BACKGROUND AND RATIONALE Sample Clauses
BACKGROUND AND RATIONALE. Neuroimmunological diseases (“NIDs”) including multiple sclerosis (“MS”), neuromyelitis optica (“NMO”) and myasthenia gravis (“MG”) are chronic inflammatory diseases of the nervous system and are common causes of neurological disability in adults. The effects of NIDs are characterised by attacks of neurological symptoms and signs with variable recovery. MS patients can additionally develop a progressive clinical course. The clinical course of NIDs is highly variable. People with NIDs often receive immunosuppressive or immunomodulatory treatments, sequentially or in combination. There is a global requirement for patients, doctors, regulators and the pharmaceutical industry to understand the risk factors, course and outcomes of these diseases including: • Short and long-term outcomes of NIDs as assessed by standard clinical rating scales and outcome measures • Clinical and paraclinical outcome predictors including imaging results, blood tests and self-monitoring devices and applications • Medication exposure patterns and their short and long-term efficacy • Individualised prediction of treatment response • Safety of medications in the real-world setting, in particular long-term safety • Pregnancy and infant risks and outcomes in women exposed to medications during conception, in pregnancy and during breastfeeding The challenges for multi-centre investigator-initiated clinical research of this nature include harmonisation of protocols and minimum datasets, a suitably flexible data collection platform, retention of data ownership, the identification of collaborators, ongoing communication between study sites, data quality assurance, legal data storage, data management platforms and study governance. The MSBase Foundation provides Investigators with the best possible logistic solutions to meet these challenges at no cost.
BACKGROUND AND RATIONALE. The chemical composition of sorghum biomass will significantly influence the logistics of harvesting, transport, storage, processing, pretreatment processes, conversion efficiency and yield of biofuels per dry ton. Therefore, an early objective of this project is to characterize the range of biomass composition present in sorghum germplasm and to identify biomass composition traits that need to be selected for during the breeding process. In addition, the capability to conduct rapid NIR-based composition analysis for sorghum will allow allelic variation that modulates composition to be mapped and the corresponding genes identified and patented. CERES is establishing a state-of-the-art biomass composition-testing laboratory in California. This laboratory will be able to carry out chemical analysis of biomass required to establish standard curves for NIR-based analysis. TAES/CERES propose to establish a biomass composition-testing laboratory at TAES in order to assay several thousand samples generated each cycle of sorghum breeding and to enable genetic analysis of composition traits. The details of this activity are described below.
BACKGROUND AND RATIONALE sequencing platforms allow sequence-based genotyping — sequencing platforms allow digital expression profiling — (i.e., Genome Sequencer-20 System, Solexa, ABI-based systems) — Sb genome sequence/genetic map alignment allows sequence/SNP mapping — haplotypes or graphical genotypes are revealed at sufficient marker density — graphical genotypes of germplasm will allow better parent/progeny selection — graphical genotyping will accelerate QTL mapping to gene discovery — graphical genotyping may replace targeted marker-assisted-breeding — TAES has developed a graphical genotyping method called Restriction Site Localized sequencing technology (RSL sequencing technology) — TAES has tested RSL-technology on rice/sorghum using 454 technology — RSL-sequencing provides a way to sequence genomes at specific sites — RSL provides a way to re-sequence the same sub-sample of any genome — the number of sites sequenced can be varied depending on need — Solexa can collect 1B bp of sequence per run (25-35bp/read) (~$3,000/run) — sequence sampling every ~4 kbp (two reads/site) = 10 Mbp of sequence — predicted SNP discovery rate = 1 SNP/82kbp (@ 1SNP/1000bp) — indexing allows ~100 genotypes per run (~$30/genotype for sequencing) — more genotypes can be run at lower sequence/SNP coverage — @ $3/~500 marker-genotype this may replace the need for MAB — a high quality genome sequence aligned to a genetic map is required
BACKGROUND AND RATIONALE. Provide a detailed description, including the issue to be addressed and potential findings.
BACKGROUND AND RATIONALE. Scientists at TAES have been developed a sorghum genome technology platform consisting of integrated genetic, cytogenetic and comparative genome maps since 1998. The TAES sorghum genetic map contains over 3,000 DNA markers based on data collected from 137 RIL lines derived from BTx623 X IS3620C. A physical map that is aligned to the sorghum genetic map has been constructed from ~16X deep BAC libraries, HICF fingerprinting, 6D BAC pooling, and ~5,000 EST-STS linkers. BACs from this map have been end-sequences and sequence scanned providing information for aligning DOE sequence assemblies to the map. The sorghum genome sequence assemblies produced by DOE based on 8X shotgun coverage of the genome are large (up to 14 Mbp). Test alignment of DOE sequence assemblies to SBI03 is promising revealing 6 miss-assemblies in the euchromatic region (~47Mbp) that were easily corrected. Funding is requested to accelerate the next set of sorghum genome map platform improvements including aligning the DOE [***] to the TAES [***] and [***] followed by [***] and resolution of issues related to [***] [***]/[***]. In addition, [***] of the [***] will be done in a targeted manner ([***], [***]/[***]) at different levels depending on need (automated [***] and by [***] analysis, [***] models, [***], etc.). For example, DOE funding will allow implementation of [***] of sorghum [***] matching [***] in [***] in 20[***] in collaboration with Xxxxxx Xxxx/Xxxxxxx Xxxxx (Cold Spring Harbor). We will focus [***] efforts on [***] relevant to [***] with funding from DOE. We also plan to bring in [***] of [***] (from prior [***], RT-PCR data, plus [***]/[***] data when it becomes available). Comparative genetic maps and the comparative aligned genome sequences focused on sorghum, rice, maize, and switchgrass will be updated on a regular basis. The TAES sorghum genome map platform is a key resource for all future QTL mapping, annotation, and gene discovery projects done at TAES and those carried out in collaboration with CERES. As such, the genome map/sequence platform provides our group an advantage in terms of gene discovery/IP capture. For QTL mapping and gene discovery research it would be ideal if TAES and CERES were operating with a common genome sequence/genetic map framework. If CERES provides funding to help TAES to continue development of the TAES genome map/sequence platform, then TAES will make the genome map/sequence platform available to CERES with regular quality and annotatio...
BACKGROUND AND RATIONALE. <Explain the purpose and rationale for the proposal, including previous/related projects, Cabinet/University Council decisions, etc. Please document with whom you have consulted in the development of this project.>
BACKGROUND AND RATIONALE why next generation institutional transnationalism?
BACKGROUND AND RATIONALE. (a) In July 2005, the United States Government announced a five-year,
(b) PMI is committed to continuing its support of NMCPs in achieving high coverage levels of IRS, to ensure that malaria transmission levels are knocked down and kept down, while simultaneously expanding the capacity of NMCPs to plan, execute, and monitor IRS programs.
BACKGROUND AND RATIONALE. Threat assessment and behavioral intervention teams have become an important and needed tool for learning institutions. The Auraria Campus Assessment and Response Team (CART) was created to allow the Auraria Campus Institutions to share information about students of concern in order to enhance the health and safety for the Auraria Campus. CART has identified several students of concern who have posed and continue to pose threats to the Auraria Campus (sexual assault, attempted murder, murder, kidnapping, assault, etc.). Several CART students have been adjudicated by their respective institutions and/or the courts and found responsible or guilty for violent and sexual offenses and have subsequently been suspended or expelled from their institution. Several of these students have then applied, been admitted, and enrolled at another Auraria Campus Institution and repeated the negative behaviors at their new institution and continue to pose a threat to the Auraria Campus. Currently, each Auraria Campus Institution includes language in their student codes of conduct that allow for exclusion from the Auraria Campus. However, once a student is granted admission at another Auraria Campus Institution the restriction is no longer enforceable, thus effectively overturning the initial decision of the conduct officer and allowing the student to be on campus. A new process that encourages additional sharing of information will allow for Auraria Campus restrictions to be honored by all Auraria Campus Institutions and empower the Auraria Police Department to assist in the enforcement of this restriction. Such a policy is intended to help protect all Auraria Campus Institutions and the Auraria Campus community from individuals known to pose a threat or risk. The purpose of this MOU is to establish a formal agreement, including the adoption of required processes and procedures at each Auraria Campus Institution, that prohibits a student suspended, expelled, or otherwise removed for violent, concerning, or threatening behavior from one Auraria Campus Institution from enrolling at another during the term of the suspension, expulsion, or removal. Furthermore, this MOU establishes processes so that the Auraria Campus Institutions honor sanctions of suspension (including interim suspension) and expulsion imposed by other Auraria Campus Institutions when the sanction is imposed due to a student’s violent or threatening behavior. In particular, this MOU is intended...
BACKGROUND AND RATIONALE. Dimple Well Infant School and Nursery is an inclusive school that strives to ensure that all children feel safe when with us. Our values focus on openness, honesty and trust alongside working with the strengths of each individual child to ensure that they achieve to the best of their abilities. Around 41,000 children are bereaved of a parent every year in the UK. That’s nearly two children under 16 every hour. Many more are bereaved of a grandparent, sibling, friend or other significant person1. Experiencing a bereavement can make children more vulnerable. Bereavement, whether it is an expected death because of illness or a sudden and unexpected death or suicide, is something that can impact on members of our school community at any time. Our school is committed to the emotional health and well-being of its staff and children. We wish to work towards this in all aspects of school life, and to provide an ethos, environment and curriculum that prepares children for coping with bereavement. This policy is for all staff, children, parents and carers, governors, visitors and partner agencies working within the school. It provides guidelines and procedures as to how our school can best prepare for, and respond to, bereavement in the school community. We recognise that members of the school community will be affected by a range of losses including separation and divorce. Some aspects of this policy may also be helpful in these cases. This policy was based on an exemplar developed by the national xxxxxxx Xxxxxxx’x Wish. It has included input from our staff and our governing body.