SNCA definition
Examples of SNCA in a sentence
Over the years, point mutations [4] and multiplications of the SNCA gene, coding for α- syn, have been linked to PD.
For example, mutations in the SNCA promoter have been shown to increase the risk of developing PD but are not directly causative (Pals et al.
Furthermore, a single nucleotide polymorphism (SNP) of the SNCA gene has also been linked to increased PD susceptibility (▇▇▇▇▇ et al.
For example, α-synuclein accumulation into LBs is also a prevalent feature of sporadic PD, despite a lack of SNCA mutations (▇▇▇▇ et al.
SNCA mutations are characterised by α-synuclein accumulation into cellular structures known as Lewy bodies (LB, figure 1.4), a classical histological hallmark of both familial and sporadic PD (▇▇▇▇ et al.
The SNCA gene encodes the protein α-synuclein and was the first gene to be directly associated with PD (▇▇▇▇▇▇▇▇▇▇▇▇▇▇ et al.
Mutations of SNCA include single point mutations and gene multiplications causing early onset autosomal-dominant PD (▇▇▇▇▇▇ & ▇▇▇▇▇ 2009, ▇▇▇▇▇▇▇▇▇ 2013).
The BAC construct contains all of the regulatory sequences required for expression of the human SNCA gene under the DBH promoter.
SNCA or α-synuclein is a 144 amino-acid protein with unknown function.