TMZ definition

TMZ means temozolomide.
Sample 1

Examples of TMZ in a sentence

  • TMZ, the current standard of treatment for glioblastoma, has limited efficacy.

  • In the remaining 60% of patients, Berubicin could become the primary drug treatment because TMZ is ineffective in this patient population.

  • However, because nearly all these patients will quickly become resistant, Berubicin could be prescribed after failure with TMZ.

  • When used in combination with radiotherapy following surgery, TMZ provided a median survival of 58.4 weeks for newly diagnosed GBM patients compared to 48.4 weeks for radiotherapy alone.

  • First-line treatment for primary GBM generally includes surgical resection of the bulk tumor to the maximal extent possible, followed by radiotherapy, often in combination with chemotherapy consisting of TMZ.

  • The approval of TMZ represented a breakthrough in treatment; the drug offers improvements in overall survival (“OS”), although the actual benefits are modest.

  • TMZ is less effective in GBM patients who harbor unmethylated O6-methylguanine-methyltransferase (“MGMT”) promoters in the tumor tissue; more than half of GBM patients have unmethylated MGMT promoters.

  • DCVax-L is being evaluated in newly diagnosed GBM patients who have received a complete surgical resection and received radiotherapy and concurrent TMZ.

  • In practice, even patients without MGMT promoter methylation are prescribed TMZ because of a lack of approved treatment alternatives.Recurrent Glioblastoma (rGBM)Unlike treatment of newly diagnosed GBM, no consensus exists regarding the optimal treatment of rGBM.

  • Less than 40% of glioblastoma patients have a genetic variation which makes their tumors initially more responsive to TMZ.

Related to TMZ

  • EPG means electronic program guide maintained by a DPO on its Digital Distribution Platform which lists the television channels and programs, and scheduling and programming information therein and includes any enhanced electronic guide that allows Subscribers to navigate and select such available channels and programs.

  • MB means megabyte, which is equal to 1024 kilobytes or 1,048,576 bytes of digital information.

  • Constellation has the meaning assigned to that term in the Recitals.

  • GLJ means GLJ Petroleum Consultants Ltd.;

  • ESMP means an environmental and social management plan (including any pest management plan), acceptable to the Association and consistent with the ESMF, adopted for the purposes of a Micro-project, and giving details of the magnitude of the environmental impacts, as well as the specific actions, measures and policies designed to facilitate the achievement of the objective of the ESMF under the Micro-project, including the budget and cost estimates, and sources of funding, along with the institutional and procedural measures needed to implement such actions, measures and policies, as such ESMP may be amended form time to time with the prior written agreement of the Association.

  • Wp means Watt Peak.

  • SoftBank means Softbank Group Corp.

  • CEC means the California Energy Commission or its successor agency.

  • CCMA means the Commission for Conciliation, Mediation and Arbitration established in terms of section 112 of the Labour Relations Act, 1995;

  • CW means current City of Winnipeg Standard Construction Specification;

  • GLO means the Texas General Land Office and its officers, employees, and designees, acting in their official capacities.

  • PSI means pounds per square inch.

  • CCI means Charter Communications, Inc., a Delaware corporation, and any successor Person thereto.

  • SBS means the New York City Department of Small Business Services.

  • TM has the meaning set forth in Section 10.2.

  • EG means the Enforcement Guide;

  • SNA means State Nodal Agency.