Aptamer definition

Aptamer means (a) any naturally or non-naturally occurring oligonucleotide identified through the SELEX Process that binds with high specificity and affinity to a Target, and (b) any oligonucleotide Derived from an oligonucleotide of clause (a) that has such high specificity and affinity to a Target.
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Aptamer means any oligonucleotide that binds to a target through means other than Xxxxxx-Xxxxx base-pairing.
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Aptamer means (i) any pegylated or unpegylated naturally or non-naturally occurring oligonucleotide that binds to a Target and (ii) any pegylated or unpegylated oligonucleotide Derived from an oligonucleotide of clause (i) that binds to a Target.
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Examples of Aptamer in a sentence

  • Principal Investigator of the Clinical Trial: “Eyetech Pharmaceuticals Phase II/III Clinical Trial with Anti-VRGF Pegylated Aptamer (EYE001) in patients with Exudative Age-Related Macular Degeneration”.

  • Gotrik MR, Feagin TA, Csordas AT, Nakamoto MA, Soh HT (2016) Advancements in Aptamer Discovery Technologies.

  • Aptamer- based proteomic platform identifies novel protein predictors of incident heart failure and echocardiographic traits.

  • Reproducibility and Variability of Protein Analytes Measured Using a Multiplexed Modified Aptamer Assay.

  • Aptamer concentration = 1 mM.Each test was done in triplicate; error bars represent standard deviation.(Fig.

  • P2P1P3P3P2linkerP15'C G A C G C3'A Aptamer I Aptamer II Aptamer I Aptamer II P3 P3P2P2 P1 P1 Kladwang et al.

  • Recent Advances in SELEX Technology and Aptamer Applications in Biomedicine.

  • Blind M, Blank M (2015) Aptamer selection technology and recent advances.

  • The association of CFX with Aptamer A is significantly favoured over CFX association with the riboswitches, which indicates profound differences in the degree of preformation and the interactions estab- lished upon first encounter.

  • Aptamer, NP, NP+Apt (+EDC), NP+Apt (-EDC), washed NP+Apt (+EDC), and washed NP+Apt (-EDC) were separated by PAGE.


More Definitions of Aptamer

Aptamer. Aptamer shall mean an oligonucleotide identified through the SELEX Process.
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Aptamer means a non-naturally occurring nucleic acid ligand, which may be identified, e.g., through the SELEX Process, having a specific binding affinity for a target molecule, including without limitation, small molecules and proteins, and any structural variations and modifications, derivatives, homologs, analogs or mimetics thereof, but excluding Photoaptamers.
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Aptamer means an oligonucleotide that (i) specifically binds to a target protein, and (ii) is covered by a claim within U.S. Patent [***] or, but for the expiration, earlier termination, or decision of a court or other governmental agency of competent jurisdiction holding all claims permanently revoked, unenforceable or invalid of U.S. Patent [***], would have been covered by a claim within U.S. Patent [***].
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Aptamer means an oligonucleotide that was designed to specifically bind, and does specifically bind, to a target protein.
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Aptamer means oligonucleotide sequence composed of nucleic acids and their analogs utilized solely for the recognition and binding of target molecules, including protein(s), peptides, hormones, post translational modifications of any of the foregoing, or sensing of individual or sequence of amino acid residues.
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Aptamer means any naturally or non-naturally occurring oligonucleotide identified through the SELEX Process but excluding Spiegelmers.
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Related to Aptamer

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  • Licensed Compounds means any EZH2 Compound(s) that is:

  • Collaboration Compound means any of the following: (a) FG-4592, (b) any HIF Compound (other than FG-4592) that is added to this Agreement pursuant to Section 3.6, and (c) any salts, esters, complexes, chelates, crystalline and amorphous morphic forms, pegylated forms, enantiomers (excluding regioisomers), prodrugs, solvates, metabolites and catabolites of any of the foregoing ((a) or (b)).

  • Licensed Compound means [***].

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  • Compounds means any or all of the following chemicals, as the context requires:

  • Product Candidate means any pharmaceutical product developed, manufactured and/or tested by or on behalf of the Company that has not received a Regulatory Authorization for commercial distribution other than in connection with pre-clinical or clinical trials.

  • Lead Compound means any compound of lead other than galena which, when treated in the manner described below, yields to an aqueous solution of hydrochloric acid a quantity soluble lead compound exceeding, when calculated as lead monoxide, five percent of the dry weight of the portion taken analysis.

  • Development Candidate means a Collaboration Compound designated by Biogen Idec as a Development Candidate in accordance with Section 2.6.

  • Collaboration Target means the Initial Collaboration Targets set forth on Exhibit F and any Additional Target or Substitute Target that is selected in accordance with Section 3.3 of this Agreement.

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  • Opioid antagonist means a drug that binds to opioid

  • Collaboration Product means a pharmaceutical product containing or comprising Compound in any dosage form alone, or in combination with, one or more other pharmaceutically active ingredients, and any and all Improvements thereto.

  • Diagnostic Product means any test or assay for diagnosing or detecting a disease, disorder, medical condition, or symptom.

  • Back-Up Compound means, with reference to any particular Development Candidate or Drug Product Candidate, a Compound which (a) has the same principal mode of action (i.e., Potentiator or Corrector) as that Development Candidate or Drug Product Candidate; and (b) was among the group of Compounds, identified by VERTEX as potential additional lead molecules having the same principal mode of action, from which the Development Candidate was selected.

  • Biosimilar Product means, with respect to a Licensed Product in any country, any biosimilar product sold by a Third Party not authorized by or on behalf of Celgene, its Affiliates or Sublicensees, (a) that is a biosimilar biological product, as defined in 21 USC 379j-51 (or any successor or replacement thereof), a similar biological medicinal product, as defined in Annex I to Directive 2001/83/EC (or any successor or replacement thereof), or any similar biosimilar or generic product under the Laws of any country or jurisdiction, or (b) regarding which Regulatory Approval is obtained by referencing Regulatory Data of such Licensed Product.

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  • Biosimilar means a biological product that is highly similar to a specific reference biological

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  • Biological product means a virus, therapeutic serum, toxin, antitoxin, vaccine, blood, blood component or derivative, allergenic product, protein other than a chemically synthesized polypeptide, or analogous product, or arsphenamine or any derivative of arsphenamine or any other trivalent organic arsenic compound, applicable to the prevention, treatment, or cure of a disease or condition of human beings.

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