PTEN definition

PTEN means the human phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase expressed by the human phosphatase and tensin homolog gene.
PTEN means the human phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase expressed by the human phosphatase and tensin homolog gene. [*] Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

Examples of PTEN in a sentence

  • PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer.

  • PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.

  • Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome.

  • Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma.

  • Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN.

  • The Company’s overall risk management program seeks to mitigate these risks and reduce the volatility on the Company’s financial performance.

  • Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations.

  • Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer.

  • KRAS, BRAF, PIK3CA, and PTEN mutations: implications for targeted therapies in metastatic colorectal cancer.

  • Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate.

Related to PTEN

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  • Panchayat means an institution (by whatever name called) of self-government constituted under article 243B, for the rural areas;

  • IST means Indian Standard Time.

  • Nematode means invertebrate animals of the phylum nemathelminthes, and class nematoda, i.e., unsegmented round worms with elongated, fusiform, or saclike bodies covered with cuticle, and inhabiting soil, water, plants, or plant parts, may also be called nemas or eelworms.

  • Dementia means an illness characterized by multiple cognitive deficits which represent a decline from previous levels of functioning and include memory impairment and one or more of the following cognitive disturbances: aphasia, apraxia, agnosia, and disturbance in executive functioning.

  • thalassemia means a group of inherited disorders characterised by reduced or absent amounts of haemoglobin.

  • Cannabidiol means a finished preparation containing, of its total cannabinoid content, at least 98 percent cannabidiol and not more than 0.90 percent tetrahydrocannabinol by volume that has been extracted from marijuana or synthesized in a laboratory.

  • DAS means the State of Oregon acting through its Department of Administrative Services.

  • Tabarru’ means donation for the purpose of solidarity and cooperation among the Takaful Participants and to be used to help all Takaful Participants in times of misfortune. In the context of the Company, Tabarru’ will be allocated into the Participants’ Risk Fund.

  • glider means a non-power-driven heavier-than-air aircraft, deriving its lift in flight chiefly from aerodynamic reactions on surfaces, which remain fixed under given conditions of flight;

  • Brachytherapy means a method of radiation therapy in which sealed sources are utilized to deliver a radiation dose at a distance of up to a few centimeters, by surface, intracavitary, or interstitial application.

  • Cat means the consolidated audit trail contemplated by SEC Rule 613.

  • Cannabinoid means any of the chemical compounds that are the active constituents of marijuana.

  • Dyslexia means a disorder of constitutional origin manifested by a difficulty in learning to read, write, or spell, despite conventional instruction, adequate intelligence, and sociocultural opportunity.

  • Seed means seed in the botanical sense other than seed not intended for planting;

  • Embryo/fetus means the developing human organism from conception until the time of birth.

  • Roentgen means the special unit of exposure. One roentgen (R) equals 2.58 × 10-4 coulombs/kilogram of air (see “Exposure” and 38.4(4)).

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  • coronavirus means severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2);

  • Parade means any procession or body of pedestrians, except members of the Armed Forces, numbering more than 30, standing, marching or walking on any street or sidewalk, or any group of vehicles numbering ten or more, except funeral processions, standing or moving on any street;

  • PIR means Problem Identification Report.

  • Cosmetology means any one and/or combination of practices generally and usually performed by and known as the occupation of beauty culturalist, cosmeticians, cosmetologists or hairdressers or any person holding him or herself out as practicing cosmetology in or upon a place or premises. Cosmetology shall include, but otherwise not be limited to, the following: embellishing, arranging, dressing, curling, waving, cleansing, beautifying, cutting, singeing, bleaching, coloring, or similar work upon the hair of any person by any means and with hands or mechanical or electrical apparatuses, devices or appliances or by use of cosmetic preparations, antiseptics, tonics, lotions, creams or otherwise, massaging, cleansing, stimulating, manipulating, exercising, beautifying or similar work, the scalp, face, neck, arms, hands, bust or upper part of the body, or manicuring, pedicuring or sculpting the nails of any person.

  • Embryo or "fetus" means the developing human organism from conception until time of birth.

  • Becquerel (Bq) means the SI unit of activity. One becquerel is equal to 1 disintegration or transformation per second (dps or tps).