Common use of Xxxxx Xxxx Clause in Contracts

Xxxxx Xxxx. Xxxxxx Kanarek -------------------------------------- Xxx: 000-000-6406 Print Name: Sven H. Borho Fxx: 000-000-6444 Print Tixxx: Xxxxxxx; OrbiMed Advisors LLC Subscriptiox Xxxxxx: $023,710.69 ------------------- Shares Purchased: 49,673 ----------------------- SECURITY DELIVERY INSTRUCTIONS (IF DIFFERENT THAN NOTICE ADDRESS) [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT] KNIGHTSBRIDGE POST VENTURE IV L.P. --------------------------------------- Address for Notice: Print Entity Name ------------------ OrbiMed Advisors LLC 767 Third Avenue 00xx Xxxxx Xxx Xxxx, XX 00000

Xxxxx Xxxx. Xxxxxx Kanarek Xxxarek -------------------------------------- XxxTel: 000-000-6406 0000 Print Name: Sven H. Borho FxxFax: 000-000-6444 0000 Print TixxxTitle: Xxxxxxx; OrbiMed XxxiMed Advisors LLC Subscriptiox Xxxxxx: $023,710.69 00,472 ------------------- Shares Purchased: 49,673 2,400 ----------------------- SECURITY DELIVERY INSTRUCTIONS (IF DIFFERENT THAN NOTICE ADDRESS) [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT] KNIGHTSBRIDGE POST VENTURE CAPITAL IV L.P. --------------------------------------- Address for Notice: Print Entity Name ------------------ OrbiMed Advisors LLC 767 Third Avenue 00xx Xxxxx Avenue, 30th Floor Xxx Xxxx, XX 00000

Xxxxx Xxxx. Xxxxxx Kanarek -------------------------------------- Xxx: 000-000-6406 Print Name: Sven H. Borho Fxx: 000-000-6444 Print Tixxx: Xxxxxxx; OrbiMed Advisors LLC Subscriptiox Xxxxxx: $023,710.69 007,080 ------------------- Shares Purchased: 49,673 36,000 ----------------------- SECURITY DELIVERY INSTRUCTIONS (IF DIFFERENT THAN NOTICE ADDRESS) [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT] KNIGHTSBRIDGE POST VENTURE IV NETHERLANDS II, L.P. --------------------------------------- ----------------------------------- Address for Notice: Print Entity Name ------------------ OrbiMed Advisors LLC 767 Third Avenue 00xx Xxxxx Xxx Xxxx, XX 00000

Xxxxx Xxxx. Xxxxxx Kanarek Xxxarek -------------------------------------- XxxTel: 000-000-6406 0000 Print Name: Sven H. Borho FxxFax: 000-000-6444 0000 Print TixxxTitle: Xxxxxxx; OrbiMed XxxiMed Advisors LLC Subscriptiox Xxxxxx: $023,710.69 07,768 ------------------- Shares Purchased: 49,673 5,600 ----------------------- SECURITY DELIVERY INSTRUCTIONS (IF DIFFERENT THAN NOTICE ADDRESS) [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT] KNIGHTSBRIDGE POST VENTURE IV L.P. --------------------------------------- INTEGRATED HOLDINGS II LIMITED ------------------------------------------- Address for Notice: Print Entity Name ------------------ OrbiMed Advisors LLC 767 Third Avenue 00xx Xxxxx Avenue, 30th Floor Xxx Xxxx, XX 00000

Xxxxx Xxxx. Xxxxxx Kanarek -------------------------------------- Xxx: 000-000-6406 Print Name: Sven H. Borho Fxx: 000-000-6444 Print Tixxx: Xxxxxxx; OrbiMed Advisors LLC Subscriptiox Xxxxxx: $023,710.69 019,477 ------------------- Shares Purchased: 49,673 60,900 ----------------------- SECURITY DELIVERY INSTRUCTIONS (IF DIFFERENT THAN NOTICE ADDRESS) [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT] KNIGHTSBRIDGE POST VENTURE IV L.P. CAPITAL III LP --------------------------------------- Address for Notice: Print Entity Name ------------------ OrbiMed Advisors LLC 767 Third Avenue 00xx Xxxxx Avenue, 30th Floor Xxx Xxxx, XX 00000

Xxxxx Xxxx. Xxxxxx Kanarek -------------------------------------- Xxx: 000-000-6406 Print Name: Sven H. Borho Fxx: 000-000-6444 Print Tixxx: Xxxxxxx; OrbiMed Advisors LLC Subscriptiox Xxxxxx: $023,710.69 068,041 ------------------- Shares Purchased: 49,673 19,700 ----------------------- SECURITY DELIVERY INSTRUCTIONS (IF DIFFERENT THAN NOTICE ADDRESS) [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT] KNIGHTSBRIDGE POST VENTURE IV L.P. --------------------------------------- INTEGRATED HOLDINGS, V, LP ----------------------------------------- Address for Notice: Print Entity Name ------------------ OrbiMed Advisors LLC 767 Third Avenue 00xx Xxxxx Xxx Xxxx, XX 00000

Xxxxx Xxxx. Xxxxxx Kanarek Xanarek -------------------------------------- XxxTxx: 000-000-6406 0006 Print Name: Sven H. Borho FxxFax: 000-000-6444 0044 Print TixxxTitlx: Xxxxxxx; OrbiMed XrbiMed Advisors LLC Subscriptiox Xxxxxx: $023,710.69 001,962 ------------------- Shares Purchased: 49,673 35,400 ----------------------- SECURITY DELIVERY INSTRUCTIONS (IF DIFFERENT THAN NOTICE ADDRESS) [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT] KNIGHTSBRIDGE INTEGRATED HOLDINGS IV POST VENTURE IV L.P. --------------------------------------- VENTURE, LP ---------------------------------------------------- Address for Notice: Print Entity Name ------------------ OrbiMed Advisors LLC 767 Third Avenue 00xx Xxxxx Xxx Xxxx, XX 00000

Xxxxx Xxxx. Xxxxxx Kanarek Xxxarek -------------------------------------- XxxTel: 000-000-6406 0000 Print Name: Sven H. Borho FxxFax: 000-000-6444 0000 Print TixxxTitle: Xxxxxxx; OrbiMed XxxiMed Advisors LLC Subscriptiox Xxxxxx: $023,710.69 021,581 ------------------- Shares Purchased: 49,673 37,700 ----------------------- SECURITY DELIVERY INSTRUCTIONS (IF DIFFERENT THAN NOTICE ADDRESS) [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT] KNIGHTSBRIDGE POST VENTURE IV L.P. --------------------------------------- NETHERLANDS III - LP ------------------------------------------- Address for Notice: Print Entity Name ------------------ OrbiMed Advisors LLC 767 Third Avenue 00xx Xxxxx Avenue, 30th Floor Xxx Xxxx, XX 00000

Xxxxx Xxxx. Xxxxxx Kanarek Xxxarek -------------------------------------- XxxTel: 000-000-6406 0000 Print Name: Sven H. Borho FxxFax: 000-000-6444 0000 Print TixxxTitle: Xxxxxxx; OrbiMed XxxiMed Advisors LLC Subscriptiox Xxxxxx: $023,710.69 07,768 ------------------- Shares Purchased: 49,673 5,600 ----------------------- SECURITY DELIVERY INSTRUCTIONS (IF DIFFERENT THAN NOTICE ADDRESS) [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT] KNIGHTSBRIDGE POST VENTURE IV L.P. --------------------------------------- NETHERLAND I LP ----------------------------- Address for Notice: Print Entity Name ------------------ OrbiMed Advisors LLC 767 Third Avenue 00xx Xxxxx Avenue, 30th Floor Xxx Xxxx, XX 00000