Common use of Settlement Upon Conversion Clause in Contracts

Settlement Upon Conversion. 40 Section 5.04. Reserve and Status of Common Stock Issued Upon Conversion. 41 Section 5.05. Adjustments to the Conversion Rate. 42 Section 5.06. Voluntary Adjustments. 52 Section 5.07. Adjustments to the Conversion Rate in Connection with a Make-Whole Fundamental Change. 53 Section 5.08. Exchange in Lieu of Conversion. 54 Section 5.09. Effect of Common Stock Change Event. 54 Article 6. Successors 56 Section 6.01. When the Company May Merge, Etc. 56 Section 6.02. Successor Corporation Substituted. 57 Article 7. Defaults and Remedies 57 Section 7.01. Events of Default. 57 Section 7.02. Acceleration. 59 Section 7.03. Sole Remedy for a Failure to Report. 59 Section 7.04. Other Remedies. 60 Section 7.05. Waiver of Past Defaults. 61 Section 7.06. Control by Majority. 61 Section 7.07. Limitation on Suits. 61 Section 7.08. Absolute Right of Holders to Institute Suit for the Enforcement of the Right to Receive Payment and Conversion Consideration. 62 Section 7.09. Collection Suit by Trustee. 62 Section 7.10. Trustee May File Proofs of Claim. 62 Section 7.11. Priorities. 63 Section 7.12. Undertaking for Costs. 63 Article 8. Amendments, Supplements and Waivers 64 Section 8.01. Without the Consent of Holders. 64 Section 8.02. With the Consent of Holders. 64 Section 8.03. Notice of Amendments, Supplements and Waivers. 65 Section 8.04. Revocation, Effect and Solicitation of Consents; Special Record Dates; Etc. 66 Section 8.05. Notations and Exchanges. 66 Section 8.06. Trustee to Execute Supplemental Indentures. 67 Article 9. Satisfaction and Discharge; Defeasance of Certain Covenants 67 Table of Contents Section 9.01. Termination of Company’s Obligations. 67 Section 9.02. Repayment to Company. 68 Section 9.03. Reinstatement. 68 Section 9.04. Defeasance of Restrictive Covenants. 68 Article 10. Trustee 69 Section 10.01. Duties of the Trustee. 69 Section 10.02. Rights of the Trustee. 70 Section 10.03. Individual Rights of the Trustee. 71 Section 10.04. Trustee’s Disclaimer. 72 Section 10.05. Notice of Defaults. 72 Section 10.06. Compensation and Indemnity. 72 Section 10.07. Replacement of the Trustee. 73 Section 10.08. Successor Trustee by Merger, Etc. 74 Section 10.09. Eligibility; Disqualification. 74 Article 11. Miscellaneous 74 Section 11.01. Notices. 74 Section 11.02. Delivery of Officer’s Certificate and Opinion of Counsel as to Conditions Precedent. 76 Section 11.03. Statements Required in Officer’s Certificate and Opinion of Counsel. 76 Section 11.04. Rules by the Trustee, the Registrar and the Paying Agent. 76 Section 11.05. No Personal Liability of Directors, Officers, Employees and Stockholders. 77 Section 11.06. Governing Law; Waiver of Jury Trial. 77 Section 11.07. Submission to Jurisdiction. 77 Section 11.08. No Adverse Interpretation of Other Agreements. 77 Section 11.09. Successors. 77 Section 11.10. Force Majeure. 78 Section 11.11. U.S.A. PATRIOT Act. 78 Section 11.12. Calculations. 78 Section 11.13. Severability. 78 Section 11.14. Counterparts. 78 Section 11.15. Table of Contents, Headings, Etc. 78 Section 11.16. Withholding Taxes. 79 Exhibits Exhibit A: Form of Note A-1 Exhibit B-1A: Form of Restricted Note Legend (Non-Affiliate Note) B1A-1 Exhibit B-1B: Form of Restricted Note Legend (Affiliate Note) B1B-1 Exhibit B-2: Form of Global Note Legend B2-1 Exhibit B-3: Form of Non-Affiliate Legend B3-1 Table of Contents INDENTURE, dated as of December 7, 2020, between Progenity, Inc., a Delaware corporation, as issuer (the “Company”), and The Bank of New York Mellon Trust Company, N.A., as trustee (the “Trustee”). Each party to this Indenture (as defined below) agrees as follows for the benefit of the other party and for the equal and ratable benefit of the Holders (as defined below) of the Company’s 7.25% Convertible Senior Notes due 2025 (the “Notes”).

Settlement Upon Conversion. 40 45 Section 5.04. Reserve and Status of Common Stock Issued Upon Conversion. 41 49 Section 5.05. Adjustments to the Conversion Rate. 42 49 Section 5.06. Voluntary Adjustments. 52 60 Section 5.07. Adjustments to the Conversion Rate in Connection with a Make-Whole Fundamental Change. 53 60 Section 5.08. Exchange in Lieu of Conversion. 54 61 Section 5.09. Effect of Common Stock Change Event. 54 62 Article 6. Successors 56 64 Section 6.01. When the Company May Merge, Etc. 56 64 Section 6.02. Successor Corporation Entity Substituted. 57 65 Section 6.03. Exclusion for Asset Transfers with Wholly Owned Subsidiaries. 65 Article 7. Defaults and Remedies 57 65 Section 7.01. Events of Default. 57 65 Section 7.02. Acceleration. 59 67 Section 7.03. Sole Remedy for a Failure to Report. 59 68 Section 7.04. Other Remedies. 60 69 Section 7.05. Waiver of Past Defaults. 61 69 Section 7.06. Control by Majority. 61 69 Section 7.07. Limitation on Suits. 61 69 Section 7.08. Absolute Right of Holders to Institute Suit for the Enforcement of the Right to Receive Payment and Conversion Consideration. 62 70 Section 7.09. Collection Suit by Trustee. 62 70 Section 7.10. Trustee May File Proofs of Claim. 62 70 Section 7.11. Priorities. 63 71 Section 7.12. Undertaking for Costs. 63 71 Article 8. Amendments, Supplements and Waivers 64 72 Section 8.01. Without the Consent of Holders. 64 72 Section 8.02. With the Consent of Holders. 64 73 Section 8.03. Notice of Amendments, Supplements and Waivers. 65 74 Section 8.04. Revocation, Effect and Solicitation of Consents; Special Record Dates; Etc. 66 74 Section 8.05. Notations and Exchanges. 66 75 Section 8.06. Trustee to Execute Supplemental Indentures. 67 75 Article 9. Satisfaction and Discharge; Defeasance of Certain Covenants 67 Table of Contents Discharge 75 Section 9.01. Termination of Company’s Obligations. 67 75 Section 9.02. Repayment to Company. 68 76 Section 9.03. Reinstatement. 68 Section 9.04. Defeasance of Restrictive Covenants. 68 76 Article 10. Trustee 69 76 Section 10.01. Duties of the Trustee. 69 76 Section 10.02. Rights of the Trustee. 70 78 Section 10.03. Individual Rights of the Trustee. 71 78 Section 10.04. Trustee’s Disclaimer. 72 79 Section 10.05. Notice of Defaults. 72 79 Section 10.06. Compensation and Indemnity. 72 79 Section 10.07. Replacement of the Trustee. 73 80 Section 10.08. Successor Trustee by MergerXxxxxx, Etc. 74 81 Section 10.09. Eligibility; Disqualification. 74 81 Article 11. Miscellaneous 74 82 Section 11.01. Notices. 74 82 Section 11.02. Delivery of Officer’s Certificate and Opinion of Counsel as to Conditions Precedent. 76 84 Section 11.03. Statements Required in Officer’s Certificate and Opinion of Counsel. 76 84 Section 11.04. Rules by the Trustee, the Registrar Registrar, the Paying Agent and the Paying Conversion Agent. 76 84 Section 11.05. No Personal Liability of Directors, Officers, Employees and Stockholders. 77 84 Section 11.06. Governing Law; Waiver of Jury Trial. 77 85 Section 11.07. Submission to Jurisdiction. 77 85 Section 11.08. No Adverse Interpretation of Other Agreements. 77 85 Section 11.09. Successors. 77 85 Section 11.10. Force Majeure. 78 85 Section 11.11. U.S.A. PATRIOT Act. 78 86 Section 11.12. Calculations. 78 86 Section 11.13. Severability. 78 86 Section 11.14. Counterparts. 78 86 Section 11.15. Table of Contents, Headings, Etc. 78 86 Section 11.16. Withholding Taxes. 79 87 Exhibits Exhibit A: Form of Note A-1 Exhibit B-1AB-1: Form of Restricted Note Legend (NonB1-Affiliate Note) B1A-1 Exhibit B-1B: Form of Restricted Note Legend (Affiliate Note) B1B-1 1 Exhibit B-2: Form of Global Note Legend B2-1 Exhibit B-3: Form of Non-Affiliate Legend B3-1 Table of Contents INDENTURE, dated as of December 7October 11, 20202023, between ProgenityRivian Automotive, Inc., a Delaware corporation, as issuer (the “Company”), and The U.S. Bank of New York Mellon Trust Company, N.A.National Association, as trustee (the “Trustee”). Each party to this Indenture (as defined below) agrees as follows for the benefit of the other party and for the equal and ratable benefit of the Holders (as defined below) of the Company’s 7.253.625% Green Convertible Senior Notes due 2025 2030 (the “Notes”).

Settlement Upon Conversion. 40 39 Section 5.04. Reserve and Status of Common Stock Issued Upon Conversion. 41 42 Section 5.05. Adjustments to the Conversion Rate. 42 43 Section 5.06. Voluntary Adjustments. 52 53 Section 5.07. Adjustments to the Conversion Rate in Connection with a Make-Whole Fundamental Change. 53 Section 5.08. Exchange in Lieu of Conversion. 54 Section 5.09. Effect of Common Stock Change Event. 54 55 Article 6. Successors 56 57 Section 6.01. When the Company May Merge, Etc. 56 57 Section 6.02. Successor Corporation Substituted. 57 Section 6.03. Exclusion for Certain Asset Transfers. 57 Article 7. Defaults and Remedies 57 Section 7.01. Events of Default. 57 Section 7.02. Acceleration. 59 Section 7.03. Sole Remedy for a Failure to Report. 59 60 Section 7.04. Other Remedies. 60 61 Section 7.05. Waiver of Past Defaults. 61 Section 7.06. Control by Majority. 61 Section 7.07. Limitation on Suits. 61 Section 7.08. Absolute Right of Holders to Institute Suit for the Enforcement of the Right to Receive Payment and Conversion Consideration. 62 Section 7.09. Collection Suit by Trustee. 62 Section 7.10. Trustee May File Proofs of Claim. 62 Section 7.11. Priorities. 63 Section 7.12. Undertaking for Costs. 63 Article 8. Amendments, Supplements and Waivers 64 63 Section 8.01. Without the Consent of Holders. 64 63 Section 8.02. With the Consent of Holders. 64 Section 8.03. Notice of Amendments, Supplements and Waivers. 65 Section 8.04. Revocation, Effect and Solicitation of Consents; Special Record Dates; Etc. 66 65 Section 8.05. Notations and Exchanges. 66 Section 8.06. Trustee to Execute Supplemental Indentures. 67 66 Article 9. Satisfaction and Discharge; Defeasance of Certain Covenants 67 Table of Contents Discharge 66 Section 9.01. Termination of Company’s Obligations. 67 66 Section 9.02. Repayment to Company. 68 67 Section 9.03. Reinstatement. 68 Section 9.04. Defeasance of Restrictive Covenants. 68 67 Article 10. Trustee 69 67 Section 10.01. Duties of the Trustee. 69 67 Section 10.02. Rights of the Trustee. 70 69 Section 10.03. Individual Rights of the Trustee. 71 69 Section 10.04. Trustee’s Disclaimer. 72 69 Section 10.05. Notice of Defaults. 72 70 Section 10.06. Compensation and Indemnity. 72 70 Section 10.07. Replacement of the Trustee. 73 71 Section 10.08. Successor Trustee by Merger, Etc. 74 72 Section 10.09. Eligibility; Disqualification. 74 72 Article 11. Miscellaneous 74 72 Section 11.01. Notices. 74 72 Section 11.02. Delivery of Officer’s Certificate and Opinion of Counsel as to Conditions Precedent. 76 73 Section 11.03. Statements Required in Officer’s Certificate and Opinion of Counsel. 76 74 Section 11.04. Rules by the Trustee, the Registrar and Registrar, the Paying Agent and Conversion Agent. 76 74 Section 11.05. No Personal Liability of Directors, Officers, Employees and Stockholders. 77 74 Section 11.06. Governing Law; Waiver of Jury Trial. 77 74 Section 11.07. Submission to Jurisdiction. 77 74 Section 11.08. No Adverse Interpretation of Other Agreements. 77 75 Section 11.09. Successors. 77 75 Section 11.10. Force Majeure. 78 75 Section 11.11. U.S.A. PATRIOT Act. 78 75 Section 11.12. Calculations. 78 75 Section 11.13. Severability. 78 76 Section 11.14. Counterparts. 78 76 Section 11.15. Table of Contents, Headings, Etc. 78 76 Section 11.16. Withholding Taxes. 79 76 Exhibits Exhibit A: Form of Note A-1 Exhibit B-1AX-0 Xxxxxxx X-0: Form of Restricted Note Legend (NonB1-Affiliate Note) B1A-1 Exhibit B-1B: Form of Restricted Note Legend (Affiliate Note) B1B-1 1 Exhibit B-2: Form of Global Note Legend B2-1 Exhibit B-3: Form of Non-Affiliate Legend B3-1 Table of Contents INDENTURE, dated as of December 7January 19, 20202022, between ProgenityVirgin Galactic Holdings, Inc., a Delaware corporation, as issuer (the “Company”), and The U.S. Bank of New York Mellon Trust Company, N.A.National Association, as trustee (the “Trustee”). Each party to this Indenture (as defined below) agrees as follows for the benefit of the other party and for the equal and ratable benefit of the Holders (as defined below) of the Company’s 7.252.50% Convertible Senior Notes due 2025 (the “Notes”)2027.

Settlement Upon Conversion. 40 45 Section 5.04. Reserve and Status of Common Stock Shares Issued Upon Conversion. 41 48 Section 5.05. Adjustments to the Conversion Rate. 42 49 Section 5.06. Voluntary Adjustments. 52 59 Section 5.07. Adjustments to the Conversion Rate in Connection with a Make-Whole Fundamental Change. 53 59 Section 5.08. Exchange in Lieu of Conversion. 54 61 Section 5.09. Effect of Common Stock Share Change Event. 54 61 ​ ​ Article 6. Successors 56 63 ​ ​ ​ Section 6.01. When the Company May Merge, Etc. 56 63 Section 6.02. Successor Corporation Substituted. 57 64 ​ ​ Article 7. Defaults and Remedies 57 64 ​ ​ ​ Section 7.01. Events of Default. 57 64 Section 7.02. Acceleration. 59 66 Section 7.03. Sole Remedy for a Failure to Report. 59 67 Section 7.04. Other Remedies. 60 68 Section 7.05. Waiver of Past Defaults. 61 68 Section 7.06. Control by Majority. 61 68 Section 7.07. Limitation on Suits. 61 69 Section 7.08. Absolute Right of Holders to Institute Suit for the Enforcement of the Right to Receive Payment and Conversion Consideration. 62 69 Section 7.09. Collection Suit by Trustee. 62 69 Section 7.10. Trustee May File Proofs of Claim. 62 70 Section 7.11. Priorities. 63 70 Section 7.12. Undertaking for Costs. 63 71 ​ ​ Article 8. Amendments, Supplements and Waivers 64 71 ​ ​ ​ Section 8.01. Without the Consent of Holders. 64 71 Section 8.02. With the Consent of Holders. 64 72 Section 8.03. Notice of Amendments, Supplements and Waivers. 65 73 Section 8.04. Revocation, Effect and Solicitation of Consents; Special Record Dates; Etc. 66 73 Section 8.05. Notations and Exchanges. 66 74 Section 8.06. Trustee to Execute Supplemental Indentures. 67 74 ​ ​ Article 9. Guarantees 74 ​ - ii - ​ ​ Section 9.01. Guarantees. 74 Section 9.02. Limitation on Guarantor Liability. 76 Section 9.03. Execution and Delivery of Guarantee. 76 Section 9.04. When the Guarantor May Merge, Etc. 76 Section 9.05. Application of Certain Provisions to the Guarantor. 77 ​ ​ Article 10. Satisfaction and Discharge; Defeasance of Certain Covenants 67 Table of Contents Discharge 77 ​ ​ ​ Section 9.0110.01. Termination of Company’s Obligations. 67 77 Section 9.0210.02. Repayment to Company. 68 78 Section 9.0310.03. Reinstatement. 68 Section 9.04. Defeasance of Restrictive Covenants. 68 78 ​ ​ Article 1011. Trustee 69 79 ​ ​ ​ Section 10.0111.01. Duties of the Trustee. 69 79 Section 10.0211.02. Rights of the Trustee. 70 80 Section 10.0311.03. Individual Rights of the Trustee. 71 81 Section 10.0411.04. Trustee’s Disclaimer. 72 81 Section 10.0511.05. Notice of Defaults. 72 81 Section 10.0611.06. Compensation and Indemnity. 72 81 Section 10.0711.07. Replacement of the Trustee. 73 82 Section 10.0811.08. Successor Trustee by Merger, Etc. 74 83 Section 10.0911.09. Eligibility; Disqualification. 74 83 ​ ​ Article 1112. Miscellaneous 74 83 ​ ​ ​ Section 11.0112.01. Notices. 74 83 Section 11.0212.02. Delivery of Officer’s Certificate and Opinion of Counsel as to Conditions Precedent. 76 85 Section 11.0312.03. Statements Required in Officer’s Certificate and Opinion of Counsel. 76 86 Section 11.0412.04. Rules by the Trustee, the Registrar Registrar, the Paying Agent and the Paying Conversion Agent. 76 Section 11.05. No Personal Liability of Directors, Officers, Employees and Stockholders. 77 Section 11.06. Governing Law; Waiver of Jury Trial. 77 Section 11.07. Submission to Jurisdiction. 77 Section 11.08. No Adverse Interpretation of Other Agreements. 77 Section 11.09. Successors. 77 Section 11.10. Force Majeure. 78 Section 11.11. U.S.A. PATRIOT Act. 78 Section 11.12. Calculations. 78 Section 11.13. Severability. 78 Section 11.14. Counterparts. 78 Section 11.15. Table of Contents, Headings, Etc. 78 Section 11.16. Withholding Taxes. 79 Exhibits Exhibit A: Form of Note A-1 Exhibit B-1A: Form of Restricted Note Legend (Non-Affiliate Note) B1A-1 Exhibit B-1B: Form of Restricted Note Legend (Affiliate Note) B1B-1 Exhibit B-2: Form of Global Note Legend B2-1 Exhibit B-3: Form of Non-Affiliate Legend B3-1 Table of Contents INDENTURE, dated as of December 7, 2020, between Progenity, Inc., a Delaware corporation, as issuer (the “Company”), and The Bank of New York Mellon Trust Company, N.A., as trustee (the “Trustee”). Each party to this Indenture (as defined below) agrees as follows for the benefit of the other party and for the equal and ratable benefit of the Holders (as defined below) of the Company’s 7.25% Convertible Senior Notes due 2025 (the “Notes”).86

Settlement Upon Conversion. 40 44 Section 5.04. Reserve and Status of Common Stock Issued Upon Conversion. 41 48 Section 5.05. Adjustments to the Conversion Rate. 42 48 Section 5.06. Voluntary Adjustments. 52 59 Section 5.07. Adjustments to the Conversion Rate in Connection with a Make-Whole Fundamental Change. 53 59 Section 5.08. Exchange in Lieu of Conversion. 54 61 Section 5.09. Effect of Common Stock Change Event. 54 61 Article 6. Successors 56 63 Section 6.01. When the Company May Merge, Etc. 56 63 Section 6.02. Successor Corporation Entity Substituted. 57 64 Section 6.03. Exclusion for Asset Transfers with Wholly Owned Subsidiaries. 64 Article 7. Defaults and Remedies 57 64 Section 7.01. Events of Default. 57 64 Section 7.02. Acceleration. 59 66 Section 7.03. Sole Remedy for a Failure to Report. 59 67 Section 7.04. Other Remedies. 60 68 Section 7.05. Waiver of Past Defaults. 61 68 Section 7.06. Control by Majority. 61 68 Section 7.07. Limitation on Suits. 61 68 Section 7.08. Absolute Right of Holders to Institute Suit for the Enforcement of the Right to Receive Payment and Conversion Consideration. 62 69 Section 7.09. Collection Suit by Trustee. 62 69 Section 7.10. Trustee May File Proofs of Claim. 62 69 Section 7.11. Priorities. 63 70 Section 7.12. Undertaking for Costs. 63 70 Article 8. Amendments, Supplements and Waivers 64 71 Section 8.01. Without the Consent of Holders. 64 71 Section 8.02. With the Consent of Holders. 64 72 Section 8.03. Notice of Amendments, Supplements and Waivers. 65 73 Section 8.04. Revocation, Effect and Solicitation of Consents; Special Record Dates; Etc. 66 73 Section 8.05. Notations and Exchanges. 66 74 Section 8.06. Trustee to Execute Supplemental Indentures. 67 74 Article 9. Satisfaction and Discharge; Defeasance of Certain Covenants 67 Table of Contents Discharge 74 Section 9.01. Termination of Company’s Obligations. 67 74 Section 9.02. Repayment to Company. 68 75 Section 9.03. Reinstatement. 68 Section 9.04. Defeasance of Restrictive Covenants. 68 75 Article 10. Trustee 69 75 Section 10.01. Duties of the Trustee. 69 75 Section 10.02. Rights of the Trustee. 70 76 Section 10.03. Individual Rights of the Trustee. 71 77 Section 10.04. Trustee’s Disclaimer. 72 78 Section 10.05. Notice of Defaults. 72 78 Section 10.06. Compensation and Indemnity. 72 78 Section 10.07. Replacement of the Trustee. 73 79 Section 10.08. Successor Trustee by MergerXxxxxx, Etc. 74 80 Section 10.09. Eligibility; Disqualification. 74 80 Article 11. Miscellaneous 74 81 Section 11.01. Notices. 74 81 Section 11.02. Delivery of Officer’s Certificate and Opinion of Counsel as to Conditions Precedent. 76 83 Section 11.03. Statements Required in Officer’s Certificate and Opinion of Counsel. 76 83 Section 11.04. Rules by the Trustee, the Registrar Registrar, the Paying Agent and the Paying Conversion Agent. 76 83 Section 11.05. No Personal Liability of Directors, Officers, Employees and Stockholders. 77 83 Section 11.06. Governing Law; Waiver of Jury Trial. 77 84 Section 11.07. Submission to Jurisdiction. 77 84 Section 11.08. No Adverse Interpretation of Other Agreements. 77 84 Section 11.09. Successors. 77 84 Section 11.10. Force Majeure. 78 84 Section 11.11. U.S.A. PATRIOT Act. 78 85 Section 11.12. Calculations. 78 85 Section 11.13. Severability. 78 85 Section 11.14. Counterparts. 78 85 Section 11.15. Table of Contents, Headings, Etc. 78 85 Section 11.16. Withholding Taxes. 79 86 Exhibits Exhibit A: Form of Note A-1 Exhibit B-1AB-1: Form of Restricted Note Legend (NonB1-Affiliate Note) B1A-1 Exhibit B-1B: Form of Restricted Note Legend (Affiliate Note) B1B-1 1 Exhibit B-2: Form of Global Note Legend B2-1 Exhibit B-3: Form of Non-Affiliate Resale Legend B3-1 Table of Contents iii INDENTURE, dated as of December 7March 20, 20202023, between ProgenityFreshpet, Inc., a Delaware corporation, as issuer (the “Company”), and The U.S. Bank of New York Mellon Trust Company, N.A.National Association, as trustee (the “Trustee”). Each party to this Indenture (as defined below) agrees as follows for the benefit of the other party and for the equal and ratable benefit of the Holders (as defined below) of the Company’s 7.253.00% Convertible Senior Notes due 2025 2028 (the “Notes”).

Settlement Upon Conversion. 40 ‌ 46 Section 5.04. Reserve and Status of Common Stock Issued Upon upon Conversion. 41 ‌ 49 Section 5.05. Adjustments to the Conversion Rate. 42 ‌ 49 Section 5.06. Voluntary Adjustments. 52 ‌ 59 Section 5.07. Adjustments to the Conversion Rate in Connection with a Make-Whole Fundamental Change. 53 ‌ 59 Section 5.08. Exchange in Lieu of Conversion. 54 ‌ 61 Section 5.09. Effect of Common Stock Change Event. 54 ‌ 61 Article 6. 6 Successors 56 ‌ 63 Section 6.01. When the Company May Merge, Etc. 56 ‌ 63 Section 6.02. Successor Corporation Substituted. 57 ‌ 64 Article 7. 7 Defaults and Remedies 57 ‌ 64 Section 7.01. Events of Default. 57 ‌ 64 Section 7.02. Acceleration. 59 ‌ 66 Section 7.03. Sole Remedy for a Failure to Report. 59 ‌ 67 Section 7.04. Other Remedies. 60 ‌ 68 Section 7.05. Waiver of Past Defaults. 61 ‌ 68 Section 7.06. Control by Majority. 61 ‌ 68 Section 7.07. Limitation on Suits. 61 ‌ 69 Section 7.08. Absolute Right of Holders to Institute Suit for the Enforcement of the Right to Receive Payment and Conversion Consideration. 62 ‌ 69 Section 7.09. Collection Suit by Trustee. 62 ‌ 69 Section 7.10. Trustee May File Proofs of Claim. 62 ‌ 70 Section 7.11. Priorities. 63 ‌ 70 Section 7.12. Undertaking for Costs. 63 ‌ 71 Article 8. 8 Amendments, Supplements and Waivers 64 ‌ 71 Section 8.01. Without the Consent of Holders. 64 ‌ 71 Section 8.02. With the Consent of Holders. 64 ‌ 72 Section 8.03. Notice of Amendments, Supplements and Waivers. 65 ‌ 73 Section 8.04. Revocation, Effect and Solicitation of Consents; Special Record Dates; Etc. 66 ‌ 73 Section 8.05. Notations and Exchanges. 66 ‌ 74 Section 8.06. Trustee to Execute Supplemental Indentures. 67 ‌ 74 Article 9. 9 Satisfaction and Discharge; Defeasance of Certain Covenants 67 Table of Contents Discharge ‌ 74 Section 9.01. Termination of Company’s Obligations. 67 ‌ 74 Section 9.02. Repayment to Company. 68 ‌ 75 Section 9.03. Reinstatement. 68 Section 9.04. Defeasance of Restrictive Covenants. 68 ‌ 75 - ii - ‌ ​ ​ ​ Article 10. 10 Trustee 69 ‌ 75 Section 10.01. Duties of the Trustee. 69 ‌ 75 Section 10.02. Rights of the Trustee. 70 ‌ 76 Section 10.03. Individual Rights of the Trustee. 71 ‌ 78 Section 10.04. Trustee’s Disclaimer. 72 ‌ 78 Section 10.05. Notice of Defaults. 72 ‌ 78 Section 10.06. Compensation and Indemnity. 72 ‌ 78 Section 10.07. Replacement of the Trustee. 73 ‌ 79 Section 10.08. Successor Trustee by MergerXxxxxx, Etc. 74 ‌ 80 Section 10.09. Eligibility; Disqualification. 74 ‌ 80 Article 11. 11 Miscellaneous 74 ‌ 80 Section 11.01. Notices. 74 ‌ 80 Section 11.02. Delivery of Officer’s Certificate and Opinion of Counsel as to Conditions Precedent. 76 Section 11.03. Statements Required in Officer’s Certificate and Opinion of Counsel. 76 Section 11.04. Rules by the Trustee, the Registrar and the Paying Agent. 76 Section 11.05. No Personal Liability of Directors, Officers, Employees and Stockholders. 77 Section 11.06. Governing Law; Waiver of Jury Trial. 77 Section 11.07. Submission to Jurisdiction. 77 Section 11.08. No Adverse Interpretation of Other Agreements. 77 Section 11.09. Successors. 77 Section 11.10. Force Majeure. 78 Section 11.11. U.S.A. PATRIOT Act. 78 Section 11.12. Calculations. 78 Section 11.13. Severability. 78 Section 11.14. Counterparts. 78 Section 11.15. Table of Contents, Headings, Etc. 78 Section 11.16. Withholding Taxes. 79 Exhibits Exhibit A: Form of Note A-1 Exhibit B-1A: Form of Restricted Note Legend (Non-Affiliate Note) B1A-1 Exhibit B-1B: Form of Restricted Note Legend (Affiliate Note) B1B-1 Exhibit B-2: Form of Global Note Legend B2-1 Exhibit B-3: Form of Non-Affiliate Legend B3-1 Table of Contents INDENTURE, dated as of December 7, 2020, between Progenity, Inc., a Delaware corporation, as issuer (the “Company”), and The Bank of New York Mellon Trust Company, N.A., as trustee (the “Trustee”). Each party to this Indenture (as defined below) agrees as follows for the benefit of the other party and for the equal and ratable benefit of the Holders (as defined below) of the Company’s 7.25% Convertible Senior Notes due 2025 (the “Notes”).‌ 82

Settlement Upon Conversion. 40 45 Section 5.04. Reserve and Status of Common Stock Issued Upon Conversion. 41 48 Section 5.05. Adjustments to the Conversion Rate. 42 49 Section 5.06. Voluntary Adjustments. 52 60 Section 5.07. Adjustments to the Conversion Rate in Connection with a Make-Whole Fundamental Change. 53 61 Section 5.08. Exchange in Lieu of Conversion. 54 62 Section 5.09. Effect of Common Stock Change Event. 54 63 Article 6. Successors 56 65 Section 6.01. When the Company May Merge, Etc. 56 65 Section 6.02. Successor Corporation Substituted. 57 65 Article 7. Defaults and Remedies 57 66 Section 7.01. Events of Default. 57 66 Section 7.02. Acceleration. 59 68 Section 7.03. Sole Remedy for a Failure to Report. 59 68 Section 7.04. Other Remedies. 60 69 Section 7.05. Waiver of Past Defaults. 61 70 Section 7.06. Control by Majority. 61 70 Section 7.07. Limitation on Suits. 61 70 Section 7.08. Absolute Right of Holders to Institute Suit for the Enforcement of the Right to Receive Payment and Conversion Consideration. 62 71 Section 7.09. Collection Suit by Trustee. 62 71 Section 7.10. Trustee May File Proofs of Claim. 62 71 Section 7.11. Priorities. 63 72 Section 7.12. Undertaking for Costs. 63 72 Article 8. Amendments, Supplements and Waivers 64 73 Section 8.01. Without the Consent of Holders. 64 73 Section 8.02. With the Consent of Holders. 64 74 Section 8.03. Notice of Amendments, Supplements and Waivers. 65 75 Section 8.04. Revocation, Effect and Solicitation of Consents; Special Record Dates; Etc. 66 75 Section 8.05. Notations and Exchanges. 66 76 Section 8.06. Trustee to Execute Supplemental Indentures. 67 76 Article 9. Satisfaction and Discharge; Defeasance of Certain Covenants 67 Table of Contents Discharge 76 Section 9.01. Termination of Company’s Obligations. 67 76 Section 9.02. Repayment to Company. 68 77 Section 9.03. Reinstatement. 68 Section 9.04. Defeasance of Restrictive Covenants. 68 77 Article 10. Trustee 69 77 Section 10.01. Duties of the Trustee. 69 77 Section 10.02. Rights of the Trustee. 70 79 Section 10.03. Individual Rights of the Trustee. 71 80 Section 10.04. Trustee’s Disclaimer. 72 80 Section 10.05. Notice of Defaults. 72 81 Section 10.06. Compensation and Indemnity. 72 81 Section 10.07. Replacement of the Trustee. 73 82 Section 10.08. Successor Trustee by Merger, Etc. 74 83 Section 10.09. Eligibility; Disqualification. 74 83 Article 11. Miscellaneous 74 83 Section 11.01. Notices. 74 83 Section 11.02. Delivery of Officer’s Certificate and Opinion of Counsel as to Conditions Precedent. 76 85 Section 11.03. Statements Required in Officer’s Certificate and Opinion of Counsel. 76 86 Section 11.04. Rules by the Trustee, the Registrar and Registrar, the Paying Agent and Conversion Agent. 76 Section 11.05. No Personal Liability of Directors, Officers, Employees and Stockholders. 77 Section 11.06. Governing Law; Waiver of Jury Trial. 77 Section 11.07. Submission to Jurisdiction. 77 Section 11.08. No Adverse Interpretation of Other Agreements. 77 Section 11.09. Successors. 77 Section 11.10. Force Majeure. 78 Section 11.11. U.S.A. PATRIOT Act. 78 Section 11.12. Calculations. 78 Section 11.13. Severability. 78 Section 11.14. Counterparts. 78 Section 11.15. Table of Contents, Headings, Etc. 78 Section 11.16. Withholding Taxes. 79 Exhibits Exhibit A: Form of Note A-1 Exhibit B-1A: Form of Restricted Note Legend (Non-Affiliate Note) B1A-1 Exhibit B-1B: Form of Restricted Note Legend (Affiliate Note) B1B-1 Exhibit B-2: Form of Global Note Legend B2-1 Exhibit B-3: Form of Non-Affiliate Legend B3-1 Table of Contents INDENTURE, dated as of December 7, 2020, between Progenity, Inc., a Delaware corporation, as issuer (the “Company”), and The Bank of New York Mellon Trust Company, N.A., as trustee (the “Trustee”). Each party to this Indenture (as defined below) agrees as follows for the benefit of the other party and for the equal and ratable benefit of the Holders (as defined below) of the Company’s 7.25% Convertible Senior Notes due 2025 (the “Notes”).86

Settlement Upon Conversion. 40 45 Section 5.04. Reserve and Status of Common Stock Issued Upon Conversion. 41 49 Section 5.05. Adjustments to the Conversion Rate. 42 50 Section 5.06. Voluntary Adjustments. 52 60 Section 5.07. Adjustments to the Conversion Rate in Connection with a Make-Whole Fundamental Change. 53 61 Section 5.08. Exchange in Lieu of Conversion. 54 62 Section 5.09. Effect of Common Stock Change Event. 54 63 Section 5.10. Responsibility of Trustee. 65 Article 6. Successors 56 65 Section 6.01. When the Company May Merge, Etc. 56 65 Section 6.02. Successor Corporation Entity Substituted. 57 66 Section 6.03. Exclusion for Asset Transfers with Wholly Owned Subsidiaries. 66 Article 7. Defaults and Remedies 57 66 Section 7.01. Events of Default. 57 66 Section 7.02. Acceleration. 59 68 Section 7.03. Sole Remedy for a Failure to Report. 59 69 Section 7.04. Other Remedies. 60 70 Section 7.05. Waiver of Past Defaults. 61 70 Section 7.06. Control by Majority. 61 70 Section 7.07. Limitation on Suits. 61 71 Section 7.08. Absolute Right of Holders to Institute Suit for the Enforcement of the Right to Receive Payment and Conversion Consideration. 62 71 Section 7.09. Collection Suit by Trustee. 62 71 Section 7.10. Trustee May File Proofs of Claim. 62 72 Section 7.11. Priorities. 63 72 Section 7.12. Undertaking for Costs. 63 73 Article 8. Amendments, Supplements and Waivers 64 73 Section 8.01. Without the Consent of Holders. 64 73 Section 8.02. With the Consent of Holders. 64 74 Section 8.03. Notice of Amendments, Supplements and Waivers. 65 75 Section 8.04. Revocation, Effect and Solicitation of Consents; Special Record Dates; Etc. 66 75 Section 8.05. Notations and Exchanges. 66 76 Section 8.06. Trustee to Execute Supplemental Indentures. 67 Article 9. Satisfaction and Discharge; Defeasance of Certain Covenants 67 Table of Contents Section 9.01. Termination of Company’s Obligations. 67 Section 9.02. Repayment to Company. 68 Section 9.03. Reinstatement. 68 Section 9.04. Defeasance of Restrictive Covenants. 68 Article 10. Trustee 69 Section 10.01. Duties of the Trustee. 69 Section 10.02. Rights of the Trustee. 70 Section 10.03. Individual Rights of the Trustee. 71 Section 10.04. Trustee’s Disclaimer. 72 Section 10.05. Notice of Defaults. 72 Section 10.06. Compensation and Indemnity. 72 Section 10.07. Replacement of the Trustee. 73 Section 10.08. Successor Trustee by Merger, Etc. 74 Section 10.09. Eligibility; Disqualification. 74 Article 11. Miscellaneous 74 Section 11.01. Notices. 74 Section 11.02. Delivery of Officer’s Certificate and Opinion of Counsel as to Conditions Precedent. 76 Section 11.03. Statements Required in Officer’s Certificate and Opinion of Counsel. 76 Section 11.04. Rules by the Trustee, the Registrar and the Paying Agent. 76 Section 11.05. No Personal Liability of Directors, Officers, Employees and Stockholders. 77 Section 11.06. Governing Law; Waiver of Jury Trial. 77 Section 11.07. Submission to Jurisdiction. 77 Section 11.08. No Adverse Interpretation of Other Agreements. 77 Section 11.09. Successors. 77 Section 11.10. Force Majeure. 78 Section 11.11. U.S.A. PATRIOT Act. 78 Section 11.12. Calculations. 78 Section 11.13. Severability. 78 Section 11.14. Counterparts. 78 Section 11.15. Table of Contents, Headings, Etc. 78 Section 11.16. Withholding Taxes. 79 Exhibits Exhibit A: Form of Note A-1 Exhibit B-1A: Form of Restricted Note Legend (Non-Affiliate Note) B1A-1 Exhibit B-1B: Form of Restricted Note Legend (Affiliate Note) B1B-1 Exhibit B-2: Form of Global Note Legend B2-1 Exhibit B-3: Form of Non-Affiliate Legend B3-1 Table of Contents INDENTURE, dated as of December 7, 2020, between Progenity, Inc., a Delaware corporation, as issuer (the “Company”), and The Bank of New York Mellon Trust Company, N.A., as trustee (the “Trustee”). Each party to this Indenture (as defined below) agrees as follows for the benefit of the other party and for the equal and ratable benefit of the Holders (as defined below) of the Company’s 7.25% Convertible Senior Notes due 2025 (the “Notes”).76

Settlement Upon Conversion. 40 48 Section 5.04. Reserve and Status of Common Stock Ordinary Shares Issued Upon upon Conversion. 41 50 Section 5.05. Adjustments to the Conversion Rate. 42 51 Section 5.06. Voluntary Adjustments. 52 61 Section 5.07. Adjustments to the Conversion Rate in Connection with a Make-Whole Fundamental Change. 53 61 Section 5.08. Exchange in Lieu of ConversionRestriction on Conversions. 54 63 Section 5.09. Effect of Common Stock Ordinary Share Change Event. 54 63 Article 6. Successors 56 65 Section 6.01. When the Company May Merge, Etc. 56 65 Section 6.02. Successor Corporation Substituted. 57 66 Article 7. Defaults and Remedies 57 66 Section 7.01. Events of Default. 57 66 Section 7.02. Acceleration. 59 68 Section 7.03. Sole Remedy for a Failure to Report. 59 69 Section 7.04. Other Remedies. 60 70 Section 7.05. Waiver of Past Defaults. 61 70 Section 7.06. Control by Majority. 61 70 Section 7.07. Limitation on Suits. 61 71 Section 7.08. Absolute Right of Holders to Institute Suit for the Enforcement of the Right to Receive Payment and Conversion Consideration. 62 71 Section 7.09. Collection Suit by Trustee. 62 71 Section 7.10. Trustee May File Proofs of Claim. 62 72 Section 7.11. Priorities. 63 72 Section 7.12. Undertaking for Costs. 63 73 Article 8. Amendments, Supplements and Waivers 64 73 Section 8.01. Without the Consent of Holders. 64 73 Section 8.02. With the Consent of Holders. 64 74 Section 8.03. Notice of Amendments, Supplements and Waivers. 65 75 Section 8.04. Revocation, Effect and Solicitation of Consents; Special Record Dates; Etc. 66 75 Section 8.05. Notations and Exchanges. 66 76 Section 8.06. Trustee to Execute Supplemental Indentures. 67 76 Article 9. Guarantees 76 Section 9.01. Guarantees. 76 Section 9.02. Limitation on Guarantor Liability. 78 Section 9.03. Execution and Delivery of Guarantee. 78 Section 9.04. When Guarantors May Merge, Etc. 78 Section 9.05. Future Guarantors. 79 Section 9.06. Application of Certain Provisions to the Guarantors. 79 Article 10. Satisfaction and Discharge; Defeasance of Certain Covenants 67 Table of Contents Discharge 80 Section 9.0110.01. Termination of Company’s Obligations. 67 80 Section 9.0210.02. Repayment to Company. 68 80 Section 9.0310.03. Reinstatement. 68 Section 9.04. Defeasance of Restrictive Covenants. 68 80 Article 1011. Trustee 69 81 Section 10.0111.01. Duties of the Trustee. 69 81 Section 10.0211.02. Rights of the Trustee. 70 82 Section 10.0311.03. Individual Rights of the Trustee. 71 83 Section 10.0411.04. Trustee’s Disclaimer. 72 83 Section 10.0511.05. Notice of Defaults. 72 83 Section 10.0611.06. Compensation and Indemnity. 72 83 Section 10.0711.07. Replacement of the Trustee. 73 84 Section 10.0811.08. Successor Trustee by Merger, Etc. 74 85 Section 10.0911.09. Eligibility; Disqualification. 74 85 Article 1112. Miscellaneous 74 85 Section 11.0112.01. Notices. 74 85 Section 11.0212.02. Delivery of Officer’s Certificate and Opinion of Counsel as to Conditions Precedent. 76 87 Section 11.0312.03. Statements Required in Officer’s Certificate and Opinion of Counsel. 76 87 Section 11.0412.04. Rules by the Trustee, the Registrar and the Paying Agent. 76 87 Section 11.0512.05. No Personal Liability of Directors, Officers, Employees and StockholdersShareholders. 77 88 Section 11.0612.06. Governing Law; Waiver of Jury Trial. 77 88 Section 11.0712.07. Submission to Jurisdiction. 77 88 Section 11.0812.08. No Adverse Interpretation of Other Agreements. 77 88 Section 11.0912.09. Successors. 77 89 Section 11.1012.10. Force Majeure. 78 89 Section 11.1112.11. U.S.A. PATRIOT Act. 78 89 Section 11.1212.12. Calculations. 78 89 Section 11.1312.13. Severability. 78 89 Section 11.1412.14. Counterparts. 78 89 Section 11.1512.15. Table of Contents, Headings, Etc. 78 90 Section 11.1612.16. Withholding Taxes. 79 90 Section 12.17. Trust Indenture Act Controls. 90 Exhibits Exhibit A: Form of Note A-1 Exhibit B-1A: Form of Restricted Note Legend (Non-Affiliate Note) B1A-1 Exhibit B-1B: Form of Restricted Note Legend (Affiliate Note) B1B-1 Exhibit B-2B: Form of Global Note Legend B2-1 Exhibit B-3: Form of Non-Affiliate Legend B3-1 Table of Contents B-1 INDENTURE, dated as of December 7[closing date], 2020, between Progenityamong Aegerion Pharmaceuticals, Inc., a Delaware corporation, as issuer (the “Company”), [New Parent], a company incorporated in England and The Bank of New York Mellon Trust CompanyWales (the “Parent”), N.A.Amryt Pharma plc, a company incorporated in England and Wales (“Old Parent”), the additional guarantors listed on the signature pages hereto, as guarantors (together with the Parent and Old Parent, the “Guarantors”), and [trustee’s legal name], as trustee (the “Trustee”). Each party to this Indenture (as defined below) agrees as follows for the benefit of the other party and for the equal and ratable benefit of the Holders (as defined below) of the Company’s 7.255.00% Convertible Senior Notes due 2025 [maturity year] (the “Notes”).

Settlement Upon Conversion. 40 39 Section 5.04. Reserve and Status of Common Stock Issued Upon upon Conversion. 41 42 Section 5.05. Adjustments to the Conversion Rate. 42 43 Section 5.06. Voluntary Adjustments. 52 54 Section 5.07. Adjustments to the Conversion Rate in Connection with a Make-Whole Fundamental Change. 53 54 Section 5.08. Exchange in Lieu of Conversion. 54 55 Section 5.09. Effect of Common Stock Change Event. 54 56 Article 6. Successors 56 57 Section 6.01. When the Company May Merge, Etc. 56 57 Section 6.02. Successor Corporation Substituted. 57 58 Article 7. Defaults and Remedies 57 58 Section 7.01. Events of Default. 57 58 Section 7.02. Acceleration. 59 60 Section 7.03. Sole Remedy for a Failure to Report. 59 61 Section 7.04. Other Remedies. 60 62 Section 7.05. Waiver of Past Defaults. 61 62 Section 7.06. Control by Majority. 61 62 Section 7.07. Limitation on Suits. 61 63 Section 7.08. Absolute Right of Holders to Institute Suit for the Enforcement of the Right to Receive Payment and Conversion Consideration. 62 63 Section 7.09. Collection Suit by Trustee. 62 63 Section 7.10. Trustee May File Proofs of Claim. 62 64 Section 7.11. Priorities. 63 64 Section 7.12. Undertaking for Costs. 63 65 Article 8. Amendments, Supplements and Waivers 64 65 Section 8.01. Without the Consent of Holders. 64 65 Section 8.02. With the Consent of Holders. 64 66 Section 8.03. Notice of Amendments, Supplements and Waivers. 65 67 Section 8.04. Revocation, Effect and Solicitation of Consents; Special Record Dates; Etc. 66 67 Section 8.05. Notations and Exchanges. 66 68 Section 8.06. Trustee to Execute Supplemental Indentures. 67 Article 9. Satisfaction and Discharge; Defeasance of Certain Covenants 67 Table of Contents Section 9.01. Termination of Company’s Obligations. 67 Section 9.02. Repayment to Company. 68 Section 9.03. Reinstatement. 68 Section 9.04. Defeasance of Restrictive Covenants. 68 Article 10. Trustee 69 Section 10.01. Duties of the Trustee. 69 Section 10.02. Rights of the Trustee. 70 Section 10.03. Individual Rights of the Trustee. 71 Section 10.04. Trustee’s Disclaimer. 72 Section 10.05. Notice of Defaults. 72 Section 10.06. Compensation and Indemnity. 72 Section 10.07. Replacement of the Trustee. 73 Section 10.08. Successor Trustee by Merger, Etc. 74 Section 10.09. Eligibility; Disqualification. 74 Article 11. Miscellaneous 74 Section 11.01. Notices. 74 Section 11.02. Delivery of Officer’s Certificate and Opinion of Counsel as to Conditions Precedent. 76 Section 11.03. Statements Required in Officer’s Certificate and Opinion of Counsel. 76 Section 11.04. Rules by the Trustee, the Registrar and the Paying Agent. 76 Section 11.05. No Personal Liability of Directors, Officers, Employees and Stockholders. 77 Section 11.06. Governing Law; Waiver of Jury Trial. 77 Section 11.07. Submission to Jurisdiction. 77 Section 11.08. No Adverse Interpretation of Other Agreements. 77 Section 11.09. Successors. 77 Section 11.10. Force Majeure. 78 Section 11.11. U.S.A. PATRIOT Act. 78 Section 11.12. Calculations. 78 Section 11.13. Severability. 78 Section 11.14. Counterparts. 78 Section 11.15. Table of Contents, Headings, Etc. 78 Section 11.16. Withholding Taxes. 79 Exhibits Exhibit A: Form of Note A-1 Exhibit B-1A: Form of Restricted Note Legend (Non-Affiliate Note) B1A-1 Exhibit B-1B: Form of Restricted Note Legend (Affiliate Note) B1B-1 Exhibit B-2: Form of Global Note Legend B2-1 Exhibit B-3: Form of Non-Affiliate Legend B3-1 Table of Contents INDENTURE, dated as of December 7, 2020, between Progenity, Inc., a Delaware corporation, as issuer (the “Company”), and The Bank of New York Mellon Trust Company, N.A., as trustee (the “Trustee”). Each party to this Indenture (as defined below) agrees as follows for the benefit of the other party and for the equal and ratable benefit of the Holders (as defined below) of the Company’s 7.25% Convertible Senior Notes due 2025 (the “Notes”).68