Background and Rationale Sample Clauses
Background and Rationale. Neuroimmunological diseases (“NIDs”) including multiple sclerosis (“MS”), neuromyelitis optica (“NMO”) and myasthenia gravis (“MG”) are chronic inflammatory diseases of the nervous system and are common causes of neurological disability in adults. The effects of NIDs are characterised by attacks of neurological symptoms and signs with variable recovery. MS patients can additionally develop a progressive clinical course. The clinical course of NIDs is highly variable. People with NIDs often receive immunosuppressive or immunomodulatory treatments, sequentially or in combination. There is a global requirement for patients, doctors, regulators and the pharmaceutical industry to understand the risk factors, course and outcomes of these diseases including: • Short and long-term outcomes of NIDs as assessed by standard clinical rating scales and outcome measures • Clinical and paraclinical outcome predictors including imaging results, blood tests and self-monitoring devices and applications • Medication exposure patterns and their short and long-term efficacy • Individualised prediction of treatment response • Safety of medications in the real-world setting, in particular long-term safety • Pregnancy and infant risks and outcomes in women exposed to medications during conception, in pregnancy and during breastfeeding The challenges for multi-centre investigator-initiated clinical research of this nature include harmonisation of protocols and minimum datasets, a suitably flexible data collection platform, retention of data ownership, the identification of collaborators, ongoing communication between study sites, data quality assurance, legal data storage, data management platforms and study governance. The MSBase Foundation provides Investigators with the best possible logistic solutions to meet these challenges at no cost.
Background and Rationale. The chemical composition of sorghum biomass will significantly influence the logistics of harvesting, transport, storage, processing, pretreatment processes, conversion efficiency and yield of biofuels per dry ton. Therefore, an early objective of this project is to characterize the range of biomass composition present in sorghum germplasm and to identify biomass composition traits that need to be selected for during the breeding process. In addition, the capability to conduct rapid NIR-based composition analysis for sorghum will allow allelic variation that modulates composition to be mapped and the corresponding genes identified and patented. CERES is establishing a state-of-the-art biomass composition-testing laboratory in California. This laboratory will be able to carry out chemical analysis of biomass required to establish standard curves for NIR-based analysis. TAES/CERES propose to establish a biomass composition-testing laboratory at TAES in order to assay several thousand samples generated each cycle of sorghum breeding and to enable genetic analysis of composition traits. The details of this activity are described below.
Background and Rationale sequencing platforms allow sequence-based genotyping — sequencing platforms allow digital expression profiling — (i.e., Genome Sequencer-20 System, Solexa, ABI-based systems) — Sb genome sequence/genetic map alignment allows sequence/SNP mapping — haplotypes or graphical genotypes are revealed at sufficient marker density — graphical genotypes of germplasm will allow better parent/progeny selection — graphical genotyping will accelerate QTL mapping to gene discovery — graphical genotyping may replace targeted marker-assisted-breeding — TAES has developed a graphical genotyping method called Restriction Site Localized sequencing technology (RSL sequencing technology) — TAES has tested RSL-technology on rice/sorghum using 454 technology — RSL-sequencing provides a way to sequence genomes at specific sites — RSL provides a way to re-sequence the same sub-sample of any genome — the number of sites sequenced can be varied depending on need — Solexa can collect 1B bp of sequence per run (25-35bp/read) (~$3,000/run) — sequence sampling every ~4 kbp (two reads/site) = 10 Mbp of sequence — predicted SNP discovery rate = 1 SNP/82kbp (@ 1SNP/1000bp) — indexing allows ~100 genotypes per run (~$30/genotype for sequencing) — more genotypes can be run at lower sequence/SNP coverage — @ $3/~500 marker-genotype this may replace the need for MAB — a high quality genome sequence aligned to a genetic map is required
Background and Rationale. Provide a detailed description, including the issue to be addressed and potential findings.
Background and Rationale. Scientists at TAES have been developed a sorghum genome technology platform consisting of integrated genetic, cytogenetic and comparative genome maps since 1998. The TAES sorghum genetic map contains over 3,000 DNA markers based on data collected from 137 RIL lines derived from BTx623 X IS3620C. A physical map that is aligned to the sorghum genetic map has been constructed from ~16X deep BAC libraries, HICF fingerprinting, 6D BAC pooling, and ~5,000 EST-STS linkers. BACs from this map have been end-sequences and sequence scanned providing information for aligning DOE sequence assemblies to the map. The sorghum genome sequence assemblies produced by DOE based on 8X shotgun coverage of the genome are large (up to 14 Mbp). Test alignment of DOE sequence assemblies to SBI03 is promising revealing 6 miss-assemblies in the euchromatic region (~47Mbp) that were easily corrected. Funding is requested to accelerate the next set of sorghum genome map platform improvements including aligning the DOE [***] to the TAES [***] and [***] followed by [***] and resolution of issues related to [***] [***]/[***]. In addition, [***] of the [***] will be done in a targeted manner ([***], [***]/[***]) at different levels depending on need (automated [***] and by [***] analysis, [***] models, [***], etc.). For example, DOE funding will allow implementation of [***] of sorghum [***] matching [***] in [***] in 20[***] in collaboration with ▇▇▇▇▇▇ ▇▇▇▇/▇▇▇▇▇▇▇ ▇▇▇▇▇ (Cold Spring Harbor). We will focus [***] efforts on [***] relevant to [***] with funding from DOE. We also plan to bring in [***] of [***] (from prior [***], RT-PCR data, plus [***]/[***] data when it becomes available). Comparative genetic maps and the comparative aligned genome sequences focused on sorghum, rice, maize, and switchgrass will be updated on a regular basis. The TAES sorghum genome map platform is a key resource for all future QTL mapping, annotation, and gene discovery projects done at TAES and those carried out in collaboration with CERES. As such, the genome map/sequence platform provides our group an advantage in terms of gene discovery/IP capture. For QTL mapping and gene discovery research it would be ideal if TAES and CERES were operating with a common genome sequence/genetic map framework. If CERES provides funding to help TAES to continue development of the TAES genome map/sequence platform, then TAES will make the genome map/sequence platform available to CERES with regular quality and annotatio...
Background and Rationale. <Explain the purpose and rationale for the proposal, including previous/related projects, Cabinet/University Council decisions, etc. Please document with whom you have consulted in the development of this project.>
Background and Rationale. Pursuant to a subscription agreement dated 21 November 2023, the Company has raised approximately S$1.1 million in net proceeds through the issuance of 98,500,000 shares to the Subscriber. On 30 November 2023, the Company fully repaid the outstanding debt owed to Clearbridge BSA Pte Ltd, improving the working capital of the Company and Group. On 21 December 2023, the Company entered into a subscription agreement with ▇▇. ▇▇▇▇ ▇▇▇▇, on the share subscription of 83,000,000 new ordinary shares in the issued share capital of the Company at an issue price of S$0.0121 per subscription share, to raise gross proceeds of approximately S$1.004 million. The Company has fully utilised the net proceeds of approximately S$1.004 million from the share subscription for working capital purposes. Save for (i) the placement of Shares to ▇▇. ▇▇▇▇ ▇▇▇▇ and Mr. ▇▇▇ ▇▇▇ which was completed on 11 January 2024 (the “2024 Placement”) and 28 November 2023 respectively (the “2023 Placement”, and together with the 2024 Placement, the “Past Placements”) and (ii) the right issues which were completed on 2 December 2022, the Company has not raised cash from an issue of securities in the market in the last 24 months. Pursuant to Rule 704(30) of the Catalist Rule, a breakdown of the use of the proceeds from the Past Placements has been disclosed in full-year unaudited results of the Company for the financial year ended 31 December 2023. As disclosed above in section 3 of this announcement, the Company has entered into the Loan Agreement and as at the date of this announcement, S$1,054,000 has been disbursed by the Subscriber to the Company for its working capital pursuant to the ZH Loan. As at the date of this announcement, the ZH Loan has not been repaid and remains owing by the Company to the Subscriber. Pursuant to the considerations above, the Directors are of the view that the Proposed Subscription is beneficial to the Group as it will increase resources and working capital available to the Company so as to improve cash flow, as part of management’s strategy to achieve continued trading status on Catalist and deliver shareholder value. The Proposed Subscription will improve the working capital of the Company and the Group.
Background and Rationale why next generation institutional transnationalism?
Background and Rationale. (a) In July 2005, the United States Government announced a five-year,
(b) PMI is committed to continuing its support of NMCPs in achieving high coverage levels of IRS, to ensure that malaria transmission levels are knocked down and kept down, while simultaneously expanding the capacity of NMCPs to plan, execute, and monitor IRS programs.
Background and Rationale. The regional project for the management, monitoring and control of species of wild fauna and flora threatened by trade (Bioamazon Project) is based on the commitment of the Amazon Cooperation Treaty Organization (ACTO) and the German government to finance a regional program in the area of biodiversity conservation with non-refundable collaborative financial funds through the German Development Bank (KfW). The project aims to contribute to the conservation of the Amazonian biodiversity and, particularly, of species listed in the Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES), increasing the efficiency and effectiveness of management, monitoring and control of wild species threatened by trade in ACTO Member Countries; and has three components: 1) National and regional information and knowledge management systems; 2) Regional harmonization and strengthening of national electronic permitting mechanisms/ systems /processes; and 3) Strengthening sustainable management initiatives and traceability mechanisms for Amazonian species. Most Amazonian countries promote, individually and separately, initiatives to control and combat common problems associated with deforestation and forest degradation. Such actions often have little effectiveness. Similarly, government institutions often lack reliable, or periodically updated, technical information for territorial planning and decision-making on the use and management of forest resources, as well as other natural resources. Thus, for the sustainable management of Amazonian forests relevant information should be produced and be available through integrated reports within the Amazon basin, to ensure coordinated work between forest and environmental authorities of the governments of ACTO Member Countries, promoting articulated decision-making and guiding public policies for the conservation and sustainable use of forest resources. Within the actions of Component 1 of the project, ACTO has been fostering the implementation of the Amazon Regional Observatory (ARO), which has been conceptualized as a permanent virtual forum, which will enable information flow, through ACTO's website, among institutions and intergovernmental authorities of the Member Countries devoted to the study of the Amazon with emphasis on biodiversity. This flow and the exchange of information will have their premises defined in the conceptual design of the ARO, as well as in the components and strategic actions de...