Modulate or “Modulation” means, with respect to a Molecular Target, modulation or modification of the expression of a product of such Molecular Target [***].
Modulate means, with respect to a Target[***].
Modulate or “Modulation” means to edit, engineer, modify, or modulate a gene or locus, including by means of gene knock-out, gene tagging, gene disruption, gene mutation, gene insertion, gene deletion, gene activation, gene silencing, or gene knock-in, which includes knock-in of a heterologous gene to a genomic locus, for example, a safe harbor genomic locus or a target genomic locus.
Examples of Modulate in a sentence
Modulate dampers and measure fan-motor amperage to ensure that no overload will occur.
Modulate dampers and measure fan-motor amperage to ensure that no overload occurs.
Modulate OA, RA, and EA dampers from fully open to fully closed positions.
Waking State: Rapid Variations Modulate Neural and Behavioral Responses.
Modulate dampers and measure fan-motor amperage to ensure no overload will occur.
More Definitions of Modulate
Modulate means, with respect to a Target [***].
Modulate or “Modulation” means to edit, engineer, modify, or modulate a gene or locus, including by means of gene knock-out, gene tagging, gene disruption, gene mutation, gene addition,
Modulate or “Modulation” means the inhibition or activation of a Coagulation Cascade Protein using a Short Acting Coagulation Cascade Aptamer. As used in this definition, “inhibition” means either (a) inhibition at a therapeutically useful level of a Short Acting Coagulation Cascade Aptamer by binding of a Short Acting Coagulation Cascade Aptamer to a pre-selected Coagulation Cascade Protein or (b) inhibition at a therapeutically useful level of a Short Acting Coagulation Cascade Aptamer of a second pre-selected Coagulation Cascade Protein by binding at a therapeutically useful level of a Short Acting Coagulation Cascade Aptamer to a first pre-selected Coagulation Cascade Protein. As used in this definition, “activation” means either (a) activation at a therapeutically useful level of a Short Acting Coagulation Cascade Aptamer by binding of a Short Acting Coagulation Cascade Aptamer to a pre-selected Coagulation Cascade Protein or (b) activation at a therapeutically useful level of a Short Acting Coagulation Cascade Aptamer of a second pre-selected Coagulation Cascade Protein by binding at a therapeutically useful level of a Short Acting Coagulation Cascade Aptamer to a first pre-selected Coagulation Cascade Protein.
Modulate or “Modulation” means the inhibition or activation of a Coagulation Cascade Protein using a Short Acting Coagulation Cascade Aptamer. As used in this definition, “inhibition” means either (a) inhibition at a therapeutically useful level of a Short Acting Coagulation Cascade Aptamer by binding of a Short Acting Coagulation Cascade Aptamer to a pre-selected Coagulation Cascade Protein or (b) inhibition at a therapeutically useful level of a Short Acting Coagulation Cascade Aptamer of a second pre-selected Coagulation Cascade Protein by binding at a therapeutically useful level of a Short Acting Coagulation Cascade Aptamer to a first pre-selected Coagulation Cascade Protein. As used in
Modulate means, with respect to a compound and a Program Target, that such compound (a) directly binds to such Program Target and (b) activates, inhibits, agonizes, antagonizes or otherwise modulates such Program Target.
Modulate means, with reference to a compound, that it: (i) has any activity with an [****] or [****] for the S1P1 receptor that equals or is less than [****] and (ii) is or was developed at least in part because of its modulatory effect on the S1P1 receptor, giving consideration to the overall intent as evidenced, for example, by patent applications, scientific publications or Regulatory Filings of the developing Party related to such compound. For purposes of this definition, [****] means the[****] of a compound, which produces [****] of the maximum possible response in a biological assay and [****] means the [****] of a compound, which produces [****] of the maximum possible inhibitory response in a biological assay.
Modulate means, with regard to a particular Target, that the compound or product at issue activates, inhibits, agonizes, antagonizes, or otherwise regulates or adjusts such Target, and such activation, inhibition, agonizing, antagonizing, or other regulation or adjustment causes pharmacologically relevant activity with respect to such Target.