2007 Uses in Grant of Option Clause

Grant of Option from Incentive Stock Option Agreement

Grant of Option. This agreement evidences the grant by Mersana Therapeutics, Inc., a Delaware corporation (the Company), on [insert date of Board approval] (the Grant Date) to [insert name of Participant], an employee of the Company (the Participant), of an option to purchase, in whole or in part, on the terms provided herein and in the Companys 2007 Stock Incentive Plan (the Plan), a total of [insert number of option shares] shares (the Shares) of common stock, $.0001 par value per share, of the Company (Common Stock) at $[insert exercise price] per Share. Unless earlier terminated, this option shall expire at 5:00 p.m., Eastern time, on [insert date that is ten years minus one day after Board approval] (the Final Exercise Date). It is intended that the option evidenced by this agreement shall be an incentive stock option as defined in Section 422 of the Internal Revenue Code of 1986, as amended, and any regulations promulgated thereunder (the Code). Except as otherwise indicated by the context, the term Participant, as used in this option, shall be deemed to include any person who acquires the right to exercise this option validly under its terms.

Grant of Option from Nonstatutory Stock Option Agreement

Grant of Option. This agreement evidences the grant by Mersana Therapeutics, Inc., a Delaware corporation (the Company), on [insert date of Board approval] (the Grant Date) to [insert name of Participant], an [insert employee, consultant or director, as applicable] of the Company (the Participant), of an option to purchase, in whole or in part, on the terms provided herein and in the Companys 2007 Stock Incentive Plan (the Plan), a total of [insert number of option shares] shares (the Shares) of common stock, $.0001 par value per share, of the Company (Common Stock) at $[insert exercise price] per Share. Unless earlier terminated, this option shall expire at 5:00 p.m., Eastern time, on [insert date that is ten years minus one day after Board approval] (the Final Exercise Date). It is intended that the option evidenced by this agreement shall not be an incentive stock option as defined in Section 422 of the Internal Revenue Code of 1986, as amended, and any regulations promulgated thereunder (the Code). Except as otherwise indicated by the context, the term Participant, as used in this option, shall be deemed to include any person who acquires the right to exercise this option validly under its terms.

Grant of Option from Nonstatutory Stock Option Agreement

Grant of Option. This agreement evidences the grant by Mersana Therapeutics, Inc., a Delaware corporation (the Company), on [insert date of Board approval] (the Grant Date) to [insert name of Participant], an [insert employee, consultant or director, as applicable] of the Company (the Participant), of an option to purchase, in whole or in part, on the terms provided herein and in the Companys 2007 Stock Incentive Plan (the Plan), a total of [insert number of option shares] shares (the Shares) of common stock, $.0001 par value per share, of the Company (Common Stock) at $[insert exercise price] per Share. Unless earlier terminated, this option shall expire at 5:00 p.m., Eastern time, on [insert date that is ten years minus one day after Board approval] (the Final Exercise Date). It is intended that the option evidenced by this agreement shall not be an incentive stock option as defined in Section 422 of the Internal Revenue Code of 1986, as amended, and any regulations promulgated thereunder (the Code). Except as otherwise indicated by the context, the term Participant, as used in this option, shall be deemed to include any person who acquires the right to exercise this option validly under its terms.

Grant of Option from Incentive Stock Option Agreement

Grant of Option. This agreement evidences the grant by Mersana Therapeutics, Inc., a Delaware corporation (the Company), on [insert date of Board approval] (the Grant Date) to [insert name of Participant], an employee of the Company (the Participant), of an option to purchase, in whole or in part, on the terms provided herein and in the Companys 2007 Stock Incentive Plan (the Plan), a total of [insert number of option shares] shares (the Shares) of common stock, $.0001 par value per share, of the Company (Common Stock) at $[insert exercise price] per Share. Unless earlier terminated, this option shall expire at 5:00 p.m., Eastern time, on [insert date that is ten years minus one day after Board approval] (the Final Exercise Date). It is intended that the option evidenced by this agreement shall be an incentive stock option as defined in Section 422 of the Internal Revenue Code of 1986, as amended, and any regulations promulgated thereunder (the Code). Except as otherwise indicated by the context, the term Participant, as used in this option, shall be deemed to include any person who acquires the right to exercise this option validly under its terms.

Grant of Option from Incentive Plan

Grant of Option. This certificate evidences an incentive stock option (this "Stock Option") granted by Galena Biopharma, Inc., a Delaware corporation (the "Company"), on DATE OF GRANT (the "Date of Grant") to NAME, an employee of the Company (the "Participant") pursuant to the Company's 2007 Incentive Plan (as from time to time in effect, the "Plan"). Under this Stock Option, the Participant may purchase, in whole or in part, on the terms herein provided, a total of NUMBER OF SHARES shares of common stock of the Company (the "Shares") at STRIKE PRICE per Share, which is not less than the fair market value of the Shares on the Date of Grant. The latest date on which this Stock Option, or any part thereof, may be exercised is 10 YEARS FROM DATE OF GRANT (the "Final Exercise Date"). The Stock Option evidenced by this certificate is intended to be an incentive stock option as defined in section 422 of the Internal Revenue Code of 1986, as amended from time to time (the "Code").*This Stock Option shall vest and become exercisable in equal quarterly installments over four years beginning three months after the Grant Date.Notwithstanding the foregoing, upon termination of the Participant's Employment, any portion of this Stock Option that is not then exercisable will immediately expire and the remainder of this Stock Option will remain exercisable for three months (unless termination of the Participant's Employment resulted from reasons that in the determination of the Administrator cast such discredit on the Participant as to justify immediate forfeiture of this Stock Option, in which case this entire Option shall immediately expire and no portion thereof shall remain exercisable); provided, that any portion of this Stock Option held by the Participant immediately prior to the Participant's death, to the extent then exercisable, will remain exercisable for one year following the Participant's death; and further provided, that in no event shall any portion of this Stock Option be exercisable after the Final Exercise Date.

Grant of Option from Employment Agreement

This Employment Agreement (the "Agreement") is made as of this 9th day of July, 2015, by and between Simulations Plus, Inc., a California corporation (the "Company") and Walter S. Woltosz, an individual (the "Employee") with reference to the following facts:

Grant of Option. The Employee shall be granted an option under the 2007 Stock Option Plan, exercisable for five (5) years, to purchase six (6) shares of Common Stock for each one thousand dollars ($1,000) of net income before taxes that the Company earns at the end of each fiscal year (up to a maximum of twelve thousand [12,000] options over the term of this Agreement) at an exercise price 10% over the market value per share as of the date of grant. The maximum number of options under this grant shall be adjusted accordingly for any stock split or reverse split after the date of this agreement. Option grants under this agreement shall be issued within ten days after the filing of the annual report (10-K) for the fiscal year for which the option is granted.

Grant of Option from Nonstatutory Stock Option Agreement

Grant of Option. This agreement evidences the grant by Tokai Pharmaceuticals, Inc., a Delaware corporation (the Company), on [ ] (the Grant Date) to [ ], a director of the Company (the Participant), of an option to purchase, in whole or in part, on the terms provided herein and in the Companys 2007 Stock Incentive Plan, as amended (the Plan), a total of [ ] shares (the Shares) of common stock, $0.001 par value per share, of the Company (Common Stock) at an exercise price of $[ ] per Share. Unless earlier terminated, this option shall expire at 5:00 p.m., Eastern time, on [ ] (the Final Exercise Date). It is intended that the option evidenced by this agreement shall not be an incentive stock option as defined in Section 422 of the Internal Revenue Code of 1986, as amended, and any regulations promulgated thereunder (the Code). Except as otherwise indicated by the context, the term Participant, as used in this option, shall be deemed to include any person who acquires the right to exercise this option validly under its terms.

Grant of Option from Incentive Stock Option Agreement

Grant of Option. This agreement evidences the grant by Tokai Pharmaceuticals, Inc., a Delaware corporation (the Company), on [ ] (the Grant Date) to [ ], an employee of the Company (the Participant), of an option to purchase, in whole or in part, on the terms provided herein and in the Companys 2007 Stock Incentive Plan, as amended (the Plan), a total of [ ] shares (the Shares) of common stock, $0.001 par value per share, of the Company (Common Stock) at an exercise price of $[ ] per Share. Unless earlier terminated, this option shall expire at 5:00 p.m., Eastern time, on [ ] (the Final Exercise Date). It is intended that the option evidenced by this agreement shall be an incentive stock option as defined in Section 422 of the Internal Revenue Code of 1986, as amended, and any regulations promulgated thereunder (the Code). Except as otherwise indicated by the context, the term Participant, as used in this option, shall be deemed to include any person who acquires the right to exercise this option validly under its terms.

Grant of Option from Nonstatutory Stock Option Agreement

Grant of Option. This agreement evidences the grant by Tokai Pharmaceuticals, Inc., a Delaware corporation (the Company), on [ ] (the Grant Date) to [ ], a director of the Company (the Participant), of an option to purchase, in whole or in part, on the terms provided herein and in the Companys 2007 Stock Incentive Plan, as amended (the Plan), a total of [ ] shares (the Shares) of common stock, $0.001 par value per share, of the Company (Common Stock) at an exercise price of $[ ] per Share. Unless earlier terminated, this option shall expire at 5:00 p.m., Eastern time, on [ ] (the Final Exercise Date). It is intended that the option evidenced by this agreement shall not be an incentive stock option as defined in Section 422 of the Internal Revenue Code of 1986, as amended, and any regulations promulgated thereunder (the Code). Except as otherwise indicated by the context, the term Participant, as used in this option, shall be deemed to include any person who acquires the right to exercise this option validly under its terms.

Grant of Option from Incentive Stock Option Agreement

Grant of Option. This agreement evidences the grant by Tokai Pharmaceuticals, Inc., a Delaware corporation (the Company), on [ ] (the Grant Date) to [ ], an employee of the Company (the Participant), of an option to purchase, in whole or in part, on the terms provided herein and in the Companys 2007 Stock Incentive Plan, as amended (the Plan), a total of [ ] shares (the Shares) of common stock, $0.001 par value per share, of the Company (Common Stock) at an exercise price of $[ ] per Share. Unless earlier terminated, this option shall expire at 5:00 p.m., Eastern time, on [ ] (the Final Exercise Date). It is intended that the option evidenced by this agreement shall be an incentive stock option as defined in Section 422 of the Internal Revenue Code of 1986, as amended, and any regulations promulgated thereunder (the Code). Except as otherwise indicated by the context, the term Participant, as used in this option, shall be deemed to include any person who acquires the right to exercise this option validly under its terms.