0001193125-10-179304 Sample Contracts

NOTE PURCHASE AGREEMENT
Note Purchase Agreement • August 5th, 2010 • Exelixis Inc • Services-commercial physical & biological research • New York

NOTE PURCHASE AGREEMENT (this “Agreement”), dated as of June 2, 2010, between Exelixis, Inc., a Delaware corporation (the “Borrower”), Deerfield Private Design Fund, L.P., a Delaware limited partnership, and Deerfield Private Design International, L.P., a limited partnership organized under the laws of the British Virgin Islands, (individually, a “Purchaser” and together, the “Purchasers” and, together with the Borrower, the “Parties”).

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SECURITY AGREEMENT
Security Agreement • August 5th, 2010 • Exelixis Inc • Services-commercial physical & biological research • New York

This Security Agreement (this “Agreement”), dated as of July 1, 2010, is entered into between Exelixis Inc. (“Obligor”) in favor of Deerfield Private Design Fund, L.P. and Deerfield Private Design International, L.P (together, the “Secured Party”).

REGISTRATION RIGHTS AGREEMENT between EXELIXIS, INC. and SYMPHONY EVOLUTION HOLDINGS LLC Dated as of June 9, 2005
Registration Rights Agreement • August 5th, 2010 • Exelixis Inc • Services-commercial physical & biological research • Delaware

REGISTRATION RIGHTS AGREEMENT (this “Agreement”), dated as of June 9, 2005, by and between EXELIXIS, INC., a Delaware corporation (“Exelixis”), and SYMPHONY EVOLUTION HOLDINGS LLC, a Delaware limited liability company (together with its permitted successors, assigns and transferees, “Holdings”).

TENTH AMENDMENT TO LOAN AND SECURITY AGREEMENT
Loan and Security Agreement • August 5th, 2010 • Exelixis Inc • Services-commercial physical & biological research

THIS TENTH AMENDMENT to Loan and Security Agreement (this “Amendment”) is entered into this 2nd day of June, 2010, by and between Silicon Valley Bank (“Bank”) and Exelixis, Inc., a Delaware corporation (“Borrower”), whose address is 170 Harbor Way, South San Francisco, California 94083.

Second Amendment to the Collaboration Agreement
The Collaboration Agreement • August 5th, 2010 • Exelixis Inc • Services-commercial physical & biological research

This second amendment (the “Second Amendment”) to the Collaboration Agreement dated December 22, 2006 (the “Agreement”) between Exelixis, Inc. (“Exelixis”) and Genentech, Inc. (“Genentech”) is made and entered into by Exelixis and Genentech effective as of April 30, 2010 (the “Second Amendment Effective Date”). All capitalized terms not expressly defined in this Second Amendment shall have the meaning assigned to them in the Agreement.

WARRANT PURCHASE AGREEMENT between EXELIXIS, INC. and SYMPHONY EVOLUTION HOLDINGS, LLC Dated as of June 9, 2005
Warrant Purchase Agreement • August 5th, 2010 • Exelixis Inc • Services-commercial physical & biological research • Delaware

This WARRANT PURCHASE AGREEMENT is dated as of June 9, 2005 (this “Agreement”) by and between Exelixis, Inc., a Delaware corporation (“Exelixis”), and Symphony Evolution Holdings LLC, a Delaware limited liability company (together with its permitted successors, assigns and transferees, “Holdings”).

Re: Additional Terms Re: Termination of Collaboration Agreement Re: XL184
Exelixis Inc • August 5th, 2010 • Services-commercial physical & biological research

This Letter is intended to set forth the Parties’ mutual understandings with respect to the termination of the Agreement with respect to XL184, pursuant to that certain Letter, dated as of the date hereof, from BMS to Exelixis (the “Termination”).

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