Lead Optimization definition

Lead Optimization means the stage of early drug discovery where promising

Lead Optimization. Lead Optimization means the discovery phase dedicated to the evaluation of new AAV Capsid Variants derived from an AAV Capsid Variant Library following a Research Selection Process to identify one or more Research Compounds that meet Delivery Success Criteria.

Lead Optimization means the program of medicinal chemistry research intended to identify structure-activity relationships and apply the knowledge of those relationships to produce compounds having superior properties relative to a Lead Compound.

Examples of Lead Optimization in a sentence

• Lead Optimization Mapper: Automating Free Energy Calculations for Lead Optimization.

• Binding Free Energy Calculations for Lead Optimization: Assessment of Their Accuracy in an Industrial Drug Design Context.

• Mills, Chemistry Challenges in Lead Optimization: Silicon Isosteres in Drug Discovery, 8 DRUG DISCOVERY TODAY 551, 551 (2003).

• From Lead Nomination onwards and throughout Lead Optimization, the structures of Other Compounds and Collaboration Compounds in the Lead Optimization phase shall be shared with the Roche project team members (including Collaboration Compounds meeting Lead Series Identified Criteria, CLS Criteria and CCS Criteria).

• Magnuson, Lead Optimization of a 4-Aminopyridine Benzamide Scaffold To Identify Potent, Selective, and Orally Bioavailable TYK2 Inhibitors, J.

More Definitions of Lead Optimization

Lead Optimization means the preclinical development activities performed for each Collaboration Target following Lead Nomination, with the goal to identify Collaboration Compounds suitable for GLP Tox Studies and meeting CCS Criteria.

Lead Optimization means the preclinical development activities performed for each Target following Lead Identification, with the goal to identify Degronimids suitable for GLP Tox Studies and satisfying CCS Criteria for such Target.

Lead Optimization means: (a) the application of medicinal chemistry to improve specificity; (b) optimization of pharmacokinetics and bioavailability; and (c) testing in preclinical studies in animals.

Lead Optimization means the process of ***.

Lead Optimization has the meaning given in Section 2.d.

Lead Optimization means the set of activities comprising molecular engineering, and biological and physical testing of Development Candidates with the aim of improving on-target activity, reducing off-target activities and improving physicochemical properties. The result of lead optimization is a molecule that possesses the desired in vitro and in vivo biological and physicochemical properties, as defined by the Parties and, ready to be advanced into GLP toxicology Studies.

Lead Optimization means a program of medicinal chemistry and related research efforts as set forth in the Research Plan the intent of which is to develop a Lead Compound into an IND Candidate.