{"component": "definition", "props": {"groups": [{"samples": [{"hash": "anT0bvrk6nI", "uri": "https://www.legis.iowa.gov/docs/iac/agency/02-19-2025.653.pdf", "label": "Amendment", "score": 23.9553890228, "published": false}, {"hash": "lIPBnUJirh5", "uri": "https://www.legis.iowa.gov/docs/aco/arc/8701C.pdf", "label": "Notice", "score": 23.7949886322, "published": false}, {"hash": "jQKCO35mP9n", "uri": "https://www.legis.iowa.gov/docs/iac/agency/04-30-2025.653.pdf", "label": "www.legis.iowa.gov", "score": 20.2247219086, "published": false}], "size": 81, "snippet": "means an unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage. 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resulting from an injury by accident or occupational disease.", "snippet_links": [{"key": "resulting-from", "type": "definition", "offset": [11, 25]}, {"key": "occupational-disease", "type": "definition", "offset": [51, 71]}], "hash": "a3e143941075ea63cf903b10ddd2a485", "id": 7}, {"samples": [{"hash": "7H4wPE5r2a1", "uri": "https://www.tunxis.edu/wp-content/uploads/2011/02/2013-201337-2-Brochure-v2.pdf", "label": "Notice", "score": 10.7604379654, "published": false}, {"hash": "5ukIxM0JnHs", "uri": "https://www.tunxis.edu/wp-content/uploads/2011/02/Student-Insurance-plan-for-2012-2013.pdf", "label": "www.tunxis.edu", "score": 6.3415470123, "published": false}], "size": 5, "snippet": "means a sensation in which a person experiences severe discomfort, distress or suffering due to provocation of sensory nerves, and \u201cPain Management Specialist\u201d means a Physician who is credentialed by the American Academy of Pain Management or who is a board-certified anesthesiologist, neurologist, oncologist or radiation oncologist with additional training in pain management.", "snippet_links": [{"key": "a-person", "type": "clause", "offset": [27, 35]}, {"key": "pain-management-specialist", "type": "definition", "offset": [132, 158]}, {"key": "radiation-oncologist", "type": "definition", "offset": [314, 334]}, {"key": "additional-training", "type": "definition", "offset": [340, 359]}], "hash": "65219df78f27162e499117c6e54fef38", "id": 8}, {"samples": [{"hash": "hOz4Kw3KBWl", "uri": "https://www.nmlegis.gov/sessions/05%20Regular/final/HB0727.pdf", "label": "www.nmlegis.gov", "score": 5.0, "published": false}, {"hash": "lEN3QD2xaeW", "uri": "https://scholarworks.iupui.edu/bitstream/handle/1805/829/Achieving%20balance%20in%20federal%20and%20state%20pain%20policy%20-%20part%204.pdf?sequence=1", "label": "scholarworks.iupui.edu", "score": 5.0, "published": false}], "size": 2, "snippet": "means a condition of bodily sensation of serious physical discomfort that requires the services of a health care provider to alleviate, including discomfort that is persistent and chronic in duration; and", "snippet_links": [{"key": "condition-of", "type": "clause", "offset": [8, 20]}, {"key": "the-services", "type": "definition", "offset": [83, 95]}, {"key": "health-care-provider", "type": "clause", "offset": [101, 121]}], "hash": "455288a222066f532002365461f50e24", "id": 9}, {"samples": [{"hash": "ggkOtB2tzKL", "uri": "/contracts/ggkOtB2tzKL#pain", "label": "Collaboration Agreement (Axys Pharmecueticals Inc)", "score": 18.0, "published": true}], "size": 2, "snippet": "means[*].", "snippet_links": [], "hash": "e8bcbadec0992f524c3ed0e03275763d", "id": 10}], "next_curs": "ClESS2oVc35sYXdpbnNpZGVyY29udHJhY3Rzci0LEhpEZWZpbml0aW9uU25pcHBldEdyb3VwX3Y1NiINcGFpbiMwMDAwMDAwYQyiAQJlbhgAIAA=", "definition": {"title": "Pain", "size": 267, "snippet": "means an unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage. Pain is an individual, multifactorial experience influenced by culture, previous pain events, beliefs, mood and ability to cope.", "id": "pain", "examples": ["Assuming a pooled standard deviation of 2.35, this corresponds to a standardized effect size of approximately 0.34, an effect size comparable to effect sizes observed in recent diabetic neuropathic <strong>pain</strong> studies using efficacious agents such as duloxetine and pregabalin (\u2587\u2587\u2587\u2587\u2587 et al, Journal of <strong>Pain</strong>, 2018).", "Patients will participate in the study for up to ~34 weeks, inclusive of the Screening, <strong>Pain</strong> Observation, double-blind, placebo-controlled Treatment, open label Safety Extension, and washout Follow-up periods.", "<strong>Pain</strong> medications taken on an occasional or as needed basis (3 or less days in most weeks) must have been discontinued for at least 7 days prior to starting the <strong>Pain</strong> Observation period.", "During her presentation she focused on common conditions treated like Neck <strong>pain</strong> ,Shoulder <strong>pain</strong>, Back <strong>Pain</strong> ( Upper, Middle and Lower), Osteoarthritis,Headaches, Tightness/ Stiffness/muscle spasm, Sprains/ strains, Hip <strong>pain</strong>,Disc bulges/herniation, Sciatica ( Low back <strong>pain</strong> going down the leg).", "Following the baseline <strong>Pain</strong> Observation period, patients who meet entry criteria will be randomized in a 1:1 ratio to receive either ricolinostat or placebo.", "Any <strong>pain</strong> medication that a patient has been previously taking on a regular basis but no longer takes must have been discontinued for at least one month prior to starting the <strong>Pain</strong> Observation period.", "The study is comprised of a Screening, Washout, <strong>Pain</strong> Observation, Treatment, Safety Extension, and Follow-up period as outlined in the sections below.", "During the <strong>Pain</strong> Observation period, patients will be dosed daily with placebo under single-blind conditions.", "Initial Reports All SAEs occurring from the time of first dose (start of <strong>Pain</strong> Observation period) of study drug until 30 days following the final dose of study drug must be reported to Medpace Clinical Safety within 24 hours of the knowledge of the occurrence.", "Prior to randomization, patients will be enrolled in a baseline <strong>Pain</strong> Observation period from Day -14 to Day -1, during which the NRS (average and worst <strong>pain</strong>) will be recorded daily using an electronic daily diary that will be completed by patients to allow patients to familiarize themselves with the <strong>pain</strong> rating procedures, and to establish a baseline and confirm eligibility to participate."], "related": [["infection", "Infection", "Infection"], ["covid-19-symptoms", "COVID-19 symptoms", "COVID-19 symptoms"], ["trauma", "Trauma", "Trauma"], ["stroke", "Stroke", "Stroke"], ["psychotherapy", "Psychotherapy", "Psychotherapy"]], "related_snippets": [], "updated": "2025-07-10T05:58:13+00:00"}, "json": true, "cursor": ""}}