Study populations. We used the genetic data from the UK Biobank (UKB), a large-scale population-based prospective cohort study of approximately 500,000 individuals aged 40-69 years at recruitment across the United Kingdom between March 2006 and October 2010. The ethical collection of sample and full details of the genotyping and imputation are described elsewhere [14], [15]. Our study populations for each of the three disease outcomes are defined as follows: • The breast cancer eligible population was women who had not had breast cancer, carcinoma in situ or mastectomy prior to baseline. • For the hypertension eligible population, we excluded individuals with missing or implausible systolic blood pressure (SBP) measurements (< 70 or > 270 mmHg) at baseline, and those with prior Major Adverse Cardiovascular Events (XXXX). • The dementia eligible population was restricted to individuals without prior diagnosis of dementia or Alzheimer’s disease. Disease ascertainment of UKB during the following-up period utilised linkage to death registry, cancer registry, and Hospital Episode Statistics (HES). Hypertension is defined as SBP>=140 at baseline; the International Classification of Diseases (ICD) code for breast cancer and dementia can be found in Supplementary Tables 13-15.
Study populations. The UN and WHO classify adolescence as a period of development and transition in between childhood and adulthood, between the ages of 10- to 19-years-old (WHO, 2017). In addition, “young people” are those aged 10 to 24, and “youth” are those aged 15 to 24 years (UN General Assembly, 1981). Our target population was adolescent girls and young adult women between the ages of 10 to 24 at the time the outcome was measured. We examined GBV exposures occurring in childhood and adolescence and young adulthood. Countries and Geographic Regions Using the World Bank classifications of country income levels (World Bank, 2017), we focused on LMICs (including lower middle and upper middle) for this review. Specific country names, as well as general terms, such as “developing country,” were used (Table 2). Refugees from LMICs and resettled populations in high-income countries were not included. Because of the difficulties to group shared experiences due to different contextual factors, resettled and refugee populations and their experiences with GBV and SRH required their own systematic review of reviews. Procedure Information sources and search strategy Table 2 displays the final search strings and search results for all three databases. The authors employed a systematic search strategy using PubMed and PsycINFO electronic databases on November 1, 2016. The PsycINFO search yielded no reviews that matched the
Study populations. The following study populations are defined for analysis: Intention-to-treat (ITT) and Safety.
