Pharsight Corp Sample Contracts

Exhibit 10.6 LOAN AND SECURITY AGREEMENT Agreement No._______________ Dated as of March 31, 1998
Loan and Security Agreement • April 17th, 2000 • Pharsight Corp • California
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RECITALS
Noncompetition Agreement • April 17th, 2000 • Pharsight Corp • Massachusetts
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Asset Purchase Agreement • April 17th, 2000 • Pharsight Corp • California
UNDERWRITING AGREEMENT
Underwriting Agreement • June 12th, 2000 • Pharsight Corp • Services-prepackaged software • New York
RECITALS
Database License Agreement • August 4th, 2000 • Pharsight Corp • Services-prepackaged software • North Carolina
Export-Import Bank of the United States Working Capital Guarantee Program Borrower Agreement
Borrower Agreement • July 1st, 2002 • Pharsight Corp • Services-prepackaged software

THIS BORROWER AGREEMENT (this “Agreement”) is made and entered into by the entity identified as Borrower on the signature page hereof (“Borrower”) in favor of the Export-Import Bank of the United States (“Ex-Im Bank”) and the institution identified as Lender on the signature page hereof (“Lender”).

AGREEMENT AND PLAN OF MERGER BY AND AMONG TRIPOS (DE), INC. PEARSON MERGER CORPORATION AND PHARSIGHT CORPORATION Dated as of September 8, 2008
Agreement and Plan of Merger • September 9th, 2008 • Pharsight Corp • Services-prepackaged software • Delaware

This AGREEMENT AND PLAN OF MERGER (this “Agreement”) is made and entered into as of September 8, 2008, by and among Tripos (DE), Inc., a Delaware corporation (“Parent”), Pearson Merger Corporation, a Delaware corporation and direct wholly-owned subsidiary of Parent (“Merger Sub”), and Pharsight Corporation, a Delaware corporation (the “Company”).

TABLE OF CONTENTS
Loan and Security Agreement • April 17th, 2000 • Pharsight Corp
SIXTH AMENDMENT TO LOAN AND SECURITY AGREEMENT
Loan and Security Agreement • February 12th, 2007 • Pharsight Corp • Services-prepackaged software

THIS SIXTH AMENDMENT to Loan and Security Agreement (this “Amendment”) is entered into this 2nd day of January, 2007, by and between Silicon Valley Bank (“Bank”) and Pharsight Corporation, a Delaware corporation (“Borrower”) whose address is 321 East Evelyn Avenue, 3 rd Floor, Mountain View, California 94041.

LOAN MODIFICATION AGREEMENT
Loan Modification Agreement • July 8th, 2002 • Pharsight Corp • Services-prepackaged software

This Loan Modification Agreement is entered into as of June 26, 2002 by and between PHARSIGHT CORPORATION (the “Borrower”) and Silicon Valley Bank (“Bank”).

LOAN AGREEMENT ALLOY CORPORATE 2000, L.P.
Loan Agreement • July 8th, 2002 • Pharsight Corp • Services-prepackaged software
September 27, 2002 VIA HAND DELIVERY Daniel Weiner Pharsight Corporation Dear Dan:
Pharsight Corp • November 14th, 2002 • Services-prepackaged software • California

As we have discussed, Pharsight Corporation (“Pharsight” or the “Company”) is offering you continued employment through December 31, 2002 and severance benefits under the terms and conditions set forth below (the “Agreement”).

LOAN MODIFICATION AGREEMENT
Loan Modification Agreement • November 14th, 2002 • Pharsight Corp • Services-prepackaged software

This Loan Modification Agreement is entered into as of October 23, 2002 by and between PHARSIGHT, INC. (the “Borrower”) and Silicon Valley Bank (“Bank”). This loan modification agreement is hereby amended to reflect “PHARSIGHT CORPORATION” as the name of the Borrower.

RECITALS
Co-Ownership Agreement • April 17th, 2000 • Pharsight Corp • California
SEVENTH AMENDMENT TO LOAN AND SECURITY AGREEMENT
Loan and Security Agreement • June 26th, 2007 • Pharsight Corp • Services-prepackaged software

THIS SEVENTH AMENDMENT to Loan and Security Agreement (this “Amendment”) is entered into this 21st day of June, 2007, by and between Silicon Valley Bank (“Bank”) and Pharsight Corporation, a Delaware corporation (“Borrower”) whose address is 321 East Evelyn Avenue, 3rd Floor, Mountain View, California 94041.

EXPORT-IMPORT BANK LOAN AND SECURITY AGREEMENT PHARSIGHT CORPORATION
Export-Import • June 27th, 2002 • Pharsight Corp • Services-prepackaged software
RECITALS
Database License Agreement • April 17th, 2000 • Pharsight Corp • North Carolina
THIRD AMENDMENT TO THE LEASE
The Lease • June 10th, 2003 • Pharsight Corp • Services-prepackaged software
LOAN MODIFICATION AGREEMENT
Loan Modification Agreement • July 1st, 2002 • Pharsight Corp • Services-prepackaged software

This Loan Modification Agreement is entered into as of June 18, 2002 by and between PHARSIGHT, INC. (the “Borrower”) and Silicon Valley Bank (“Bank”).

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August 20, 2002
Inventions Agreement • November 14th, 2002 • Pharsight Corp • Services-prepackaged software • California

As we discussed, this letter sets forth the terms and conditions of your new employment agreement (the “Agreement”) with PHARSIGHT CORPORATION (“Pharsight” or the “Company”).

LOAN AND SECURITY AGREEMENT SILICON VALLEY BANK and PHARSIGHT, INC. June 13, 2001
Loan and Security Agreement • June 27th, 2002 • Pharsight Corp • Services-prepackaged software • Delaware

This LOAN AND SECURITY AGREEMENT (this “Agreement”) dated June 13, 2001, between SILICON VALLEY BANK (“Bank”) and PHARSIGHT, INC., a Delaware corporation (“Borrower”), provides the terms on which Bank will lend to Borrower and Borrower will repay Bank. The parties agree as follows:

EIGHTH AMENDMENT TO LOAN AND SECURITY AGREEMENT
Loan and Security Agreement • August 13th, 2008 • Pharsight Corp • Services-prepackaged software

THIS EIGHTH AMENDMENT to Loan and Security Agreement (this “Amendment”) is entered into this 5th day of June, 2008, by and between Silicon Valley Bank (“Bank”) and Pharsight Corporation, a Delaware corporation (“Borrower”) whose address is 321 East Evelyn Avenue, 3rd Floor, Mountain View, California 94041.

March 20, 2003
Pharsight Corp • June 10th, 2003 • Services-prepackaged software

As we have discussed with you, Pharsight Corporation (the “Company”) in conjunction with Execustaff, Inc., is pleased to offer you a promotion to the position of Chief Executive Officer under the terms set forth in this letter. Your promotion and the terms set forth in this letter agreement (“Agreement”) shall be effective as of February 13, 2003.

VOTING AGREEMENT
Voting Agreement • September 9th, 2008 • Pharsight Corp • Services-prepackaged software • Delaware

VOTING AGREEMENT, dated as of September 8, 2008 (this “Agreement”) between Tripos (DE), Inc., a Delaware corporation (“Parent”), and the person listed as “Stockholder” on the signature page hereto (“Stockholder”).

RECITALS
Certain • August 4th, 2000 • Pharsight Corp • Services-prepackaged software • California
LOAN MODIFICATION AGREEMENT
Loan Modification Agreement • July 1st, 2002 • Pharsight Corp • Services-prepackaged software

This Loan Modification Agreement is entered into as of June 13, 2002, by and between PHARSIGHT, INC. (the “Borrower”) and Silicon Valley Bank (“Bank”).

LOAN MODIFICATION AGREEMENT
Loan Modification Agreement • June 29th, 2005 • Pharsight Corp • Services-prepackaged software

This Loan Modification Agreement is entered into as of February 10, 2005, by and between Pharsight Corporation (the “Borrower”) and Silicon Valley Bank (“Bank”).

November 16, 2001 VIA HAND DELIVERY Mike Emley Dear Mike:
Pharsight Corp • February 14th, 2002 • Services-prepackaged software

This letter sets forth the substance of the separation agreement (the “Agreement”) that Pharsight Corporation (the “Company”) is offering to you to aid in your employment transition.

LOAN MODIFICATION AGREEMENT
Loan Modification Agreement • July 6th, 2005 • Pharsight Corp • Services-prepackaged software

This Loan Modification Agreement is entered into as of June 20, 2005, by and between PHARSIGHT CORPORATION (the “Borrower”) and Silicon Valley Bank (“Bank”).

NEGATIVE PLEDGE AGREEMENT
Negative Pledge Agreement • June 27th, 2002 • Pharsight Corp • Services-prepackaged software

In connection with, among other documents, the Loan and Security Agreement (the “Loan Documents’) being concurrently executed herewith between Borrower and Bank, Borrower agrees as follows:

October 16, 2002 Alloy Ventures
Pharsight Corp • February 13th, 2003 • Services-prepackaged software
March 13, 2003
Information and Inventions Agreement • June 10th, 2003 • Pharsight Corp • Services-prepackaged software • California

As we have discussed, Pharsight Corporation (“Pharsight” or the “Company”) is offering you continued employment through April 30, 2003 and severance benefits under the terms and conditions set forth below (the “Agreement”).

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