{"component": "clause", "props": {"groups": [{"size": 6, "snippet_links": [{"key": "except-to-the-extent", "type": "clause", "offset": [0, 20]}, {"key": "applicable-law", "type": "clause", "offset": [45, 59]}, {"key": "legal-process", "type": "definition", "offset": [81, 94]}, {"key": "in-accordance-with", "type": "clause", "offset": [121, 139]}, {"key": "section-124", "type": "clause", "offset": [145, 157]}, {"key": "with-respect-to", "type": "clause", "offset": [181, 196]}, {"key": "public-announcements", "type": "clause", "offset": [255, 275]}, {"key": "press-releases", "type": "definition", "offset": [277, 291]}, {"key": "other-public-disclosures", "type": "clause", "offset": [295, 319]}, {"key": "agreement-or", "type": "definition", "offset": [335, 347]}, {"key": "the-terms", "type": "definition", "offset": [348, 357]}, {"key": "subject-matter", "type": "clause", "offset": [365, 379]}, {"key": "consent-of", "type": "clause", "offset": [456, 466]}, {"key": "confidentiality-obligations", "type": "definition", "offset": [771, 798]}, {"key": "a-third-party", "type": "clause", "offset": [802, 815]}, {"key": "confidential-treatment-requested", "type": "definition", "offset": [910, 942]}, {"key": "for-review", "type": "clause", "offset": [943, 953]}, {"key": "in-advance", "type": "clause", "offset": [991, 1001]}, {"key": "right-to-review", "type": "clause", "offset": [1066, 1081]}, {"key": "changes-to", "type": "clause", "offset": [1096, 1106]}, {"key": "in-good-faith", "type": "definition", "offset": [1148, 1161]}, {"key": "by-novartis", "type": "clause", "offset": [1211, 1222]}, {"key": "regulatory-filings-and-approvals", "type": "definition", "offset": [1519, 1551]}, {"key": "major-markets", "type": "clause", "offset": [1555, 1568]}, {"key": "reimbursement-matters", "type": "clause", "offset": [1570, 1591]}, {"key": "phase-iii-clinical-trials", "type": "definition", "offset": [1620, 1645]}, {"key": "new-indications", "type": "clause", "offset": [1660, 1675]}, {"key": "sales-projections", "type": "clause", "offset": [1734, 1751]}, {"key": "by-akcea", "type": "clause", "offset": [2088, 2096]}, {"key": "notwithstanding-the-foregoing", "type": "clause", "offset": [2098, 2127]}, {"key": "performed-by", "type": "clause", "offset": [2275, 2287]}, {"key": "will-provide", "type": "clause", "offset": [2336, 2348]}, {"key": "review-and-comment-rights", "type": "clause", "offset": [2362, 2387]}, {"key": "mutually-agreed", "type": "definition", "offset": [2506, 2521]}, {"key": "ticker-symbol", "type": "clause", "offset": [2750, 2763]}], "snippet": "Except to the extent required to comply with applicable law, regulation, rule or legal process or as otherwise permitted in accordance with this Section 12.4, after Option Exercise with respect to a Product, neither Akcea nor its Affiliates will make any public announcements, press releases or other public disclosures regarding this Agreement or the terms or the subject matter hereof, or that will materially impact a Product, without the prior written consent of Novartis, which consent will not be unreasonably withheld, conditioned or delayed. If, after Option exercise, Akcea or its Affiliates intend to make any public announcements, press releases or other public disclosures that will materially impact a Product, (i) unless Akcea\u2019s or its Affiliate\u2019s existing confidentiality obligations to a Third Party prohibit it from doing so, Akcea will submit such proposed public disclosure to Novartis * ***Confidential Treatment Requested for review at least [***] ([***]) Business Days in advance of such proposed public disclosure, (ii) Novartis will have the right to review and recommend changes to such communication, and (iii) Akcea will in good faith consider any changes that are timely recommended by Novartis. If, after Option Exercise with respect to a Product, Novartis intends to make any public announcements, press releases or other public disclosures regarding this Agreement or the terms or the subject matter hereof, or that are significant to a Product (limited to disclosures concerning Product regulatory filings and approvals in Major Markets, reimbursement matters in Major Markets, data from Phase III clinical trials or supporting new indications regulatory filings, safety or efficacy issues, pricing or sales projections), (i) Novartis will submit such proposed public disclosure to Akcea for review at least [***] ([***]) Business Days in advance of such proposed public disclosure, (ii) Akcea will have the right to review and recommend changes to such communication, and (iii) Novartis will in good faith consider any changes that are timely recommended by Akcea. Notwithstanding the foregoing, any public announcements, press releases or other public disclosures that involve work conducted by Akcea with a Product will (A) for work solely performed by Akcea, not require Novartis\u2019 consent (but Akcea will provide Novartis the review and comment rights above), (B) for work jointly performed by Novartis and Akcea, be issued jointly by Akcea and Novartis with content as mutually agreed, (C) acknowledge Akcea\u2019s and Ionis\u2019 role in discovering and developing such Product, and (D) contain Akcea\u2019s and Ionis\u2019 stock ticker symbols (e.g., Nasdaq: IONS) only to the extent such public disclosures include Novartis stock ticker symbol.", "samples": [{"hash": "cIfi7ZSFifj", "uri": "/contracts/cIfi7ZSFifj#after-option-exercise", "label": "Strategic Collaboration, Option and License Agreement (Akcea Therapeutics, Inc.)", "score": 28.2717323303, "published": true}, {"hash": "ipMa91ZVQmH", "uri": "/contracts/ipMa91ZVQmH#after-option-exercise", "label": "Strategic Collaboration, Option and License Agreement (Akcea Therapeutics, Inc.)", "score": 28.2334022522, "published": true}, {"hash": "lQsOs6WeYJy", "uri": "/contracts/lQsOs6WeYJy#after-option-exercise", "label": "Strategic Collaboration, Option and License Agreement (Akcea Therapeutics, Inc.)", "score": 28.1184120178, "published": true}], "hash": "9f028c8588dcec9509a8181dd6864701", "id": 1}, {"size": 4, "snippet_links": [{"key": "days-after", "type": "definition", "offset": [26, 36]}, {"key": "will-provide", "type": "clause", "offset": [74, 86]}, {"key": "finished-drug-product", "type": "definition", "offset": [126, 147]}, {"key": "study-material", "type": "definition", "offset": [170, 184]}, {"key": "the-price", "type": "clause", "offset": [239, 248]}, {"key": "receipt-of", "type": "clause", "offset": [350, 360]}, {"key": "inventory-list", "type": "definition", "offset": [366, 380]}, {"key": "written-request", "type": "definition", "offset": [402, 417]}, {"key": "confidential-treatment-requested", "type": "definition", "offset": [763, 795]}, {"key": "by-novartis", "type": "clause", "offset": [813, 824]}, {"key": "by-akcea", "type": "clause", "offset": [845, 853]}, {"key": "provide-the", "type": "clause", "offset": [975, 986]}, {"key": "with-respect-to", "type": "clause", "offset": [1023, 1038]}, {"key": "not-completed", "type": "clause", "offset": [1094, 1107]}, {"key": "during-the-option-period", "type": "clause", "offset": [1108, 1132]}, {"key": "in-accordance-with", "type": "clause", "offset": [1165, 1183]}, {"key": "section-710", "type": "clause", "offset": [1184, 1196]}, {"key": "to-acquire", "type": "definition", "offset": [1355, 1365]}, {"key": "the-parties-will", "type": "clause", "offset": [1382, 1398]}, {"key": "if-required", "type": "definition", "offset": [1598, 1609]}, {"key": "the-parties-shall", "type": "clause", "offset": [1611, 1628]}, {"key": "negotiate-in-good-faith", "type": "definition", "offset": [1629, 1652]}, {"key": "terms-and-conditions-of", "type": "clause", "offset": [1657, 1680]}, {"key": "supply-and-quality-agreement", "type": "definition", "offset": [1683, 1711]}], "snippet": "(a) Within [***] calendar days after Option Exercise for a Product, Akcea will provide Novartis with an inventory of any API, Finished Drug Product and packaged Clinical Study material for such Product in Akcea\u2019s possession (together with the price Akcea was charged by Ionis ([***] for such material). If, within [***] calendar days after Novartis\u2019 receipt of such inventory list, Novartis delivers a written request to Akcea to purchase any such material, then Akcea will sell such material to Novartis [***] ([***]) for such material calculated [***]. Promptly after Akcea receives such order from Novartis, Akcea will ship such material to Novartis and Novartis will pay Akcea within [***] ([***]) calendar days after Novartis\u2019 receipt of such material. * ***Confidential Treatment Requested\n(b) If requested by Novartis and mutually agreed by Akcea (such agreement not to be unreasonably withheld, delayed or conditioned), after Option Exercise, Akcea shall continue to provide the manufacturing transition assistance with respect to any activities contemplated by Section 1.3.2 that were not completed during the Option Period. Novartis will compensate Akcea in accordance with Section 7.10 for Akcea\u2019s and its Affiliates\u2019 activities conducted under this Section 1.3.3(b).\n(c) If, after Option Exercise, Novartis notifies Akcea that Novartis wishes to acquire additional API, the Parties will discuss in good faith and endeavor to mutually agree through the JDCC on the quantity and timelines for the supply of any such additional API on terms and conditions as set forth in SCHEDULE 1.3.\n1. If required, the Parties shall negotiate in good faith the terms and conditions of a Supply and Quality Agreement.", "samples": [{"hash": "cIfi7ZSFifj", "uri": "/contracts/cIfi7ZSFifj#after-option-exercise", "label": "Strategic Collaboration, Option and License Agreement (Akcea Therapeutics, Inc.)", "score": 28.2717323303, "published": true}, {"hash": "ipMa91ZVQmH", "uri": "/contracts/ipMa91ZVQmH#after-option-exercise", "label": "Strategic Collaboration, Option and License Agreement (Akcea Therapeutics, Inc.)", "score": 28.2334022522, "published": true}, {"hash": "lQsOs6WeYJy", "uri": "/contracts/lQsOs6WeYJy#after-option-exercise", "label": "Strategic Collaboration, Option and License Agreement (Akcea Therapeutics, Inc.)", "score": 28.1184120178, "published": true}], "hash": "d545438c260dbb8cadb5b218f0af6d10", "id": 2}, {"size": 4, "snippet_links": [{"key": "crispr-breach-event", "type": "definition", "offset": [5, 24]}, {"key": "with-respect-to", "type": "clause", "offset": [66, 81]}, {"key": "section-1132", "type": "clause", "offset": [176, 190]}, {"key": "the-option", "type": "clause", "offset": [259, 269]}, {"key": "subject-to", "type": "clause", "offset": [282, 292]}, {"key": "in-the-case", "type": "clause", "offset": [319, 330]}, {"key": "crispr-program-breach", "type": "definition", "offset": [336, 357]}, {"key": "collaboration-targets", "type": "definition", "offset": [372, 393]}, {"key": "crispr-agreement-breach", "type": "definition", "offset": [412, 435]}, {"key": "notice-of", "type": "definition", "offset": [459, 468]}, {"key": "full-force-and-effect", "type": "definition", "offset": [541, 562]}, {"key": "to-exercise", "type": "clause", "offset": [662, 673]}, {"key": "rights-under-this-section", "type": "clause", "offset": [678, 703]}, {"key": "sole-remedy", "type": "definition", "offset": [829, 840]}, {"key": "in-connection-with", "type": "clause", "offset": [841, 859]}, {"key": "rights-hereunder", "type": "clause", "offset": [913, 929]}, {"key": "the-relevant", "type": "clause", "offset": [969, 981]}, {"key": "no-obligation-to-cure", "type": "clause", "offset": [1025, 1046]}, {"key": "right-to", "type": "definition", "offset": [1086, 1094]}, {"key": "pursuant-to-this-agreement", "type": "clause", "offset": [1163, 1189]}, {"key": "the-right", "type": "clause", "offset": [1260, 1269]}, {"key": "of-the-parties", "type": "clause", "offset": [1314, 1328]}, {"key": "applicable-law", "type": "clause", "offset": [1423, 1437]}, {"key": "agreement-or", "type": "definition", "offset": [1481, 1493]}, {"key": "capital-expenditures", "type": "clause", "offset": [1554, 1574]}, {"key": "to-the-extent", "type": "clause", "offset": [1619, 1632]}, {"key": "additional-research", "type": "clause", "offset": [1659, 1678]}, {"key": "responsibility-for", "type": "clause", "offset": [1729, 1747]}, {"key": "obligation-to-fund", "type": "clause", "offset": [1798, 1816]}, {"key": "section-74", "type": "clause", "offset": [1848, 1859]}, {"key": "to-assume", "type": "clause", "offset": [1901, 1910]}, {"key": "continue-to-perform", "type": "clause", "offset": [1959, 1978]}, {"key": "to-reimburse", "type": "definition", "offset": [2020, 2032]}, {"key": "research-costs", "type": "clause", "offset": [2044, 2058]}, {"key": "arising-out-of", "type": "definition", "offset": [2059, 2073]}], "snippet": "If a CRISPR Breach Event occurs after Vertex exercises its Option with respect to a particular Collaboration Target, Vertex may elect the alternative remedy provisions of this Section 11.3.2 with respect to any Collaboration Target for which it has exercised the Option and that is subject to such CRISPR Breach Event (in the case of a CRISPR Program Breach), or all such Collaboration Targets (in the case of a CRISPR Agreement Breach), by providing written notice of such election to CRISPR, in which case, this Agreement will continue in full force and effect with the following modifications with respect to each Collaboration Target for which Vertex elects to exercise its rights under this Section 11.3.2, each at Vertex\u2019s election. If Vertex exercises its rights under this Section 11.3.2, such exercise shall be Vertex\u2019s sole remedy in connection with such CRISPR Breach Event; Vertex shall have no other rights hereunder or at law or in equity with respect to the relevant CRISPR Breach Event; and CRISPR shall have no obligation to cure such CRISPR Breach Event.\n(a) CRISPR\u2019s right to [***];\n(b) Vertex may [***] required or permitted [***] established pursuant to this Agreement in connection with the [***]; provided, however, Vertex will not have the right to: (i) [***] of this Agreement; (ii) [***] of the Parties, (iii) [***] under this Agreement; (iv) exercise its [***] would constitute a violation of an Applicable Law; (v) make a determination [***] under this Agreement or (vi) require [***], whether internal or external, including capital expenditures for which [***] as provided herein; and\n(c) to the extent CRISPR is then conducting Additional Research, Vertex may, but will not be obligated to, assume responsibility for such Additional Research, in which case, Vertex\u2019s obligation to fund such activities as provided in Section 7.4 will terminate. If Vertex does not elect to assume responsibility for such activities, CRISPR will continue to perform such activities and Vertex will continue to reimburse CRISPR for Research Costs arising out of such activities as provided herein.", "samples": [{"hash": "550s9kYTeLb", "uri": "/contracts/550s9kYTeLb#after-option-exercise", "label": "Strategic Collaboration, Option and License Agreement (CRISPR Therapeutics AG)", "score": 27.7652301788, "published": true}, {"hash": "jdr0xImj5BW", "uri": "/contracts/jdr0xImj5BW#after-option-exercise", "label": "Strategic Collaboration, Option and License Agreement (CRISPR Therapeutics AG)", "score": 27.516084671, "published": true}, {"hash": "2fcTrAnDc6t", "uri": "/contracts/2fcTrAnDc6t#after-option-exercise", "label": "Strategic Collaboration, Option and License Agreement (Vertex Pharmaceuticals Inc / Ma)", "score": 27.1245727539, "published": true}], "hash": "5b14b4feef242a83c5994dc60072812f", "id": 3}, {"size": 4, "snippet_links": [{"key": "biogen-idec", "type": "definition", "offset": [23, 34]}, {"key": "responsible-for", "type": "clause", "offset": [50, 65]}, {"key": "costs-and-expenses", "type": "definition", "offset": [70, 88]}, {"key": "related-to", "type": "definition", "offset": [89, 99]}, {"key": "the-development", "type": "clause", "offset": [100, 115]}, {"key": "commercialization-of-products", "type": "clause", "offset": [133, 162]}], "snippet": "After Option exercise, Biogen Idec will be solely responsible for the costs and expenses related to the Development, Manufacture and Commercialization of Products.", "samples": [{"hash": "fGQeBomJl4p", "uri": "/contracts/fGQeBomJl4p#after-option-exercise", "label": "Neurology Drug Discovery and Development Collaboration, Option and License Agreement (Isis Pharmaceuticals Inc)", "score": 24.1594791412, "published": true}, {"hash": "2FDnVS8nyJ3", "uri": "/contracts/2FDnVS8nyJ3#after-option-exercise", "label": "DMPK Research, Development, Option and License Agreement (Isis Pharmaceuticals Inc)", "score": 23.5954818726, "published": true}], "hash": "2481984ff1c3aab06991a96d065d91f6", "id": 4}, {"size": 3, "snippet_links": [{"key": "licensed-program", "type": "definition", "offset": [5, 21]}, {"key": "exercise-of-the-option", "type": "clause", "offset": [61, 83]}, {"key": "first-right", "type": "definition", "offset": [120, 131]}, {"key": "the-obligation", "type": "clause", "offset": [141, 155]}, {"key": "action-or-proceeding", "type": "definition", "offset": [182, 202]}, {"key": "a-third-party", "type": "clause", "offset": [211, 224]}, {"key": "infringement-of", "type": "clause", "offset": [229, 244]}, {"key": "program-patent", "type": "definition", "offset": [286, 300]}, {"key": "joint-patent-right", "type": "definition", "offset": [310, 328]}, {"key": "curis-territory", "type": "definition", "offset": [371, 386]}, {"key": "with-respect-to", "type": "clause", "offset": [387, 402]}, {"key": "infringing-activity", "type": "definition", "offset": [407, 426]}, {"key": "program-compound", "type": "definition", "offset": [454, 470]}, {"key": "the-right", "type": "clause", "offset": [560, 569]}, {"key": "action-by", "type": "clause", "offset": [621, 630]}, {"key": "alleged-infringement", "type": "clause", "offset": [759, 779]}, {"key": "time-limit", "type": "definition", "offset": [809, 819]}, {"key": "laws-and-regulations", "type": "clause", "offset": [858, 878]}, {"key": "right-to", "type": "definition", "offset": [963, 971]}], "snippet": "On a Licensed Program-by-Licensed Program basis after Curis\u2019 exercise of the Option for a Program, Curis shall have the first right, but not the obligation, to bring and control any action or proceeding against a Third Party for infringement of any Aurigene Patent Right (including any Program Patent Right or Joint Patent Right) relevant to such Licensed Program in the Curis Territory with respect to any infringing activity that is competitive with a Program Compound or Product, at its own expense and by counsel of its own choice, and Aurigene shall have the right, at its own expense, to be represented in any such action by counsel of its own choice. 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