0001558370-15-001259 Sample Contracts

AMENDMENT TO EMPLOYMENT AGREEMENT
Employment Agreement • July 30th, 2015 • Alkermes Plc. • Pharmaceutical preparations

WHEREAS, Alkermes, Inc., a Pennsylvania corporation (the “Company”) and Mark P. Stejbach of Concord, MA (“Executive”) have previously entered into an Employment Agreement dated as of February 29, 2012 (the “Agreement”); and

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FOURTH AMENDMENT TO LEASE
Lease • July 30th, 2015 • Alkermes Plc. • Pharmaceutical preparations

THIS FOURTH AMENDMENT TO LEASE (this “Amendment”) is made and entered into as of December 30, 2014, by and between GI TC 850 WINTER STREET, LLC, a Delaware limited liability company (“Landlord”), and ALKERMES, INC., a Pennsylvania corporation (“Tenant”).

AMENDMENT TO EMPLOYMENT AGREEMENT
Employment Agreement • July 30th, 2015 • Alkermes Plc. • Pharmaceutical preparations

WHEREAS, Alkermes, Inc., a Pennsylvania corporation (the “Company”) and Iain Brown of Alkermes, Inc. (“Vice President”) have previously entered into an Employment Agreement dated as of the 30th day of September, 2008 (the “Agreement”); and

THIS EXHIBIT HAS BEEN REDACTED AND IS THE SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST. REDACTED MATERIAL IS MARKED WITH "*" AND HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION. ADDENDUM TO MANUFACTURING AND SUPPLY AGREEMENT
Manufacturing and Supply Agreement • July 30th, 2015 • Alkermes Plc. • Pharmaceutical preparations

This Addendum to Manufacturing and Supply Agreement (this "Addendum"), dated as of the 1st day of August, 2001 (the "Effective Date") is by and between JPI PHARMACEUTICA INTERNATIONAL, a division of Cilag AG International Zug, a company duly organized and existing under the laws of\ Switzerland, having its principal office in CH-6300 Zug, Kollerstrasse 38, Switzerland ("JPI") and JANSSEN PHARMACEUTICA Inc., 1125 Trenton-Harbourton Road, Titusville, NJ 08560, USA ("Janssen US" and, together with JPI, "Janssen") on the one hand and Alkermes Controlled Therapeutics Inc. II, a company organized and existing under the laws of the Commonwealth of Pennsylvania, having its principal office at 64 Sidney Street, Cambridge MA 02139-4136, USA ("ACTII") on the other hand.

EMPLOYMENT AGREEMENT
Employment Agreement • July 30th, 2015 • Alkermes Plc. • Pharmaceutical preparations • Massachusetts

This Employment Agreement (“Agreement”) is made as of the 30 day of September 2008 between Alkermes, Inc., a Pennsylvania corporation (the “Company”), and Iain M. Brown (“Vice President”).

LICENSE AGREEMENT
License Agreement • July 30th, 2015 • Alkermes Plc. • Pharmaceutical preparations

This Agreement is made as of the 13 day February of 1996, between MEDISORB TECHNOLOGIES INTERNATIONAL L.P., a Delaware limited partnership (hereinafter "Medisorb") and JANSSEN PHARMACEUTICA INC., a New Jersey corporation ("Janssen US").

AMENDMENT TO MANUFACTURING AND SUPPLY AGREEMENT
Manufacturing and Supply Agreement • July 30th, 2015 • Alkermes Plc. • Pharmaceutical preparations

THIS AMENDMENT (the "Amendment") is made and entered into as of December 22, 2003 to the Manufacturing and Supply Agreement entered into as of August 6, 1997 by and between JPI PHARMACEUTICA INTERNATIONAL, a division of Cilag AG International Zug ("JPI"), JANSSEN PHARMACEUTICA INC. ("JANSSEN US") and ALKERMES CONTROLLED THERAPEUTICS INC. II ("ACT II"), as amended (the "Agreement") (any terms used but not defined herein shall have the meaning set forth in the Agreement).

LICENSE AGREEMENT
License Agreement • July 30th, 2015 • Alkermes Plc. • Pharmaceutical preparations

This Agreement is made as of the 21 day February of 1996, between MEDISORB TECHNOLOGIES INTERNATIONAL L.P., a Delaware limited partnership (hereinafter "Medisorb") and JANSSEN PHARMACEUTICA INTERNATIONAL, a division of Cilag International AG, a Swiss business corporation ("Janssen").

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