Description of the Work Carried Out Sample Clauses

Description of the Work Carried Out. The work performed at the FIOH focused on assessing the genotoxic and immunotoxic effects of the NFC materials. In vivo studies in mice were used to investigate both acute and subacute responses (24-h and 28-d follow up). For genotoxicity assessment in vivo, the comet assay was performed on lung cells and broncho- alveolar lavage (BAL) fluid cells and the micronucleus assay on bone marrow polychromatic erythrocytes, after single pharyngeal aspiration to female C57BL/6 mice (doses 10, 40, 80 and 200 μg/mouse). Inflammatory effects in vivo were assessed by investigating the influx of inflammatory cells in BAL, mRNA expression levels of relevant cytokines, and histopathological changes in lungs (doses 10 and 40 μg/mouse). These tests, together with in vitro testing performed with the same material under WP5, provide indication, whether the NFC materials studied are able to cause cellular damage or systemic effects. Our study provides new information about the toxicity of NFC and thereby contributes to the hazard assessment of these materials.
Sample 1
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Description of the Work Carried Out. The ProSafe partners of T3.2, in particular JRC, have first proposed the adoption of ISA-TAB-Nano for streamlined nanoEHS experimental data recording within the large FP7 project NANoREG, where the system was adopted in March 2014. As set in the DoW of T3.2, the task leader has established a strong link with FP7 eNanoMapper right from the start of ProSafe. This has led to a positive collaboration between ProSafe WP3 and eNanoMapper (especially UMaastricht and IDEA) that has lasted for the whole duration of ProSafe. eNanoMapper was the 'technical implementation arm' of a streamlined data management strategy within the EU NanoSafety Cluster (NSC), to serve the data needs of any project in that arena. In its technical development of ISA-TAB-Nano tools for the NSC community, eNanoMapper received support from this ProSafe task 3.2. The task leader relayed on several occasions, such as bilateral JRC-UMaastricht/IDEA teleconferences, participation in eNM-promoted NSC meetings in 2016, monthly TC calls of the NanoSafety Cluster WG4 US-EU CoR meetings on databases, etc. the needs of the nanoEHS community, especially of the large project NANoREG, where it has been leading the ISA-TAB-Nano technical implementation. Around early 2016, it appeared that a sufficiently wide community in the NSC endorses the use of ISA-TAB-Nano, as a way to structure the collection of nanoEHS data, be it experimental or literature-based. For experimental data, the approach promoted by JRC in NANoREG for a 'keep I simple' version of ISA-TAB-Nano has been paying off. The US have shown marked interest for this strategy, for instance after the public release by JRC of the NANoREG templates1. Given its specifically dedicated role in the development of, among others, ISA-TAB-Nano, eNanoMapper has published recently a fully descriptive deliverable on this matter2.
Sample 1
Description of the Work Carried Out. Analytical task and sample preparation The analytical contract includes the determination of cerium in organic material (lung, lymph nodes (LALN)) after inhalation exposure (retention and clearance) in samples from the 28-day BASF CeO2-study as part of the UBA research project Z6-55410-31/8 (project code: 371261 206) and refers to studies for the GLP test "Assessment of chronic toxicity / carcinogenicity of selected nanomaterials" with the test number 05G12036 ITEM (subproject within the preliminary study, work package 1). The quantitative determination of the cerium content in the samples is performed after appropriate sample preparation using the ICP-MS. For sample preparation, the steps freeze-drying, plasma ashing and microwave digestion and dilution of the respective digestion solution are required. Freeze-drying The (roughly chopped) lung material (for already prepared LALN no further preparation is needed) is freeze-dried in aluminium trays (flat) initially ≥ 6 h (0.37 mbar). The body weights before and after freeze-drying are logged. Plasma ashing The freeze-dried material is then subjected of a plasma ashing (cool plasma conditions, 400 W, about 1 mbar O2) overnight (≥ 12 h), homogenized and transferred to appropriate storage vessels. The ash weight is if fully implemented, usually by> 12 h less than 5% of the original wet weight and can be used as a parameter for assessing the ashing quality. The logging of ash weights is required. Microwave digestion The freeze-dried and plasma ashed samples (each time the total amount of present sample) are finally subjected to microwave digestion. To effect complete digestion, the use of sulfuric acid (96%, suprapur) is required. The following table shows the individual steps of the microwave program are summarized. step programme phase power (W) time (min) 1 pre-heating 250 5 2 rest 0 1 3 heat-up 500 5 4 rest 0 1 5 heat-up 400 8 6 rest 0 1 7 heat-up 400 8 8 ventilation/cooling VENT 15 After cooling, the samples were quantitatively transferred into volumetric flasks 25 mL (KS), filled up to the mark with ultrapure water and then placed in 50 mL plastic containers until analysis stored cool. To avoid analyte disappearances during the digestion of the material, the following system is used:  cleaning digestion (before experiments start)  air G0 exposure concentration: 0 mg/m3 (control)  CeO2 G1 exposure concentration: 0.5 mg/m3 (low dose)  CeO2 G2 exposure concentration: 5 mg/m3 (mid dose)  CeO2 G3 exposure...
Sample 1
Description of the Work Carried Out 
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