ALBUMIN Sample Clauses

ALBUMIN. At Mallinckrodt's request after it becomes authorized to manufacture any Albunex Product under SECTIONS 2.03(c)(3) AND 7.01(a), MBI shall authorize its vendor to use a portion of the vendor's allocation of USP Human Serum Albumin to MBI to sell to Mallinckrodt for Mallinckrodt to manufacture the Albunex Product in question in the authorized quantities or to manufacture ALBUNEX as reasonably required in connection with Mallinckrodt's limited validated manufacturing.
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ALBUMIN. As albumin binds bilirubin, it is thought that extra administered albumin can lower serum bilirubin levels. However, sufficiently powered trials on the clinical benefits are lacking and albumin administration is not recommended as standard care at this moment.10 A small randomised controlled trial in India by Xxxxxxx et al. showed evidence that albumin administration prior to exchange transfusion is beneficial to lower total serum bilirubin levels post-exchange and lower the mean duration of phototherapy.41 A subsequent randomised controlled trial did not show the same effects.42 The AAP marks it as an option to measure the serum albumin level in neonates with hyperbilirubinaemia and to consider an albumin level below 3.0 g/dL as an extra risk factor to lower the phototherapy threshold. Furthermore, if an exchange transfusion is being considered, the serum albumin level should always be measured and with the bilirubin/albumin ratio used in determining the need for exchange transfusions. Albumin supplementation is not recommended.10
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ALBUMIN. Cisplatin binds preferentially to haemoglobin, followed by albumin.37 The efficient binding to the latter can be explained by the high affinity of platinum to sulfur. Hence, the most likely binding point of cisplatin to albumin is the cysteine-34 residue. Cisplatin irreversible binding leads to cleavage of albumin disulfide bonds, inducing changes in the structure of the protein, thus affecting its activity. Other platinum compounds, such as oxaliplatin (see chapter 1, section 1.3), display the same behaviour with albumin; the interaction between albumin and transplatin is reported to be not very significant.37
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Related to ALBUMIN

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