Drug Interactions Methylphenidate Sample Clauses

Drug Interactions Methylphenidate. May inhibit the metabolism of coumarin anticoagulants, some anticonvulsants, phenylbutazone and tricyclic antidepressants. The dosage of these drugs may need to be reduced Caution with pressor agents and MAOIs Dexamfetamine Should not be used with MAOI's nor initiated within two weeks of cessation of treatment with an MAOI as may precipitate a hypertensive crisis Adrenoreceptor blocking agents e.g. propranolol, lithium and α methyltyrosine may antagonise the effects of dexamfetamine. Concurrent use with beta blockers may precipitate a hypertensive crisis Use with tricyclic antidepressants may increase risk of cardiovascular side effects Acute dystonias have been noted with concurrent administration of haloperidol Phenothiazines may inhibit the actions of dexamfetamine Dexamfetamine may inhibit the absorption of ethosuximide, phenobarbital and phenytoin Atomoxetine Atomoxetine can be used initially in combination with methylphenidate as trials show no cardiovascular effects beyond that caused with methylphenidate alone Caution with pressor agents or drugs affecting NA, e.g. venlafaxine, mirtazepine Should not be used with MAOI's nor initiated within two weeks of cessation of treatment with an MAOI as may precipitate a hypertensive crisis Caution with drugs which prolong the QT interval e.g. anti-arrhythmics, erythromycin, tricyclic antidepressants, lithium etc Caution in patients on high dose nebulised/systemic salbutamol Caution with drugs which lower the convulsive threshold e.g. tricyclic antidepressants & neuroleptics.
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