5:00 p.m. Uses in Grant of Option Clause

Grant of Option from Option Agreement

This option satisfies in full all commitments that the Company has to the Participant with respect to the issuance of stock, stock options or other equity securities.

Grant of Option. This agreement evidences the grant by the Company, on the grant date (the Grant Date) set forth in the Notice of Grant that forms part of this agreement (the Notice of Grant), to the Participant of an option to purchase, in whole or in part, on the terms provided herein and in the Companys 2017 Equity Incentive Plan (the Plan), the number of Shares set forth in the Notice of Grant of common stock, $0.001 par value per share, of the Company (Common Stock), at the exercise price per Share set forth in the Notice of Grant. Unless earlier terminated, this option shall expire at 5:00 p.m., Eastern time, on the Final Exercise Date set forth in the Notice of Grant (the Final Exercise Date). It is intended that the option evidenced by this agreement shall not be an incentive stock option as defined in Section 422 of the Internal Revenue Code of 1986, as amended, and any regulations promulgated thereunder (the Code). Except as otherwise indicated by the context, the term Participant, as used in this option, shall be deemed to include any person who acquires the right to exercise this option validly under its terms.

Grant of Option from Stock Option Agreement

Grant of Option. This agreement (this "Agreement") evidences the grant by Eco Science Solutions, Inc., a Nevada corporation (the "Company"), on June 21, 2017 (the "Grant Date") to Randall Oveson, an employee, director, consultant or advisor of the Company (the "Participant"), of an option (the "Option") to purchase, in whole or in part, on the terms provided herein and in the Company's 2017 Equity Incentive Plan (the "Plan"), a total of 1,500,000 shares (the "Shares") of the Company's common stock, $0.0001 par value per share (the "Common Stock"), at $2.00 per Share. Unless earlier terminated, this option shall expire at 5:00 p.m., Eastern Time, on June 21, 2027 (the "Final Exercise Date"). It is not intended that the Option evidenced by this Agreement be an incentive stock option as defined in Section 422 of the Internal Revenue Code of 1986, as amended, and any regulations promulgated thereunder (the "Code"). Accordingly, the Option shall be treated as a non-qualified stock option. Except as otherwise indicated by the context, the term "Participant", as used in this Agreement, shall be deemed to include any person who acquires the right to exercise this option validly under its terms. The Participant agrees to report sales of Shares that were issued pursuant to Option exercises to the Company within five (5) business days after such sale is concluded. The Participant also agrees to pay to the Company, within ten (10) business days after such sale is concluded, the amount necessary for the Company to satisfy its withholding requirement required by the Code in the manner specified in Section 13 of the Plan. Nothing herein is intended as a representation that the Shares may be sold without registration under state and federal securities laws or an exemption therefrom or that such registration or exemption will be available at any specified time.

Grant of Option from Stock Option Agreement

Grant of Option. This agreement (this "Agreement") evidences the grant by Eco Science Solutions, Inc., a Nevada corporation (the "Company"), on June 21, 2017 (the "Grant Date") to Wendy Maguire, an employee, director, consultant or advisor of the Company (the "Participant"), of an option (the "Option") to purchase, in whole or in part, on the terms provided herein and in the Company's 2017 Equity Incentive Plan (the "Plan"), a total of 1,250,000 shares (the "Shares") of the Company's common stock, $0.0001 par value per share (the "Common Stock"), at $2.00 per Share. Unless earlier terminated, this option shall expire at 5:00 p.m., Eastern Time, on June 21, 2027 (the "Final Exercise Date"). It is not intended that the Option evidenced by this Agreement be an incentive stock option as defined in Section 422 of the Internal Revenue Code of 1986, as amended, and any regulations promulgated thereunder (the "Code"). Accordingly, the Option shall be treated as a non-qualified stock option. Except as otherwise indicated by the context, the term "Participant", as used in this Agreement, shall be deemed to include any person who acquires the right to exercise this option validly under its terms. The Participant agrees to report sales of Shares that were issued pursuant to Option exercises to the Company within five (5) business days after such sale is concluded. The Participant also agrees to pay to the Company, within ten (10) business days after such sale is concluded, the amount necessary for the Company to satisfy its withholding requirement required by the Code in the manner specified in Section 13 of the Plan. Nothing herein is intended as a representation that the Shares may be sold without registration under state and federal securities laws or an exemption therefrom or that such registration or exemption will be available at any specified time.

Grant of Option from Stock Option Agreement

Grant of Option. This agreement (this "Agreement") evidences the grant by Eco Science Solutions, Inc., a Nevada corporation (the "Company"), on June 21, 2017 (the "Grant Date") to Andy Tucker, an employee, director, consultant or advisor of the Company (the "Participant"), of an option (the "Option") to purchase, in whole or in part, on the terms provided herein and in the Company's 2017 Equity Incentive Plan (the "Plan"), a total of 3,000,000 shares (the "Shares") of the Company's common stock, $0.0001 par value per share (the "Common Stock"), at $2.00 per Share. Unless earlier terminated, this option shall expire at 5:00 p.m., Eastern Time, on June 21, 2027 (the "Final Exercise Date"). It is not intended that the Option evidenced by this Agreement be an incentive stock option as defined in Section 422 of the Internal Revenue Code of 1986, as amended, and any regulations promulgated thereunder (the "Code"). Accordingly, the Option shall be treated as a non-qualified stock option. Except as otherwise indicated by the context, the term "Participant", as used in this Agreement, shall be deemed to include any person who acquires the right to exercise this option validly under its terms. The Participant agrees to report sales of Shares that were issued pursuant to Option exercises to the Company within five (5) business days after such sale is concluded. The Participant also agrees to pay to the Company, within ten (10) business days after such sale is concluded, the amount necessary for the Company to satisfy its withholding requirement required by the Code in the manner specified in Section 13 of the Plan. Nothing herein is intended as a representation that the Shares may be sold without registration under state and federal securities laws or an exemption therefrom or that such registration or exemption will be available at any specified time.

Grant of Option from Stock Option Agreement

Grant of Option. This agreement (this "Agreement") evidences the grant by Eco Science Solutions, Inc., a Nevada corporation (the "Company"), on June 21, 2017 (the "Grant Date") to Dante Jones, an employee, director, consultant or advisor of the Company (the "Participant"), of an option (the "Option") to purchase, in whole or in part, on the terms provided herein and in the Company's 2017 Equity Incentive Plan (the "Plan"), a total of 1,250,000 shares (the "Shares") of the Company's common stock, $0.0001 par value per share (the "Common Stock"), at $2.00 per Share. Unless earlier terminated, this option shall expire at 5:00 p.m., Eastern Time, on June 21, 2027 (the "Final Exercise Date"). It is not intended that the Option evidenced by this Agreement be an incentive stock option as defined in Section 422 of the Internal Revenue Code of 1986, as amended, and any regulations promulgated thereunder (the "Code"). Accordingly, the Option shall be treated as a non-qualified stock option. Except as otherwise indicated by the context, the term "Participant", as used in this Agreement, shall be deemed to include any person who acquires the right to exercise this option validly under its terms. The Participant agrees to report sales of Shares that were issued pursuant to Option exercises to the Company within five (5) business days after such sale is concluded. The Participant also agrees to pay to the Company, within ten (10) business days after such sale is concluded, the amount necessary for the Company to satisfy its withholding requirement required by the Code in the manner specified in Section 13 of the Plan. Nothing herein is intended as a representation that the Shares may be sold without registration under state and federal securities laws or an exemption therefrom or that such registration or exemption will be available at any specified time.

Grant of Option from Stock Option Agreement

Grant of Option. This agreement (this "Agreement") evidences the grant by Eco Science Solutions, Inc., a Nevada corporation (the "Company"), on June 21, 2017 (the "Grant Date") to Michael Rountree, an employee, director, consultant or advisor of the Company (the "Participant"), of an option (the "Option") to purchase, in whole or in part, on the terms provided herein and in the Company's 2017 Equity Incentive Plan (the "Plan"), a total of 1,000,000 shares (the "Shares") of the Company's common stock, $0.0001 par value per share (the "Common Stock"), at $2.00 per Share. Unless earlier terminated, this option shall expire at 5:00 p.m., Eastern Time, on June 21, 2027 (the "Final Exercise Date"). It is not intended that the Option evidenced by this Agreement be an incentive stock option as defined in Section 422 of the Internal Revenue Code of 1986, as amended, and any regulations promulgated thereunder (the "Code"). Accordingly, the Option shall be treated as a non-qualified stock option. Except as otherwise indicated by the context, the term "Participant", as used in this Agreement, shall be deemed to include any person who acquires the right to exercise this option validly under its terms. The Participant agrees to report sales of Shares that were issued pursuant to Option exercises to the Company within five (5) business days after such sale is concluded. The Participant also agrees to pay to the Company, within ten (10) business days after such sale is concluded, the amount necessary for the Company to satisfy its withholding requirement required by the Code in the manner specified in Section 13 of the Plan. Nothing herein is intended as a representation that the Shares may be sold without registration under state and federal securities laws or an exemption therefrom or that such registration or exemption will be available at any specified time.

Grant of Option from Stock Option Agreement

Grant of Option. This agreement (this "Agreement") evidences the grant by Eco Science Solutions, Inc., a Nevada corporation (the "Company"), on June 21, 2017 (the "Grant Date") to L. John Lewis, an employee, director, consultant or advisor of the Company (the "Participant"), of an option (the "Option") to purchase, in whole or in part, on the terms provided herein and in the Company's 2017 Equity Incentive Plan (the "Plan"), a total of 2,500,000 shares (the "Shares") of the Company's common stock, $0.0001 par value per share (the "Common Stock"), at $2.00 per Share. Unless earlier terminated, this option shall expire at 5:00 p.m., Eastern Time, on June 21, 2027 (the "Final Exercise Date"). It is not intended that the Option evidenced by this Agreement be an incentive stock option as defined in Section 422 of the Internal Revenue Code of 1986, as amended, and any regulations promulgated thereunder (the "Code"). Accordingly, the Option shall be treated as a non-qualified stock option. Except as otherwise indicated by the context, the term "Participant", as used in this Agreement, shall be deemed to include any person who acquires the right to exercise this option validly under its terms. The Participant agrees to report sales of Shares that were issued pursuant to Option exercises to the Company within five (5) business days after such sale is concluded. The Participant also agrees to pay to the Company, within ten (10) business days after such sale is concluded, the amount necessary for the Company to satisfy its withholding requirement required by the Code in the manner specified in Section 13 of the Plan. Nothing herein is intended as a representation that the Shares may be sold without registration under state and federal securities laws or an exemption therefrom or that such registration or exemption will be available at any specified time.

Grant of Option from Nonstatutory Stock Option Agreement

Grant of Option. This agreement evidences the grant by Ocular Therapeutix, Inc., a Delaware corporation (the Company), on June 20, 2017 (the Grant Date) to Antony Mattessich, who is party to an agreement to become chief executive officer of the Company (the Participant), of an option to purchase, in whole or in part, on the terms provided herein, a total of 590,000 shares (the Shares) of common stock, $0.0001 par value per share, of the Company (Common Stock) at $10.94 per Share. Unless earlier terminated, this option shall expire at 5:00 p.m., Eastern time, on June 19, 2027 (the Final Exercise Date). The option evidenced by this agreement was granted to the Participant pursuant to the inducement grant exception under NASDAQ Stock Market Rule 5635(c)(4), and not pursuant to the Companys 2014 Stock Incentive Plan (the Plan) or any equity incentive plan of the Company, as an inducement that is material to the Participants employment with the Company. It is intended that the option evidenced by this agreement shall not be an incentive stock option as defined in Section 422 of the Internal Revenue Code of 1986, as amended, and any regulations promulgated thereunder (the Code). Except as otherwise indicated by the context, the term Participant, as used in this option, shall be deemed to include any person who acquires the right to exercise this option validly under its terms.

Grant of Option from Nonstatutory Stock Option Agreement

Grant of Option. This agreement evidences the grant by Aileron Therapeutics, Inc., a Delaware corporation (the Company), on , 200[ ] (the Grant Date) to [ ], an [employee], [consultant], [director] of the Company (the Participant), of an option to purchase, in whole or in part, on the terms provided herein and in the Companys 2006 Stock Incentive Plan (the Plan), a total of [ ] shares (the Shares) of common stock, $0.001 par value per share, of the Company (Common Stock) at an exercise price of $[ ] per Share. Unless earlier terminated, this option shall expire at 5:00 p.m., Eastern time, on [ ] (the Final Exercise Date). It is intended that the option evidenced by this agreement shall not be an incentive stock option as defined in Section 422 of the Internal Revenue Code of 1986, as amended, and any regulations promulgated thereunder (the Code). Except as otherwise indicated by the context, the term Participant, as used in this option, shall be deemed to include any person who acquires the right to exercise this option validly under its terms.

Grant of Option from Incentive Stock Option Agreement

Grant of Option. This Incentive Stock Option Agreement (the Agreement) evidences the grant by Aileron Therapeutics, Inc., a Delaware corporation (the Company), on [ , 20 ] (the Grant Date) to [ ], an employee of the Company (the Participant), of an option to purchase, in whole or in part, on the terms provided herein and in the Companys 2016 Stock Incentive Plan (the Plan), a total of [ ] shares (the Shares) of common stock, $0.001 par value per share, of the Company (Common Stock) at $[ ] per Share. Unless earlier terminated, this option shall expire at 5:00 p.m., Eastern time, on [ , 20 ] [date is ten years minus one day from grant date] (the Final Exercise Date). It is intended that the option evidenced by this Agreement shall be an incentive stock option as defined in Section 422 of the Internal Revenue Code of 1986, as amended, and any regulations promulgated thereunder (the Code). Except as otherwise indicated by the context, the term Participant, as used in this option, shall be deemed to include any person who acquires the right to exercise this option validly under its terms.