IL-1 Inhibitor definition

IL-1 Inhibitor means any recombinant human Interleukin-1 (“IL-1”) binding protein that binds to IL-1, thereby reducing the binding of IL-1 to the target cell membrane receptors.
Sample 1Sample 2
IL-1 Inhibitor or “IL-1 Inhibitor product” means any molecule capable of binding to human Interleukin-1 (“IL-1"), thereby reducing the binding of IL-1 to the target cell membrane receptors, which molecule is comprised of all of, or an IL-1 binding portion of, an IL-1 receptor (Type I or Type II) and all of, or an active portion of, the IL-1 accessory protein.
Sample 1Sample 2

Examples of IL-1 Inhibitor in a sentence

  • Entry into the United States neutrophil regeneration, TNF Inhibitor, and IL-1 Inhibitor product markets would not be timely, likely, or sufficient in its magnitude, character, and scope to deter or counteract the anticompetitive effects of the merger.

  • Amgen, Immunex, and Regeneron were the only companies developing second-generation Interleukin-1 (IL-1) Inhibitors, and Regeneron was unlikely to succeed in commercializing its IL-1 Inhibitor product because its product likely infringed on Immunex’s patent rights.

  • Regeneron, the only other company in clinical development of an IL-1 Inhibitor, is about to begin Phase II trials of its IL-1 Inhibitor product called IL-1 Trap.

  • The necessary intellectual property includes the respective DNA sequences, methods of making and using neutrophil regeneration, TNF Inhibitor, and IL-1 Inhibitor products.

  • Entry into the neutrophil regeneration, TNF Inhibitor, and IL-1 Inhibitor product markets requires lengthy preclinical and clinical trials, data collection and analysis, and expenditures of significant resources over many years to qualify manufacturing facilities with the FDA.

  • The Commission alleged the loss of potential competition even though Immunex’s IL-1 Inhibitor was only in Phase I clinical trials.320In Roche/Genentech the Commission alleged harm to future competition in three markets, where one or both of the parties were no further along than the early-stage research or development of a product.

  • Immunex is in Phase I trials of its IL-1 Inhibitor product, known as IL-I Type II.

  • Patent litigation initiated by Pfizer with the most significant potential entrants was likely to prevent entry in the two years following the merger.In Amgen/Immunex, the Commission alleged that Amgen’s proposed acquisition of Immunex would reduce innovation competition in the research, development, and commercialization of IL-1 Inhibitor products, and eliminate potential competition in the market for IL-1 Inhibitor products.

  • Amgen’s product, Kineret, was the first IL-1 Inhibitor approved by the FDA.

  • Amgen and Immunex are two of only three companies clinically developing or marketing IL-1 Inhibitor products to treat RA and other autoimmune diseases by blocking the activity of the pro-inflammatory cytokine IL-1.

Related to IL-1 Inhibitor

  • Biomarker means a parameter or characteristic in a patient or Patient Sample, the measurement of which is useful (a) for purposes of selecting appropriate therapies or patient populations or monitoring disease susceptibility, severity or state, or monitoring therapies for such patient and/or (b) for predicting the outcome of a particular treatment of such patient.

  • Antibody means a molecule or a gene encoding such a molecule comprising or containing one or more immunoglobulin variable domains or parts of such domains or any existing or future fragments, variants, modifications or derivatives thereof.

  • Receptor means enclosed spaces, conduits, protected groundwater sources, drinking and non-drinking water wells, surface water bodies, and public water systems which when impacted by chemicals of concern may result in exposure to humans and aquatic life, explosive conditions or other adverse effects on health, safety and the environment as specified in these rules.

  • Corrosion inhibitor means a substance capable of reducing the corrosivity of water toward metal plumbing materials, especially lead and copper, by forming a protective film on the interior surface of those materials.

  • Opioid antagonist means a drug that binds to opioid

  • Collaboration Compound means any of the following: (a) FG-4592, (b) any HIF Compound (other than FG-4592) that is added to this Agreement pursuant to Section 3.6, and (c) any salts, esters, complexes, chelates, crystalline and amorphous morphic forms, pegylated forms, enantiomers (excluding regioisomers), prodrugs, solvates, metabolites and catabolites of any of the foregoing ((a) or (b)).

  • Opioid antidote means any drug, regardless of dosage amount or method of administration, which has been approved by the United States Food and Drug Administration (FDA) for the treatment of an opioid overdose. “Opioid antidote” includes, but is not limited to, naloxone hydrochloride, in any dosage amount, which is administered through nasal spray or any other FDA-approved means or methods.

  • Vaccine means a specially prepared antigen which, upon administration to a person, will result in immunity and, specifically for the purposes of this rule, shall mean influenza and pneumococcal vaccines.

  • Diagnostic Product means any test or assay for diagnosing or detecting a disease, disorder, medical condition, or symptom.

  • Licensed Compound means [***].

  • Anti-Static Product means a product that is labeled to eliminate, prevent, or inhibit the accumulation of static electricity. “Anti-Static Product” does not include “Electronic Cleaner,” “Floor Polish or Wax,” “Floor Coating,” and products that meet the definition of “Aerosol Coating Product” or “Architectural Coating.”

  • Collaboration Target means the Initial Collaboration Targets set forth on Exhibit F and any Additional Target or Substitute Target that is selected in accordance with Section 3.3 of this Agreement.

  • Milk product or "dairy product" means cottage cheese, dry curd cottage cheese, reduced fat cottage cheese, lowfat cottage cheese, cream, light cream, light whipping cream, heavy cream, heavy whipping cream, whipped cream, whipped light cream, sour cream, acidified sour cream, cultured sour cream, half-and-half, sour half-and-half, acidified sour half-and-half, cultured sour half-and-half, reconstituted or recombined milk and milk products, concentrated milk, concentrated milk products, skim milk, lowfat milk, frozen milk concentrate, flavored milk, eggnog, buttermilk, cultured milk, cultured lowfat milk, cultured skim milk, yogurt, lowfat yogurt, nonfat yogurt, acidified milk, acidified lowfat milk, acidified skim milk, low-sodium milk, low-sodium lowfat milk, low-sodium skim milk, lactose-reduced milk, lactose-reduced lowfat milk, lactose-reduced skim milk, aseptically processed and packaged milk, milk products with added safe and suitable microbial organisms, and any other milk product made by the addition or subtraction of milkfat or addition of safe and suitable optional ingredients for protein, vitamin, or mineral fortification. Unless a product is considered a milk product under this subdivision, milk product does not include dietary products, infant formula, ice cream or other desserts, cheese, or butter. Milk products include the following:

  • Bioassay means the determination of kinds, quantities or concentrations and, in some cases, the locations of radioactive material in the human body, whether by direct measurement, in vivo counting, or by analysis and evaluation of materials excreted or removed from the human body. For purposes of these rules, “radiobioassay” is an equivalent term.

  • Licensed Compounds means any EZH2 Compound(s) that is:

  • Cannabinoid means any of the chemical compounds that are the active constituents of marijuana.

  • Gene Therapy means a product or service for the treatment or prevention of a disease that utilizes ex vivo or in vivo delivery (via viral or nonviral gene transfer methods or systems) of Genetic Material, including any cell incorporating Genetic Material.

  • Image receptor means any device, such as a fluorescent screen or radiographic film, which transforms incident X-ray photons either into a visible image or into another form which can be made into a visible image by further transformations.

  • genocide means any of the following acts committed with intent to destroy, in whole or in part, a national, ethnical, racial or religious group, as such:

  • Cannabinoid edible means food or potable liquid into which a cannabinoid concentrate, cannabinoid extract or dried marijuana leaves or flowers have been incorporated.

  • Cannabinoid extract means a substance obtained by separating cannabinoids from marijuana by:

  • Library means a code module that cannot be installed or executed separately from an Application and that is developed by You in compliance with the Documentation and Program Requirements only for use with iOS Products, Apple Watch, or Apple TV.

  • complex product means a product which is composed of multiple components which can be replaced permitting disassembly and re-assembly of the product.

  • Isomer means all enantiomers and diastereomers.

  • Nicotine product means a product that contains nicotine and is not any of the following:

  • Biological product means a virus, therapeutic serum, toxin, antitoxin, vaccine, blood, blood component or derivative, allergenic product, protein other than a chemically synthesized polypeptide, or analogous product, or arsphenamine or any derivative of arsphenamine or any other trivalent organic arsenic compound, applicable to the prevention, treatment, or cure of a disease or condition of human beings.