0001564590-18-006509 Sample Contracts

DEPOSIT AGREEMENT
Deposit Agreement • March 22nd, 2018 • NuCana PLC • Pharmaceutical preparations • New York

DEPOSIT AGREEMENT, dated as of October 2, 2017, by and among (i) NuCana plc, a public limited company incorporated under the laws of England and Wales and its successors (the “Company”), (ii) CITIBANK, N.A., a national banking association organized under the laws of the United States of America (“Citibank”) acting in its capacity as depositary, and any successor depositary hereunder (Citibank in such capacity, the “Depositary”), and (iii) all Holders and Beneficial Owners of American Depositary Shares issued hereunder (all such capitalized terms as hereinafter defined).

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Lease • March 22nd, 2018 • NuCana PLC • Pharmaceutical preparations
Research, Collaboration and Licence Agreement
Licence Agreement • March 22nd, 2018 • NuCana PLC • Pharmaceutical preparations
REGISTRATION RIGHTS AGREEMENT dated as of September 20, 2017 among NUCANA PLC and THE INVESTORS PARTY HERETO
Registration Rights Agreement • March 22nd, 2018 • NuCana PLC • Pharmaceutical preparations • Delaware

THIS REGISTRATION RIGHTS AGREEMENT (this “Agreement”), is made as of the 20th day of September, 2017, by and among NuCana plc, a company incorporated under the laws of England and Wales (the “Company”), each of the shareholders listed on Schedule A hereto (the “Major Investors”) and each of the shareholders listed on Schedule B hereto (the “Original Investors”) who become party hereto prior to the Effectiveness Date (as defined below). The Major Investors and the Original Investors are collectively referred to herein as the “Investors” and each is referred to herein as an “Investor”.

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