Agreement for Clinical Trial Sample Contracts

Contract
Agreement for Clinical Trial • February 15th, 2021

Amendment 2 Emendamento 2 To AGREEMENT FOR CLINICAL TRIAL alla CONVENZIONE PER LA SPERIMENTAZIONE CLINICA Protocol No. ACE-536-B-THAL-004 Protocollo n. ACE-536-B-THAL-004 This amendment (“Amendment”) is made by: Il presente emendamento (“Emendamento”) è stipulato da: Celgene Corporation, having its principal office at 86 Morris Avenue, Summit, NJ 07901, USA (“Company or Sponsor”) represented for the purposes of this Amendment by Celgene International Sàrl, a limited liability company organized under the laws of Switzerland having its principal office at Route de Perreux 1, 2017 Boudry, Switzerland, Celgene Corporation, con sede principale presso 86 Morris Avenue, Summit, NJ 07901, USA (“Promotore” o “Società”) rappresentata ai fini del presente Emendamento da Celgene International S.à.r.l, una società a responsabilità limitata organizzata ai sensi delle leggi svizzere e con sede principale presso Route de Perreux 1, 2017 Boudry, Svizzera, For the only purposes of signing this Amendment

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Agreement for Clinical Trial • December 28th, 2020

Amendment 3 Emendamento 3 To AGREEMENT FOR CLINICAL TRIAL alla CONVENZIONE PER LA SPERIMENTAZIONE CLINICA Protocol No. ACE-536-B-THAL-001 Protocollo n. ACE-536-B-THAL-001 This amendment (“Amendment”) is made by: Il presente emendamento (“Emendamento”) è stipulato da: Celgene Corporation, having its principal office at 86 Morris Avenue, Summit, NJ 07901, USA (“Company or Sponsor”) represented for the purposes of this Amendment by Celgene International Sàrl, a limited liability company organized under the laws of Switzerland having its principal office at Route de Perreux 1, 2017 Boudry, Switzerland, Celgene Corporation, con sede principale presso 86 Morris Avenue, Summit, NJ 07901, USA (“Promotore o Società”) rappresentata ai fini del presente Emendamento da Celgene International S.à.r.l, una società a responsabilità limitata organizzata ai sensi delle leggi svizzere e con sede principale presso Route de Perreux 1, 2017 Boudry, Svizzera, For the only purposes of signing this Amendme

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Agreement for Clinical Trial • January 29th, 2021

Amendment 1 Emendamento 1 To AGREEMENT FOR CLINICAL TRIAL alla CONVENZIONE PER LA SPERIMENTAZIONE CLINICA Protocol No. ACE-536-LTFU-001 Protocollo n. ACE-536-LTFU-001 This amendment (“Amendment”) is made by: Il presente emendamento (“Emendamento”) è stipulato da: Celgene Corporation, having its principal office at 86 Morris Avenue, Summit, NJ 07901, USA (“Sponsor”) represented for the purposes of this Amendment by Celgene International II Sàrl, a limited liability company organized under the laws of Switzerland having its principal office at Rue du Pré-Jorat 14, 2108 Couvet, Switzerland, Celgene Corporation, con sede principale presso 86 Morris Avenue, Summit, NJ 07901, USA (“Promotore”) rappresentata ai fini del presente Emendamento da Celgene International II Sàrl una società a responsabilità limitata organizzata ai sensi delle leggi svizzere e con sede principale presso all’indirizzo Rue du Pré-Jorat 14, 2108 Couvet, Svizzera, For the only purposes of signing this Amendment, Sponsor

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