Common use of Submitting Investigator Clause in Contracts

Submitting Investigator. An investigator who submitted a genomic dataset to an NIH designated data repository (e.g., dbGaP). Study specific DUC addendum phs000206 : CGEMS Pancreatic Cancer (PanScan) Public Posting of Genomic Summary Results - Not Allowed. NIH Data Access Committee (DAC) : NCI DAC Important Contacts : XXXXXX@xxxx.xxx.xxx; XXX@xxxx.xxx.xxx In the event of a data management incident, within 24 hours, please contact emails above. This project was funded in whole or in part with federal funds from the National Cancer Institute (NCI), US National Institutes of Health (NIH) under contract number HHSN261200800001E. Additional support was received from NIH/NCI K07 CA140790, the American Society of Clinical Oncology Conquer Cancer Foundation, the Xxxxxx Xxxxxx Medical Institute, the Xxxxxxxxxx Foundation, the Xxxxxx X. and Xxxxxx X. Xxxx Fund for Acknowledgement Statement : Pancreatic Cancer Research and Promises for Purple. A full list of acknowledgments for each participating study is provided in the Supplementary Note of the manuscript with PubMed ID: 25086665. The datasets have been accessed through the NIH database for Genotypes and Phenotypes (dbGaP) under accession #phs000206. If these dataset(s) were used, please cite manuscripts with PubMed IDs: 25086665, 20101243, and 19648918 in all oral or written presentations, disclosures, or publication. Name : Cancer in all age groups, other diseases in adults only, and methods Consent Group # : 1 Abbreviation : CADM Data Use Limitation : The informed consent document signed by the PanScan GWAS participants allows use of these data by investigators for discovery and hypothesis generation in the investigation of the genetic contributions to cancer in all age groups and other diseases in adults only, as well as development of novel analytical approaches for GWAS. Name : Disease-Specific (Pancreatic Cancer, GSO) Consent Group # : 2 Abbreviation : DS-PACA-GSO Data Use Limitation : Use of the data must be related to Pancreatic Cancer. Use of the data is limited to genetic studies only. Name : Disease-Specific (Pancreatic Cancer, IRB, COL, GSO) Consent Group # : 4 Abbreviation : O-DS-PACA-IRB-COL-GSO Use of the data must be related to Pancreatic Cancer.? Requestor must provide documentation of JHU IRB approval.? Requestor must provide a letter of collaboration with the primary study investigator(s).? Use of the data is limited to genetic studies only.? Requestor(s) should obtain the Xxxxx Xxxxxxx PanScan II Collaborator Agreement Data Use Limitation : (xxxx://xxx.xxxx.xxx.xxx.xxx/projects/gap/cgi-bin/GetPdf.cgi?document_name=PANScanCA.pdf). This agreement which governs access to, and use and disclosure of PanScan data maintained in the NIH dbGaP database, will need to be completed and submitted to the JHU IRB for review. For instruction on how to submit your completed Collaborative Agreement to JHU, please contact the iNCI DAC (xXXX_XXX@xxxx.xxx.xxx). Upon JHU IRB approval, the Requestor will receive a signed copy of this form which should be appended to the dbGaP application. Upon successful submission, the request will be reviewed by the iNCI DAC for completeness. Name : General Research Use Consent Group # : 5 Abbreviation : GRU Data Use Limitation : Use of the data is limited only by the terms of the model Data Use Certification. Name : Health/Medical/Biomedical (PUB, NPU, MDS, GSO) Consent Group # : 6 Abbreviation : HMB-PUB-NPU-MDS-GSO Use of this data is limited to health/medical/biomedical purposes, does not include the study of population origins or ancestry. Data Use Limitation : Requestor agrees to make results of studies using the data available to the larger scientific community. Use of the data is limited to not-for-profit organizations.

Submitting Investigator. An investigator who submitted a genomic dataset to an NIH designated data repository (e.g., dbGaP). Study specific DUC addendum phs000206 phs000180 : CGEMS Pancreatic Cancer Type 1 Diabetes Genetics Consortium (PanScanT1DGC) GWAS Public Posting of Genomic Summary Results - Not Allowed. NIH Data Access Committee (DAC) : NCI DAC NIDDK Central Repository GWAS Data Access Committee Important Contacts : XXXXXX@xxxx.xxx.xxxxxxxx-xxx@xxxx.xxx.xxx; xxxxx-xxx@xxxx.xxx.xxx ; XXX@xxxx.xxx.xxx In the event of a data management incident, within 24 hours, please contact emails above. For T1DGC GWAS and TaqMan data in the GRID study: "This project was funded in whole or in part with federal funds from research utilizes resources provided by the Type 1 Diabetes Genetics Consortium (T1DGC), a collaborative clinical study sponsored by the National Cancer Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute of Allergy and Infectious Diseases (NIAID), National Human Genome Research Institute (NCINHGRI), US National Institutes Institute of Child Health and Human Development (NIHNICHD), and the Juvenile Diabetes Research Foundation International (JDRF) under contract number HHSN261200800001E. Additional support and supported by U01 DK062418. The UK case series collection was received from NIH/NCI K07 CA140790additionally funded by the JDRF and Wellcome Trust and the National Institute for Health Research Cambridge Biomedical Centre, at the American Society Cambridge Institute for Medical Research, UK (CIMR), which is in receipt of Clinical Oncology Conquer Cancer Foundation, the Xxxxxx Xxxxxx Medical Institute, the Xxxxxxxxxx Foundation, the Xxxxxx X. and Xxxxxx X. Xxxx Fund for a Acknowledgement Statement : Pancreatic Cancer Research and Promises for PurpleWellcome Trust Strategic Award (079895). A full list of acknowledgments for each participating The data from the T1DGC study is provided were supplied by dbGAP. This manuscript was not prepared in the Supplementary Note collaboration with Investigators of the manuscript with PubMed IDT1DGC study and does not necessarily reflect the opinions or views of the T1DGC study or the study sponsors." For other T1DGC datasets: 25086665. The datasets have been accessed through "This research was performed under the NIH database for Genotypes auspices of the Type 1 Diabetes Genetics Consortium, a collaborative clinical study sponsored by the National Institute of Diabetes and Phenotypes Digestive and Kidney Diseases (dbGaP) under accession #phs000206. If these dataset(s) were usedNIDDK), please cite manuscripts with PubMed IDs: 25086665National Institute of Allergy and Infectious Diseases (NIAID), 20101243National Human Genome Research Institute (NHGRI), National Institute of Child Health and Human Development (NICHD), and 19648918 in all oral or written presentations, disclosures, or publication. Juvenile Diabetes Research Foundation International (JDRF)." Name : Cancer in all age groupsDisease-Specific (Type 1 diabetes, its complications and other diseases in adults onlyautoimmune diseases, and methods IRB) Consent Group # : 1 Abbreviation : CADM DS-T1DR-IRB Data Use Limitation : The informed consent document signed by the PanScan GWAS participants allows use of these data by investigators for discovery and hypothesis generation in the investigation of the genetic contributions to cancer in all age groups and other diseases in adults only, as well as development of novel analytical approaches for GWAS. Name : Disease-Specific (Pancreatic Cancer, GSO) Consent Group # : 2 Abbreviation : DS-PACA-GSO Data Use Limitation : Use of the data must be related to Pancreatic Cancer. Use of the data is limited to genetic studies only. Name : Disease-Specific (Pancreatic Cancer, IRB, COL, GSO) Consent Group # : 4 Abbreviation : O-DS-PACA-IRB-COL-GSO Use of the data must be related to Pancreatic Cancer.? Requestor must provide documentation of JHU IRB approval.? Requestor must provide a letter of collaboration with the primary study investigator(s).? Use of the data is limited to genetic studies only.? Requestor(s) should obtain the Xxxxx Xxxxxxx PanScan II Collaborator Agreement Data Use Limitation : (xxxx://xxx.xxxx.xxx.xxx.xxx/projects/gap/cgi-bin/GetPdf.cgi?document_name=PANScanCA.pdf). This agreement which governs access to, and use and disclosure of PanScan data maintained in the NIH dbGaP database, will need to be completed and submitted to the JHU IRB for review. For instruction on how to submit your completed Collaborative Agreement to JHU, please contact the iNCI DAC (xXXX_XXX@xxxx.xxx.xxx). Upon JHU IRB approval, the Requestor will receive a signed copy of this form which should be appended to the dbGaP application. Upon successful submission, the request will be reviewed by the iNCI DAC for completeness. Name : General Research Use Consent Group # : 5 Abbreviation : GRU Data Use Limitation : Use of the data is limited only by the terms of the model Data Use Certification. Name : Health/Medical/Biomedical (PUB, NPU, MDS, GSO) Consent Group # : 6 Abbreviation : HMB-PUB-NPU-MDS-GSO Use of this data is limited to health/medical/biomedical purposes, does not include the study of population origins or ancestry. Data Use Limitation : Requestor agrees to make results of studies using the data available to the larger scientific community. Use of the data is limited to not-for-profit organizations.:

Submitting Investigator. An investigator who submitted a genomic dataset to an NIH designated data repository (e.g., dbGaP). Study specific DUC addendum phs000206 phs001154 : CGEMS Pancreatic Cancer (PanScan) Indexing Genes Impacted by Copy Number Variation in Developmental Disorders Public Posting of Genomic Summary Results - Not Allowed. NIH Data Access Committee (DAC) : NCI NICHD-DAC Important Contacts : XXXXXX@xxxx.xxx.xxxXX-XXX@xxxx.xxx.xxx; XXX@xxxx.xxx.xxx In the event of a data management incident, within 24 hours, please contact emails above. This project The use of the "Indexing Genes Impacted by Copy Number Variation in Developmental Disorders" dataset requires local IRB approval. All requestors and data users must provide a local Institutional Review board [IRB] letter from their respective institution approving conduct of the proposed research project. Only full or expedited approvals will be accepted. The IRB letter must explicitly reference the use of the “Indexing Genes Impacted by IC Specific Access Term : Copy Number Variation in Developmental Disorders” dataset. The requestor of this dataset agrees to make the results of studies available to the research community. The use of this dataset is limited to genetics studies only by not-for-profit organizations. The annual progress report should cite work done that relates specifically to this dataset [Indexing Genes Impacted by Copy Number Variation in Developmental Disorders] and not just a generic report for a series of datasets that may also have been requested at the same time. “The dataset used for the analyses described in this manuscript was funded in whole or in part with federal funds obtained from the National Cancer Institute database of Genotype and Phenotype (NCI)dbGaP) found at xxxx://xxx.xxxx.xxx.xxx.xxx/gap [Accession Number: phs xxxxxx]. Samples and associated genotypic data from the dataset, US National Institutes of Health (NIH) under contract number HHSN261200800001E. Additional support was received from NIH/NCI K07 CA140790entitled “Genes Impacted by Copy Number Variation in Acknowledgement Statement : Developmental Disorders,” were provided by Xxxxxxx Xxxxxxx, Xxxxx Xxxxxxxxxxxx and their colleagues at The Centre for Applied Genomics, which is funded by Genome Canada and the American Society of Clinical Oncology Conquer Cancer Foundation, the Xxxxxx Xxxxxx Medical Ontario Genomics Institute, the Xxxxxxxxxx FoundationCanada Foundation for Innovation, the Xxxxxx X. University of Toronto XxXxxxxxxx Centre and Xxxxxx X. Xxxx Fund the Hospital for Acknowledgement Statement : Pancreatic Cancer Research and Promises for Purple. A full list of acknowledgments for each participating study is provided in the Supplementary Note of the manuscript with PubMed ID: 25086665. The datasets have been accessed through the NIH database for Genotypes and Phenotypes (dbGaP) under accession #phs000206. If these dataset(s) were used, please cite manuscripts with PubMed IDs: 25086665, 20101243, and 19648918 in all oral or written presentations, disclosures, or publication. Name : Cancer in all age groups, other diseases in adults only, and methods Consent Group # : 1 Abbreviation : CADM Data Use Limitation : The informed consent document signed by the PanScan GWAS participants allows use of these data by investigators for discovery and hypothesis generation in the investigation of the genetic contributions to cancer in all age groups and other diseases in adults only, as well as development of novel analytical approaches for GWAS. Name : Disease-Specific (Pancreatic Cancer, GSO) Consent Group # : 2 Abbreviation : DS-PACA-GSO Data Use Limitation : Use of the data must be related to Pancreatic Cancer. Use of the data is limited to genetic studies only. Name : Disease-Specific (Pancreatic Cancer, IRB, COL, GSO) Consent Group # : 4 Abbreviation : O-DS-PACA-IRB-COL-GSO Use of the data must be related to Pancreatic CancerSick Children.? Requestor must provide documentation of JHU IRB approval.? Requestor must provide a letter of collaboration with the primary study investigator(s).? Use of the data is limited to genetic studies only.? Requestor(s) should obtain the Xxxxx Xxxxxxx PanScan II Collaborator Agreement Data Use Limitation : (xxxx://xxx.xxxx.xxx.xxx.xxx/projects/gap/cgi-bin/GetPdf.cgi?document_name=PANScanCA.pdf). This agreement which governs access to, and use and disclosure of PanScan data maintained in the NIH dbGaP database, will need to be completed and submitted to the JHU IRB for review. For instruction on how to submit your completed Collaborative Agreement to JHU, please contact the iNCI DAC (xXXX_XXX@xxxx.xxx.xxx). Upon JHU IRB approval, the Requestor will receive a signed copy of this form which should be appended to the dbGaP application. Upon successful submission, the request will be reviewed by the iNCI DAC for completeness. Name : General Research Use Consent Group # : 5 Abbreviation : GRU Data Use Limitation : Use of the data is limited only by the terms of the model Data Use Certification. ” Name : Health/Medical/Biomedical (IRB, PUB, NPU, MDS, GSO) Consent Group # : 6 1 Abbreviation : HMB-IRB-PUB-NPU-MDS-GSO Use of this data is limited to health/medical/biomedical purposes, does not include the study of population origins or ancestry. Data Use Limitation : Requestor must provide documentation of local IRB approval. Requestor agrees to make results of studies using the data available to the larger scientific community. Use of the data is limited to not-for-profit organizations.

Submitting Investigator. An investigator who submitted a genomic dataset to an NIH designated data repository (e.g., dbGaP). Study specific DUC addendum phs000206 phs001522 : CGEMS Pancreatic Cancer (PanScan) Germline De Novo Mutations with Parent of Origin in WGS Trios Public Posting of Genomic Summary Results - Not Allowed. NIH Data Access Committee (DAC) : NCI NICHD-DAC Important Contacts : XXXXXX@xxxx.xxx.xxxXX-XXX@xxxx.xxx.xxx; XXX@xxxx.xxx.xxx In the event of a data management incident, within 24 hours, please contact emails above. The use of the “Germline De Novo Mutations with parent of origin in WGS trios” dataset requires local Institutional Review Board [IRB] approval. All requesters and data users must provide a letter from their respective institution’s IRB approving conduct of their proposed research project. Only full or expedited approvals will be accepted. The IRB letter must explicitly reference the use of “Germline De Novo Mutations with parent of origin in WGS trios” IC Specific Access Term : dataset. The annual progress report should cite work done that relates specifically to the “Germline De Novo Mutations with parent of origin in WGS trios” dataset and not just a generic report for a series of datasets that may also have been requested at the same time. This project study was funded in whole or in part by the Inova Health System with federal funds support from Fairfax County and the philanthropic support from the National Cancer Institute (NCI), US National Institutes of Health (NIH) under contract number HHSN261200800001E. Additional support was received from NIH/NCI K07 CA140790, Xxxxx family. We thank the American Society of Clinical Oncology Conquer Cancer Foundation, Inova translational medicine institute staff for supporting the Xxxxxx Xxxxxx Medical Institute, the Xxxxxxxxxx Foundation, the Xxxxxx X. and Xxxxxx X. Xxxx Fund for study. We also Acknowledgement Statement : Pancreatic Cancer Research and Promises for Purple. A full list of acknowledgments for each participating study is provided thank the families who participated in the Supplementary Note of genomic studies that made this research possible. This work was partly financially supported by grants from the manuscript with PubMed ID: 25086665. The datasets have been accessed through the NIH database Netherlands Organization for Genotypes Scientific Research (000-00-000 to C.G. and Phenotypes (dbGaP) under accession #phs000206. If these dataset(s) were used, please cite manuscripts with PubMed IDs: 25086665, 20101243000-00-000 to J.A.V.), and 19648918 in all oral or written presentations, disclosures, or publicationthe European Research Council (ERC Starting xxxxx XXXXXX 281964 to J.A.V.). Name : Cancer in all age groups, other diseases in adults only, and methods General Research Use (IRB) Consent Group # : 1 Abbreviation : CADM GRU-IRB Data Use Limitation : The informed consent document signed by the PanScan GWAS participants allows use of these data by investigators for discovery and hypothesis generation in the investigation of the genetic contributions to cancer in all age groups and other diseases in adults only, as well as development of novel analytical approaches for GWAS. Name : Disease-Specific (Pancreatic Cancer, GSO) Consent Group # : 2 Abbreviation : DS-PACA-GSO Data Use Limitation : Use of the data must be related to Pancreatic Cancer. Use of the data is limited to genetic studies only. Name : Disease-Specific (Pancreatic Cancer, IRB, COL, GSO) Consent Group # : 4 Abbreviation : O-DS-PACA-IRB-COL-GSO Use of the data must be related to Pancreatic Cancer.? Requestor must provide documentation of JHU IRB approval.? Requestor must provide a letter of collaboration with the primary study investigator(s).? Use of the data is limited to genetic studies only.? Requestor(s) should obtain the Xxxxx Xxxxxxx PanScan II Collaborator Agreement Data Use Limitation : (xxxx://xxx.xxxx.xxx.xxx.xxx/projects/gap/cgi-bin/GetPdf.cgi?document_name=PANScanCA.pdf). This agreement which governs access to, and use and disclosure of PanScan data maintained in the NIH dbGaP database, will need to be completed and submitted to the JHU IRB for review. For instruction on how to submit your completed Collaborative Agreement to JHU, please contact the iNCI DAC (xXXX_XXX@xxxx.xxx.xxx). Upon JHU IRB approval, the Requestor will receive a signed copy of this form which should be appended to the dbGaP application. Upon successful submission, the request will be reviewed by the iNCI DAC for completeness. Name : General Research Use Consent Group # : 5 Abbreviation : GRU Data Use Limitation : Use of the data is limited only by the terms of the model Data Use Certification. Name : Health/Medical/Biomedical (PUB, NPU, MDS, GSO) Consent Group # : 6 Abbreviation : HMB-PUB-NPU-MDS-GSO Use of this data is limited to health/medical/biomedical purposes, does not include the study of population origins or ancestry. Data Use Limitation : Requestor agrees to make results of studies using the data available to the larger scientific community. Use of the data is limited to not-for-profit organizations.:

Submitting Investigator. An investigator who submitted a genomic dataset to an NIH designated data repository (e.g., dbGaP). Study specific DUC addendum phs000206 phs000218 : CGEMS Pancreatic National Cancer Institute (PanScanNCI) TARGET: Therapeutically Applicable Research to Generate Effective Treatments Public Posting of Genomic Summary Results - Not Allowed. NIH Data Access Committee (DAC) : NCI DAC Important Contacts : XXXXXX@xxxx.xxx.xxx; XXX@xxxx.xxx.xxx In the event of a data management incident, within 24 hours, please contact emails above. This project was funded in whole or in part with federal funds from Data for Therapeutically Applicable Research to Generate Effective Treatments (TARGET) are stored within the National Cancer Institute (NCI), US National Institutes NCBI database of Health (NIH) under contract number HHSN261200800001E. Additional support was received from NIH/NCI K07 CA140790, the American Society of Clinical Oncology Conquer Cancer Foundation, the Xxxxxx Xxxxxx Medical Institute, the Xxxxxxxxxx Foundation, the Xxxxxx X. and Xxxxxx X. Xxxx Fund for Acknowledgement Statement : Pancreatic Cancer Research and Promises for Purple. A full list of acknowledgments for each participating study is provided in the Supplementary Note of the manuscript with PubMed ID: 25086665. The datasets have been accessed through the NIH database for Genotypes and Phenotypes (dbGaPdbGaP)/Sequence Read Archive (SRA) under or the NCI Genomic Data Commons (GDC) and the TARGET Data Coordinating Center (DCC). Approved users who plan to submit manuscripts using the TARGET pediatric cancer data that would be of comparable scope to the initial TARGET disease-specific comprehensive analysis publication, are expected to abide by TARGET's publication process as outlined on the TARGET Publication Guidelines webpage (xxxx://xxx.xxxxxx.xxx/programs/target/target-publication-guidelines). Specifically, comparable scope is defined as global genome-wide analysis of TARGET disease-specific data from one or more than one platform or a trans-TARGET manuscript. Publication involving such analyses is restricted prior to each of the first TARGET disease-specific publications.Approved Users shall reference the TARGET dbGaP accession #phs000206number: phs000218. If these dataset(s) were used, please cite manuscripts with PubMed IDs: 25086665, 20101243, and 19648918 in all oral or written presentations, disclosures, or publication. Name : Cancer in all age groups, other diseases in adults only, and methods Consent Group # : 1 Abbreviation : CADM Data Use Limitation : The informed consent document signed by the PanScan GWAS participants allows use of these data by investigators for discovery and hypothesis generation in the investigation of the genetic contributions to cancer in all age groups and other diseases in adults only, as well as development of novel analytical approaches for GWAS. Name : Disease-Specific (Pancreatic Cancer, GSO) Consent Group # : 2 Abbreviation : DS-PACA-GSO Data Use Limitation : Use of the data must be related to Pancreatic Cancer. Use of the data is limited to genetic studies only. Name from a single disease studied in TARGET, then the substudy dbGaP accession number is appropriate: Disease-Specific Acute Lymphoblastic Leukemia Pilot (Pancreatic Cancer, IRB, COL, GSOALL P1) Consent Group # – phs000463; Acute Lymphoblastic Leukemia Expansion (ALL P2) – phs000464; Acute Myeloid Leukemia (AML) – phs000465; Kidney Tumors: 4 Abbreviation : O-DS-PACA-IRB-COL-GSO Use Clear Cell Sarcoma of the Kidney (CCSK) – phs000466; Kidney Tumors: Rhabdoid Tumor (RT) – phs000470; Kidney Tumors: Wilms tumor (WT) – phs000471; Model Systems (MDLS): Cell Lines & Xenografts (including PPTP) – phs000469; Neuroblastoma (NBL) – phs000467; Osteosarcoma (OS) – xxx000000. TARGET DCC Version Reference: When data must be related to Pancreatic Cancer.? Requestor must provide documentation of JHU IRB approval.? Requestor must provide a letter of collaboration with stored at the primary study investigator(s).? Use TARGET Data Coordinating Center (e.g. VCF or MAF sequence files, chip-based data) are used, Approved Users shall reference the version of the data is limited TARGET Data Matrix and include IC Specific Access Term : “Therapeutically Applicable Research to genetic studies onlyGenerate Effective Treatments Data Matrix. Retrieve Month Day, Year. Website, xxxxx://xxx.xxxxxx.xxx/programs/target/data-matrix.? Requestor(s) ” Citing TARGET Publications in Manuscripts Using TARGET Data: Additionally, manuscripts using the entire TARGET dataset should obtain cite each of the Xxxxx Xxxxxxx PanScan II Collaborator Agreement Data Use Limitation : landscape papers published by TARGET project teams (xxxx://xxx.xxxx.xxx.xxx.xxx/projects/gap/cgi-bin/GetPdf.cgi?document_name=PANScanCA.pdfsee list below). This agreement which governs access toFor those manuscripts using data from only a single substudy or from a few select substudies, and use and disclosure of PanScan data maintained in but not the NIH dbGaP databaseentire TARGET dataset, will need the investigators should cite the appropriate first paper(s) published for each. *Note: As the remaining substudy project teams publish their first manuscript, the reference to be completed and submitted to the JHU IRB for reviewcited will be added below. For instruction on how to submit your completed Collaborative Agreement to JHUAcute lymphoblastic leukemia pilot (ALL P1): Xxxxxxxxx, please contact the iNCI DAC X.X., Xx, X., Xxxxx, X., Xxxxxx, X., Xxxxxxxx, L.A., Xxxxxx, X.X., Xx, X., Xxx, X., Xxxxx, X., Xxxxxxxx, X.X., et al. (xXXX_XXX@xxxx.xxx.xxx2009). Upon JHU IRB approvalDeletion of IKZF1 and prognosis in acute lymphoblastic leukemia. N Engl J Med 360, 470-480. Acute Myeloid Leukemia: Xxxxxxx H, Xxxxxx XX, Xxxxxx X Xx, Xxxx RE, Xxx EL, Xxxxxx XX, Xx Y, Xxxxx R, Xxxxxxx XX, Xxxxx MA et al. (2017). The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions. Nat Med 24(10, 103-112); Neuroblastoma (NBL): Xxxx X.X., Xxxxxxxx X., Xxxxxxx X.X., Xxxxxxxxxxx X., Xxx X.X., Xxxxxxx D., Xxxxxx X.X., Xxxxxxxxx X., Xxxxx X., et al. (2013). The genetic landscape of high-risk neuroblastoma. Nat Genet 45(3):279-84; Wilms tumor: Xxxx S, Xxxx V, Xxxx AL, Xxxx AHAG, Xxxxxxxxx XX, Xxxxxxx XX, Xxxxx MA, Xxxxx JMG, Xxxxxxxxx D et al. (2017). A Children's Oncology Group and TARGET initiative exploring the Requestor will receive a signed copy genetic landscape of this form which should be appended to the dbGaP applicationWilms tumor. Upon successful submissionNat Genet 49(10):1487-1494; trans-TARGET: Ma, the request will be reviewed by the iNCI DAC for completenessX., Xxx, X., Xxx, X., Xxxxxxxxxx, L., Xxxxxxxx, M., Xxxxxx, X., Xxxx, X., Xx, X., Xxxxx, M., Xxxxxx, X. et al.(2018). Name : General Research Use Consent Group # : 5 Abbreviation : GRU Data Use Limitation : Use Pan-cancer genome and transcriptome analyses of the data is limited only by the terms of the model Data Use Certification1,699 paediatric leukaemias and solid tumours. Name : Health/Medical/Biomedical (PUB, NPU, MDS, GSO) Consent Group # : 6 Abbreviation : HMBNature 555(7696):371-PUB-NPU-MDS-GSO Use of this data is limited to health/medical/biomedical purposes, does not include the study of population origins or ancestry. Data Use Limitation : Requestor agrees to make results of studies using the data available to the larger scientific community. Use of the data is limited to not-for-profit organizations376.

Submitting Investigator. An investigator who submitted a genomic dataset to an NIH designated data repository (e.g., dbGaP). Study specific DUC addendum phs000206 phs000092 : CGEMS Pancreatic Cancer GENEVA Study of Addiction: Genetics and Environment (PanScanSAGE) Public Posting of Genomic Summary Results - Not Allowed. NIH Data Access Committee (DAC) : NCI DAC National Human Genome Research Institute Important Contacts : XXXXXX@xxxx.xxx.xxxxxxxxxxx@xxxx.xxx.xxx; XXX@xxxx.xxx.xxx In the event of a data management incident, within 24 hours, please contact emails above. This project Funding support for the Study of Addiction: Genetics and Environment (SAGE) was provided through the NIH Genes, Environment and Health Initiative [GEI] (U01 HG004422). SAGE is one of the genome-wide association studies funded in whole or in as part of the Gene Environment Association Studies (GENEVA) under GEI. Assistance with federal funds from phenotype harmonization and genotype cleaning, as well as with general study coordination, was provided by the GENEVA Coordinating Center (U01 HG004446). Assistance with data cleaning was provided by the National Cancer Institute (NCI), US National Institutes Center for Biotechnology Information. Support for collection of Health (NIH) under contract number HHSN261200800001E. Additional support datasets and samples was received from NIH/NCI K07 CA140790, provided by the American Society Collaborative Study on the Genetics of Clinical Oncology Conquer Cancer Foundation, the Xxxxxx Xxxxxx Medical Institute, the Xxxxxxxxxx Foundation, the Xxxxxx X. and Xxxxxx X. Xxxx Fund for Alcoholism Acknowledgement Statement : Pancreatic Cancer Research (COGA; U10 AA008401), the Collaborative Genetic Study of Nicotine Dependence (COGEND; P01 CA089392), and Promises the Family Study of Cocaine Dependence (FSCD; R01 DA013423). Funding support for Purple. A full list of acknowledgments genotyping, which was performed at the Xxxxx Xxxxxxx University Center for each participating study is Inherited Disease Research, was provided in by the Supplementary Note of NIH GEI (U01HG004438), the manuscript with PubMed ID: 25086665National Institute on Alcohol Abuse and Alcoholism, the National Institute on Drug Abuse, and the NIH contract "High throughput genotyping for studying the genetic contributions to human disease" (HHSN268200782096C). The datasets have been accessed used for the analyses described in this manuscript were obtained from dbGaP at xxxx://xxx.xxxx.xxx.xxx.xxx/projects/gap/cgi-bin/study.cgi?study_id=phs000092.v1.p1 through the NIH database for Genotypes and Phenotypes (dbGaP) under dbGaP accession #phs000206. If these dataset(s) were used, please cite manuscripts with PubMed IDs: 25086665, 20101243, and 19648918 in all oral or written presentations, disclosures, or publicationnumber phs000092.v1.p. Name : Cancer in all age groups, other diseases in adults only, and methods Health Research Consent Group # : 1 Abbreviation : CADM HR Data Use Limitation : The informed consent document signed by the PanScan GWAS participants allows use of these data by investigators May be used for discovery and hypothesis generation in the investigation of the genetic contributions studies to cancer in all age groups and other diseases in adults onlylearn about, as well as development of novel analytical approaches for GWAS. prevent, or treat health problems Name : Disease-Specific (Pancreatic Cancer, GSO) Alcoholism and Related Conditions Consent Group # : 2 Abbreviation : DS-PACA-GSO ARC Limited to genetic studies of alcohol dependence and related conditions. Related conditions include dependence Data Use Limitation : Use of the data must be related to Pancreatic Cancer. Use of the data is limited to genetic studies only. Name : Disease-Specific (Pancreatic Canceron other substances including nicotine, IRB, COL, GSO) Consent Group # : 4 Abbreviation : O-DS-PACA-IRB-COL-GSO Use of the data must be related to Pancreatic Cancer.? Requestor must provide documentation of JHU IRB approval.? Requestor must provide a letter of collaboration with the primary study investigator(s).? Use of the data is limited to genetic studies only.? Requestor(s) should obtain the Xxxxx Xxxxxxx PanScan II Collaborator Agreement Data Use Limitation : (xxxx://xxx.xxxx.xxx.xxx.xxx/projects/gap/cgi-bin/GetPdf.cgi?document_name=PANScanCA.pdf). This agreement which governs access tomarijuana, and use and disclosure of PanScan data maintained in the NIH dbGaP databaseother illicit drugs (e.g., will need to be completed and submitted to the JHU IRB for review. For instruction on how to submit your completed Collaborative Agreement to JHUstimulants, please contact the iNCI DAC (xXXX_XXX@xxxx.xxx.xxxsedatives, opiates). Upon JHU IRB approval, the Requestor will receive a signed copy of this form which should be appended to the dbGaP application. Upon successful submission, the request will be reviewed by the iNCI DAC for completeness. Name : General Research Use Consent Group # : 5 Abbreviation : GRU Data Use Limitation : Use of the data is limited only by the terms of the model Data Use Certification. Name : Health/Medical/Biomedical (PUB, NPU, MDS, GSO) Consent Group # : 6 Abbreviation : HMB-PUB-NPU-MDS-GSO Use of this data is limited to health/medical/biomedical purposes, does not include the study of population origins or ancestry. Data Use Limitation : Requestor agrees to make results of studies using the data available to the larger scientific community. Use of the data is limited to not-for-profit organizations.as