Common use of Profit Sharing Clause in Contracts

Profit Sharing. (a) The Commercialization Entities shall share the Collaboration Operating Profit/Loss in the Applicable Commercial Territory on an Eisai Collaboration Product-by-Eisai Collaboration Product basis as set forth below: Commercial Territory Biogen Commercialization Entity’s Percentage Share of Collaboration Operating Profit/Loss Eisai Commercialization Entity’s Percentage Share of Collaboration Operating Profit/Loss United States and its territories 50% 50%

Profit Sharing. (a) The Commercialization Entities shall share the Collaboration Operating Profit/Loss in the Applicable Commercial Territory on an Eisai Collaboration Product-by-Eisai Collaboration Product basis as set forth below: Commercial Territory Biogen Commercialization Entity’s Percentage Share of Collaboration Operating Profit/Loss Eisai Commercialization Entity’s Percentage Share of Collaboration Operating Profit/Loss United States and its territories Asia Territory 50% 50%

Profit Sharing. (a) The Commercialization Entities shall share the Collaboration Operating Profit/Loss in the Applicable Commercial Territory on an Eisai Collaboration Product-by-Eisai Collaboration Product basis as set forth below: Commercial Territory Biogen Commercialization Entity’s Percentage Share of Collaboration Operating Profit/Loss Eisai Commercialization Entity’s Percentage Share of Collaboration Operating Profit/Loss United States and its territories Japan 50% 50%

Profit Sharing. (a) The Commercialization Entities shall share the Collaboration Operating Profit/Loss in the Applicable Commercial Territory on an Eisai Collaboration Product-by-Eisai Collaboration Product basis as set forth below: Commercial Territory Biogen Commercialization Entity’s Percentage Share of Collaboration Operating Profit/Loss Eisai Commercialization Entity’s Percentage Share of Collaboration Operating Profit/Loss United States and its territories European Territory 50% 50%

Profit Sharing. (a) The Commercialization Entities shall share the Collaboration Operating Profit/Loss in the Applicable Commercial Territory on an Eisai Collaboration Product-by-Eisai Collaboration Product basis as set forth below: Commercial Territory Biogen Commercialization Entity’s Percentage Share of Collaboration Operating Profit/Loss Eisai Commercialization Entity’s Percentage Share of Collaboration Operating Profit/Loss United States and its territories Rest of World Territory 50% 50%