Confidential Materials omitted and filed separately with the
Securities and Exchange Commission. Double asterisks denote omissions.
THIS SECOND AMENDMENT TO DEVELOPMENT AGREEMENT (the “Second
Amendment”) is entered into by and between SAINT-GOBAIN PERFORMANCE PLASTICS CORPORATION, a California corporation
having an office at 31500 Solon Road, Solon, OH 44139 (“SGPPL”), and ARGOS THERAPEUTICS, INC., a Delaware corporation
having an office at 4233 Technology Drive, Durham, NC 27704 (“Argos”). SGPPL and Argos are hereafter referred to collectively
as the “Parties,” “Other Party,” or individually as a “Party”, as applicable.
SGPPL and Argos entered into that certain Development Agreement, dated as of January 5, 2015 (the “Development Agreement”).
SGPPL and Argos entered into that certain Development Agreement, with an effective date of dated as of December 31, 2015
(the “First Amendment Agreement”).
SGPPL and Argos desire to amend the Development Agreement and the First Amendment upon all of the terms and conditions set
NOW, THEREFORE, in consideration of the foregoing and other good
and valuable consideration, SGPPL and Argos hereby amend the Development Agreement as follows:
Amendment of Section 9.1. Section 9.1 of the Development Agreement is hereby deleted in its entirety and replaced with the
9.1 Term. This Agreement will commence on the
Effective Date and will remain in force until December 31, 2017 unless prior to such date the term of this Agreement is (a) mutually
extended or terminated by written agreement of the Parties or (b) terminated pursuant to the provisions of Section 9.3 (the “Term”).
Notwithstanding the foregoing sentence, this Agreement will automatically terminate on March 1, 2017, unless the Parties (y) have
entered into the Supply Agreement by such date or (z) mutually agree in writing to waive such automatic termination.
Ratification; Miscellaneous. The Development Agreement, as amended by this First Amendment, shall remain in full force and
effect. , All of the terms, conditions and provisions of the Development Agreement are hereby ratified and affirmed in all respects.
This First Amendment shall control to the extent any terms, conditions and obligations contained in this First Amendment conflict
with the terms in the Development Agreement. This First Amendment may be executed in multiple counterparts, all of which taken
together shall constitute one and the same instrument.
Amendment of Section 3.5 (f). Section 3.5 (f) of the Development Agreement is hereby deleted in its entirety and
replaced with the following language:
(f) The deferred tooling amounts as of the effective date of this Agreement are
$[**]. The repayment structure will be as follows:
Argos will pay an SGPPL $[**] on or before March 1, 2017.
Argos will pay SGPPL $[**] on or before June 1, 2017.
In consideration for deferring the tooling amounts above, Argos will pay SGPPL a tooling stocking fee of $[**] to be paid no
less than [**] after receipt of invoice and in no case later than December 20, 2016.
In the event both Parties agree to further defer items 3.1 and or 3.2, a [**]% interest rate will apply.
(g) For engineering and validation services rendered to date, Argos
will pay SGPPL $[**] to be paid [**] days after receipt of invoice and in no case later than March 1, 2017.
(h) Argos will purchase $[**] of product from SGPPL in 2017
in form of take or pay.
4. Amendment of Section
5.2 (D) (i) and (ii). Section 5.2 (D) (i) and (ii) of the Development Agreement is hereby amended with the following (i) [**]
percent for Products and (ii) [**] percent for specified components which are acquired but nor manufactured by SGPPL. All other
language in section 5.2 remains.
IN WITNESS WHEREOF, the undersigned have duly executed this First
Amendment effective as of December 1, 2016.