TEAM. The laboratory specializes in the genetic analysis of Escherichia coli as well as its phages, plasmids and transposons. The aim of this research is to understand precisely how the poison/antidote systems work by investigating the targets of the poisons and by analy- zing the molecular interactions between poisons and targets in order to develop new classes of antibiotics; by analyzing the molecular interactions between anti- dotes and ATP-dependent proteases; by analyzing the regulation mechanisms that trigger the programmed death of the bacteria caused by these systems. In ad- dition, the laboratory is using the poison/antidote sys- tems to develop innovative technological tools. Some of these tools are now used throughout the world in cloning experiments, i.e. the production of DNA frag- ments which are genetically identical.
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