------------------------------
19625 @ FUS1p-HIS3 his3 lys2 GPA1G@q(5) can1 cyh2 far1*1442 leu2 CP1930
pho3*4602 pho4::KANMX2 sst2*1056 ste14::trp1::LYS2
ste3*1156 xxx0-0 xxx0
trp1::TRP1::STE12p-SV40NLS(MGAPPKKKRKVA)-PHO4
(228-312)-STE12(1-587,EAS,670-688)-ADH1t
--------------------------------------------------------------------------------------------------------------------------
A-16
34
--------------------------------------------------------------------------------------------------------------------------
STRAIN_ID MATINGTYPE XXXXXXXXXXX X0XXXX X0XXXX X0XXXX
--------------------------------------------------------------------------------------------------------------------------
19888 @ FUS1p-HIS3 GPA1p-G@sD229S his3 lys2 ade2*3447 ade8*3457
can1 far1*1442 leu2 ste14::trp1::LYS2 ste18*2377
ste3*1156 stp22::hisG tbt1-1 trp1 ura3 ste18g26-5363
--------------------------------------------------------------------------------------------------------------------------
19888 @ FUS1p-HIS3 GPA1p-G@sD229S his3 lys2 ade2*3447 ade8*3457
can1 far1*1442 leu2 ste14::trp1::LYS2 ste18*2377
ste3*1156 stp22::hisG tbt1-1 trp1 ura3 ste18g26-5363
--------------------------------------------------------------------------------------------------------------------------
19889 @ FUS1p-HIS3 GPA1p-G@sD229S his3 lys2 ade2*3447 ade8*3457 CP6280 CP5899 CP6684
can1 far1*1442 leu2 ste14::trp1::LYS2 ste18*2377
ste3*1156 stp22::hisG tbt1-1 trp1 ura3 ste18g26-5363
--------------------------------------------------------------------------------------------------------------------------
19910 @ FUS1p-HIS3 his3 lys2 sst2*2 can1 far1*1442 leu2
ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1 ura3 GPA1G@z(5)
STE18g6-3841
--------------------------------------------------------------------------------------------------------------------------
19928 @ FUS1p-HIS3 his3 lys2 sst2*2 can1 far1*1442 leu2 CP6490 CP1584
ste14::trp1::LYS2 ste3*1156 tbt1-1 trp1 ura3 GPA1G@16(6)
--------------------------------------------------------------------------------------------------------------------------
All Mammalian Cell Lines
A-17
35
EXHIBIT B
-------------------------------------------------------------------------------
NOTE: US PROVISIONAL APPLICATIONS HAVE SERIAL NUMBERS STARTING WITH "60" AND
DOCKET NUMBER ENDING IN "-1"
-------------------------------------------------------------------------------
NOTE: FOREIGN APPLICATIONS ARE SHOWN IN BOLD W/SHADING
Docket No. Serial No. Title Filing Status
Date
CPI-012CP9 09/201,396 Methods and Compositions for Identifying 11/30/98 PENDING
Receptor Effectors
CPI-12CP9PC PCT/US99/27909 Methods and Compositions for Identifying 11/24/99 PENDING
Receptor Effectors
CPI-088 09/378,046 Cells Having Amplified Signal Transduction 8/30/99 PENDING
Pathway Responses and Uses Therefor
CPI-091 09/305,923 Yeast Cells Having Mutations in STP22 and 5/5/99 PENDING
Uses Therefor
CPI-096 09/426,332 Yeast Cells Having Mutations in CAV1 and 10/25/99 PENDING
Uses Therefor
CPI-099 09/362,286 Expression of G Protein Coupled Receptors 7/27/99 PENDING
with Altered Ligand Binding and/or
Coupling Properties
CPI-102 09/241,888 Cell Based Signal Generation 2/1/99 PENDING
CPI-122-l 60/153,300 Yeast Alpha Agglutinins and Use Thereof as 9/10/99 PENDING
Indicators of Activation of the Yeast (Conversion
Pheromone Response Pathway date is
9/09/00)
CPI-123-l 60/139,021 Mating Factor Alpha System for Detection 6/14/99 PENDING
of a Functional Interaction Between A (Conversion
Compound and a Cellular Receptor date is
6/13/00)
B-1
