Modulate definition

Modulate or “Modulation” means, with respect to a Molecular Target, modulation or modification of the expression of a product of such Molecular Target [***].

Split View

AI-Powered Contracts

Draft, Review & Redline at the Speed of AI

Get StartedBook a Demo

Modulate means, with respect to a Target[***].

Modulate or “Modulation” means to edit, engineer, modify, or modulate a gene or locus, including by means of gene knock-out, gene tagging, gene disruption, gene mutation, gene insertion, gene deletion, gene activation, gene silencing, or gene knock-in, which includes knock-in of a heterologous gene to a genomic locus, for example, a safe harbor genomic locus or a target genomic locus.

Examples of Modulate in a sentence

• This Agreement will commence on the Effective Date and, unless otherwise terminated pursuant to Section 16.2 (Termination), will continue on a Target-by-Target basis until the expiration of all applicable Royalty Terms with respect to all Products that Modulate such Target on a country-by-country-basis in the Territory (the “Term”).

• During the Research Term for the Target Research Activities and in accordance with the terms and conditions of this Agreement, the Parties will collaborate to identify and synthesize Candidates that Modulate each Target according to the applicable Target Research Plan for such Target, with the aim of identifying IND-ready Candidates for treatment of the corresponding Indication for such Target.

• During the Research Term, if HMI reasonably believes that any Candidate has achieved the Success Criteria for Candidates that Modulate such Target, HMI will submit to the JSC for its review and approval a report that: (a) identifies all such Candidate(s); and (b) provides all data and documentation that supports HMI’s determination of achievement of the Success Criteria for Candidates that Modulate such Target (each, a “Success Criteria Report”).

• Each Target Notice will specify the Omega Controller(s) and the Human Genome Target(s) that each Omega Controller is designed to Genome Modulate.

• For the avoidance of doubt, the identity of potential Reserved Targets or any Omega Reserved Targets and the information contained in any Target Notice submitted by Omega to the Escrow Agent, including any Omega Controller sequence information and the Human Genome Target(s) any such Omega Controller is designed to Genome Modulate, are the Confidential Information of Omega.

More Definitions of Modulate

Modulate or “Modulation” means the inhibition or activation of a Coagulation Cascade Protein using a Short Acting Coagulation Cascade Aptamer. As used in this definition, “inhibition” means either (a) inhibition at a therapeutically useful level of a Short Acting Coagulation Cascade Aptamer by binding of a Short Acting Coagulation Cascade Aptamer to a pre-selected Coagulation Cascade Protein or (b) inhibition at a therapeutically useful level of a Short Acting Coagulation Cascade Aptamer of a second pre-selected Coagulation Cascade Protein by binding at a therapeutically useful level of a Short Acting Coagulation Cascade Aptamer to a first pre-selected Coagulation Cascade Protein. As used in this definition, “activation” means either (a) activation at a therapeutically useful level of a Short Acting Coagulation Cascade Aptamer by binding of a Short Acting Coagulation Cascade Aptamer to a pre-selected Coagulation Cascade Protein or (b) activation at a therapeutically useful level of a Short Acting Coagulation Cascade Aptamer of a second pre-selected Coagulation Cascade Protein by binding at a therapeutically useful level of a Short Acting Coagulation Cascade Aptamer to a first pre-selected Coagulation Cascade Protein.

Modulate or “Modulation” means to edit, engineer, modify, or modulate a gene or locus, including by means of gene knock-out, gene tagging, gene disruption, gene mutation, gene addition,

Modulate means, with respect to a Target [***].

Modulate here means that the main carrier signal is multiplied by the message-bearing

Modulate or “Modulation” means the inhibition or activation of a Coagulation Cascade Protein using a Short Acting Coagulation Cascade Aptamer. As used in this definition, “inhibition” means either (a) inhibition at a therapeutically useful level of a Short Acting Coagulation Cascade Aptamer by binding of a Short Acting Coagulation Cascade Aptamer to a pre-selected Coagulation Cascade Protein or (b) inhibition at a therapeutically useful level of a Short Acting Coagulation Cascade Aptamer of a second pre-selected Coagulation Cascade Protein by binding at a therapeutically useful level of a Short Acting Coagulation Cascade Aptamer to a first pre-selected Coagulation Cascade Protein. As used in

Modulate means, with regard to a particular Target, that the compound or product at issue activates, inhibits, agonizes, antagonizes, or otherwise regulates or adjusts such Target, and such activation, inhibition, agonizing, antagonizing, or other regulation or adjustment causes pharmacologically relevant activity with respect to such Target.

Modulate means, with reference to a compound, that it: (i) has any activity with an [****] or [****] for the S1P1 receptor that equals or is less than [****] and (ii) is or was developed at least in part because of its modulatory effect on the S1P1 receptor, giving consideration to the overall intent as evidenced, for example, by patent applications, scientific publications or Regulatory Filings of the developing Party related to such compound. For purposes of this definition, [****] means the[****] of a compound, which produces [****] of the maximum possible response in a biological assay and [****] means the [****] of a compound, which produces [****] of the maximum possible inhibitory response in a biological assay.