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"<strong>EC50</strong> value is calculated with four parameter logistic equation: Y=Bottom + (Top-Bottom)/ (1+10^ ((LogEC50-X)*HillSlope)) X is the logarithm of concentration.", "The <strong>EC50</strong> value (i.e., the molar concentration of insulin that produces 50% of the maximum possible response that insulin is capable of) for suppression of lipolysis by insulin is between 7 and 16 \u00b5U/mL76,88-92, whereas the EC values G G G G I G I G I G G I G I G I Figure 2.", "A 48-step optimization process significantly improved the potency (<strong>EC50</strong> to 20 nM) and the pharmacokinetic properties of the drug (Hadida et al., 2014).", "While displaying unimpressive potency (<strong>EC50</strong> \u2248 2 \u00b5M), this lead was attractive because it showed higher in vitro efficacy than a benchmark investigational CFTR potentiator (genistein), and it was able to potentiate both G551D- and temperature- corrected F508del-CFTR currents from human bronchial epithelial cells (Hadida et al., 2014).", "Human myotubes when dosed with SMT C1100 for 7 days demonstrated and increase of utrophin protein of around 50% when compared to vehicle with an <strong>EC50</strong> of 0.2\u00b5M (Fig 1c).", "For each CART Activated Receptor subject to screening, Arena shall use Best Reasonable Commercial Efforts to identify at least [** *****************************] and to determine the IC50 Value and/or <strong>EC50</strong> Value, whichever is applicable, with respect to such CART Identified Ingredient.", "This may lead to differences in the estimation of ke0 and <strong>EC50</strong> compared to conventional approaches, as has been shown in the paragraph above.", "Sankyo shall screen each Secondary Compound for selected activity in relation to the Selected Target and provide all data (including but not limited to the EC\\50\\ for each Secondary Compound) resulting therefrom (&quot;Secondary Results&quot;) to Telik within [ * ] of Sankyo&#x27;s receipt of the Secondary Compounds.", "Sankyo shall screen each Tertiary Compound for selected activity in relation to the Selected Target and provide all data (including but not limited to the EC\\50\\ for each Tertiary Compound) resulting therefrom (&quot;Tertiary Results&quot;) to Telik within [ * ] of Sankyo&#x27;s receipt of the Tertiary Compounds."], "related": [["lc50", "LC50", "LC50"], ["grab-sample", "Grab sample", "Grab sample"], ["anaerobic-digester", "Anaerobic digester", "Anaerobic digester"], ["pm10", "PM10", "PM10"], ["mi-61-101", "MI 61-101", "MI 61-101"]], "related_snippets": [], "updated": "2025-07-12T05:45:48+00:00"}, "json": true, "cursor": ""}}