Common use of No Substitution Clause in Contracts

No Substitution. Institution and Principal Investigator may not reassign the conduct of the Trial to a different Principal Investigator without prior written authorization from Sponsor. Any replacement Principal Investigator will be required to agree to the terms and conditions of this Agreement in a separate writing. In the event Sponsor does not approve a replacement Principal Investigator, Sponsor or CRO may terminate this Agreement in accordance with the Termination provisions below. 1.4.

No Substitution. Institution and Principal Investigator may not reassign the conduct of the Trial to a different Principal Investigator without prior written authorization from Sponsor. Any replacement Principal Investigator will be required to agree to the terms and conditions of this Agreement in a separate writing. In the event Sponsor does not approve a replacement Principal Investigator, Sponsor or CRO may terminate this Agreement in accordance with the Termination provisions below. 1.42.

No Substitution. Institution and Principal Investigator may not reassign the conduct of the Trial to a different Principal Investigator without prior written authorization from Sponsor. Any replacement Principal Investigator will be required to agree to the terms and conditions of this Agreement in a separate writing. In the event Sponsor does not approve a replacement Principal Investigator, Sponsor or CRO may terminate this Agreement in accordance with the Termination provisions below. 1.4.

No Substitution. Institution and Principal Investigator may not reassign the conduct of the Trial to a different Principal Investigator without prior written authorization from Sponsor. Any replacement Principal Investigator will be required to agree to the terms and conditions of this Agreement in a separate writing. In the event Sponsor does not approve a replacement Principal Investigator, Sponsor or CRO may terminate this Agreement in accordance with the Termination provisions below. The amendment to this Agreement shall be executed in case of change of Principal Investigator. 1.4.

No Substitution. Institution and Principal Investigator may not reassign the conduct of the Trial to a different Principal Investigator without prior written authorization from Sponsor. Any replacement Principal Investigator will be required to agree to the terms and conditions of this Agreement in a separate writing. In the event Sponsor does not approve a replacement Principal InvestigatorInvestigator and this dissaproval will not be unjutisfied, Sponsor or CRO may terminate this Agreement in accordance with the Termination provisions below. 1.41.5.

No Substitution. Institution and Principal Investigator may not reassign the conduct of the Trial to a different Principal Investigator without prior written authorization from Sponsor. Any replacement Principal Investigator will be required to agree enter into a separate agreement with Sponsor in respect to the terms and conditions of this Agreement in a separate writingTrial. In the event Sponsor does not approve a replacement Principal Investigator, Sponsor or CRO may terminate this Agreement in accordance with the Termination provisions below. 1.4.

No Substitution. Institution and Principal Investigator may not reassign the conduct of the Trial to a different Principal Investigator investigator without prior written authorization from Sponsor. Any replacement Principal Investigator principal investigator will be required to agree to the terms and conditions of this Agreement in a separate writing. In the event Sponsor does not approve a replacement Principal Investigatorprincipal investigator, Sponsor or CRO may terminate this Agreement in accordance with the Termination termination provisions below. 1.4.

No Substitution. Institution and Principal Investigator may not reassign the conduct of the Trial to a different Principal Investigator without prior written authorization from Sponsor. Any replacement Principal Investigator will be required to agree to the terms and conditions of this Agreement in a separate writing. In the event Sponsor does not approve a replacement Principal Investigator, Sponsor or CRO may terminate this Agreement in accordance with the Termination provisions below. 1.4.

No Substitution. Institution and Principal Investigator may not reassign the conduct of the Trial to a different Principal Investigator without prior written authorization from Sponsor. Any replacement Principal Investigator will be required to agree to the terms and conditions of this Agreement in a separate writing. In the event Sponsor does not approve a replacement Principal Investigator, Sponsor or CRO may terminate this Agreement in accordance with the Termination provisions below. 1.4.

No Substitution. Institution and Principal Investigator may not reassign the conduct of the Trial to a different Principal Investigator without prior written authorization from Sponsor. Any replacement Principal Investigator will be required to agree to the terms and conditions of this Agreement in a separate writing. In the event Sponsor does not approve a replacement Principal Investigator, Sponsor or CRO may terminate this Agreement in accordance with the Termination termination provisions below. 1.4.

No Substitution. Institution Provider and Principal Investigator may not reassign the conduct of the Trial to a different Principal Investigator without prior written authorization from Sponsor. Any replacement Principal Investigator will be required to agree to the terms and conditions of this Agreement in a separate writing. In the event Sponsor does not approve a replacement Principal Investigator, Sponsor or CRO may terminate this Agreement or CRO per Sponsor’s request may terminate in accordance with the Termination provisions below. 1.4.

No Substitution. Institution and Principal Investigator may not reassign the conduct of the Trial to a different Principal Investigator without prior written authorization from Sponsor. Any replacement Principal Investigator will be required to agree to the terms and conditions of this Agreement in a separate writing. In the event Sponsor does not approve a replacement Principal Investigator, Sponsor or CRO may terminate this Agreement in accordance with the Termination termination provisions below. 1.4.

No Substitution. Institution Provider and Principal Investigator may not reassign the conduct of the Trial to a different Principal Investigator without prior written authorization from Sponsor. Any replacement Principal Investigator will be required to agree to the terms and conditions of this Agreement in a separate writing. In the event Sponsor does not approve a replacement Principal Investigator, Sponsor or CRO Syneos Health may terminate this Agreement in accordance with the Termination provisions below. 1.42.

No Substitution. Institution Provider and Principal Investigator may not reassign the conduct of the Trial to a different Principal Investigator without prior written authorization from Sponsor. Any replacement Principal Investigator will be required to agree to the terms and conditions of this Agreement in a separate writingwritten amendment to this Agreement. In the event Sponsor does not approve a replacement Principal Investigator, Sponsor or CRO may terminate this Agreement in accordance with the Termination provisions below. 1.4.

No Substitution. Institution and Principal Investigator may not reassign the conduct of the Trial to a different Principal Investigator without prior written authorization from Sponsor. Any replacement Principal Investigator will be required to agree to the terms and conditions of this Agreement in a separate writingamendment. In the event Sponsor does not approve a replacement Principal Investigator, any contracting party or Sponsor or CRO may terminate this Agreement in accordance with immediate effect. Sponsor and CRO acknowledge that Institution has right to terminate employment relationship with Principal Investigator and this will not be considered as breach of the Termination provisions belowAgreement. 1.4.

No Substitution. Institution Provider and Principal Investigator may not reassign the conduct of the Trial to a different Principal Investigator without prior written authorization from Sponsor. Any replacement Principal Investigator will be required to agree to the terms and conditions of this Agreement in a separate writing. In the event Sponsor does not approve a replacement Principal Investigator, Sponsor or CRO may terminate this Agreement in accordance with the Termination provisions below. 1.4.1.5

No Substitution. Institution and Principal Investigator may not reassign the conduct of the Trial to a different Principal Investigator without prior written authorization from Sponsor. Any replacement Principal Investigator will be required to agree to the terms and conditions of this Agreement in a separate writing. In the event Sponsor does not approve a replacement Principal Investigator, Sponsor or CRO Syneos Health may terminate this Agreement in accordance with the Termination provisions below. 1.4.

No Substitution. Institution and Principal Investigator may not reassign the conduct of the Trial to a different Principal Investigator without prior written authorization from Sponsor/CRO. Any replacement Principal Investigator will be required to agree to the terms and conditions of this Agreement in a separate writing. In the event Sponsor Sponsor/CRO does not approve a replacement Principal InvestigatorInvestigator and this dissaproval will not be unjutisfied, Sponsor or CRO may terminate this Agreement in accordance with the Termination provisions below. 1.4.