Common Contracts

as Guarantors AND Iterum Holders’ Representative LLC, as Holders’ Representative, AND Computershare Trust Company, N.A., as Trustee INDENTURE Dated as of January 21, 2020 Limited Recourse Royalty-Linked Subordinated Notes

Indenture • March 12th, 2020 • Iterum Therapeutics PLC • Pharmaceutical preparations • New York

• Contract Type
  Indenture
• Filed
  March 12th, 2020
• Company
  Iterum Therapeutics PLC
• Industry
  Pharmaceutical preparations
• Jurisdiction
  New York

INDENTURE, dated as of January 21, 2020, between Iterum Therapeutics Bermuda Limited, a company formed under the laws of Bermuda, as Notes issuer (the “Company”, as more fully set forth in Section 1.01), Iterum Therapeutics plc, a company formed under the laws of Ireland, as guarantor (the “Parent Guarantor”, as more fully set forth in Section 1.01), Iterum Therapeutics International Limited, a company formed under the laws of Ireland, as guarantor (the “Irish Guarantor”), Iterum Therapeutics US Limited, a Delaware corporation, as guarantor (“Iterum U.S. Limited”), Iterum Therapeutics US Holding Limited, a Delaware corporation, as guarantor (“Iterum U.S. Holding” and, together with Parent Guarantor, the Irish Guarantor, Iterum U.S. Limited and any guarantor added pursuant to a supplemental indenture in accordance with Section 10.01(c) hereof, the “Guarantors”), Iterum Holders’ Representative LLC, a Delaware limited liability company, as the representative of the noteholders hereunder (

ITERUM THERAPEUTICS BERMUDA LIMITED as Notes Issuer AND ITERUM THERAPEUTICS PLC, ITERUM THERAPEUTICS INTERNATIONAL LIMITED, ITERUM THERAPEUTICS US LIMITED, and ITERUM THERAPEUTICS US HOLDING LIMITED as Guarantors AND ITERUM HOLDERS’ REPRESENTATIVE...

Indenture • January 17th, 2020 • Iterum Therapeutics PLC • Pharmaceutical preparations • New York

• Contract Type
  Indenture
• Filed
  January 17th, 2020
• Company
  Iterum Therapeutics PLC
• Industry
  Pharmaceutical preparations
• Jurisdiction
  New York

INDENTURE, dated as of January [●], 2020, between Iterum Therapeutics Bermuda Limited, a company formed under the laws of Bermuda, as Notes issuer (the “Company”, as more fully set forth in Section 1.01), ITERUM THERAPEUTICS PLC, a company formed under the laws of Ireland, as guarantor (the “Parent Guarantor”, as more fully set forth in Section 1.01), Iterum Therapeutics International Limited, a company formed under the laws of Ireland, as guarantor (the “Irish Guarantor”), Iterum Therapeutics US Limited, a Delaware corporation, as guarantor (“Iterum U.S. Limited”), Iterum Therapeutics US Holding Limited, a Delaware corporation, as guarantor (“Iterum U.S. Holding” and, together with Parent Guarantor, the Irish Guarantor, Iterum U.S. Limited and any guarantor added pursuant to a supplemental indenture in accordance with Section 10.01(c) hereof, the “Guarantors”), Iterum Holders’ Representative LLC, a Delaware limited liability company, as the representative of the noteholders hereunder