Exhibit 4.1 SECOND AMENDED AND RESTATED STOCKHOLDERS AGREEMENT SECOND AMENDED AND RESTATED STOCKHOLDERS AGREEMENT dated as of the 23rd day of December, 1999, by and among ORAPHARMA, INC., a Delaware corporation (the "Company"), and those stockholders...Stockholders Agreement • December 30th, 1999 • Orapharma Inc • New Jersey
RECITALS --------License Agreement • March 8th, 2000 • Orapharma Inc • Pharmaceutical preparations • Minnesota
BACKGROUNDRights Agreement • November 13th, 2002 • Orapharma Inc • Pharmaceutical preparations • New York
Exhibit 1.1 ----------- JOINT FILING AGREEMENT The undersigned hereby agree that the Statement on this Schedule 13G/A, dated February 14, 2003, (the "Schedule 13G/A"), with respect to the Common Stock, par value $0.001 per share, of Orapharma, Inc. is...Joint Filing Agreement • February 14th, 2003 • Orapharma Inc • Pharmaceutical preparations
The undersigned hereby agree that the Statement on this Schedule 13G/A, dated February 14, 2003, (the "Schedule 13G/A"), with respect to the Common Stock, par value $0.001 per share, of Orapharma, Inc. is filed on behalf of each of us pursuant to and in accordance with the provisions of Rule 13d-1(k) under the Securities and Exchange Act of 1934, as amended, and that this Agreement shall be included as an Exhibit to this Schedule 13G/A. Each of the undersigned agrees to be responsible for the timely filing of the Schedule 13G/A, and for the completeness and accuracy of the information concerning itself contained therein. This Agreement may be executed in any number of counterparts, all of which taken together shall constitute one and the same instrument. same instrument.
STOCK PURCHASE AGREEMENT (this "Agreement") dated as of the 23 day of --------- December, 1999, by and among OraPharma, Inc., a Delaware corporation (theStock Purchase Agreement • December 30th, 1999 • Orapharma Inc • New Jersey
Exhibit 4.11 RESTRICTED STOCK AGREEMENT --------------------------Restricted Stock Agreement • December 30th, 1999 • Orapharma Inc • New Jersey
EXHIBIT 2.2Stockholder Agreement • November 13th, 2002 • Orapharma Inc • Pharmaceutical preparations • Delaware
andRights Agreement • August 16th, 2002 • Orapharma Inc • Pharmaceutical preparations • New York
Exhibit 10.7 LICENSE AGREEMENTLicense Agreement • December 30th, 1999 • Orapharma Inc • New York
Exhibit 10.16 DISTRIBUTION AGREEMENT This AGREEMENT (the "Agreement") dated as of August 19, 2002 (the "Effective Date") between Kensey Nash Corporation, a Delaware corporation, having its principal place of business at 55 East Uwchlan Avenue, Exton,...Confidential Treatment • November 6th, 2002 • Orapharma Inc • Pharmaceutical preparations • Pennsylvania
AGREEMENT ---------Loan Modification Agreement • February 22nd, 2000 • Orapharma Inc • Pharmaceutical preparations • Massachusetts
forLease • March 8th, 2000 • Orapharma Inc • Pharmaceutical preparations • Pennsylvania
THIS RESTRICTED STOCK PURCHASE AGREEMENT (this "Agreement") is dated as of --------- the 26th day of February, 1997, by and between OraPharma, Inc., a Delaware corporation (the "Corporation") and Oak VI Affiliates Fund, Limited Partnership,...Restricted Stock Purchase Agreement • February 7th, 2000 • Orapharma Inc • Pharmaceutical preparations • New Jersey
AmongAgreement and Plan of Merger • November 13th, 2002 • Orapharma Inc • Pharmaceutical preparations • Delaware
Exhibit 10.15 DISTRIBUTION AGREEMENT ---------------------- This Distribution Agreement ("Agreement") is made as of March 28, 2001 (the "Effective Date"), between OraPharma, Inc., a Delaware corporation, having its principal place of business at 732...Distribution Agreement • May 10th, 2001 • Orapharma Inc • Pharmaceutical preparations • Tennessee
AGREEMENTAgreement • March 8th, 2000 • Orapharma Inc • Pharmaceutical preparations • New Jersey
Exhibit 4.13 RESTRICTED STOCK PURCHASE AGREEMENT -----------------------------------Restricted Stock Purchase Agreement • December 30th, 1999 • Orapharma Inc • New Jersey
Exhibit 4.12 THIS WARRANT AND THE SECURITIES TO BE ISSUED UPON EXERCISE HEREOF HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR THE SECURITIES LAWS OF ANY STATE AND MAY NOT BE OFFERED, SOLD, TRANSFERRED, PLEDGED, HYPOTHECATED...Stock Warrant Agreement • December 30th, 1999 • Orapharma Inc • New York
RECITALSManufacture and Supply Agreement • May 10th, 2001 • Orapharma Inc • Pharmaceutical preparations • North Carolina
Exhibit 10.5 CHILDREN'S HOSPITAL SPONSORED RESEARCH AGREEMENT THIS AGREEMENT is entered into effective the 31st day of December, 1998 (the "Effective Date") by and between CHILDREN'S HOSPITAL, a charitable corporation duly organized and existing under...S Hospital Sponsored Research Agreement • March 8th, 2000 • Orapharma Inc • Pharmaceutical preparations • Massachusetts
EXHIBIT 1.1 Underwriting Agreement March [__], 2000 FleetBoston Robertson Stephens Inc. U.S. Bancorp Piper Jaffray Inc. Gerard Klauer Mattison & Co., Inc. As Representatives of the Several Underwriters c/o FleetBoston Robertson Stephens Inc. 555...Underwriting Agreement • February 28th, 2000 • Orapharma Inc • Pharmaceutical preparations • New York
STOCK PURCHASE AGREEMENT (this "Agreement") dated as of the 26th day of --------- February, 1997 by and among OraPharma, Inc., a Delaware corporation (the "Company"), and the persons listed on Schedule 1 attached hereto (the "Buyers"). ------- ------7 Stock Purchase Agreement • February 7th, 2000 • Orapharma Inc • Pharmaceutical preparations • New Jersey
FIRST AMENDMENTOrapharma Inc • March 27th, 2001 • Pharmaceutical preparations
Exhibit 10.8 RESEARCH AND CONSULTING AGREEMENTResearch and Consulting Agreement • December 30th, 1999 • Orapharma Inc • New York
STOCK PURCHASE AGREEMENT (this "Agreement") dated as of the 1st day of --------- December, 1998, by and among OraPharma, Inc., a Delaware corporation (the8 Stock Purchase Agreement • February 7th, 2000 • Orapharma Inc • Pharmaceutical preparations • New Jersey
Exhibit 10.6 EXCLUSIVE LICENSE AGREEMENT This Agreement is made and entered into as of December 31, 1998 (the Effective Date), by and between CHILDREN'S MEDICAL CENTER CORPORATION, a charitable corporation duly organized and existing under the laws of...Exclusive License Agreement • December 30th, 1999 • Orapharma Inc • Massachusetts
Exhibit 4.32 THIS WARRANT AND THE SECURITIES TO BE ISSUED UPON EXERCISE HEREOF HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR THE SECURITIES LAWS OF ANY STATE AND MAY NOT BE OFFERED, SOLD, TRANSFERRED, PLEDGED, HYPOTHECATED...Stock Warrant Agreement • February 7th, 2000 • Orapharma Inc • Pharmaceutical preparations • New York
AGREEMENT ---------Orapharma Inc • December 30th, 1999 • New Jersey
BACKGROUNDPackaging Agreement • March 27th, 2001 • Orapharma Inc • Pharmaceutical preparations • Pennsylvania
RECITALSManufacture and Supply Agreement • March 27th, 2001 • Orapharma Inc • Pharmaceutical preparations • North Carolina
