EXHIBIT 10.46 ------------- AMENDMENT NO. 5 AND SUPPLEMENT TO RESEARCH COLLABORATION AND LICENSE AGREEMENTSynaptic Pharmaceutical Corp • March 25th, 1999 • Services-commercial physical & biological research
Exhibit 4.2 ----------- FIRST AMENDMENT TO RIGHTS AGREEMENT FIRST AMENDMENT, dated October 19, 2001 (this "Amendment"), between Synaptic Pharmaceutical Corporation, a Delaware corporation (the "Company") and Mellon Investor Services LLC, a New Jersey...Rights Agreement • February 13th, 2002 • Synaptic Pharmaceutical Corp • Biological products, (no disgnostic substances) • Delaware
MAY, 1996Synaptic Pharmaceutical Corp • February 10th, 1997 • Services-commercial physical & biological research
Non-Plan Option NONTRANSFERABLE NONQUALIFIED STOCK OPTION AGREEMENTNonqualified Stock Option Agreement • November 14th, 2002 • Synaptic Pharmaceutical Corp • Biological products, (no disgnostic substances) • New Jersey
EMPLOYMENT AGREEMENT dated as of September 9, 2002, between SYNAPTIC PHARMACEUTICAL CORPORATION, a Delaware corporation (the "Company"), and Errol de Souza (the "Employee"). Effective as of the Start Date (as defined below), the Employee is hereby...Employment Agreement • November 14th, 2002 • Synaptic Pharmaceutical Corp • Biological products, (no disgnostic substances) • New Jersey
EMPLOYMENT AGREEMENT dated as of April 1, 1998 (the "Effective Date"), between SYNAPTIC PHARMACEUTICAL CORPORATION, a Delaware corporation (the "Company"), and THERESA A. BRANCHEK (the "Employee"). Immediately prior to the Effective Date, the Employee...Employment Agreement • May 8th, 1998 • Synaptic Pharmaceutical Corp • Services-commercial physical & biological research • New Jersey
EXHIBIT 10.45 ------------- FIRST AMENDMENT TO LEASE THIS FIRST AMENDMENT TO LEASE (this "Amendment") is entered into as of November 25, 1998, by and between AREB215 COLLEGE ROAD, LLC, a Delaware limited liability company ("Landlord"), and SYNAPTIC...Lease • March 25th, 1999 • Synaptic Pharmaceutical Corp • Services-commercial physical & biological research
Exhibit 10.33 ------------- SEPARATION AGREEMENT This Separation Agreement (the "Agreement") is entered into effective as of November 26, 2001 (the "Effective Date"), by and between Synaptic Pharmaceutical Corporation (the "Company"), a Delaware...Separation Agreement • April 1st, 2002 • Synaptic Pharmaceutical Corp • Biological products, (no disgnostic substances) • New Jersey
This Executive Employment Agreement (the "Agreement") is entered into effective as of October 1, 1997 (the "Effective Date"), between Synaptic Pharmaceutical Corporation (the "Company"), a Delaware corporation, and Dr. Kathleen P. Mullinix (the...Executive Employment Agreement • March 27th, 1998 • Synaptic Pharmaceutical Corp • Services-commercial physical & biological research • New Jersey
ST&B DRAFT 10/23/97 2,500,000 Shares of Common Stock SYNAPTIC PHARMACEUTICAL CORPORATION UNDERWRITING AGREEMENT ____________, 1997Synaptic Pharmaceutical Corp • October 30th, 1997 • Services-commercial physical & biological research • New York
AMENDMENT NO. 1 TO COOPERATION AGREEMENT ---------------------Cooperation Agreement • November 6th, 1998 • Synaptic Pharmaceutical Corp • Services-commercial physical & biological research
EXHIBIT 10.36 AMENDMENT NO. 2 AND SUPPLEMENT TO RESEARCH COLLABORATION AND LICENSE AGREEMENTCollaboration and License Agreement • March 21st, 1997 • Synaptic Pharmaceutical Corp • Services-commercial physical & biological research
COLLABORATIVE RESEARCH AND LICENSE AGREEMENTCollaborative Research and License Agreement • November 7th, 1997 • Synaptic Pharmaceutical Corp • Services-commercial physical & biological research • New Jersey
RESEARCH AND LICENSE AGREEMENTResearch and License Agreement • February 10th, 1997 • Synaptic Pharmaceutical Corp • Services-commercial physical & biological research • New York
EXHIBIT 10.40 ------------- AMENDMENT NO. 4 TO RESEARCH COLLABORATION AND LICENSE AGREEMENTResearch Collaboration and License Agreement • March 27th, 1998 • Synaptic Pharmaceutical Corp • Services-commercial physical & biological research
ANDOption and License Agreement • March 25th, 1999 • Synaptic Pharmaceutical Corp • Services-commercial physical & biological research
ISO Plan Option NONTRANSFERABLE INCENTIVE STOCK OPTION AGREEMENTNontransferable Incentive Stock Option Agreement • November 14th, 2002 • Synaptic Pharmaceutical Corp • Biological products, (no disgnostic substances) • New Jersey
NQL Plan Option NONTRANSFERABLE NONQUALIFIED STOCK OPTION AGREEMENTNontransferable Nonqualified Stock Option Agreement • November 14th, 2002 • Synaptic Pharmaceutical Corp • Biological products, (no disgnostic substances) • New Jersey
AGREEMENT AND PLAN OF MERGER Dated as of November 21, 2002, Among H. LUNDBECK A/S, VIKING SUB CORPORATION And SYNAPTIC PHARMACEUTICAL CORPORATIONAgreement and Plan of Merger • November 22nd, 2002 • Synaptic Pharmaceutical Corp • Biological products, (no disgnostic substances) • Delaware
EXHIBIT 10.36 ------------- AMENDMENT NO. 3 AND SUPPLEMENT TO RESEARCH COLLABORATION AND LICENSE AGREEMENTSynaptic Pharmaceutical Corp • March 27th, 1998 • Services-commercial physical & biological research
SECOND AMENDMENT TO RIGHTS AGREEMENTRights Agreement • November 22nd, 2002 • Synaptic Pharmaceutical Corp • Biological products, (no disgnostic substances) • Delaware
SECOND AMENDMENT, dated as of November 21, 2002 (the "Amendment"), to the Rights Agreement, dated as of December 11, 1995 and amended on October 19, 2001 (as amended, the "Rights Agreement"), between Synaptic Pharmaceutical Corporation, a Delaware corporation (the "Company"), and Mellon Investor Services LLC (formerly known as Chemical Mellon Shareholder Services), as rights agent (the "Rights Agent").
AGREEMENT BETWEENSynaptic Pharmaceutical Corp • March 27th, 1998 • Services-commercial physical & biological research
Exhibit No. 10.1 ---------------- STOCK PURCHASE AGREEMENT This STOCK PURCHASE AGREEMENT is dated as of the 2nd day of August, 2001 by and among Synaptic Pharmaceutical Corporation, a Delaware corporation with its principal office at 215 College Road,...Stock Purchase Agreement • August 6th, 2001 • Synaptic Pharmaceutical Corp • Biological products, (no disgnostic substances) • Delaware
SUBLEASESynaptic Pharmaceutical Corp • May 11th, 2000 • Services-commercial physical & biological research • New Jersey
