Exhibit 10.42 CRITICAL THERAPEUTICS, INC. 2005 COMPANY GOALS GOAL ONE: TO ENHANCE THE COMMERCIAL VALUE OF ZILEUTON - Make regulatory filings - Launch Zyflo(R) - Achieve business development goals GOAL TWO: TO PROGRESS THE COMPANY RESEARCH AND DEVELOPMENT PIPELINE - Achieve pre-clinical and clinical development milestones and business development goals for other product candidates GOAL THREE: MAINTAIN THE COMPANY'S FINANCIAL POSITION - Manage cash balance GOAL FOUR: CREATE AN EFFECTIVE ORGANIZATION - Recruit and retain employees - Make important key appointments