Quark Biotech Inc Sample Contracts

FORM OF UNDERWRITING AGREEMENT QUARK PHARMACEUTICALS, INC. 5,000,000 Shares of Common Stock
Underwriting Agreement • June 25th, 2007 • Quark Pharmaceuticals Inc • Pharmaceutical preparations • New York

Quark Pharmaceuticals, Inc., a California corporation (the “Company”), proposes to issue and sell to the several Underwriters listed in Schedule 1 hereto (the “Underwriters”), for whom you are acting as Representatives (the “Representatives”), an aggregate of 5,000,000 shares of common stock, par value $0.001 per share, of the Company (the “Underwritten Shares”) and, at the option of the Underwriters, up to an additional 750,000 shares of common stock of the Company (the “Option Shares”). The Underwritten Shares and the Option Shares are herein referred to as the “Shares”. The shares of common stock of the Company to be outstanding after giving effect to the sale of the Shares are herein referred to as the “Stock”.

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INDEMNITY AGREEMENT
Indemnity Agreement • September 24th, 2010 • Quark Pharmaceuticals Inc • Pharmaceutical preparations • Delaware

THIS INDEMNITY AGREEMENT (this “Agreement”) dated as of , 20 , is made by and between QUARK BIOTECH, INC., a Delaware corporation (the “Company”), and (“Indemnitee”).

LICENSE AGREEMENT
License Agreement • November 24th, 2010 • Quark Pharmaceuticals Inc • Pharmaceutical preparations • New York

General. When used in this Agreement, each of the following terms, whether used in the singular or plural, will have the meanings set forth in this Article I. Capitalized terms not defined herein may be defined in the CRT Agreement, as specifically referenced in the context of the sentence applying such capitalized term(s).

LICENSE AGREEMENT
License Agreement • November 24th, 2010 • Quark Pharmaceuticals Inc • Pharmaceutical preparations • New York

General. When used in this Agreement, each of the following terms, whether used in the singular or plural, will have the meanings set forth in this Article I.

QUARK BIOTECH, INC.
Stock Option Agreement • April 16th, 2007 • Quark Biotech Inc • Pharmaceutical preparations • California

Unless otherwise defined herein, the terms defined in the Plan shall have the same defined meanings in this Option Agreement.

QUARK PHARMACEUTICALS, INC. WARRANT TO PURCHASE SERIES H PREFERRED STOCK
Quark Pharmaceuticals Inc • September 24th, 2010 • Pharmaceutical preparations • California

This Certifies That, for value received, «WarrantHolder», or assigns (the “Holder”), is entitled to subscribe for and purchase at the Exercise Price (defined below) from Quark Pharmaceuticals, Inc., a California corporation, with its principal office at 6501 Dumbarton Circle, Fremont, California 94555 (the “Company”) up to «NumberOfShares» shares of the Series H Preferred Stock of the Company (the “Preferred Stock”).

EXCLUSIVE LICENSE AGREEMENT “ISOLATION AND APPLICATION OF P53 INHIBITORS TO CONTROLLING TISSUE RESPONSE TO A VARIETY OF STRESSES AND FACILITATING ANTI- CANCER TREATMENT” (UIC Tech ID #CS01)
Exclusive License Agreement • November 24th, 2010 • Quark Pharmaceuticals Inc • Pharmaceutical preparations • Illinois

This EXCLUSIVE LICENSE AGREEMENT is effective on the date last subscribed below (the “Effective Date”), and is by and between THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, a body corporate and politic of the State of Illinois (“UNIVERSITY”) with offices in Chicago, Illinois 60612, and QUARK BIOTECH, INC., a California corporation with principal offices at 1059 Serpentine Lane, Pleasanton, California 94566, (“QBI”).

Amendment No. 1
Quark Pharmaceuticals Inc • November 24th, 2010 • Pharmaceutical preparations

This Amendment No. 1 (the “Amendment”) is entered into by and between ALNYLAM PHARMACEUTICALS, INC., a corporation organized under the laws of the State of Delaware having a principal office at 300 Third Street, Cambridge MA 02142 U.S.A. (“ALNYLAM”), and QUARK PHARMACEUTICALS, INC (previously known as Quark Biotech, Inc.), a corporation organized under the laws of the State of California having offices located at 6501 Dumbarton Circle Fremont, CA 94555 U.S.A. (“QUARK”).

LEASE AGREEMENT
Lease Agreement • September 24th, 2010 • Quark Pharmaceuticals Inc • Pharmaceutical preparations

THIS “LEASE”, made this 8th day of September, 2006, between JOHN ARRILLAGA, Trustee, or his Successor Trustee, UTA dated 7/20/77 (JOHN ARRILLAGA SURVIVOR’S TRUST) as amended, and RICHARD T. PEERY, Trustee, or his Successor Trustee, UTA dated 7/20/77 (RICHARD T. PEERY SEPARATE PROPERTY TRUST) as amended, hereinafter called Landlord, and QUARK BIOTECH, INC., a California corporation, hereinafter called Tenant.

AMENDMENT TO COLLABORATION AGREEMENT
Collaboration Agreement • November 24th, 2010 • Quark Pharmaceuticals Inc • Pharmaceutical preparations

This Amendment to the Collaboration Agreement (“Amendment”) is made as of May 25, 2006 (“Effective Date”) by and between Quark Biotech, Inc., a private limited company incorporated under the laws of California with a principal office at 6540 Kaiser Drive, Fremont, California 94555 (hereinafter “Quark”) and QBI Enterprises Ltd., a private company incorporated under the laws of the State of Israel with a principal office at Weizmann Science Park, P.O. Box 4071, Nes Ziona 70400, Israel (together hereinafter “QBI”), and Atugen AG, a company incorporated under the laws of Germany with a registered office at Robert-Rössle-Strasse 10, D-13125 Berlin, Germany (“Atugen”).

QUARK BIOTECH, INC. EMPLOYMENT AGREEMENT
Employment Agreement • September 24th, 2010 • Quark Pharmaceuticals Inc • Pharmaceutical preparations • California

THIS EMPLOYMENT AGREEMENT (THE “AGREEMENT”) is dated as of March 9, 2003 by and between Quark Biotech, Inc., a California corporation (the “Company”), and Shai Erlich (the “Employee”).

LICENSE AGREEMENT BY AND BETWEEN QUARK BIOTECH INC. AND
License Agreement • November 24th, 2010 • Quark Pharmaceuticals Inc • Pharmaceutical preparations • New York

This License Agreement (this “Agreement”), dated as of September 25, 2006, is by and between Quark Biotech Inc., a California corporation with offices located at 6536 Kaiser Avenue, Fremont, California 94555, U.S.A. (“Quark”) and Pfizer Inc., a Delaware corporation with offices located at 235 East 42nd Street, New York, New York, 10017, U.S.A. (“Pfizer”).

EMPLOYMENT AGREEMENT
Employment Agreement • November 24th, 2010 • Quark Pharmaceuticals Inc • Pharmaceutical preparations

WHEREAS, the Executive is currently an employee of the Company pursuant to an employment agreement between the Executive and the Company dated January 20 th , 1995, as amended form time to time, (the “Prior Agreement”);

COLLABORATION AGREEMENT
Collaboration Agreement • November 24th, 2010 • Quark Pharmaceuticals Inc • Pharmaceutical preparations

atugen AG, a company incorporated under the laws of Germany, whose registered office is at Robert-Rössle-Str. 10, D13125 Berlin, Germany (hereinafter “Atugen”), of the first Part; and

Option Agreement By And Between Novartis International Pharmaceutical Limited And Quark Pharmaceuticals, Inc.
Option Agreement • December 17th, 2010 • Quark Pharmaceuticals Inc • Pharmaceutical preparations

[ * ] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended.

FIRST AMENDMENT TO THE LICENSE AGREEMENT BETWEEN THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS AND QUARK BIOTECHNOLOGY, INC.
The Exclusive License Agreement • November 24th, 2010 • Quark Pharmaceuticals Inc • Pharmaceutical preparations

THIS FIRST AMENDMENT TO THE EXCLUSIVE LICENSE AGREEMENT (the “First Amendment”) is made and entered into as of March 23, 2007 (“Amendment Date”) by and between THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, a body corporate and politic of the State of Illinois, 1737 W. Polk St., Chicago, IL 60612 (“UNIVERSITY”) and QUARK BIOTECH, INC a California corporation, with a principal place of business at 6536 Kaiser Drive, Fremont, CA 94555 (“LICENSEE”).

Contract
License and Collaboration Agreement • December 17th, 2010 • Quark Pharmaceuticals Inc • Pharmaceutical preparations

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 406 OF THE SECURITIES ACT OF 1933, AS AMENDED.

EMPLOYMENT AGREEMENT
Employment Agreement • March 30th, 2007 • Quark Biotech Inc

THIS AGREEMENT, made and entered into as of March 7, 2007, by and between, Q.B.I. Enterprises Ltd. (the “Company”) and Yaron Garmazi (the “Executive”);

QUARK BIOTECH, INC. EMPLOYMENT AGREEMENT
Employment Agreement • March 30th, 2007 • Quark Biotech Inc • California

THIS EMPLOYMENT AGREEMENT (THE “AGREEMENT”) is dated as of January 1, 2002 by and between Quark Biotech, Inc., a California corporation (the “Company”), and Daniel Zurr (“Executive”).

FIRST AMENDMENT TO THE LICENSE AGREEMENT BETWEEN THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS AND QUARK BIOTECHNOLOGY, INC.
Exclusive License Agreement • December 17th, 2010 • Quark Pharmaceuticals Inc • Pharmaceutical preparations

THIS FIRST AMENDMENT TO THE EXCLUSIVE LICENSE AGREEMENT (the “First Amendment”) is made and entered into as of March 23, 2007 (“Amendment Date”) by and between THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, a body corporate and politic of the State of Illinois, 1737 W. Polk St., Chicago, IL 60612 (“UNIVERSITY”) and QUARK BIOTECH, INC a California corporation, with a principal place of business at 6536 Kaiser Drive, Fremont, CA 94555 (“LICENSEE”).

LICENSE AGREEMENT
License Agreement • April 16th, 2007 • Quark Biotech Inc • Pharmaceutical preparations • California

THIS LICENSE AGREEMENT (the “Agreement”) is made as of December 17, 2004 by and between QUARK BIOTECH, INC., a California corporation having its principal place of business at 6536 Kaiser Drive, Fremont CA 94555, U.S.A. (hereinafter referred to as “Quark”) and SANWA KAGAKU KENKYUSHO CO., LTD., a corporation organized and existing under the laws of Japan and having its principal place of business at 35 Higashisotobori-cho, Higashi-ku, Nagoya 461-8631, Japan (hereinafter referred to as “SKK”).

QUARK BIOTECH, INC. AT WILL EMPLOYMENT AGREEMENT
At Will Employment Agreement • May 11th, 2007 • Quark Biotech Inc • Pharmaceutical preparations • California

THIS EMPLOYMENT AGREEMENT (THE “AGREEMENT”) by and between Quark Biotech, Inc., a California corporation (the “Company”), and Gavin Samuels (the Employee”),

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AMENDMENT NO. 2 TO LICENSE AGREEMENT
License Agreement • March 18th, 2011 • Quark Pharmaceuticals Inc • Pharmaceutical preparations • New York

This Amendment No. 2 to License Agreement (the “Second Amendment”) is made and entered into as of March 4, 2011 (the “Second Amendment Effective Date”) by and between Quark Pharmaceuticals, Inc., (formerly Quark Biotech, Inc.) a California corporation having a place of business at 6501 Dumbarton Circle, Fremont, CA 94555 (“Quark”), and Pfizer Inc., a Delaware corporation having a place of business at 235 East 42nd Street, New York, New York 10017 (“Pfizer”). Quark and Pfizer are individually referred to as a “Party” or collectively as the “Parties”.

Amendment No. 2 To Option and License Agreement
Option and License Agreement • January 24th, 2011 • Quark Pharmaceuticals Inc • Pharmaceutical preparations

This Amendment (the “Amendment”) to the Option and License Agreement between Silence Therapeutics AG, a company incorporated under the laws of Germany (“Silence”), on the one hand, and Quark Pharmaceuticals, Inc., a California corporation, and QBI Enterprises Ltd., a company incorporated under the laws of the State of Israel (together referred to as “QBI”) (Silence and QBI together being referred to as the “Parties”), is made and entered into as of the 16th day of December, 2010 (the “Amendment Effective Date”).

EMPLOYMENT AGREEMENT
Employment Agreement • September 24th, 2010 • Quark Pharmaceuticals Inc • Pharmaceutical preparations • California

THIS EMPLOYMENT AGREEMENT, effective as of January 1, 2008 (the “Effective Date”), is made by and between Quark Pharmaceuticals, Inc., a California Corporation (the “Company”), and Daniel Zurr (“Executive”).

EMPLOYMENT AGREEMENT
Employment Agreement • November 24th, 2010 • Quark Pharmaceuticals Inc • Pharmaceutical preparations

This Agreement, is made on 1 August, 2010 (Effective date 1 August 2010), by and between, Q.B.I. Enterprises Ltd. (the “Company”) and Sagit Reich (the “Executive”);

EMPLOYMENT AGREEMENT
Employment Agreement • November 24th, 2010 • Quark Pharmaceuticals Inc • Pharmaceutical preparations

THIS AGREEMENT is entered into as of the 14th day of September, 1997, by and between Q. B. I. ENTERPRISES LTD. (the “Company”) and Ms. Smadar Samirah, Israel I.D. number 022498802 (the “Employee”).

Amendment No. 1
Quark Pharmaceuticals Inc • November 24th, 2010 • Pharmaceutical preparations

This Amendment No. 1 (the “Amendment”) is entered into by and between ALNYLAM PHARMACEUTICALS, INC., a corporation organized under the laws of the State of Delaware having a principal office at 300 Third Street, Cambridge MA 02142 U.S.A. (“ALNYLAM”), and QUARK PHARMACEUTICALS, INC (previously known as Quark Biotech, Inc.), a corporation organized under the laws of the State of California having offices located at 6501 Dumbarton Circle Fremont, CA 94555 U.S.A. (“QUARK”).

Option and Licence Agreement
Quark Biotech Inc • April 16th, 2007 • Pharmaceutical preparations

Atugen AG, a company incorporated under the laws of Germany, whose registered office is at Robert-Rössle-Str. 10, D13125 Berlin, Germany of the first Part;

AMENDMENT NUMBER TWO TO THE LICENSE AGREEMENT BETWEEN THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS AND QUARK PHARMACEUTICALS, INC.
Exclusive License Agreement • November 24th, 2010 • Quark Pharmaceuticals Inc • Pharmaceutical preparations

THIS AMENDMENT #2 TO THE EXCLUSIVE LICENSE AGREEMENT (the “Second Amendment”) is made and entered into as of December 22, 2009 (the “Amendment Date”) by and between THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, a body corporate and politic of the State of Illinois, 352 Henry Administration Building, 506 S. Wright St., Urbana, Illinois 61801 (“UNIVERSITY”) and QUARK PHARMACEUTICALS, INC. (previously QUARK BIOTECH, INC.), a California corporation, with a principal place of business at 6501 Dumbarton Circle, Fremont, CA 94555 (“LICENSEE”).

QUARK BIOTECH, INC. AT WILL EMPLOYMENT AGREEMENT
Employment Agreement • April 16th, 2007 • Quark Biotech Inc • Pharmaceutical preparations • California

THIS EMPLOYMENT AGREEMENT (THE “AGREEMENT”) is made as of November 13, 2006 by and between Quark Biotech, Inc., a California corporation (the “Company”), and Smadar Shakked (the Employee”),

Contract
Quark Pharmaceuticals Inc • November 24th, 2010 • Pharmaceutical preparations

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 406 OF THE SECURITIES ACT OF 1933, AS AMENDED.

PATENT LICENSE AGREEMENT
Patent License Agreement • November 24th, 2010 • Quark Pharmaceuticals Inc • Pharmaceutical preparations • New York

This Patent License Agreement (“Agreement”) is made and entered into as of the 29th day of January 2010 (the “Effective Date”) by and between Dharmacon, Inc., a wholly owned subsidiary of Thermo Fisher Scientific, Inc., with a principal place of business at 2650 Crescent Drive, #100, Lafayette, CO 80026 (“Licensor”) and Quark Pharmaceuticals, Inc., with a principal place of business at 6501 Dumbarton Circle, Fremont, CA 94555 (“Quark”). Licensor and Quark are each referred to herein individually as a “Party” and collectively as the “Parties.”

to Option and License Agreement
Option and License Agreement • November 24th, 2010 • Quark Pharmaceuticals Inc • Pharmaceutical preparations

This Addendum No. 1 (the “Addendum” is made and entered Into as of this 13th day of July, 2007 (the “Effective Date”) between Silence Therapeutics AG, (formerly known as Atugen AG) a company incorporated under the laws of Germany, whose registered office is at Robert-Rössle-Str. 10, D13125 Berlin, Germany (hereinafter referred to as “ST”), and Quark Pharmaceuticals, Inc. (formerly known as Quark Biotech, Inc.), a corporation incorporated under the laws of California whose principal office is at 6501 Dumbarton Circle Fremont, CA 94555 and QBI Enterprises Ltd., a private company incorporated under the laws of the State of Israel whose principal office is at Weizmann Science Park, P.O. box 4071, Nes Ziona 70400, ISRAEL (together hereinafter referred to as “QBI”)

Quark Biotech, Inc.
Will Employment Agreement • May 11th, 2007 • Quark Biotech Inc • Pharmaceutical preparations

This letter agreement will amend your At Will Employment Agreement with Quark Biotech, Inc. dated as of March 1, 2007 (the “Employment Agreement”).

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