Guggenheim Defined Portfolios, Series 2543 Sample Contracts

abrdn Medical Science Innovation Portfolio, Series 11 US Capital Strength Portfolio, Series 31 REFERENCE TRUST AGREEMENT
Reference Trust Agreement • November 17th, 2025 • Guggenheim Defined Portfolios, Series 2543

This Reference Trust Agreement dated as of November 17, 2025, between Guggenheim Funds Distributors, LLC, as Depositor, and The Bank of New York Mellon, as Trustee, sets forth certain provisions in full and incorporates other provisions by reference to the document entitled “Standard Terms and Conditions of Trust For Series Formed on or Subsequent to December 18, 2001” (herein called the “Standard Terms and Conditions of Trust”), and such provisions as are set forth in full and such provisions as are incorporated by reference constitute a single instrument. All references herein to Articles and Sections are to Articles and Sections of the Standard Terms and Conditions of Trust.

Portfolio Support and License Agreement
Portfolio Support and License Agreement • November 17th, 2025 • Guggenheim Defined Portfolios, Series 2543 • Illinois

This Portfolio Support and License Agreement (the “Agreement”), dated as of November 17, 2025, is made by and between abrdn Inc., a Delaware corporation (“Consultant/Licensor”), and Guggenheim Funds Distributor, LLC., (“GFD” or “Licensee”) as sponsor to, abrdn Medical Science Innovation Portfolio, Series 11 (the “Trust”).