Common use of Text Messages Clause in Contracts

Text Messages. If you agree, the study staff, or a company working on behalf of Pfizer, may send text messages using an automated system to remind you of: • Upcoming study appointments • Other study-related information o Standard text messaging rates apply to all text messages. Message rates differ from carrier to carrier. Please contact your wireless phone provider to ask about the details of your plan o The contact information you have provided will be used for the sole purpose of communicating with you about the study o The text messages received through this program may appear on your mobile phone screen as soon as they are received. This may happen even when the phone is locked. These messages could be seen and read by others who are near your phone when the message is received o To discontinue receiving text messages, please contact the Pfizer New Haven CRU at 000-000-0000 You will be asked to make your choice at the end of this document. What happens to my personal information that is sent outside the CRU? Before the study staff transfers your personal information outside the CRU, the study staff will: • Replace your name with a unique code • Remove information that directly identifies you This is called "Coded Information". The link between the code and your personal information will be kept confidential by the study staff. Your Coded Information will be used by the following: • Pfizer and its representatives (including its affiliated companies) • People and/or organizations providing services to or collaborating with Pfizer • Any organization that obtains all or part of Pfizer's business or the rights to the product under study • Other researchers • Advarra IRB • Government or regulatory authorities The above parties may use your coded information for the following purposes: • Conducting the study, including: o Examining your response to the study drug o Understanding the study and the study results and learning more about metastatic or advanced solid tumor o Assessing the safety of the study drug • Complying with legal and regulatory duties such as: o Ensuring the study is conducted according to good clinical practice o Making required disclosures to IRB(s), or government or regulatory authorities o Seeking approval from government or regulatory authorities to market the study drug ▪ It is possible that these government or regulatory authorities may disclose your Coded Information to other researchers for the conduct of future scientific research o Sharing study data with other researchers not affiliated with the study staff or Pfizer. This includes through publication on the internet or other ways. However, information that could directly identify you will not be made available to other researchers • Publishing summaries of the study results: o In medical journals o On the internet o At educational meetings of other researchers You will not be directly identified in any publication or report of the study. But some journal representatives may need access to your Coded Information to verify the study results and ensure the research meets the journal's quality standards. Also, journals may require that genetic and other information from the study that does not directly identify you be made available to other researchers for further research projects. • Improving the quality, design, and safety of this study and other research studies How are my biological samples handled? If biological samples are taken during the study, those samples will be handled in the same way as your Coded Information. All samples will be treated as required by law. Can my coded information and biological samples be used for other research? Your Coded Information and biological samples may be used in other research projects to advance scientific research and public health. At this time, we do not know the specific details of these other research projects.

Text Messages. If you agree, the study staff, or a company working on behalf of Pfizer, may send text messages using an automated system to remind you of: •  Upcoming study appointments •  Other study-related information o Standard text messaging rates apply to all text messages. Message rates differ from carrier to carrier. Please contact your wireless phone provider to ask about the details of your plan o The contact information you have provided will be used for the sole purpose of communicating with you about the study o The text messages received through this program may appear on your mobile phone screen as soon as they are received. This may happen even when the phone is locked. These messages could be seen and read by others who are near your phone when the message is received o To discontinue receiving text messages, please contact the Pfizer New Haven CRU at 000-000-0000 You will be asked to make your choice at the end of this document. What happens to my personal information that is sent outside the CRU? Before the study staff transfers your personal information outside the CRU, the study staff will: •  Replace your name with a unique code •  Remove information that directly identifies you This is called "Coded Information". The link between the code and your personal information will be kept confidential by the study staff. Your Coded Information will be used by the following: •  Pfizer and its representatives (including its affiliated companies) •  People and/or organizations providing services to or collaborating with Pfizer •  Any organization that obtains all or part of Pfizer's business or the rights to the product under study •  Other researchers •  Advarra IRB •  Government or regulatory authorities The above parties may use your coded information for the following purposes: •  Conducting the study, including: o Examining your response to the study drug o Understanding the study and the study results and learning more about metastatic or advanced solid tumor o Assessing the safety of the study drug •  Complying with legal and regulatory duties such as: o Ensuring the study is conducted according to good clinical practice o Making required disclosures to IRB(s), or government or regulatory authorities o Seeking approval from government or regulatory authorities to market the study drug ▪  It is possible that these government or regulatory authorities may disclose your Coded Information to other researchers for the conduct of future scientific research o Sharing study data with other researchers not affiliated with the study staff or Pfizer. This includes through publication on the internet or other ways. However, information that could directly identify you will not be made available to other researchers •  Publishing summaries of the study results: o In medical journals o On the internet o At educational meetings of other researchers You will not be directly identified in any publication or report of the study. But some journal representatives may need access to your Coded Information to verify the study results and ensure the research meets the journal's quality standards. Also, journals may require that genetic and other information from the study that does not directly identify you be made available to other researchers for further research projects. •  Improving the quality, design, and safety of this study and other research studies How are my biological samples handled? If biological samples are taken during the study, those samples will be handled in the same way as your Coded Information. All samples will be treated as required by law. Can my coded information and biological samples be used for other research? Your Coded Information and biological samples may be used in other research projects to advance scientific research and public health. At this time, we do not know the specific details of these other research projects.

Text Messages. If you agree, the study staff, or a company working on behalf of Pfizer, may send text messages using an automated system to remind you of: • Upcoming study appointments • Other study-related information o Standard text messaging rates apply to all text messages. Message rates differ from carrier to carrier. Please contact your wireless phone provider to ask about the details of your plan o The contact information you have provided will be used for the sole purpose of communicating with you about the study o The text messages received through this program may appear on your mobile phone screen as soon as they are received. This may happen even when the phone is locked. These messages could be seen and read by others who are near your phone when the message is received o To discontinue receiving text messages, please contact the Pfizer New Haven CRU at 000-000-0000 You will be asked to make your choice at the end of this document. What happens to my personal information that is sent outside the CRU? Before the study staff transfers your personal information outside the CRU, the study staff will: • Replace your name with a unique code • Remove information that directly identifies you This is called "Coded Information". The link between the code and your personal information will be kept confidential by the study staff. Your Coded Information will be used by the following: • Pfizer and its representatives (including its affiliated companies) • People and/or organizations providing services to or collaborating with Pfizer • Any organization that obtains all or part of Pfizer's business or the rights to the product under study • Other researchers • Advarra IRB • Government or regulatory authorities The above parties may use your coded information for the following purposes: • Conducting the study, including: o Examining your response to the study drug o Understanding the study and the study results and learning more about metastatic or advanced solid tumor T2DM o Assessing the safety of the study drug • Complying with legal and regulatory duties such as: o Ensuring the study is conducted according to good clinical practice o Making required disclosures to IRB(s), or government or regulatory authorities o Seeking approval from government or regulatory authorities to market the study drug ▪ It is possible that these government or regulatory authorities may disclose your Coded Information to other researchers for the conduct of future scientific research o Sharing study data with other researchers not affiliated with the study staff or Pfizer. This includes through publication on the internet or other ways. However, information that could directly identify you will not be made available to other researchers • Publishing summaries of the study results: o In medical journals o On the internet o At educational meetings of other researchers You will not be directly identified in any publication or report of the study. But some journal representatives may need access to your Coded Information to verify the study results and ensure the research meets the journal's quality standards. Also, journals may require that genetic and other information from the study that does not directly identify you be made available to other researchers for further research projects. • Improving the quality, design, and safety of this study and other research studies How are my biological samples handled? If biological samples are taken during the study, those samples will be handled in the same way as your Coded Information. All samples will be treated as required by law. Can my coded information and biological samples be used for other research? Your Yes. The Sponsor may use your Coded Information Information, biological samples, images and/or audio/video recordings, if collected as part of the study, to support and biological samples may be used in advance other scientific research projects, including: • Improving the quality, design, and safety of other research projects to advance scientific research studies • Research supporting public health aims • Developing medicines, vaccines, diagnostic products, and public healthtools. At this time, we do not know the specific details of these other the research projects, however, your Coded Information, biological samples, images and/or audio/video recordings, if collected as part of the study, could be used in combination with data from other sources not related to you or this study. Reasonable safeguards will be used to protect your Coded Information, biological samples, images and/or audio/video recordings used in any future research and may include: • Limiting access to individuals bound by duties of confidentiality • Taking steps to minimize the risk that you could be reidentified • Obtaining approval of ethical review boards Furthermore, if your Coded Information, biological samples, images and/or audio/video recordings, if collected as part of the study, have identifiers removed such that they can no longer be readily identified with you, they may be used for future research purposes.

Text Messages. If you agree, the study staff, or a company working on behalf of Pfizer, may send text messages using an automated system to remind you of: • Upcoming study appointments • Other study-related information o Standard text messaging rates apply to all text messages. Message rates differ from carrier to carrier. Please contact your wireless phone provider to ask about the details of your plan o The contact information you have provided will be used for the sole purpose of communicating with you about the study o The text messages received through this program may appear on your mobile phone screen as soon as they are received. This may happen even when the phone is locked. These messages could be seen and read by others who are near your phone when the message is received o To discontinue receiving text messages, please contact the Pfizer New Haven CRU at 000-000-0000 You will be asked to make your choice at the end of this document. What happens to my personal information that is sent outside the CRU? Before the study staff transfers your personal information outside the CRU, the study staff will: • Replace your name with a unique code • Remove information that directly identifies you This is called "Coded Information". The link between the code and your personal information will be kept confidential by the study staff. Your Coded Information will be used by the following: • Pfizer and its representatives (including its affiliated companies) • People and/or organizations providing services to or collaborating with Pfizer • Any organization that obtains all or part of Pfizer's business or the rights to the product under study • Other researchers • Advarra IRB • Government or regulatory authorities The above parties may use your coded information for the following purposes: • Conducting the study, including: o Examining your response to the study drug o Understanding the study and the study results and learning more about metastatic or advanced solid tumor COVID-19 o Assessing the safety of the study drug • Complying with legal and regulatory duties such as: o Ensuring the study is conducted according to good clinical practice o Making required disclosures to IRB(s), or government or regulatory authorities o Seeking approval from government or regulatory authorities to market the study drug ▪ It is possible that these government or regulatory authorities may disclose your Coded Information to other researchers for the conduct of future scientific research o Sharing study data with other researchers not affiliated with the study staff or Pfizer. This includes through publication on the internet or other ways. However, information that could directly identify you will not be made available to other researchers • Publishing summaries of the study results: o In medical journals o On the internet o At educational meetings of other researchers You will not be directly identified in any publication or report of the study. But some journal representatives may need access to your Coded Information to verify the study results and ensure the research meets the journal's quality standards. Also, journals may require that genetic and other information from the study that does not directly identify you be made available to other researchers for further research projects. • Improving the quality, design, and safety of this study and other research studies How are my biological samples handled? If biological samples are taken during the study, those samples will be handled in the same way as your Coded Information. All samples will be treated as required by law. Can my coded information and biological samples be used for other research? Your Coded Information and biological samples may be used in other research projects to advance scientific research and public health. At this timeCurrently, we do not know the specific details of these other research projects.

Text Messages. If you agree, the study staff, or a company working on behalf of Pfizer, may send text messages using an automated system to remind you of: • Upcoming study appointments • Other study-related information o Standard text messaging rates apply to all text messages. Message rates differ from carrier to carrier. Please contact your wireless phone provider to ask about the details of your plan o The contact information you have provided will be used for the sole purpose of communicating with you about the study o The text messages received through this program may appear on your mobile phone screen as soon as they are received. This may happen even when the phone is locked. These messages could be seen and read by others who are near your phone when the message is received o To discontinue receiving text messages, please contact the Pfizer New Haven CRU at 000-000-0000 You will be asked to make your choice at the end of this document. What happens to my personal information that is sent outside the CRU? Before the study staff transfers your personal information outside the CRU, the study staff will: • Replace your name with a unique code • Remove information that directly identifies you This is called "Coded Information". The link between the code and your personal information will be kept confidential by the study staff. Your Coded Information will be used by the following: • Pfizer and its representatives (including its affiliated companies) • People and/or organizations providing services to or collaborating with Pfizer • Any organization that obtains all or part of Pfizer's business or the rights to the product under study • Other researchers • Advarra IRB • Government or regulatory authorities The above parties may use your coded information for the following purposes: • Conducting the study, including: o Examining your response to the study drug o Understanding the study and the study results and learning more about metastatic or advanced solid tumor COVID-19 o Assessing the safety of the study drug • Complying with legal and regulatory duties such as: o Ensuring the study is conducted according to good clinical practice o Making required disclosures to IRB(s), or government or regulatory authorities o Seeking approval from government or regulatory authorities to market the study drug ▪ It is possible that these government or regulatory authorities may disclose your Coded Information to other researchers for the conduct of future scientific research o Sharing study data with other researchers not affiliated with the study staff or Pfizer. This includes through publication on the internet or other ways. However, information that could directly identify you will not be made available to other researchers • Publishing summaries of the study results: o In medical journals o On the internet o At educational meetings of other researchers You will not be directly identified in any publication or report of the study. But some journal representatives may need access to your Coded Information to verify the study results and ensure the research meets the journal's quality standards. Also, journals may require that genetic and other information from the study that does not directly identify you be made available to other researchers for further research projects. • Improving the quality, design, and safety of this study and other research studies How are my biological samples handled? If biological samples are taken during the study, those samples will be handled in the same way as your Coded Information. All samples will be treated as required by law. Can my coded information and biological samples be used for other research? Your Coded Information and biological samples may be used in other research projects to advance scientific research and public health. At this time, we do not know the specific details of these other research projects.