NMR Sample Clauses

NMR. BA-058 drug substance and degraded BA-058 drug substance will be dissolved in D20 and characterized via two-dimensional NMR experiments to identify any new chemical * Confidential Treatment Requested by the Registrant. Redacted Portion Filed Separately with the Commission. functionalities present in the aged sample. Any differences observed will be analyzed to determine possible chemical reactions responsible for the formation of the impurities. We estimate this work will require [*] hours and 100 mg of BA-058.
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NMR. NMR-based measurements have offered insights into a range of physico-chemical properties including size, shape, and complexation for the study of self-assemblies in solution for decades.113,114 Multiple NMR techniques (1H, 13C, and NMR diffusometry) are adopted for investigating four selected thio-surfactants 2-10, 6-6, 8-6, and 8-8. The results are compared to DTAB and CTAB in water within the same concentration range. In this section, two systems: I. Solutions of Single Thio-surfactant and II. Mixtures of 2-10 or 6-6 with DTAB are studied.

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