February 3, 2000 Uses in Definitions Clause

Definitions from Securities Purchase Agreement

This SECURITIES PURCHASE AGREEMENT, dated as of June 17, 2007 (this Agreement), among Invus, L.P., a Bermuda limited partnership (the Investor) and Lexicon Pharmaceuticals, Inc., a Delaware corporation (the Company).

Definitions. (a) For purposes of this Agreement: affiliate of a specified person means a person who, directly or indirectly through one or more intermediaries, controls, is controlled by, or is under common control with, such specified person. Ancillary Agreements means the Warrant Agreement, the Registration Rights Agreement and the Stockholders Agreement. beneficial owner (and related terms such as beneficially owned or beneficial ownership) has the meaning ascribed to such term under Rule 13d-3 of the Exchange Act.

Definitions from Securities Purchase Agreement

This SECURITIES PURCHASE AGREEMENT, dated as of June 17, 2007 (this Agreement), among Invus, L.P., a Bermuda limited partnership (the Investor) and Lexicon Pharmaceuticals, Inc., a Delaware corporation (the Company).

Definitions. (a) For purposes of this Agreement: affiliate of a specified person means a person who, directly or indirectly through one or more intermediaries, controls, is controlled by, or is under common control with, such specified person. Ancillary Agreements means the Warrant Agreement, the Registration Rights Agreement and the Stockholders Agreement. beneficial owner (and related terms such as beneficially owned or beneficial ownership) has the meaning ascribed to such term under Rule 13d-3 of the Exchange Act.