0001641172-25-012405 Sample Contracts

PRE-FUNDED COMMON STOCK PURCHASE WARRANT PALISADE BIO, INC.
Pre-Funded Common Stock Purchase Warrant • May 27th, 2025 • Palisade Bio, Inc. • Biological products, (no disgnostic substances) • New York

THIS PRE-FUNDED COMMON STOCK PURCHASE WARRANT (the “Warrant”) certifies that, for value received, [__________] or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after the date hereof (the “Initial Exercise Date”) and until this Warrant is exercised in full (the “Termination Date”) but not thereafter, to subscribe for and purchase from Palisade Bio, Inc., a Delaware corporation (the “Company”), up to [_____] shares (as subject to adjustment hereunder, the “Warrant Shares”) of Common Stock. The purchase price of one share of Common Stock under this Warrant shall be equal to the Exercise Price, as defined in Section 2(b).

SHARES of Common Stock and [___] PRE-FUNDED Warrants TO PURCHASE UP TO [____] SHARES OF COMMON STOCK of PALISADE BIO, INC.
Underwriting Agreement • May 27th, 2025 • Palisade Bio, Inc. • Biological products, (no disgnostic substances) • New York

The undersigned, Palisade Bio, Inc., Delaware corporation (collectively with its subsidiaries, including, without limitation, all entities disclosed or described in the Registration Statement as being subsidiaries of Palisade Bio, Inc., the “Company”), hereby confirms its agreement (this “Agreement”) with the several underwriters, if any (such underwriters, including the Representative (as defined below), the “Underwriters” and each an “Underwriter”) named in Schedule I hereto for which Kingswood Capital Partners, LLC is acting as representative to the several Underwriters (the “Representative” and if there are no Underwriters other than the Representative, references to multiple Underwriters shall be disregarded and the term Representative as used herein shall have the same meaning as Underwriter) on the terms and conditions set forth herein.

UNDERWRITER COMMON STOCK PURCHASE WARRANT PALISADE BIO, INC.
Underwriter Common Stock Purchase Warrant • May 27th, 2025 • Palisade Bio, Inc. • Biological products, (no disgnostic substances) • New York

THIS UNDERWRITER COMMON STOCK PURCHASE WARRANT (the “Warrant”) certifies that, for value received, [__________] or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after [______]1 (the “Initial Exercise Date”) and on or prior to 5:00 p.m. (New York City time) on [_____], 20302 the “Termination Date”) but not thereafter, to subscribe for and purchase from Palisade Bio, Inc., a Delaware corporation (the “Company”), up to [_____] shares (as subject to adjustment hereunder, the “Warrant Shares”) of Common Stock. The purchase price of one share of Common Stock under this Warrant shall be equal to the Exercise Price, as defined in Section 2(b). This Warrant is being issued pursuant to the certain underwriting agreement, dated as of [______], 2025 by and between the Company and Kingswood Capital Partners, LLC.