Clinical Manifestations Sample Clauses

Clinical Manifestations. LF is usually acquired in early childhood, though symptoms may take many years to develop. Many individuals with LF are asymptomatic. However, despite having no outwardly visible signs of LF, these asymptomatic infections still result in multiplication and transmission of the parasite and damage to the host’s lymphatic system. As the disease progresses, LF can present with acute adenolymphangitis (pain in the lymph nodes, chills, fever), skin rashes, joint pain, and a general sense of malaise [16]. In late-stage chronic cases, over-abundance of parasites can cause blockages in the lymphatic system, clogging the circulation of fluid through tissues. These blockages lead to severe lymphedema and fibrosis (elephantiasis), and hydrocele (scrotal swelling) [17]. In addition, the flow of immune cells is restricted, exacerbating the infection. In these late-stage infections, patients are often amicrofilaraemic, and progression of the disease is mainly caused by secondary bacterial and fungal infections of the affected area, worsened by the damaged lymphatic system . Non-intuitively, those who show the most visible signs of LF are often the least likely to transmit it to others, while those with no symptoms represent a significant reservoir of potential transmission [16]. Beyond extreme pain, disfigurement, and permanent disability, there are significant mental, social, and economic impacts for individuals suffering from LF-related morbidity [3,18–22].
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Related to Clinical Manifestations

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