HER2 definition

HER2 means v-exx-b2 erythroblastic leukemia viral oncogene homolog having a Genbank ID number of 2064 and a protein sequence as shown in Exhibit 1.
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HER2 means the Target that is the protein known as human epidermal growth factor receptor 2.
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HER2 means the [***]
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Examples of HER2 in a sentence

  • The biopsy specimens were tested for HER2/ neu based on the American Society of Clinical Oncology/ College of American Pathologists guidelines.18 The HER2/neu status was determined by immunohistochemical assay and/or fluorescence in situ hybridization.

  • Unless otherwise agreed by the Parties in writing, the Parties agree that the HER2 Governance Structure shall apply to this Agreement, unless the HER2 Agreement is terminated by the Parties, or unless otherwise agreed by the Parties.

  • If not otherwise agreed for the HER2 Governance Structure, the JSC and each Subcommittee (each, a “Committee”) shall be composed of [***] representatives from each Party (or such other equal number of representatives of each of Licensee and Duality as the JSC may determine), and each Party shall notify the other Party of its initial JSC representatives within [***] days after the Effective Date.

  • The Parties have already created a governance structure and committees for the implementation of the HER2 License and Collaboration Agreement dated March 31, 2023 (“HER2 Agreement”, such governance structure the “HER2 Governance Structure”).

  • Cheang MC, Chia SK, Voduc D, et al: Ki67 index, HER2 status, and prognosis of patients with luminal B breast cancer.

  • Unless already existing under the HER2 Governance Structure, no later than [***] days after the Effective Date (unless otherwise agreed by the Parties), the JSC shall establish an intellectual property committee (the “Joint IP Committee” or “JIPC”) led by Licensee and comprised of an equal number of representatives from each Party.

  • At Licensee’s request, Duality shall perform any other Clinical Trial (in addition to the Ongoing Trials) of an Original ADC Licensed Product for an Indication other than the HER2 BC Indications and EC Indication.

  • Molecular characterization of mucinous ovarian tumours supports a stratified treatment approach with HER2 targeting in 19% of carcinomas.

  • When stratified for HER2/neu status, HER2/ neu-positive patients had an accuracy of 80%, a sensi- tivity of 75%, a specificity of 82%, and an NPV of 90%, compared with 60%, 46%, 86%, and 46%, respectively, for the HER2/neu-negative patients (Table 5).Finally, the DCE-MRI–measured response of the pri- mary tumor was compared with the residual disease in the axillary nodes.

  • Unless already existing under the HER2 Governance Structure, no later than [***] days after the Effective Date, the JSC shall establish a joint development committee (the “Joint Development Committee” or “JDC”) led by Licensee and comprised of an equal number of representatives from each Party.


More Definitions of HER2

HER2 means (a) receptor tyrosine-protein kinase erbB-2, and (b) any naturally occurring variants thereof, in each case including any isoforms, polymorphisms, variants, and truncated forms, and in each case to the extent such variant, isoform, polymorphism, variant and truncated form are produced from an allele of the same gene.
Sample 1
HER2 means human epidermal growth factor receptor 2, also known as CD340 or Her-2/neu encoded by the ERBB2 gene.
Sample 1

Related to HER2

  • HIV means human immunodeficiency virus.

  • Antibody means a molecule or a gene encoding such a molecule comprising or containing one or more immunoglobulin variable domains or parts of such domains or any existing or future fragments, variants, modifications or derivatives thereof.

  • Infection means the entry and development or multiplication of an infectious agent in the body of humans and animals that may constitute a public health risk;