Clinical significance definition

Clinical significance means that the effect is large enough to be important to patients and physicians. An effect that is clinically significant may or may not also be statistically significant. In glaucoma, the Early Manifest Glaucoma Trial, a large long-term study evaluating the effect of IOP lowering in patients with glaucoma, concluded that each 1 mmHg reduction in IOP lowered the risk of progression of optic nerve damage by 10%, indicating that each 1 mmHg reduction in IOP provides a meaningful level of protection to the patient.
View Source

Examples of Clinical significance in a sentence

  • Clinical significance: a statistical approach to defining meaningful change in psychotherapy research.

  • Systematic review of long-term weight loss studies in obese adults: Clinical significance and applicability to clinical practice.

  • Clinical significance is defined as any variation in results that has medical relevance and may result in an alteration in medical care (eg, active observation, diagnostic measures, or therapeutic measures).

  • Clinical significance : A statistical approach to defining meaningful change in psychotherapy research.

  • Clinical significance of serum vascular endothelial growth factor in colorectal cancer patients : correlation with clinicopathological factors and tumor markers.

  • Clinical significance: IOP measurement on the sclera using Schiotz can be used as an alternative to GAT.

  • Clinical significance is defined as any variation in assessment results that has medical relevance resulting in an alteration in medical care.

  • Clinical significance of drug binding, protein binding, and binding displacement drug interactions.

  • Approaches to denote treatment outcome: Clinical significance and clinical global impression compared.

  • Clinical significance: A statistical approach to defining meaningful change in psychotherapy research.