Common use of Submitting Investigator Clause in Contracts

Submitting Investigator. An investigator who submitted a genomic dataset to an NIH designated data repository (e.g., dbGaP). Study specific DUC addendum phs000734 : A Genome-wide Association Study (GWAS) of Risk for Osteosarcoma Public Posting of Genomic Summary Results - Not Allowed. NIH Data Access Committee (DAC) : NCI DAC Important Contacts : XXXXXX@xxxx.xxx.xxx; XXX@xxxx.xxx.xxx In the event of a data management incident, within 24 hours, please contact emails above. When referencing the GWAS of Risk for Osteosarcoma Dataset(s), please cite the following publication: Xxxxxx XX, Xxxxxxxxx L, Xxxx Z, Xxxxxxx-Xxxxxx XX, Xxxxxxx R, Xxxxxx C, Xxxxxxxx AM, Xxxxxxxxx R, Xxxxxxxx IL, Xxxxxx XX, Xxxxxx N, Xxxxxx-Xxxxxx A, Sierrasesúmaga L, Xxxxxxx F, Xxxxxx N, Xxxxx IE, Sari N, Xxxxx M, Acknowledgement Statement : Hattinger C, Xxxxx P, Xxxxxxx XX, Xxxxxxxxxx DA, Xxxxxx N, xx Xxxxxx SR, Xxxxxxxx AS, Xxxxx XX, Xxxxx D, Xxxxxx XX, Xxxxxxxx C, Xxxxxxx XX, Xxxxxx K, Xxxxx XX, Xxxxxx SI, Xxxxxx MP, Xxxxxxxx NE, Xxxxxx M, Xxxxxxx N, Xxxxx MT, Xxxxxxxxx XX, Xxxxx P, Xxxxxx XX, Xxxxxx N, Kogevinas M, Xxxxxxxxx S, Xxxxxx R, Xxxxxx L, Xxxxxxxx XX Xx, Xxxxxx M, Xxxxxx XX, Xxxxxxx XX. Genome-wide association study identifies two susceptibility loci for osteosarcoma. Nat Genet. 2013 Jul;45(7):799-803. Name : General Research Use Consent Group # : 1 Abbreviation : GRU

Submitting Investigator. An investigator who submitted a genomic dataset to an NIH designated data repository (e.g., dbGaP). Study specific DUC addendum phs000734 phs000812 : A Genome-wide Association Study (GWAS) of Risk for Osteosarcoma Characterizing Genetic Susceptibility to Breast and Prostate Cancer - BPC3 Public Posting of Genomic Summary Results - Not Allowed. NIH Data Access Committee (DAC) : NCI DAC Important Contacts : XXXXXX@xxxx.xxx.xxx; XXX@xxxx.xxx.xxx In the event of a data management incident, within 24 hours, please contact emails above. When referencing The Breast and Prostate Cancer Cohort Consortium (BPC3) genome-wide association studies of advanced prostate cancer and estrogen-receptor negative breast cancer was supported by the GWAS National Cancer Institute under cooperative agreements U01-CA98233, U01-CA98710, U01-CA98216, and U01-CA98758 and the Intramural Research Program of Risk for Osteosarcoma Dataset(s)the National Cancer Institute, please Division of Cancer Epidemiology and Genetics. The BPC3 investigators request that publications resulting from the use of these data cite the following publicationtheir original publications, as relevant: Xxxxxxxxxx FR, Xxxxxx SI, Xxxxxx A, Xxxxxx KB, Xxxx Z, Xxxxxxxxx S, Xxxxxxx XX, Xxxx C, Xxxxxx AM, Xxxxxx XX, Xxxxx DO, Xxxxx XX, Xxxxxx XX, Xxxxx G, Xxxxxx XX, Xxxx DE, Xxxxx FC, Xxxxxxx XX, Xxxx K, Xx Xxxxx AA, Xxxx-Xxxxx Z, Xxx X, Xxxxxx G, Xxxxxxxx H, Xxxxxx XX, Xxxxxxxx R, Xxxxxxx F, Xx J, Xxxxx NE, Xxxxxxxx XX, Xxxxxxxxxx A, Boeing H, Xxxxx-xx-Xxxxxxxx HB, Xxxxxxxx XX, Xxxxx XX, Xxxxxxxx CA, Xxxxxxx XX, Xxxxxxxxxxx EL, Xxxxxxxxx M, Xx Xxxxxxxx L, Xx J, Xxxxx S, Xxxxxxx P, Xxxxxxxx XX, Xxxxxxxxxx A, Xxxxxx P, Xxxxxxx J, Xxxxx U, Xxxxxxxxx XX, Xxxxxx M, Xxxx XX, Xxxxxxx LN, Xxxxxxxxx BE, Xxxxxxx D, Xxxxx XX, Xxxxxxxxx XX, Xxxxxx E, Xxxxxx XX, Xxxxxxx XX, Xxxxxx CA, Xxxxx P. Genome-wide association study identifies new prostate cancer susceptibility loci. Hum Mol Genet. 2011 Oct 1;20(19):3867-75. Acknowledgement Statement : Siddiq A, Xxxxx XX, Xxxx XX, Xxxxxxxxx S, Xxxxxx D, Xxxxxxxx XX, Xxxxxxxxxxx K, Xxxxx DO, Xxxxxxxx L, Xxxx XX, Xxxxxxxxx XX, Xxxxxxxxx K, Xxxxxx P, Xxxxxxxx C; Australian Breast Cancer Tissue Bank Investigators, Xxxxxxxxx L, Xxxxxxx EV, Xxxxxxxx XX, Xxxx XX, Xxxxxxxxx L, Xxxx ZXxxxxxxxx C, Xxxxxxx-Xxxxxx H, Xxxxxxx L, Xxx QM, Xxxxxx XX, Xxxx SS, Xxxxx D, Xxxxxxxxx XX, Xxxxxxx RDI, Xxxxx-Xxxxxx X, Xxxx C, Xxxxxx-Xxxxxxxx AMF, Xxxxxxxxx RXxx A, Xxxxxxxx ILXxxxx SS, Xxxxx K, Xxxxxx XX, Xxxxxx NXX, Xxxxx XX, Xxxxxxx AM, Xxxxxx L, Xxxxx XX, Xxxxxxxx PA; Familial Breast Cancer Study, Xxxxxxxxx XX, Xxxxxxxx L, Xxxxxxxx XX, Xxxxxxxx O, Xxxxxx-Xxxxx D, Xxxxxx AXX; GENICA Consortium, Sierrasesúmaga LXxxxx XX, Xxxxxxx FXxxxxxxxx-Xxx JL, Xxxxx XX, xxx Xxxx CH, Xxxxxx AK, Xxxxxx N, Xxxxx IED, Sari NXxxx P, Xxxxxxxxx XX, Xxxxxxxx A, Xxxx R, Xxxxx MJ, Acknowledgement Statement : Hattinger Xxxxxx XX, Xxxxxx XX, Xx XX, Xxxxxxxx S, Xxxxxx XX, Xxxxxxx A, Xxxxxx C, Xxxxxx KB, Xxxx EM, Xxxxxxxxxxx C, Xxxxx R, Xxxxxxx LN, Xxxxxxx GA, Xxxxxxx M, Xx Xxxxxxxx L, Xxx AM, Xxx IM, Xxxxxxx T, Xxxxxxxx P, Xxx J, Xxxx E, Xxxxxxx E, Xxxxxx XX, XxXxxx CA, Xxxxxxx-Xxxxxxxx H, Xxxxxx A, Xxxxx P, Xxxxxx XX, Xxxxxxxxxx XX, Xxxxxx-Myhsok B, Xxxxxxx S, Xxxxxx XX, Xxxxxxx C, Xxxxxxx K, Xxxxx D, Park DJ, Xxxxxx XX, Xxxxxx H, Xxxx J, Xxxxxxx P, Xxxxxx N, Xxxxxxxxxxx F, Xxxxxxx XX, Xxxxxxxxxx DAXX, Xxxxxx NS, xx Xxxxxxx MC, Xxxxxxx XX, Xxxx HP, Press MF, Xxxx E, Xxxxxx SRE, Xxxxxxxx ASXxxxxx PM, Xxxxxxxxxx FR, Xxxxxx G, Xxx Xxxxxx Xxxxx I, Xxxxx J, Xxxx M, Xxxxxx XX, Xxxxx DXxxx XX, Xxxxxx XX, Xxxxxxxx C, Xxxxxxxxxxxx AG, Waisfisz Q, Xxxx X, Xxxx Z, Xxxxxx J, Xxxxxx-Xxxxxxxxx R, Xxxxxxx XX, Xxxxxx KXxx Xxx Xxxx D, Xxxxx W, Xxxxxxx XX, Xxx E, Xxxxxxxxxx H, Xxxxxx XX, Xxxxxx SIXX, Xxxxxx MPXxxxxxxxx BE, Xxxxxxxx NEXxxxxxx XX, Xxxxxx-Xxxxxx M, Xxxxxxx N, Xxxxx MT, Xxxxxxxxx XX, Xxxxx P, Xxxxxx XX, Xxxxxx N, Kogevinas M, Xxxxxxxxx S, Xxxxxx R, Xxxxxx L, Xxxxxxxx XX Xx, Xxxxxx MCA, Xxxxxx XX, Xxxxxxx XX. GenomeA meta-analysis of genome-wide association study studies of breast cancer identifies two novel susceptibility loci for osteosarcomaat 6q14 and 20q11. Nat Hum Mol Genet. 2013 Jul;45(7):7992012 Dec 15;21(24):5373-80384. Name : General Research Use (MDS) Consent Group # : 1 Abbreviation : GRU-MDS Data Use Limitation : Use of the data is limited only by the terms of the model Data Use Certification. Use of the data includes methods development research (e.g., development of software or algorithms). Name : Health/Medical/Biomedical (PUB, MDS) Consent Group # : 2 Abbreviation : HMB-PUB-MDS Data Use Limitation : Use of this data is limited to health/medical/biomedical purposes, does not include the study of population origins or ancestry. Requestor agrees to make results of studies using the data available to the larger scientific community. Use of the data includes methods development research (e.g., development of software or algorithms). Name : Disease-Specific (Breast, Ovarian, or Endometrial Disease, MDS) Consent Group # : 3 Abbreviation : DS-BOED-MDS Data Use Limitation : Use of the data must be related to Breast, Ovarian, or Endometrial Disease. Use of the data includes methods development research (e.g., development of software or algorithms). Name : Cancer in all age groups, other disease in adults only and methods Consent Group # : 4 Abbreviation : CADM The informed consent document signed by the study participants allows use of these data by investigators for Data Use Limitation : discovery and hypothesis generation in the investigation of the genetic contributions to cancer in all age groups

Submitting Investigator. An investigator who submitted a genomic dataset to an NIH designated data repository (e.g., dbGaP). Study specific DUC addendum phs000734 phs001059 : A GenomeMaternal Plasma Folate impacts Differential DNA Methylation in an Epigenome-wide Association Study (GWAS) Meta-Analysis of Risk for Osteosarcoma Newborns Public Posting of Genomic Summary Results - Not Allowed. NIH Data Access Committee (DAC) : NCI NIEHS DAC Important Contacts : XXXXXX@xxxx.xxx.xxxxxxxxxx0@xxxxx.xxx.xxx; XXX@xxxx.xxx.xxx In the event of a data management incident, within 24 hours, please contact emails above. When referencing the GWAS of Risk for Osteosarcoma Dataset(s), please cite the following publicationIC Specific Access Term : Xxxxxx XX, Xxxxxxxxx L, Xxxx Z, Xxxxxxx-Xxxxxx XX, Xxxxxxx R, Xxxxxx C, Xxxxxxxx AM, Xxxxxxxxx R, Xxxxxxxx IL, Xxxxxx XX, Xxxxxx N, Xxxxxx-Xxxxxx A, Sierrasesúmaga L, Xxxxxxx F, Xxxxxx N, Xxxxx IE, Sari N, Xxxxx M, None Acknowledgement Statement : Hattinger CWe acknowledge Xxxxxxx, Xxxxx PBR, Xxxxxxx den Xxxxxx, XX, Xxxxxxxxxx DAXxxxx, Xxxxxx NJF, Xxxxxx, X Xxxxxxxx, S, Xxxxxxx, E, Xxxxxxxx, H, xxx Xxxxx, XX, Xxxxxxxxxxxx, AG, Xxxxxx, A, Xxxxxx, XX, Xxxxx, XX, Xxxxxx, M, Xxxxxxxxxx, XX, Xxxxxxxx, EAP, Xxxxxx, XX, Xxxxxxx, SE, Xxxxxxx, O, Xxxxxx, PM, Xxxxxx, O, Xxxxxxx, A, xx Xxxxxx SRXxxxxxx, Xxxxxxxx ASJ, Xxxxx XXXx, Xxxxx DMC, Xxxxxx XXXxxx, Xxxxxxxx CT, Xxxxxxx XXXxxxxxx, Xxxxxx KSD, Xxxxx XXJaddoe, Xxxxxx SIVWV, Xxxxxx MPXxxxxx, Xxxxxxxx NEW, Xxxxxx MDuijts, Xxxxxxx N, Xxxxx MT, Xxxxxxxxx XX, Xxxxx P, Xxxxxx XX, Xxxxxx N, Kogevinas M, Xxxxxxxxx S, Xxxxxx R, Xxxxxx L, Xxxxxxxx XX Xxand London, Xxxxxx MSJ (PI); the Intramural Research Program of the NIH, Xxxxxx XXNational Institute of Environmental Health Sciences (Z01-ES-49019), Xxxxxxx XXthe NIH Office of Dietary Supplements, the Norwegian Ministry of Health and the Ministry of Education and Research, NIH/NIEHS (contract no. GenomeNO1-ES-75558), NIH/NINDS (grant no. 1 U01 NS 047537-01, the Norwegian Research Council/FUGE (grant no. 151918/S10), Erasmus Medical Center, Rotterdam, the Erasmus University Rotterdam, and the Netherlands Organization for Health Research and Development. Maternal plasma folate impacts differential DNA methylation in an epigenome-wide association study identifies two susceptibility loci for osteosarcomameta-analysis of newborns. Nat Genet. 2013 Jul;45(7):799-803Nature Communications, 2016. Name : General Research Use Consent Group # : 1 Abbreviation : GRU

Submitting Investigator. An investigator who submitted a genomic dataset to an NIH designated data repository (e.g., dbGaP). Study specific DUC addendum phs000734 phs000689 : A GenomeGenomic Analysis of Peripheral T-wide Association Study (GWAS) of Risk for Osteosarcoma Cell Lymphomas Public Posting of Genomic Summary Results - Not Allowed. NIH Data Access Committee (DAC) : NCI DAC Important Contacts : XXXXXX@xxxx.xxx.xxx; XXX@xxxx.xxx.xxx In the event of a data management incident, within 24 hours, please contact emails above. When referencing the GWAS of Risk for Osteosarcoma Dataset(s)Xxxxxx Xxxxxxxx, please cite the following publication: Xxxxxx XXXxxxxxxx, Xxxxxxx Xxxxxxxxxx, Xx-Xxxx Xxx, Xxxxxxx Xxxxxx-Xxxxxxxxxx, Xxxxxxx Xxxxx-Xxxxxx, Xxxxxxx Xxxxxxxxx, Xxxxxxxxx LXxxxx, Xxxx ZXxxxxxxxx Xxxxxxxxxx, Xxxxxxx-X. Xxxxx Xxxxx, Xxxxxx XXXxxxx, Xxxxxxx R, Xxxxxx C, Xxxxxxxx AM, Xxxxxxxxx R, Xxxxxxxx IL, Xxxxxx XX, Xxxxxx N, Xxxxxx-Xxxxxx A, Sierrasesúmaga L, Xxxxxxx F, Xxxxxx N, Xxxxx IE, Sari N, Xxxxx M, Acknowledgement Statement : Hattinger CX. Xxxxxx, Xxxxxx Xxxxxxx, Xxxxxxxx Xxxxxx, Xxxxxxxxx Xxxxxxx, Xxxxxx Xxxxxx, Xxxxxx Xxxxx Xxxxx, Xxxxx PXxxxx, Xxxxxxx XXXxxxxxx, Xxxxxxxxxx DAXxxx Xxxxxxx and Xxxxxx Xxxxxxxx. Recurrent epigenetic, Xxxxxx NRHOA, xx Xxxxxx SR, Xxxxxxxx AS, Xxxxx XX, Xxxxx D, Xxxxxx XX, Xxxxxxxx C, Xxxxxxx XX, Xxxxxx K, Xxxxx XX, Xxxxxx SI, Xxxxxx MP, Xxxxxxxx NE, Xxxxxx M, Xxxxxxx N, Xxxxx MT, Xxxxxxxxx XX, Xxxxx P, Xxxxxx XX, Xxxxxx N, Kogevinas M, Xxxxxxxxx S, Xxxxxx R, Xxxxxx L, Xxxxxxxx XX Xx, Xxxxxx M, Xxxxxx XX, Xxxxxxx XXFYN kinase and immune surveillance escape mutations in peripheral T-cell lymphomas. Genome-wide association study identifies two susceptibility loci for osteosarcoma. Nat Genet. 2013 Jul;45(7):799-803. Nature Genetics (under review) Name : General Research Use Disease-Specific (Cancer, PUB, MDS) Consent Group # : 1 Abbreviation : GRUDS-CA-PUB-MDS Use of the data must be related to Cancer.