Common use of CLINICAL INFORMATION Clause in Contracts

CLINICAL INFORMATION. i. Prescribed indications Acamprosate is licenced for the maintenance of abstinence in alcohol dependence combined with counselling ii. Therapeutic summary Acamprosate is a synthetic taurine analogue, which acts as a functional glutamatergic NDMA antagonist and also increases GABAergic function. iii. Dose & Route of administration Adults Weighting: < 60 kg 666mg (2 tablets) at breakfast, 333mg (1 tablet) at midday and 333mg (1 tablet) at night with meals > 60 kg 666mg (2 tablets) three times a day with meals Initiate as soon as possible after abstinence. Acamprosate should not be administered to children or the elderly iv. Duration of treatment Recommended treatment period is 12 months and continued longer only following liaison with community alcohol teams. v. Adverse effects Diarrhoea, nausea, vomiting, abdominal pain, flatulence, pruritus, rashes and fluctuating libido are possible. Should not impair ability to drive or operate machinery. For full information consult SPC vi.

CLINICAL INFORMATION. i. Prescribed indications Acamprosate is licenced for the maintenance of abstinence in alcohol dependence combined with counselling ii. Therapeutic summary Acamprosate is a synthetic taurine analogue, which acts as a functional glutamatergic NDMA antagonist and also increases GABAergic function. iii. Dose & Route of administration Adults Weighting: < 60 kg 666mg (2 tablets) at breakfast, 333mg (1 tablet) at midday and 333mg (1 tablet) at night with meals > 60 kg 666mg (2 tablets) three times a day with meals Initiate as soon as possible after abstinence. Acamprosate should not be administered to children or the elderly iv. Duration of treatment Recommended treatment period is 12 months and continued longer only following liaison with community alcohol teams. To be stopped if drinking persists 4-6 weeks after starting the drug. v. Adverse effects Diarrhoea, nausea, vomiting, abdominal pain, flatulence, pruritus, rashes and fluctuating libido are possible. Should not impair ability to drive or operate machinery. For full information consult SPC vi.