Flowchart of selection of study population Sample Clauses

Flowchart of selection of study population. The response to the questionnaire was 1066 of 1519 (70%). General characteristics of the participants are shown in Table 1. Table 1. Patient characteristics* Total number of patients 638 Age in years 41 (10-87) Haemophilia type A 557 (87%) B 81 (13%) Severity of Haemophilia Mild 211 (33%) Moderate 112 (18%) Severe 315 (49%) Patients treated before 1985† 523 (82%) HIV positive 28 (5%) Patients treated before 1992‡ 638 Anti HCV positive 441 (68% of tested patients) HCV RNA positive 344 (54% of tested patients) * Information of patients treated before 1992 with a reported HCV test result. Values are medians (range) or numbers (percentage) † At risk for HIV infection due to not adequately or non-virus inactivated clotting factor products ‡ At risk for HCV infection due to not adequately or non-virus inactivated clotting factor products Hepatitis C Patients treated with clotting products before 1992 A total of 771 patients were at risk for HCV infection (i.e. treated before 1992); 599 were already treated with clotting products before 1985, 136 were treated exclusively between 1985 and 1992, whereas 36 patients reported to have been treated before 1992 but not whether they were also exposed to clotting products before 1985. 638 of these 771 patients reported their HCV status. Among the 133 patients at risk without a HCV test result, 68% had mild haemophilia. In the verification sample, 92% (85/92) reported their hepatitis C status correctly; 96% of patients with an HCV infection and 88% of patients with a cleared infection or those who where never infected. Among 638 patients treated with clotting factor products before 1992 and tested for HCV, 441 (68%) ever had an anti-HCV positive test; 344 (54%) reported to be currently infected with HCV, 97 (15%) reported an infection in the past and 197 patients (31%) had never been infected. No infections with HCV occurred in patients who were treated after 1992 only. HCV infection was related to type of haemophilia; patients with haemophilia B had been infected more often than those with type A (84% vs. 67%, P < 0.01). Among patients at risk for HCV transmission, patients with severe haemophilia had the highest prevalence of hepatitis C (severe 65%, moderate 53%, mild 37%, P < 0.001). The mean age of patients differed according to severity of haemophilia and HCV status; patients with severe haemophilia, who were never infected, were younger (mean age 23 years, 95% confidence interval (CI) 19-28) than both patients with ...
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