AMENDMENT TO THE PARTICIPATION AGREEMENT OF AUGUST 24, 1998 This Amendment to the Participation Agreement dated August 24, 1998 ("Amendment"), is entered into by and between: Ribozyme Pharmaceuticals Inc., a Delaware corporation ("Founder 1); Dr....Participation Agreement • June 16th, 1999 • Ribozyme Pharmaceuticals Inc • Pharmaceutical preparations
SECURITIES PURCHASE AGREEMENT (this "Agreement"), dated as of January --------- 7th, 2000, among Ribozyme Pharmaceuticals, Inc., a Delaware corporation (the "Company"), and Elan International Services, Ltd., a Bermuda exempted limited -------...Securities Purchase Agreement • February 8th, 2000 • Ribozyme Pharmaceuticals Inc • Pharmaceutical preparations • New York
BETWEENLicense Agreement • March 3rd, 2000 • Ribozyme Pharmaceuticals Inc • Pharmaceutical preparations • New York
DEFINITIONSService Agreement • June 16th, 1999 • Ribozyme Pharmaceuticals Inc • Pharmaceutical preparations
ESCROW AGREEMENTEscrow Agreement • July 1st, 1999 • Ribozyme Pharmaceuticals Inc • Pharmaceutical preparations • New York
THIS REGISTRATION RIGHTS AGREEMENT (the "Agreement") is made as of --------- January 7th, 2000 by and between Ribozyme Pharmaceuticals, Inc., a Delaware corporation (the "Company"), and Elan International Services, Ltd., a Bermuda ------- exempted...Registration Rights Agreement • February 8th, 2000 • Ribozyme Pharmaceuticals Inc • Pharmaceutical preparations • Delaware
EXHIBIT 4.1 COMMON STOCK PURCHASE AGREEMENT DATED AS OF DECEMBER 29, 2000 BY AND BETWEEN RIBOZYME PHARMACEUTICALS, INC.Common Stock Purchase Agreement • January 5th, 2001 • Ribozyme Pharmaceuticals Inc • Pharmaceutical preparations • New York
ARTICLE I DEFINITIONSSecurities Purchase Agreement • December 26th, 2001 • Ribozyme Pharmaceuticals Inc • Pharmaceutical preparations • New York
AMENDMENT TO EMPLOYMENT AGREEMENTEmployment Agreement • November 14th, 2001 • Ribozyme Pharmaceuticals Inc • Pharmaceutical preparations • Colorado
Exhibit 10.4 RIBOZYME PHARMACEUTICALS, INC. 2950 Wilderness Place Boulder, Colorado 80301 February 11, 2003 Elan International Services, Ltd. Clarendon House 2 Church St. Hamilton, Bermuda Attn: Boards of Directors Re: Securities Purchase Agreement,...Ribozyme Pharmaceuticals Inc • February 14th, 2003 • Pharmaceutical preparations
EXHIBIT 10.42 THE CONFIDENTIAL PORTION OF THIS CONTRACT HAS BEEN OMITTED PURSUANT TO REGULATION 240.25B-2(B) OF THE SECURITIES EXCHANGE ACT OF 1934, AND HAS BEEN FILED SEPARATELY WITH THE COMMISSION. AMENDED AND RESTATED LICENSE AGREEMENTLicense Agreement • September 18th, 1997 • Ribozyme Pharmaceuticals Inc • Pharmaceutical preparations • Connecticut
ARTICLE 1 DEFINITIONSLicense Agreement • September 18th, 1997 • Ribozyme Pharmaceuticals Inc • Pharmaceutical preparations • Colorado
Exhibit 99.3 CONFIDENTIAL PORTIONS OF THIS EXHIBIT HAVE BEEN OMITTED PURSUANT TO REGULATION 240.24B-2B OF THE SECURITIES EXCHANGE ACT OF 1934. [*] INDICATES OMITTED MATERIAL THAT IS THE SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST AND IS FILED...License Agreement • June 9th, 1999 • Ribozyme Pharmaceuticals Inc • Pharmaceutical preparations
EXHIBIT 1.2 THE CONFIDENTIAL PORTION OF THIS CONTRACT HAS BEEN OMITTED PURSUANT TO REGULATION 240.25B-2(B) OF THE SECURITIES EXCHANGE ACT OF 1934, AND HAS BEEN FILED SEPARATELY WITH THE COMMISSION. PURCHASE AGREEMENTPurchase Agreement • June 12th, 1997 • Ribozyme Pharmaceuticals Inc • Pharmaceutical preparations • New York
EXHIBIT 12 CONFIDENTIAL PORTIONS OF THIS EXHIBIT HAVE BEEN OMITTED PURSUANT TO REGULATION 240.25B-2B OF THE SECURITIES EXCHANGE ACT OF 1934. [*] INDICATES OMITTED MATERIAL THAT IS THE SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST AND IS FILED SEPARATELY...Agreement • March 3rd, 2000 • Ribozyme Pharmaceuticals Inc • Pharmaceutical preparations • Delaware
Ribozyme Pharmaceuticals, Inc. 3,150,000 Shares of Common Stock* (par value $.01 per share) UNDERWRITING AGREEMENTUnderwriting Agreement • March 2nd, 2000 • Ribozyme Pharmaceuticals Inc • Pharmaceutical preparations • New York
andRights Agreement • December 5th, 2000 • Ribozyme Pharmaceuticals Inc • Pharmaceutical preparations • Colorado
May 29, 2001 Mr. Marvin Tancer Dear Marvin: This letter shall serve to confirm the terms of employment offered to you by Ribozyme Pharmaceuticals, Inc. (the "Company") and acknowledge your acceptance of the employment on such terms as detailed below....Ribozyme Pharmaceuticals Inc • August 14th, 2001 • Pharmaceutical preparations • Colorado
SIRNA THERAPEUTICS, INC. and [ ], AS WARRANT AGENT FORM OF PREFERRED STOCK WARRANT AGREEMENT DATED AS OFPreferred Stock Warrant Agreement • November 23rd, 2005 • Sirna Therapeutics Inc • Pharmaceutical preparations • New York
PREFERRED STOCK WARRANT AGREEMENT, dated as of between Sirna Therapeutics, Inc., a Delaware corporation (the “COMPANY”) and , a [corporation] [national banking association] organized and existing under the laws of and having a corporate trust office in , as warrant agent (the “WARRANT AGENT”).
FORM OF VOTING AGREEMENTVoting Agreement • February 14th, 2003 • Ribozyme Pharmaceuticals Inc • Pharmaceutical preparations • Delaware
STOCK PURCHASE AGREEMENTStock Purchase Agreement • May 17th, 1999 • Ribozyme Pharmaceuticals Inc • Pharmaceutical preparations • Delaware
SECTION 1 --------- DEFINITIONSResearch Agreement • May 15th, 1998 • Ribozyme Pharmaceuticals Inc • Pharmaceutical preparations • Colorado
EXHIBIT 10.62 Research Collaboration and License AgreementLicense Agreement • June 10th, 1999 • Ribozyme Pharmaceuticals Inc • Pharmaceutical preparations • Illinois
FUNDING AGREEMENT FUNDING AGREEMENT made as of this 7/th/ day of January, 2000 among: (1) ELAN PHARMACEUTICAL TECHNOLOGIES, a division of ELAN CORPORATION, PLC, a public limited company incorporated under the laws of Ireland, and having its registered...Funding Agreement • February 8th, 2000 • Ribozyme Pharmaceuticals Inc • Pharmaceutical preparations • Delaware
SIRNA THERAPEUTICS, INC. and , AS WARRANT AGENT FORM OF DEBT SECURITIES WARRANT AGREEMENT DATED AS OFSecurities Warrant Agreement • November 23rd, 2005 • Sirna Therapeutics Inc • Pharmaceutical preparations • New York
DEBT SECURITIES WARRANT AGREEMENT, dated as of between Sirna Therapeutics, Inc., a Delaware corporation (the “Company”) and , a [corporation] [national banking association] organized and existing under the laws of and having a corporate trust office in , as warrant agent (the “WARRANT AGENT”).
EXHIBIT 10.62 Research Collaboration and License AgreementLicense Agreement • June 1st, 1999 • Ribozyme Pharmaceuticals Inc • Pharmaceutical preparations • Illinois
AGREEMENT AND PLAN OF MERGER by and among MERCK & CO., INC., SPINNAKER ACQUISITION CORP. a wholly owned subsidiary of MERCK & CO., INC. and SIRNA THERAPEUTICS, INC. Dated as of October 30, 2006Agreement and Plan of Merger • November 1st, 2006 • Sirna Therapeutics Inc • Pharmaceutical preparations • Delaware
AGREEMENT AND PLAN OF MERGER (this “Agreement”), dated as of October 30, 2006, by and among MERCK & CO., INC., a New Jersey corporation (“Parent”), SPINNAKER ACQUISITION CORP., a Delaware corporation and a wholly-owned subsidiary of Parent (“Merger Sub”), and SIRNA THERAPEUTICS, INC., a Delaware corporation (the “Company”).
CHINA BASIN LANDING OFFICE LEASEOffice Lease • March 31st, 2005 • Sirna Therapeutics Inc • Pharmaceutical preparations • California
This Office Lease (the “Lease”), dated as of the date set forth in Section 1 of the Summary of Basic Lease Information (the “Summary”), below, is made by and between STOCKBRIDGE/MCC-CHINA BASIN L.L.C., a Delaware limited liability company (“Landlord”), and SIRNA THERAPEUTICS, INC., a Delaware corporation (“Tenant”).
SIRNA THERAPEUTICS, INC. Issuer andDeposit Agreement • November 23rd, 2005 • Sirna Therapeutics Inc • Pharmaceutical preparations • New York
DEPOSIT AGREEMENT, dated as of [ ] among Sirna Therapeutics, Inc., a Delaware corporation, [ ], a under the laws of the State of [ ], as Depositary, and all holders from time to time of Receipts issued hereunder.
March 12, 1997Ribozyme Pharmaceuticals Inc • March 31st, 1997 • Pharmaceutical preparations • Colorado
RIBOZYME PHARMACEUTICALS, INC. 2950 Wilderness Place Boulder, Colorado 80301 USA: Purchase Agreement • February 14th, 2003 • Ribozyme Pharmaceuticals Inc • Pharmaceutical preparations
Research Collaboration and License AgreementResearch Collaboration and License Agreement • May 17th, 1999 • Ribozyme Pharmaceuticals Inc • Pharmaceutical preparations
CONFIDENTIAL EXHIBIT 10.2 THE CONFIDENTIAL PORTION OF THIS CONTRACT HAS BEEN OMITTED PURSUANT TO REGULATION 240.25B-2(B) OF THE SECURITIES EXCHANGE ACT OF 1934, AND HAS BEEN FILED SEPARATELY WITH THE COMMISSION. CHIRON CORP. - RIBOZYME...Collaboration Agreement • November 26th, 1996 • Ribozyme Pharmaceuticals Inc • Pharmaceutical preparations • California
ANDJoint Development and Operating Agreement • March 3rd, 2000 • Ribozyme Pharmaceuticals Inc • Pharmaceutical preparations • New York
WARRANT EXCHANGE AGREEMENTWarrant Exchange Agreement • January 6th, 2005 • Sirna Therapeutics Inc • Pharmaceutical preparations • Delaware
